The majority of antimicrobials that are produced are administered to animals, particularly food animals. While the overall impact of antimicrobial use in animals on antimicrobial resistance in humans and the environment is unclear, it undeniably has a role. Yet, some degree of antimicrobial use in animals is necessary for animal health and welfare purposes. Balancing the benefits and risks of antimicrobial use in animals is challenging because of the complexity of the problem and limitations in available data. However, a range (...) of measures can be implemented to reduce, refine and optimize antimicrobial use in animals, with a goal of minimizing the impact on human and environmental health while maintaining necessary therapeutic use in animals. A pandemic instrument can provide the necessary foundation for the whole-of-society and whole-of government One Health approach that is required to strengthen surveillance, communication, collaboration, and action. (shrink)

This book reflects upon the political philosophy of Muhammad Iqbal, a towering intellectual figure in South Asian history, revered by many for his poetry and his thought. He lived in India in the twilight years of the British Empire and, apart from a short but significant period studying in the West, he remained in Punjab until his death in 1938. The book studies Iqbal's critique of nationalist ideology and his attempts to chart a path for the development of the 'nation' (...) by liberating it from the centralizing and homogenizing tendencies of the modern state structure. Iqbal frequently clashed with his contemporaries over his view of nationalism as 'the greatest enemy of Islam'. He constructed his own particular interpretation of Islam - forged through an interaction with Muslim thinkers and Western intellectual traditions - that was ahead of its time, and since his death both modernists and Islamists have continued to champion his legacy. (shrink)

Flap EndoNuclease‐1 (FEN‐1) is a multifunctional and structure‐specific nuclease involved in nucleic acid processing pathways. It plays a critical role in maintaining human genome stability through RNA primer removal, long‐patch base excision repair and resolution of dinucleotide and trinucleotide repeat secondary structures. In addition to its flap endonuclease (FEN) and nick exonuclease (EXO) activities, a new gap endonuclease (GEN) activity has been characterized. This activity may be important in apoptotic DNA fragmentation and in resolving stalled DNA replication forks. The multiple (...) functions of FEN‐1 are regulated via several means, including formation of complexes with different protein partners, nuclear localization in response to cell cycle or DNA damage and post‐translational modifications. Its functional deficiency is predicted to cause genetic diseases, including Huntington's disease, myotonic dystrophy and cancers. This review summarizes the knowledge gained through efforts in the past decade to define its structural elements for specific activities and possible pathological consequences of altered functions of this multirole player. BioEssays 27:717–729, 2005. © 2005 Wiley Periodicals, Inc. (shrink)

This article explores the gender dynamics of ‘causing or allowing a child to die’, contrary to the Domestic Violence, Crime and Victims Act 2004, section 5. This offence was intended to allow for prosecution where a child had been killed and it was uncertain who had killed him/her, but also to allow for prosecution of non-violent defendants who failed to protect him/her. More women than men have been charged and convicted of this offence signifying a reversal of usual patterns of (...) prosecution and conviction. This analysis interrogates how section 5 criminalises women who have experienced domestic abuse. Drawing on a case observation, reported cases and media reports of cases, I suggest this offence derives from and perpetuates patriarchal constructs of motherhood. Grounded in a feminist approach building on women’s concrete experiences of law, I conclude that section 5 should be amended so that it is only used where it cannot be ascertained which defendant actively harmed a child. (shrink)

This pathbreaking collection of thirteen original essays examines the moral rights of the subjects of documentary film, photography, and television.

The demarcation of the private and public life leads to role of the state in private life. Many individuals have been the unflinching voice for moral dissent. In the western philosophy, debate on private morality and public life was instigated by Attorney General’s Commission Report which was submitted in 1986 and recommended no blanket ban on homosexuality and prostitution. However, a contemporary liberalist, Ronald Dworkin, castigates this Report. He argues that the report has an antagonistic approach because of its permissive (...) attitude towards pornography and the same time hospitability towards the enforcement hypothesis, which holds a preventive attitude towards pornography. In this paper, I analyse the feminists’ discourse of pornography connected with Dworkin and the Committee Report and adds more possibilities that put Dworkin’s arguments closer to the Report. Therefore, in this paper, I argue that Commission Report and Dworkin’s strategy towards pornography embodying as two sides of the same coin, and enforcement strategy is in the far away footing implies antagonistic approach. (shrink)

