Decades of public investment in molecular technologies and data integration techniques have fueled promises of precision medicine (PM) as a novel, targeted, and data-driven approach that takes into...

The convergence of increasingly efficient high throughput sequencing technology and ubiquitous Internet use by the public has fueled the proliferation of companies that provide personal genetic information (PGI) direct-to-consumers. Companies such as 23andme (Mountain View, CA) and Navigenics (Foster City, CA) are emblematic of a growing market for PGI that some argue represents a paradigm shift in how the public values this information and incorporates it into how they behave and plan for their futures. This new class of social networking (...) business ventures that market the science of the personal genome illustrates the new trend in collaborative science. In addition to fostering a consumer empowerment movement, it promotes the trend of democratizing information—openly sharing of data with all interested parties, not just the biomedical researcher—for the purposes of pooling data (increasing statistical power) and escalating the innovation process. This target article discusses the need for new approaches to studying DTC genomics using social network analysis to identify the impact of obtaining, sharing, and using PGI. As a locus of biosociality, DTC personal genomics forges social relationships based on beliefs of common genetic susceptibility that links risk, disease, and group identity. Ethical issues related to the reframing of DTC personal genomic consumers as advocates and research subjects and the creation of new social formations around health research may be identified through social network analysis. (shrink)

Using classical American pragmatism, the authors provide a philosophical framework for rethinking the nature of the corporation--how it is embedded in its natural, technological, cultural, and international environments, emphasizing throughout its pervasive relational and moral dimensions. They explore the relationship of this framework to other contemporary business ethics perspectives, as well as its implications for moral leadership in business and business education.

Although from diverse times and backgrounds, Confucius in the sixth century b. C. In china and immanuael kant in enlightenment both set forth doctrines for ethics and positive social interaction which revolve around the concept of respect. For confucius, Respect takes the form of "jen", What "ought" to occur when two people come together. Individuals are respected as social beings. In kant's case the principle of humanity demands respect for human beings "qua" rational. The difference reveals confucian dynamism versus kantian (...) universalism, Each keynotes of the respective cultural contexts. (shrink)

Must We Mean What We Say? is Stanley Cavell's first book, and, in a sense, it is his most important. It contains all the themes that Cavell continues to develop masterfully throughout his philosophy. There is a renewed usage of J. L. Austin's theory of speech acts, and, in the classic essay “The Availability of Wittgenstein's Later Philosophy,” he establishes the foundations of a radical reading of Ludwig Wittgenstein , the connections among skepticism, acknowledgement, and Shakespearean tragedy ; there is (...) the reflection on the ordinary that runs throughout his later works ; and, finally, there is the original aesthetic approach that defines Cavell's work, through his objects—which range from William Shakespeare to Samuel Beckett and pass through Hollywood comedies and melodrama, and opera—and, above all, through his style and method. (shrink)

Pierre Hadot, professor of ancient philosophy at the Collège de France, published, in the late 1950s and early 1960s, some of the earliest work on Wittgenstein to appear in French. Hadot conceived of philosophy as an activity rather than a body of doctrines and found in Wittgenstein a fruitful point of departure for ethical reflection. Hadot's understanding of philosophy as a spiritual exercise — articulated through his reading of ancient philosophy but also the American transcendentalists Henry David Thoreau and Ralph (...) Waldo Emerson — will find an echo in Wittgenstinian thinkers such as Stanley Cavell and Cora Diamond. Ultimately philosophy for Hadot is a call to personal and political transformation. (shrink)

This volume portrays the Polish or Lvov-Warsaw School, one of the most influential schools in analytic philosophy, which, as discussed in the thorough introduction, presented an alternative working picture of the unity of science.

Precision medicine relies on data and biospecimens from participants who willingly offer their personal information on the promise that this act will ultimately result in knowledge that will improv...

The rise of genomic technologies has catalyzed shifts in the health care landscape through the commercialization of genome sequencing and testing services in the genomics marketplace. The development of consumer genomics into a growing array of information technologies aimed at collecting, curating, and broadly sharing personal data and biological materials reconstitutes the meaning of health and reframes patients into biocitizens. In this context, the good biocitizen is expected to assume personal responsibility for health through consumption of genomic information and acquiescence (...) to public and private efforts at data surveillance and aggregation. These shifts raise fundamental questions about how competing interests of the public, the state, and corporate entities will be reconciled and what trade‐offs are demanded for the promise of precision health. (shrink)

Criminal violence is one of the most pressing problems in Latin America and the Caribbean, with profound political consequences. Its effects on social policy preferences, however, remain largely unexplored. This article argues that to understand such effects it is crucial to analyze victimization experiences and perceptions of insecurity as separate phenomena with distinct attitudinal consequences. Heightened perceptions of insecurity are associated with a reduced demand for public welfare provision, as such perceptions reflect a sense of the state’s failure to provide (...) public security. At the same time, acknowledging the mounting costs and needs that direct experience with crime entails, victimization is expected to increase support for social policies, particularly for health services. Survey data from twenty-four Latin American and Caribbean countries for the period 2008–12 show that perceptions of insecurity indeed reduce support for the state’s role in welfare provision, whereas crime victimization strongly increases such preferences. (shrink)

