Energy poverty is a problem that affects developed and developing economies, and its mitigation is of great significance to social welfare. EP affects Latin American countries, and policymakers have recently attempted to address this issue, particularly in the aftermath of the recent economic crisis. It is essential to measure and evaluate EP to implement strategies and policies effectively. Using a panel quantile regression approach, we investigate the heterogeneous impact of green finance, renewable energy, and energy efficiency on EP for 33 (...) Latin American countries from 2000 to 2018. Furthermore, certain associated control variables are incorporated into our model to avoid an omitted variable bias. According to empirical results, the impact of independent variables on EP is heterogeneous. Specifically, green finance is an essential source of alleviating EP, and it has a significant positive effect across all quantiles, but it is especially strong in the middle quantiles. RE and EE significantly mitigate EP, with the strongest effects occurring at higher quantiles. By including green finance, RE, and EE as the main explanatory determinants of EP, the findings urge policymakers in Latin American countries to design a comprehensive energy conservation policy to minimize the effects of massive EP. (shrink)

After reading the essays of Mr. Ts'ai and Mr. Chu, I have a few immature opinions. Generally speaking, I feel that in dealing with the errors of their opponents, both Ts'ai I in his criticism of Huang Yüeh-mien and Chu Kuang-ch'ien in his criticism of Ts'ai I are quite accurate and convincing. However, in presenting their own arguments of what is right, both of them are on shaky ground and in error. That is because in one way or another, consciously (...) or unconsciously, they either deny the objective aspect of the existence of beauty or deny the social aspect of the existence of beauty . All of them consider the objective and the social aspects of beauty as being either this or that, as mutually exclusive and irreconcilable opposites. They think that if we acknowledge the social aspect of beauty, we then have to deny the objective aspect, the fact that the existence of beauty does not depend on the subjective conditions of a person ; or if we acknowledge the objective aspect, we have to deny the social aspect, the fact that the existence of beauty depends on the social life of human beings. But in fact it is not like that. On the one hand, beauty cannot be separated from human society; on the other hand, it can have an objective existence which is independent of man's subjective consciousness. It is this question that I shall discuss. (shrink)

The relationship between professional ethical reflection and corresponding moral behavior is an important theme of moral psychology in recent years. Following Schönegger and Wagner’s research in German-speaking countries, through a replication-extension of the original US-based research carried out by Schwitzgebel and Rust, we aim at examining their results in the Chinese context. The previous researchers have shown that ethical reflection generally has no positive effect on moral behavior. A cross validation of this result was conducted in Chinese mainland, and three (...) issues concerning Confucian virtues were added. Through reaching out to 4482 professors and collecting 368 responses altogether, we attempted to explore whether professional ethical reflection can influence normative attitude and the moral attitude-behavior consistency. Unfortunately, the results failed to show a statistically significant difference between ethicists and other professors on most of the moral issues, with the exception of paying academic membership fees and vegetarianism, wherein ethicists do express more stringent normative attitudes, and their moral attitude and self-reported behavior are statistically consistent. Notably, Chinese professors mainly expressed morally neutral attitudes toward the issue of eating meat, and they tended to believe that ethical reflection contributes to more and better moral behaviors. (shrink)

Originally published in Peking in 1958, this work covers four thousand years of Chinese philosophy, into the Marxist philosophy of Mao, which it calls the culmination of the wisdom of the Chinese people.

