Here we review and discuss the link between regeneration capacity and tumor suppression comparing mammals (embryos versus adults) with highly regenerative vertebrates. Similar to mammal embryo morphogenesis, in amphibians (essentially newts and salamanders) the reparative process relies on a precise molecular and cellular machinery capable of sensing abnormal signals and actively reprograming or eliminating them. As the embryo's evil twin, tumor also retains common functional attributes. The immune system plays a pivotal role in maintaining a physiological balance to provide surveillance (...) against tumor initiation or to support its initiation and progression. We speculate that susceptibility to cancer development in adult mammals may be determined by the loss of an advanced regenerative capability during evolution and believe that gaining mechanistic insights into how regenerative capacity linked to tumor suppression is postnatally lost in mammals might illuminate an as yet unrecognized route to cancer treatment. (shrink)

Although most studies investigated the impact of infertility and its treatment on the couple, a small body of evidence suggested that infertility care providers may experience different sources of stress related for instance to excessive workload, the complexity of the technique, and relational difficulties with patients. The current study aimed at providing further insight into the understanding of the subjective experience of infertility care providers by highlighting their feelings and emotions, personal meanings, challenges, and opportunities. Following the methodological guidelines of (...) Interpretative Phenomenological Analysis, we conducted individual semi-structured interviews with 23 members of two different fertility units. Interviews were audiotaped and transcribed verbatim. Textual analysis was then conducted to identify emerging dominant themes and subthemes. Three main themes were extracted: dealing with infertile patients and their specificities, performing assisted reproductive technology, being part of a team. These themes related to participants experiencing: difficulties in establishing an empathic connection and communicating with couples, such that women were sometimes perceived as “particular patients” and men as poorly involved in the process; difficulties in dealing with a complex procedure in which errors are not allowed, with a growing number of women aged > 40 seeking assisted reproduction, despite the risks for their health; being part of a team as a resource, although the huge amount of time spent together can involve conflicts and organizational problems. These findings suggested that patients’ overpersistence represents an important source of stress for infertility care providers. At the same time, the concept of particular or difficult patient derives from the combination of multiple factors, including providers’ own history and subjective experience. The presence of mental health professionals in fertility units is essential to help providers improve the quality of doctor-patient communication and relieve the stress related to organizational issues and conflicts. (shrink)

The last years of the 20th Century have been somewhat contradictory with respect to values like loyalty, trust or truthfulness. On the one hand, (often implicitly, but sometimes very explicitly), self-interest narrowly defined seems to be the dominant force in the business world, both in theory and in practice. On the other hand, alliances, networks and other forms of cooperation have shown that self-interest has to be at least "enlightened".The academic literature has reflected both points of view, but frequently in (...) an ambiguous way, since the concepts of loyalty and trust are somewhat elusive and equivocal. This paper attempts to analyze the concept of loyalty in depth, examining the different conceptions about the word that can be found in the literature. We begin by going to the management classics (specifically, Follett, Barnard and Simon), and we then turn to the anthropological approach of Pérez López (1993), with its built-in ethical analysis, and show how trust and loyalty are crucial to the development of organizations. We end by suggesting in what ways loyalty and trust can be created and fostered in organizations. (shrink)

In this paper, we review the conventional analyses of management control systems, to conclude, first, that the illusion of control can mislead managers into believing that everything can be controlled and monitored, and, second, that no incentive system based only on extrinsic rewards can motivate individuals properly. Then, we investigate the philosophical foundations of the basic assumptions that, implicitly or explicitly, are made about the nature of the acting person. Based on personalist phenomenology, we show how the development of technical (...) and moral values is crucial to the long-run survival of organizations. We end by offering some guidelines as to what control systems should be like in order to be compatible with the nature of human persons. (shrink)

There are many theories about organizations that are mutually inconsistent with each other, which explain phenomena to very similar extents. Most of them ignore the ethical dimension completely. In this paper I put forth the basic principles for a theory of decision-making in organizations, which integrates ethics in the core of the theory. It is based on the work of Juan Antonio Pérez López [1991, Teoría de la Acción humana en las organizaciones (Ediciones Rialp, Madrid), 1993, Fundamentos de la Dirección (...) de Empresas (Ediciones Rialp, Madrid)] and is essentially a humanistic view of the interrelationships between people and its implications for organizational decision-making. I will first show that in any relationship between two people, the learning of the two is crucial for such a relationship to last; and then I will expand on the different aspects of that learning. This analysis will then be applied to the organizational context as a basis for organizational decision-making, Second, it applies the previous analysis to the organizational context as a basis for organizational decision making, showing how any decision in an organization needs to be analyzed on the basis of three criteria (short-run effectiveness, development of distinctive competence, and unity and identification with the organization) and how ethics is included in the last two. (shrink)