Environmental crises, which are consequences of resource-intensive lifestyles and are characterized to a large extent by both a changing climate and a loss of biodiversity, stress the urgent need for a global social-ecological transformation of the agro-food system. In this regard, the bioeconomy and bioeconomic innovations have frequently been seen as instrumental in addressing these grand challenges and contributing to more sustainable land use. To date, the question of how much bioeconomic innovations contribute to sustainability objectives remains unanswered. Against this (...) background, we study four bioeconomic innovations using the case study of animal production and manure utilization in relation to their potential contributions to a social-ecological transformation. The analysis is based on the application of analytical categories derived from the literature that assess the normativity of these innovations and their implicit cultural changes. The results show that the innovations examined manifest existing thought styles and the incumbent socio-technical regime rather than contribute to a more fundamental transition. In this respect, we stress the importance of evolving alterative ideas in innovation design, applying more integrative approaches, such as embedding innovation processes into transdisciplinary processes, and developing adaptive and reflective governance approaches. In return, bioeconomic innovations should adjust towards the design mission of a social-ecological transformation and include a multitude of actors to discuss and harmonize contesting imaginaries and ethical concerns. (shrink)

Spanning nearly two decades, from 1980 to 1996, this Reader investigates the debates which have best characterized feminist theory. Including such articles as Pornography and Fantasy, The Body and Cinema, Nature as Female, and A Manifesto for Cyborgs, the extracts examine thoughts on sexualtiy as a domain of exploration, the visual representation of women, what being a feminist means, and why feminists are increasingly involved in political struggles to negotiate the context and meaning of technological development. With writings by bell (...) hooks, Alice Jardine, and Andrea Dworkin, this mulit-cultural Reader reflects the dynamic nature of feminist debates and the genuine diversity within current feminist theory. Capturing the sense of the rapid movement within feminist theory and criticism, Feminisms is ideal for anyone interested in feminism and the history behind it. (shrink)

ABSTRACTBesides physiological, behavioural, and affective effects, romantic love also has cognitive effects. In this study, we tested whether individual differences in infatuation and/or attachment level predict impaired interference control even in the absence of a love booster procedure, and whether individual differences in attachment level predict reduced adaptive cognitive control as measured by conflict adaptation and post-error slowing. Eighty-three young adults who had recently fallen in love completed a Stroop-like task, which yielded reliable indices of interference control and adaptive cognitive (...) control. We did not observe the predicted negative association between infatuation or attachment level and interference control. It might be that reduced interference control with love only happens when people are actively thinking about their beloved. In addition, we observed only weak evidence for the prediction t... (shrink)

The use of robots had already been proven to encourage the promotion of social interaction and skills lacking in children with Autism Spectrum Disorders, who typically have difficulties in recognizing facial expressions and emotions. The main goal of this research is to study the influence of a humanoid robot to develop socio-emotional skills in children with ASD. The children’s performance in game scenarios aiming to develop facial expressions recognition skills is presented. Along the sessions, children who performed the game scenarios (...) with the robot and the experimenter had a significantly better performance than the children who performed the game scenarios without the robot. The main conclusions of this research support that a humanoid robot is a useful tool to develop socio-emotional skills in the intervention of children with ASD, due to the engagement and positive learning outcome observed. (shrink)

This article focuses on the Chinese traditional culture, specifically Confucian philosophy, and analyses four core concepts of Confucianism which include ‘ren’, ‘Jun zi’, ‘Tian ming’, and ‘Xiao ti’. Based on these core concepts, this study explores how social attitudes in China toward people with disabilities are formed and influenced by Confucian philosophy, and how they impact the education of people with disabilities. It suggests that the related social attitudes of sympathy, rights awareness, and criteria of success, especially school performance in (...) this case, can have both positive and negative impacts on inclusive education for children with disabilities. Strategies are suggested for encouraging attitude change, when appropriate, in order to facilitate special education and inclusion and how to do so in a manner that is culturally respectful of the core belie... (shrink)

Human-eyelid conditioning was the principal source of information on Pavlovian conditioning, especially human, in the 1950s and 1960s, but it suffered a sharp decline in productivity, beginning in the late 1960s. The present article treats the decline as a case study with potential implications concerning the survival contingencies of research specialties. We make use of questionnaire data from eyelid-conditioning researchers and examine a variety of publication, topic-of-investigation, and institutional data to identify the major factors in the decline of human-eyelid conditioning.

A correction to this paper has been published: https://doi.org/10.1007/s10551-021-04780-w.

This paper explores the growing array of initiatives aimed at creating corporate accountability with the goal of attempting to uncover the foundation principles that underlie them and create a floor below which practices are ethically questionable. Using the Global Compact's nine principles and the work of Transparency International as guides, foundational principles seem to exist in the areas of human rights, labor standards, environment, and anti-corruption initiatives.