The "thing-in-itself" theory occupies a pivotal position in the whole of Kantian philosophy, and scholars have expressed varying views on the intricate content of the theory. In the realm of epistemology, the theory implies at least three things: the origin of sensation, the limits of knowledge, and the rational idea. The last implication leads directly to moral reality in the realm of ethics. Interwoven and mutually comprehended, these implications are dipped in the general meaning of agnosticism. The first and third (...) implications are the opposites of a "thing-in-itself," and the second is a transition from the first to the third. (shrink)

This article examines the impact of the prevailing state ownership in the Chinese stock market on corporate governance and the financial regulatory system, respectively, as the internal and external monitoring mechanisms to deter corporate fraud and protect investors. In line with the literature that state ownership exaggerates the agency problem, we find that the retained state ownership in privatised firms increases the incidence of regulatory enforcements against fraud. For the state-owned enterprises (SOEs), however, larger state ownership is associated with a (...) lower incidence of enforcement actions. This is attributed to the mutual political affiliation of the fraudulent SOEs and the regulatory commission. A new regulation "Solutions for Listed Firm Checks" promulgated in March 2001 has mitigated this effect by empowering the regulatory commission to increase the severity of regulatory conditions. Our evidence confirms the improvement in the regulatory environment and investor protection in the Chinese stock market brought about by the regulatory reform and development. (shrink)

In this paper, we reconstruct the debate between Zhuangzi 莊子 and Hui Shi 惠施 that took place on the bridge over the Hao River 濠水 as a substantive debate concerning the epistemic other‐mind skepticism according to which no one mind knows the mental states of the other. We demonstrate how this reconstruction leads to substantive conclusions of the viability of Hui Shi’s position in particular and of the other‐mind skepticism in general. This demonstration is accomplished by means of the contemporary (...) philosophical development regarding, for example, whether asserting a proposition implies that the asserter knows the proposition, whether the closure principle of epistemic logic should be held, and whether knowing something is a mental state. We hold that this debate’s resolution is substantively entangled with contemporary philosophical concerns. (shrink)

CEOs increasingly engage in activism on issues such as gun control, voting rights, and abortion. Although such activism may benefit their firms, the stated goal is often to mobilize the public and precipitate change. In an experiment with 4,578 respondents, we study the effect of CEO activism on people’s willingness to contact their U.S. senators about abortion. On average, showing a CEO message supporting abortion rights is not more effective at mobilizing pro-choice citizens than showing no message or showing a (...) message from other speakers. Additionally, CEOs do not provoke countermobilization by people who oppose abortion. We explore heterogeneous treatment effects and find that CEO activism is better at motivating pro-choice citizens to engage in politics when their senators are Democrats and thus likely receptive to pro-choice activism, consistent with stakeholder alignment theory. Our findings contribute to research on leadership ethics and democracy by examining the ability of CEOs and organizations to foster engagement in the democratic process. (shrink)

The Bertrand oligopoly situation with Shubik’s demand functions is modeled as a cooperative transferable utility game in $$\beta$$ -characteristic function form. To achieve this, two sequential optimization problems are solved to describe the worth of each coalition in the associated Bertrand oligopoly transferable utility game. First, we show that these games are convex, indicating strong incentives for large-scale cooperation between firms. Second, the Shapley value of these games is fully determined by applying the linearity to a decomposition that involves the (...) difference between two convex games and two non-essential games. (shrink)

One task of historians is to construct causal ascription of singular historicals between eminent historical events. For instance, the controversy resulting from the confusing butterfly ballot of Florida’s year 2000 presidential election cost Gore his presidency. However, to research into these matters is inevitably to appeal to counterfactual deliberation in an epistemic fashion because the past is fixed. One standard idea is Max Weber’s, Weber causation: “f was a cause of φ” is assertable iff “¬f □→ ¬φ” is assertable. Reiss (...) gives an exceptionally good analysis of this topic and outlines historians’ reasoning, claiming that backtracking analyses of counterfactual conditionals employed in historical thought experiments is the signature of historical study of causal ascription of singular historicals. Nevertheless, he concludes that it is very difficult to reach an uncontroversial ascription for this sort in most cases. For this reason, he proposes to find difference-making relations that will suffice. The objective of this paper is to provide a more fine-grained, intervention-based, backtracking analysis of counterfactual conditionals upon which a more satisfactory account of causal ascription of singular historicals can be given. Reiss’ account of difference-making relation will be shown to be unsatisfactory. Moreover, a formal ground of the epistemology of historical thought experiments can be given, along with the constraints of this account resultant from the semantic features of non-transitivity and strong centering of counterfactual conditionals. Finally, some epistemological points of causal ascription of singular historicals and historical thought experiments will be given. (shrink)