Este libro es un homenaje a la trayectoria intelectual y académica de la profesora María Teresa López de la Vieja, Catedrática emérita de la Universidad de Salamanca. En él se trazan algunos de los caminos que, con su obra, nos invita a transitar. El volumen recoge contribuciones de colegas de varias nacionalidades y procedentes de diversos ámbitos de reflexión que le son afines: la filosofía moral y política, la literatura, la teoría de la argumentación, los estudios feministas, las éticas aplicadas, (...) la bioética. Los capítulos que componen este libro dan voz a varias generaciones de investigadoras e investigadores que han acompañado y acompañan su andadura académica y que aquí dialogan con ella haciendo propias sus preocupaciones intelectuales. Con su participación contribuyen al justo reconocimiento de su dedicación a la labor docente e investigadora. (shrink)

In this commentary, we criticize the argument that allowing euthanasia for people with disabilities is ableist. We analyze the distinction between facts and values in medical assistance in dying, the expressivist objection, and the problem of crypwashing.

Functions and objectives serve as an incentive for children living in Brazil to question their role as a child in society.

“Hacia una nueva ética médica” es el título del capítulo 5 de Confesiones de un médico (Triacastela, Madrid, 2011), la versión española del libro del médico y filósofo norteamericano Alfred Tauber, cuidadosamente traducida por Antonio Casado da Rocha. En él, se abordan cuestiones relacionadas con la alteración identitaria que supone la enfermedad, la deshumanización de la medicina y sus causas y la necesidad de un cambio radical en el enfoque de la relación médico-paciente para combatirla. En una sociedad que prioriza (...) la autonomía individual, dice Tauber, conviene recordar que estar enfermo supone la pérdida de esa autonomía y autosuficiencia. Por tanto, los profesionales sanitarios, cuya relación con los usuarios es necesariamente asimétrica, no sólo han de aplicar los correspondientes procedimientos técnicos, sino que han de asumir la obligación moral de restaurar la salud de sus pacientes. .. (shrink)

Este artículo se pregunta qué se conmemorará realmente en el 40° aniversario de la guerra de Malvinas (1982-2022), contrastando las modalidades de recordación pública que tendrán lugar en 2022 y las lecturas que ha aportado la academia sobre lo sucedido en aquel entonces. La reflexión elabora comparativamente estos significados y describe qué hemos hecho los investigadores argentinos en ciencias sociales con el conflicto armado anglo-argentino por las Malvinas e Islas del Atlántico Sur, examina los fundamentos que subyacen a esos significados (...) y sostiene la tesis de que los académicos universitarios hemos ignorado el carácter bélico de la iniciativa de la tercera junta de la última dictadura militar, el autodenominado Proceso de Reorganización Nacional (1976-1983). Así, este artículo muestra que los protagonistas directos de la guerra y sus analistas postulan sentidos alternativos que se reelaboran como una paradoja de difícil comprensión: una causa popular originada en una cuestión de soberanía territorial pendiente fue acometida, con éxito y respaldo popular, por una ya antipopular y sangrienta dictadura militar. (shrink)

Our aim is to put into consideration the topics of “semantics”, “types”, “lifeworld” and “intersubjectivity” following the social theories of Alfred Schutz and Niklas Luhmann. First of all, and inversely to Luhmann’s perspective which receives the schutzian theory comparing equal types and semantics, we will show that types are inherent to subjectivity. Secondly, and consequently, we state that the social systems theory in the analysis of the “lifeworld”, does not pay attention to the past character of its constitution. Last, but (...) not least, we will point out that all these aspects are framed in a critique of the phenomenological notion of intersubjectivity, which from the luhmannian point of view, ignores the autonomy of consciousness, as well as the emergent character of the social. (shrink)