This article provides empirical evidence of the social context and moral reasoning embedded within a parents’ decision to participate in autism genetics research. Based on in-depth interviews of parents who donated their family’s blood and medical information to an autism genetic database, three narratives of participation are analyzed, including the altruistic parent, the obligated parent, and the diagnostic parent. Although parents in this study were not generally concerned with bioethical principles such as autonomy and the issues of informed consent and/or (...) privacy and confidentiality of genetic information, a critical analysis reveals contextual bioethics embedded within these different narratives. These include the negotiations of responsibility that parents confront in biomedical research, the misguided hope and expectations parents place in genomic science, and the structural barriers of obtaining an autism diagnosis and educational services. Based on these findings, this article demonstrates the limits of a principle-based approach to bioethics and the emergent forms of biological citizenship that takes into account the social situations of people’s lives and the moral reasoning they negotiate when participating in autism genetic research. (shrink)

'Image Ethics in the Digital Age' brings together leading experts in the fields of journalism, media studies, & law to address the challenges presented by new technology & assess the implications for personal & societal values & behavior.

Alison Gopnik and her collaborators have recently proposed a bold and intriguing hypothesis about the relationship between scientific cognition and cognitive development in childhood. According to this view, the processes underlying cognitive development in infants and children and the processes underlying scientific cognition are _identical_. We argue that Gopnik’s bold hypothesis is untenable because it, along with much of cognitive science, neglects the many important ways in which human minds are designed to operate within a social environment. This leads to (...) a neglect of _norms_ and the processes of _social_ _transmission_ which have an important effect on scientific cognition and cognition more generally. (shrink)

In recent years, the National Crime Records Bureau recommendation is that the growth rate of crime against women has skyrocketed in India, even higher than the population growth rate. According to lawyer, Kamlesh Vaswani, the commercial exploitation of coital activity paramount in pornography is the result of crimes against women, and fills perverse traits in the roots of society. Following that, he filed a petition (2013) in the Honourable Supreme Court to blanket ban pornography with the aim of diluting the (...) subordination of women and the crimes against women in society. Taking this into consideration, I argue that the Vaswani petition draws back the issue of twentieth century Western political and philosophical debate on pornography which triggers one of the moot problems of moral legislation—whether the state should be neutral or not towards individuals’ preferences, merits, desires, and the status to live well. This article focuses on whether this discourse has any relevance in the Indian value system. In this article, through the comparison between Indian and Western values, I make an attempt to analyse the moot problem of moral legislation which is bridging the gap between public and private morality for the well-being of women as well as our society. (shrink)

As an important tool to influence stakeholders’ perception, leader messages, subsumed under public relations discourse, play an integral role in corporate communication. Drawing on the analysis of linguistic move structure and communication styles employed by researchers, this study adopts a multidimensional framework by using both discourse and quantitative analysis to compare how leaders in Global 500 corporations in China and the United States rely upon specific linguistic features to engage stakeholders in corporate discourse published on their websites. The results show (...) pertinent differences in communication styles, where Chinese corporations tend to be more instrumental, elaborate and competitive while US corporations are more affective, succinct and harmonious. These observations depart from previous findings on interpersonal communication styles in cross-cultural research. This study also extends the boundary of corporate genre analysis by suggesting that the moves adopted in the structure of corporate messages are highly specific to the particular genre. (shrink)

This book presents groundbreaking research on critical themes in Indian philosophy, challenging traditional interpretations often shaped by entrenched scholarly biases. It offers fresh perspectives on pivotal topics and includes comparative analyses of Western philosophers such as Schopenhauer and Simone Weil, who were deeply influenced by Indian philosophical thought. Their engagements with Indian philosophy are critically assessed, following a detailed exploration of their enduring interest and contributions to the field.

Pylyshyn's target article argues that perception is not inferential, but this is true only under a narrow construal of inference. A more general construal is possible, and has been used to provide formal theories of many visual capacities. This approach also makes clear that the evolution of natural constraints need not converge to the “veridical” state of the world.