Currently, there is an increasing trend in the organizations towards examining the artificial intelligence and nonartificial intelligence for the innovation and success of the new product, as well as getting the intentions of the upcoming researchers. Thus, the purpose of the ongoing study is to examine the role of artificial and nonartificial intelligence in the new product success along with the moderating role of new product innovation in the manufacturing organizations of China. The quantitative methods have been followed by the (...) study and gathered the responses from the respondents using questionnaires, and analysis has been conducted by using the smart-PLS. The results exposed that artificial intelligence and nonartificial intelligence have positive and significant nexus with the new product success. The outcomes also revealed that the new product innovation significantly moderated the links among the nonartificial intelligence and new product success, but it insignificantly moderated the links among the artificial intelligence and new product success in the manufacturing organizations of China. These findings have provided the guidelines to the manufacturing companies and their policies developing authorities that they should be developed and implement the suitable policies regarding the adoption of artificial intelligence and nonartificial intelligence that enhance the success of the new product, which ultimately enhances the success of the organization. (shrink)

The main purpose of this article is to introduce the weighted ENSC value for cooperative transferable utility games which takes into account players’ selfishness about the payoff allocations. Similar to Shapley’s idea of a one-by-one formation of the grand coalition [Shapley ], we first provide a procedural implementation of the weighted ENSC value depending on players’ selfishness as well as their marginal contributions to the grand coalition. Second, in the spirit of the nucleolus [Schmeidler ], we prove that the weighted (...) ENSC value is obtained by lexicographically minimizing a complaint vector associated with a new complaint criterion relying on players’ selfishness. (shrink)

The argument from faultless disagreement employed by the relativist purports to show that contextualism falls short of explaining cases of faultless disagreement. The demonstration is intended to give credence to the relativist semantics of epistemic modality expressions. In this paper we present some cases showing that even though cases of faultless disagreement do reveal some intrinsic features of epistemic modality claims, they do not support the relativist semantics. The sophistication of faultless disagreement goes beyond what the relativist semantics can cope (...) with. We also advance an epistemologically oriented proposal to account for faultless disagreement. (shrink)

The Daoist religion is an ancient religion that took root and flourished in China's soil. It was created in the time of Emperor Shundi of the Eastern Han dynasty and today claims a history of over 1,800 years. Its philosophical thought—which is a theory of moral and behavioral discipline whose core is a belief in immortals or supernatural beings —derived its origins from what is called "the teachings of Huang [Huangdi, or the Yellow Emperor] and Lao [Lao Zi]." Consequently, it (...) has always made its claim to being the "successor to the cultural influences of Huang and Lao" , and as such is considered to be one of the principle entities of China's traditional culture. In fact, Mr. Lu Xun went as far as to say: "All of China's roots are in the Daoist religion"1 What, however, are the real contents of the Daoist religion? And what are its cultural functions? (shrink)

Macau, as a society, is a crossroads where East–West encounters have been taking place for centuries. This paper examines some of the contemporary issues and implications for moral education. After a brief introduction to the social background of Macau, the paper describes the characteristics of Macau's education in general and the development of its moral education in particular. This has taken place in the context of the strong influences on morality of both Catholicism and Confucianism. An outline of the current (...) curriculum of moral and civic education is followed by a critical appraisal of its implementation over the last few years. By means of this case study of Macau, the paper argues that a communitarian‐oriented morality in Macau is justified, and it also suggests how, by turning attention to its history, a minimal set of values can be constructed for Macau's particular social setting. Finally, some further educational challenges for Macau's future moral and civic education are reviewed. (shrink)