In gender studies on nineteenth century Argentine literature, a woman writer has been vindicated: Juana Manuela Gorriti. Considered a succesful intellectual because she was the first who entered the literary market, she is faced to another contemporary intelectual figure, Juana Manso. Novelist, teacher and politically close to Sarmiento´s ideas, Manso was insulted by the most conservative sectors of bourgeoisie. Despite Gorriti, in the contemporary feminist analysis Manso is seen like an unsuccessful intelectual. This essay tries to explain the unlike luck (...) of both, in past an present, taking in consideration political differences between them. (shrink)

The goal of this paper is to offer a new theory of moods, according to which moods are perceptual experiences that represent undetermined objects as possessing specific evaluative properties. I start by listing a series of features that moods are typically taken to possess and claim that a satisfactory theory of moods must be able either to explain why moods genuinely possess these features or to explain these appearances away in a non-ad hoc way. I show that my account provides (...) a plausible explanation of all the main features of moods. I conclude by addressing some objections against my account. (shrink)

Este livro procura ilustrar que o ser professor não resulta de um evolucionismo natural do qual a vocação ou o dom seriam consequências lógicas. Ao contrário, a presença do docente e a presença do discente são buscadas no campo historiográfico seja pela memória individual e coletiva deles em seus escritos, seja pelos novos enfrentamentos suscitados não só pela sociedade de classes, mas também pelas diversidades que aí se aninham. Sumário - Prefácio - Carlos Roberto Jamil Cury; Apresentação - Mauro (...) Passos; Parte I - Teoria e confrontos temáticos; Parte II - História e condições de trabalho; Sobre os autores. (shrink)

We discuss the three dominant models of the phenomenological literature pertaining to temporal consciousness, namely the cinematic, the retentional, and the extensional model. This is first done by presenting the distinction between acts and contents of consciousness and the assumptions underlying the different models concerning both the extendedness and duration of these two components. Secondly, we elaborate on the consequences related to whether a perspective of direct or indirect realism about temporal perceptions is assumed. Finally, we review some relevant findings (...) from the psychology and neuroscience of temporality in order to decide which of the three models of time consciousness is better confirmed from an empirical viewpoint. Depending on the time scale, all three models of temporal consciousness might apply. We specifically argue in favor of an extensional model of time consciousness for the experienced present where the acts and contents of consciousness are both extended. The retentional model might apply to longer time intervals covered by working memory. In addition, a predictive component is highlighted as decisive for an understanding of temporality. (shrink)

En el ámbito de la situación presente de crisis de lo humano, así como de la efusión actual del fenómeno místico, esta reflexión se aproxima a la experiencia mística contemporánea a través de uno de sus testigos: Etty Hillesum. El acercamiento a la trama narrativa de su diario hizo posible que el decir del ser, el decir sobre lo humano en la experiencia mística se abriera paso a través de un ejercicio hermenéutico existencial con la mediación del relato. El asunto (...) central consistió en buscar en la experiencia mística la raíz y expresiones de su fuerza humanizadora. En este sentido, a partir de una aproximación a ‘lo humano’ desde las categorías: interioridad, actitud teologal y alteridad, la reflexión abrió el paso a la consideración sobre la experiencia mística y su conexión con ‘lo humano’ que busca humanidad. Asunto éste que hizo posible plantear algunas perspectivas que contribuyan a explicitar el potencial humanizador de la Experiencia Mística hoy. ln the ambit of the present situation of the crisis of the 'human', as well as of the current outpouring of the mystic phenomenon, this reflection approaches contemporary mystical experience by one of its witnesses: Etty Hillesum. The approach to the narrative of her diary made it possible to soy of the "being", which is to say about the human in the mystical experience would open a way through a hermeneutic existential exercise with the mediation of the story. The main issue consisted of searching in the mystical experience, the root and expressions of its humanizing force. In this sense, from an approximation to the 'human' from the categories: interiority, theological attitude and otherness, the reflection opened the way for consideration on the mystical experience and its connection with the 'human' which seeks its humanity. This matter which made it possible to set out some perspectives that contribute to make explicit the humanizing potential of the Mystical Experience today. (shrink)

O objetivo deste texto é apresentar uma discussáo das noções de puniçáo no contexto da teoria utilitarista, destacando a possibilidade de que inocentes sejam qualificados como descartáveis ou sirvam como meio aos interesses sociais. O texto analisa, ainda, a teoria de H. L. A. Hart da noçáo utilitarista de puniçáo e de justificaçáo da puniçáo, ampliando o debate aos princípios de justiça de Rawls.