As an epistemological perspective, 'nomadism' is an emerging field of scholarship, offering intersectionality with eco-criticism, feminism, post-colonialism, migration studies, and translation. Much of the scholarship that uses the precepts of nomadism to read cultural texts and phenomena is scattered as separate articles in academic journals or as single chapters in books wherein the primary focus is the intersectional fields. Few book-length publications solely focus on the ramifications of nomadism; Posthumanist Nomadisms across non-Oedipal Spatiality fills that void. The fifteen chapters in (...) this volume explore the possibilities offered by the nomadic perspective to explore a wide range of literary and cultural texts; organized into three sections, "Nomadic Assemblages," "Non-Oedipal Cartographies", and "Space-Time Montages", that work as one to negate absorption into the interiority of sovereign territory. These sections are not an attempt at corralling the nomadic spirit into separate enclosures; instead, they are bands of warriors that operate the violence of the hunted animal, dehumanized human others, and earth others. The chapters are in constant multi-vocal conversations with narratives that camp on the turbulent weathers of global transitory spaces. They charter real or intellectual turfs of interstitial/rhizomatic nomadic epistemologies as political resistance to the exclusionary practices of a violently wired world. This book will appeal to post-graduate students, researchers, and faculty in the departments of literature, comparative literary and cultural studies. Researchers in sociology, cultural anthropology, gender studies, and migration studies will also find the material applicable to the expanding approaches available in their fields. (shrink)

The persons who adapt to changes as may be necessary in the course of their existence not only survive in the struggle for existence but also thrive and enjoy their lives in the best possible way under the given circumstances. For, life consists in various relationships, which are in constant movement and change.Therefore dealing with change or change-management has got pivotal importance in all walks of humans’ lives. In order to facilitate smooth change all big and small inheritances have to (...) be shed off. Adaptation to change involves some amount of give and take. Before stepping into new shoes one has to remove old ones. Sticking to good or bad things of the past in some cases spoils the present. One should, therefore, be in a position to come out of the situation of status quoor inertia. In some cases our ego does not allow us to change. It forces us to remain in the state that we have been enjoying hitherto. If we are untouched by sense of exuberance and live a life of simplicity, we can break the fetters of ego. The crux of the problem lies in affecting the change of attitude towards the present state of affairs and performance of corresponding duty. The persons should realize that change in power, position, strength etc. is inevitable. So,they should be mentally and physically prepared for it. This can be conveniently achieved by developing adaptability to and management of change. (shrink)

Included here are some cases that highlight exceptional behaviour under the novel coronavirus pandemic that cuts across religious boundaries. The Christian cases were drawn from the United States and South Korea; Islamic cases were drawn both from India and Iran; and the Hindu and Sikh cases were highlighted from India. Of these, notably, Iran is a declared theocracy, whereas the United States and India are arguably contexts of rising Christian and Hindu theocracies. We are familiar with the evidence of the (...) positive role of religions in society. This paper brings together exceptional cases where irrationality, control and selfishness trump wisdom and altruism. The evidence highlighted here shows that people are capable of suspending reason and behaving with a motive inspired by faith, even when it is clear there might be serious personal and social costs involved. (shrink)

Converging psychophysical evidence suggests that the human visual system parses shapes into component parts for the purposes of object recognition. We examine the Schyns et al. claim of “creation” of features in light of recent work on part-based representations of visual shape, particularly the perceptual rules that human vision uses to parse shapes.

Poets are "the institutors of laws, and the founders of civil society, and the inventors of the arts of life, and the teachers who draw into a certain ...

