With the increasing number of electric vehicles, the charging demand of EVs has brought many new research hotspots, i.e., charging path planning and charging pricing strategy of the charging stations. In this paper, an integrated framework is proposed for multiobjective EV path planning with varied charging pricing strategies, considering the driving distance, total time consumption, energy consumption, charging fee such factors, while the charging pricing strategy is designed based on the objectives of maximizing the total revenues of the charging stations (...) and balancing the profits of the charging stations. First, the energy consumption model of EVs, the M/M/S queuing model of charging stations, and the charging model of charging piles are established. A novel charging path planning algorithm is proposed based on bidirectional Martins’ algorithm, which can assist EV users to select charging stations and plan charging paths. Then, a particle swarm optimization algorithm is applied to solve the optimal solution of charging station pricing designation. Finally, the method proposed in the paper is simulated on the street map of Shenzhen to verify the efficacy of the multiobjective charging path planning for EVs and the feasibility of the charging pricing strategy. (shrink)

Axons are the longest cellular structure reaching over a meter in the case of human motor axons. They have a relatively small diameter and contain several cytoskeletal elements that mediate both material and information exchange within neurons. Recently, a novel type of axonal plasticity, termed axonal radial contractility, has been unveiled. It is represented by dynamic and transient diameter changes of the axon shaft to accommodate the passages of large organelles. Mechanisms underpinning this plasticity are not fully understood. Here, we (...) first summarised recent evidence of the functional relevance for axon radial contractility, then discussed the underlying structural basis, reviewing nanoscopic evidence of the subtle changes. Two models are proposed to explain how actomyosin rings are organised. Possible roles of non‐muscle myosin II (NM‐II) in axon degeneration are discussed. Finally, we discuss the concept of periodic functional nanodomains, which could sense extracellular cues and coordinate the axonal responses. Also see the video abstract here: https://youtu.be/ojCnrJ8RCRc. (shrink)

Since the outbreak of the novel coronavirus disease at the beginning of December 2019, there have been more than 28.69 million cumulative confirmed cases worldwide as of 12th September 2020, affecting over 200 countries and regions with more than 920,463 deaths. The COVID-19 pandemic has been sweeping worldwide with unexpected rapidity. In this paper, a hybrid modelling strategy based on tessellation structure- configured SEIR model is adopted to estimate the scale of the pandemic spread. Building on the data pertaining to (...) the global pandemic transmission over the last six months around the world, key impact factors in the transmission and control procedure have been analysed, including isolation rate, number of the infected cases before taking prevention measures, degree of contact scope, and medical level, so as to capture the fundamental factor influencing the pandemic. The quantitative evaluation allowed us to illustrate the magnitude of risks of pandemic and to recommend appropriate national health policy of prevention measures for effectively controlling both intra- and interregional pandemic spread. Our modelling results clearly indicate that the early-stage preventive measures are the most effective action to be taken to contain the pandemic spread of the highly contagious nature of the COVID-19. (shrink)