Highlighting the implications of entrepreneurship education, this study examines the effects of entrepreneurship education in predicting the entrepreneurial intention of university students. The study also explores the mediating role of opportunity recognition and the moderating role of entrepreneurial learning in this process. To test our multilevel-moderated mediation model, based on a dataset containing 1,150 university students from 55 universities in the Guangdong-Hong Kong-Macao Greater Bay Area of China, hierarchical linear modeling is utilized to test the research hypotheses. The findings reveal (...) that entrepreneurship education can promote the entrepreneurial intention of students through opportunity recognition. Furthermore, entrepreneurial learning plays a moderating role in the link between entrepreneurship education and opportunity recognition. Implications for the design and delivery of entrepreneurship education are discussed. (shrink)

Extant literature suggested that executive cognitive ability is a critical perspective to answering why and how enterprises perform business model innovation. However, the effect of executive cognitive ability on business model innovation is still insufficiently explored. Drawing on entrepreneurial bricolage theory, we developed a moderated mediation model which takes entrepreneurial bricolage as the mediating mechanism and environmental dynamics as the moderating mechanism to explain how executive cognitive ability influences business model innovation. We collected the data of 316 executives of Chinese (...) start-ups through questionnaires for the model test. Results showed that new venture executives' cognitive ability significantly positively affects business model innovation by mediating with entrepreneurial bricolage. Environmental dynamism positively moderates the effect of executives' cognitive ability on business model innovation. Moreover, environmental dynamism positively moderates the mediating role of entrepreneurial bricolage in executive cognitive ability and business model innovation. This study broadens the research scope of entrepreneurial bricolage theory from the perspective of cognitive ability and provides ideas for new ventures' business model innovation. (shrink)

The advent of the intelligence age has injected new elements into the development of literature. The synergic modification of Anglo-American traumatic narrative literature by artificial intelligence technology and interactive design psychology will produce new possibilities in literary creation. First, by studying natural language processing technology, this study proposes a modification language model based on the double-layered recurrent neural network algorithm and constructs an intelligent language modification system based on the improved LM model. The results show that the performance of the (...) proposed model is excellent; only about 30% of the respondents like AAL literature; the lack of common cultural background, appreciation difficulties, and language barriers have become the main reasons for the decline of reading willingness of AAL literature. Finally, AI technology and ID psychology are used to modify a famous TN work respectively and synergically, and the modified work is appreciated by respondents to collect their comments. The results corroborate that 62% of the respondents like original articles, but their likability scores have decreased for individually modified work by AI or ID psychology. In comparison, under the synergic modification efforts of AI and ID psychology, the popularity of the modified work has increased slightly, with 65% of the respondents showing a likability to read. Therefore, it is concluded that literary modification by single ID psychology or AI technology will reduce the reading threshold by trading off the literary value of the original work. The core of literary creation depends on human intelligence, and AI might still not be able to generate high-standard literary works independently because human minds and thoughts cannot be controlled and predicted by machines. The research results provide new ideas and improvement directions for the field of AI-assisted writing. (shrink)

It has been assumed that at the whole organismal level, the mitochondrial reactive oxygen species (ROS) production is proportional to the oxygen consumption. Recently, a number of researchers have challenged this assumption, based on the observation that the ROS production per unit oxygen consumed in the resting state of mitochondrial respiration is much higher than that in the active state. Here, we develop a simple model to investigate the validity of the assumption and the challenge of it. The model highlights (...) the significance of the time budget that mitochondria operate in the different respiration states. The model suggests that under three physiologically possible conditions, the difference in ROS production per unit oxygen consumed between the respiration states does not upset the proportionality between the whole animal ROS production and oxygen consumption. The model also shows that mitochondrial uncoupling generally enhances the proportionality. (shrink)

本书是一本研究马克思主义发展理论的书籍. 主要内容包括: 新时期马克思主义中国化理论创新的前提和基础, 新时期马克思主义中国化理论创新的根据和立足点, 新时代马克思主义中国化理论创新的基础轨迹等.