A surgical instrumentation professional is an active member of the surgical team whose essence and formal objective is to maintain life with all the respect and dignity inherent in the human being. The actions of these professionals must be accompanied in a consistent way, so as to protect and preserve life, and thus give meaning to illness, suffering and pain. The objective of this descriptive and cross-sectional study of a prospective nature is to determine what the surgical instrumentation professional knows (...) about bioethical principles and values in light of Colombian Law 1164/ 2007. The target population included surgical instrumentation professionals in the city of Cartagena, specifically, from three health institutions. It was found that veracity, equality and beneficence are the ethical and bioethical principles these professionals know and apply. Those known the least are lesser evil, doing no harm, totality and the principle of the cause of double effect. The values applied the most are: humanity, dignity, responsibility, prudence and confidentiality. It was concluded that the vast majority of surgical instrumentation professionals who were surveyed apply ethical principles and values in their professional practice, but they are unable to name them or to define what they mean. It is suggested the academic community do more to delve into these issues in order to strengthen them for the sake of achieving a comprehensive level of care. (shrink)

Segmentation of post-operative glioblastoma multiforme (GBM) is essential for the planning of Tumor Treating Fields (TTFields) treatment and other clinical applications. Recent methods developed for pre-operative GBM segmentation perform poorly on post-operative GBM MRI scans. In this paper we present a method for the segmentation of GBM in post-operative patients. Our method incorporates an ensemble of segmentation networks and the Kullback–Leibler divergence agreement score in the objective function to estimate the prediction label uncertainty and cope with noisy labels and inter-observer (...) variability. Moreover, our method integrates the surgery type and computes non-tumorous tissue delineation to automatically segment the tumor. We trained and validated our method on a dataset of 340 enhanced T1 MRI scans of patients that were treated with TTFields (270 scans for train and 70 scans for test). For validation, we developed a tool that uses the uncertainty map along with the segmentation result. Our tool allows visualization and fast editing of the tissues to improve the results dependent on user preference. Three physicians reviewed and graded our segmentation and editing tool on 12 different MRI scans. The validation set average (SD) Dice scores were 0.81 (0.11), 0.71 (0.24), 0.64 (0.25), and 0.68 (0.19) for whole-tumor, resection, necrotic-core, and enhancing-tissue, respectively. The physicians rated 72% of the segmented GBMs acceptable for treatment planning or better. Another 22% can be edited manually in a reasonable time to achieve a clinically acceptable result. According to these results, the proposed method for GBM segmentation can be integrated into TTFields treatment planning software in order to shorten the planning process. To conclude, we have extended a state-of-the-art pre-operative GBM segmentation method with surgery-type, anatomical information, and uncertainty visualization to facilitate a clinically viable segmentation of post-operative GBM for TTFields treatment planning. (shrink)

The purpose of this paper is to analyse and understand how specific advancements in the area of marketing and organisation affect the overall firm performance (FP) given that there are diverse ways in which innovation boosts up corporate revenues, marketing innovation (MI), leadership innovation (LI), organizational innovation (OI), process innovation(PI), and customer engagement innovation (CEI) as the independent variables in the framework with FPbeing the dependent variable, through the collection of surveyed data from 150 firms across different industries and subsequent (...) analysis using SPSS 25. Descriptive analysis pointed out that OI was equally high with a mean of 4.2 indicating is prominent role. Multiple regression analysis identified CEI having the largest positive effect on FP (B= 0.35,p = 0.000). ANOVA result showed that PI contributed the most significant variance in the FP (F=7.89,p = 0.008). The study provides understanding on how different types of innovations create corporate success and highlights the key innovation of CEI for enhancing the FP. (shrink)

As infancy is characterized by rapid physical growth and critical periods of development, disruptions due to illness or disease reveal vulnerability associated with this period. Spinal cord injury has devastating consequences at any age, but its onset neonatally, at birth, or within the first year of life multiplies its impact. The immediate physical and physiological consequences are obvious and immense, but the effects on the typical trajectory of development are profound. Activity-based restorative therapies capitalize on activity-dependent plasticity of the neuromuscular (...) system below the lesion and when provided to children with SCI aim to improve the child’s neuromuscular capacity, health and quality of life. This is a report of an infant with a cervical SCI at birth resulting in paralysis of leg and trunk muscles and paresis of arm and hands who was enrolled in an ABRT program at 3 years of age. After 59 sessions of ABRT, the child demonstrated significant improvements in trunk control and arm function, as well as social and emotional development. Despite the chronicity of injury and low expectations for improvement with therapeutic interventions, ABRT had a positive impact on the child’s physical capacity and provided benefits across multiple developmental domains. (shrink)