There is a prevalent view against the disquotational and the minimal theories of truth, that the most sensible solution to the Liar—that is, the gappy solution—is not available to them. I would like to argue that, though this solution is unavailable to the two theories, the prevailing argument and the reasoning behind this view are wrong. This paper mainly focuses on Simmons’ “Deflationary Truth and the Liar” (1999), within which the idea that disquotationalism can take the Liar in its stridein (...) terms of the gappy option is thoroughly criticised. Albeit Simmons’ account is about disquotationalism, it is in fact about truth theories with the disquotational feature. For Horwich’s minimal theory of truth to be feasible, it is in need of providing an account of which the primary truth bearers are utterances or sentences. The reasoning behind Simmons’ account and his argument is a widely accepted but in my opinion mistaken reading of deflationary theories, reading the deflationary axiom schemata as emphasising the redundant feature of the true predicate only. By analysing and criticising this reasoning the mistakes of this interpretation of the deflationary theories of truth are revealed. Simmons bases his argument on two premises: taking disquotational theory of truth asdefinitional theory and considering the main feature of the disquotational truth predicate as eliminability. In terms of the notion of parasitic liar, I will argue that Simmons fails to show the plausibility of one crucial premise of his argument—that is, the paradoxical or the pathological feature is missing from the disquotational mirrors of the Liar. I will further show what deflationary feature is misunderstood by those accounts similar to Simmons’. (shrink)

The 85 Lao Zi bamboo slips from around 300 B. C. E. are the earliest texts of what later became known as the Tao Te King. They also contain the-until now-unknown Taoist narrative of Creation 'Great One gave Birth to Water.' These texts are very original and not yet intermingled with Confucian philosophy, governance, or ethics.This English translation presents the Tao Bamboo Slips in modern simplified Chinese characters, with commentaries and a comparison of the modern Chinese version to the old (...) characters. This bilingual Chinese-English publication is a contribution to the crosscultural visions and values of the New SiIk Road of the 21st century. (Series: Practical Ethics-Documentation / Ethik in der Praxis-Materialien, Vol. 16) [Subject: Confucianism, Chinese Studies, Philosophy]. (shrink)

Yen Fu was one of the four representatives who looked to the West for truth before the birth of the Chinese Communist Party. Our research on his life and work is still insufficient. Needless to say, both Yen Fu and Lin Shu were known as famous translators in pre-Liberation days. But Lin Shu cannot be equated with Yen Fu, insofar as their ideological and academic achievements and their contributions to modern China are concerned. From the post-Liberation days to the eve (...) of the Great Cultural Revolution, research works on Yen Fu remained scanty and he was seldom mentioned in articles on the advanced models among modern Chinese thinkers. More articles on Yen Fu appeared during the Criticize-Lin, Criticize-Confucius Campaign because Yen Fu had been mentioned by Chairman Mao. But the "Gang of Four" openly defied Chairman Mao's explicit direction by tampering with modern Chinese history, fabricating the struggle between the Confucians and the Legalists and describing Yen Fu as a Legalist. Chairman Mao pointed out: "Before the May Fourth movement, the struggle on the Chinese cultural front was one between the new bourgeois culture and the old feudal culture, and the antagonisms between modern schools and imperial examinations, between the new learning and the old learning and between Western thought and Chinese thought were all of the same nature." But, in the articles by Liang Hsiao and Lo Ssu-ting, all this has been described as the struggle between Legalists and Confucians and between Legalism and Confucianism. Thus, Chang Tai-yen, not Sun Yat-sen, is regarded as a bourgeois revolutionary and "Legalist." Yen Fu, not the "Confucian" K'ang Yu-wei, is treated as a representative of the bourgeois Reformists. This attitude has caused serious theoretical, ideological and academic chaos. We should do away with the chaos, conduct a thorough criticism of the "Gang of Four" and push forward our academic research work in accordance with the principle of "letting a hundred schools of thought contend.". (shrink)

This paper investigates the sites of intersection between artistic expression and religious philosophy from artistic and philosophical perspectives. Incorporating theoretical perspectives related to the Theory of art and religion, the first section of the paper introduces the topic and formulates the framework. The second section examines the confluence of artistic expression and religious philosophy in "Joseph and the Amazing Technicolor Dreamcoat." Based on evidence, it has been established that Joseph's musical tale is a remarkable depiction of artistic expression and religious (...) philosophy. (shrink)

In the field of modern photography, aesthetic recreations to varying degrees through the content of the images presented by photography, while forming a certain degree of philosophical aesthetic awareness, can awaken people's emotions and philosophical cognition. As a modeling language, the tone in photography is crucial in embodying the contrasting relationship between light and shade, virtual reality, and the different levels of black and white in black and white portrait photography. It is the most basic factor that constitutes a character's (...) image. Based on the unique performance characteristics of the art of black and white portrait photography, and based on the art of tone in photography and cognitive and aesthetic perspectives in philosophy, this article discusses the role, classification, and influencing factors of tone in black and white portrait photography, and expounds the different philosophical concepts of the East and the West represented by the differences in tone in black and white portrait photography. By analyzing the philosophical concepts and expressions of tone in black and white portrait photography, it can be seen that black and white portrait photography has simple and highly generalized artistic characteristics. It represents the characteristics, connotations, and aesthetic characteristics of black and white portrait photography with a unique art, and at the same time builds a bridge between the photographer and the viewer at the philosophical and aesthetic levels. (shrink)

BackgroundChildhood experiences can exert a huge impact on adult psychological conditions. Previous studies have confirmed the effects of adverse childhood experiences and benevolent childhood experiences on psychological distress separately, but few studies explored a combined effect of ACEs and BCEs on psychological distress. The aim of this study was to explore a combined effect of ACEs and BCEs on psychological distress among Chinese undergraduates.MethodsParticipants were undergraduates aged 17–24 years and completed a self-reported questionnaire. A series of regression analyses were conducted (...) to examine the association between childhood experiences and psychological distress.ResultsA total of 65.7% of undergraduates had BCEs, 27.1% of undergraduates had ACEs, and 12.9% of undergraduates had ACEs and BCEs simultaneously. Logistic regression analysis indicated that undergraduates who experienced high ACEs were more likely to have a high risk of psychological distress [odds ratio = 1.46, 1.84, and 3.15 for uncertainty stress, depressive symptoms, and suicidal ideation, respectively], while undergraduates who experienced High BCEs were less likely to have psychological distress compared with Low-Both group. The combined effect of ACEs and BCEs could also play as a protective factor in uncertainty stress and depressive symptoms.ConclusionOur findings suggested that ACEs and BCEs could not only predict the psychological distress independently, but also BCEs could counteract the negative effect of ACEs in psychological problems. There is an even greater need to identify and support the victims of ACEs and to increase BCEs in early childhood. (shrink)

With the global society aging, it is necessary to investigate suitable font size based on reading time/speed, readability and legibility for older adults. This study used a systematic review of previous and existing relevant research on font size for older adults and research on the psychophysics of reading and analyzed the outcomes based on reading time/speed, readability, legibility and the usability evaluation methods employed. Studies were selected from databases GOOGLE SCHOLAR, WEB OF SCIENCE, PUBMED, and SCIENCE DIRECT. An inclusion criterion (...) was used to remove duplicates and avoid inconsistencies. Results suggest that older adults preferred larger font sizes. However, there exists a critical size at which readability declines. Inconsistencies in evaluation methods and experimental procedures were observed in the selected articles. This study suggested a reusable catalog of usability evaluation methods, eye tracking for user testing and a questionnaire for inquiry as suitable usability evaluation methods, a uniform metrics to measure font size in arcminutes and parameters to consider when investigating font size for older adults to ensure consistency in future studies. (shrink)

There is controversy around whether presenting sub-character units such as radicals and strokes are beneficial to L2 Chinese learning. The present study explored the effects of radical markings and stroke order animations on learning Chinese characters. Forty Chinese L2 learners with native alphabetic languages were divided into high-and low-level groups. They were first required to learn Chinese characters under four conditions either: presented radical markings with stroke animations; presented no radical markings with stroke animations; presented radical markings without stroke animations; (...) or presented neither radical markings nor stroke animations. After learning, the participants were given character recognition and character-meaning matching tests. Results showed that the presentation of radical markings increased the participants’ reaction times in the character recognition test and decreased their recognition accuracy. Moreover, presenting stroke order animations also decreased the participants’ accuracy in recognizing characters. Beyond that, presenting radical markings and stroke order animations had no significant influence on character-meaning matching tests. These results indicate that providing radical and stroke information might interfere with character learning instead of facilitating character learning. The results suggest that excessive visual information introduced in the learning process may increase L2 learners’ cognition load. Also, the findings contribute to theoretical arguments about the analytic and holistic processing of Chinese characters and the pedagogical implications for teaching Chinese as a second language. (shrink)

With the increasing number of electric vehicles, the charging demand of EVs has brought many new research hotspots, i.e., charging path planning and charging pricing strategy of the charging stations. In this paper, an integrated framework is proposed for multiobjective EV path planning with varied charging pricing strategies, considering the driving distance, total time consumption, energy consumption, charging fee such factors, while the charging pricing strategy is designed based on the objectives of maximizing the total revenues of the charging stations (...) and balancing the profits of the charging stations. First, the energy consumption model of EVs, the M/M/S queuing model of charging stations, and the charging model of charging piles are established. A novel charging path planning algorithm is proposed based on bidirectional Martins’ algorithm, which can assist EV users to select charging stations and plan charging paths. Then, a particle swarm optimization algorithm is applied to solve the optimal solution of charging station pricing designation. Finally, the method proposed in the paper is simulated on the street map of Shenzhen to verify the efficacy of the multiobjective charging path planning for EVs and the feasibility of the charging pricing strategy. (shrink)

Faithful DNA replication and accurate chromosome segregation are the key machineries of genetic transmission. Disruption of these processes represents a hallmark of cancer and often results from loss of tumor suppressors. PTEN is an important tumor suppressor that is frequently mutated or deleted in human cancer. Loss of PTEN has been associated with aneuploidy and poor prognosis in cancer patients. In mice, Pten deletion or mutation drives genomic instability and tumor development. PTEN deficiency induces DNA replication stress, confers stress tolerance, (...) and disrupts mitotic spindle architecture, leading to accumulation of structural and numerical chromosome instability. Therefore, PTEN guards the genome by controlling multiple processes of chromosome inheritance. Here, we summarize current understanding of the PTEN function in promoting high-fidelity transmission of genetic information. We also discuss the PTEN pathways of genome maintenance and highlight potential targets for cancer treatment. PTEN is a guardian of the genome. However, the role of PTEN in guarding the genome has not been revealed until recently. PTEN controls multiple fundamental processes of genomic transmission. By physically interacting with key molecules in DNA replication, DNA repair/decatenation, and chromosome segregation during the cell cycle, PTEN maintains genomicintegrity and fitness. (shrink)

As physical exercise benefits both physical and psychological health of college students, it is important to promote the habit of physical exercise among them. This study adopted the Health Action Process Approach model to understand the exercise intention–action link and determine the moderating role of self-efficacy. We recruited 242 students from a university in China and asked them to complete a six-wave survey. The survey results indicated that exercise intention was positively related to both coping planning and action planning, which (...) pave the way to performing the action of exercise. However, such mediation effects varied under conditions of self-efficacy. Participants with high self-efficacy exhibited stronger relationships between intention and planning, and between planning and action. The study results suggest that planning has a time-lagged mediation effect in the relationship between intention and action. Additionally, the findings shed light on the moderating role of self-efficacy, which can be useful in developing health-promotion strategies for college students. (shrink)