Blind, deaf, and mute: the healthcare system regarding conscientious objection to abortion Resumen: A la luz de la obra de Fernando Broncano, Conocimiento expropiado (2020), este trabajo plantea la objeción de conciencia generalizada al aborto como un fenómeno que origina situaciones de injusticia epistémica. El acceso a la información, el disvalor del testimonio de las mujeres y el silencio cómplice, individual e institucional, perpetuador de la ignorancia sistémica son realidades que afectan a un número indeterminado de mujeres que requiere la (...) interrupción de su embarazo. Para hacer frente al daño generado, se plantea cómo las redes y movimientos pro-elección distribuyen información y recursos sobre el aborto fuera del ámbito clínico y se organizan como fuerzas de resistencia epistémica, capaces de crear y compartir conocimiento en un ejercicio de democracia radical, en el sentido expresado por Broncano. Abstract: In accordance with Fernando Broncano’s work, Conocimiento expropiado (2020), this paper considers the widespread conscientious objection to abortion as a phenomenon that creates situations of epistemic injustice. Access to information, devaluation of women’s testimony, as well as individual and institutional complicit silence that perpetuates systemic ignorance, are realities that affect an indeterminate number of women who require the termination of their pregnancies. In order to address the damage generated, we consider how pro-choice networks and movements distribute information and resources on abortion outside the clinical sphere. They also organise themselves as forces of epistemic resistance, capable of creating and sharing knowledge in an exercise of radical democracy, in the sense expressed by Broncano. Palabras clave: Objeción de conciencia, aborto, injusticia epistémica, ignorancia institucional, resistencia epistémica. Keywords: Conscientious objection, abortion, epistemic injustice, institutional ignorance, epistemic resistance. (shrink)

The literature on the compatibility between the time of our experience--characterized by passage or becoming--and time as is represented within spacetime theories has been affected by a persistent failure to get a clear grasp of the notion of becoming, both in its relation to an ontology of events tt"spreadtt" in a four-dimensional manifold, and in relation to temporally asymmetric physical processes.In the first part of my paper I try to remedy this situation by offering what I consider a clear and (...) faithful explication of becoming, valid independently of the particular spacetime setting in which we operate. Along the way, I will show why the metaphysical debate between the so-called tt"presentiststt" and tt"eternaliststt" is completely irrelevant to the question of becoming, as the debate itself is generated by a failure to distinguish between a tensed and a tenseless sense of tt"existencett". After a much needed distinction between absolute and relational becoming, I then show in what sense classical spacetime physics presupposes both types of becoming, for the simple reason that spacetime physics presupposes an ontology of events. As a consequence, not only does it turn out that using physics to try to provide empirical evidence for the existence of becoming amounts to putting the cart before the horses, but also that the order imposed by tt"the arrow of becomingtt" is more fundamental than any other physical arrow of time, despite the fact that becoming cannot be used to explain why entropy grows, or retarded electromagnetic radiation prevails versus advanced radiation. (shrink)

For years, the sexual and reproductive health of women with intellectual and developmental disability or disabilities has been insufficiently addressed by institutions and family members due to a lack of information, training, and, sometimes, religious issues. In this context, contraceptive digital pills can enhance the sexual and reproductive control of this population group. Digital pills could help to improve adherence to treatments aimed to prevent unwanted pregnancies, as well as allowing women and their caregivers to exert better drug intake control. (...) However, there are some ethical risks to consider that may outweigh these benefits. This study sets out to explore the ethical considerations that should be taken into account in the case of a potential roll‐out of contraceptive digital pills as a way of improving the sexual and reproductive health of these women. (shrink)

Dos místicos relativamente contemporáneos: Etty Hillesum y Benjamín González Buelta; dos estilos, dos contextos y una coincidencia establecida desde sus experiencias espirituales, en profunda conexión con la realidad, en medio de la vida y sus desafíos. Hillesum no habla propiamente de la experiencia mística, sin embargo, su proceso personal existencial en el duro contexto de guerra que le tocó vivir, la condujo a descubrirse profundamente habitada. Su experiencia de Dios le hizo posible comprender y gestionar el dolor en medio de (...) la guerra, así como la necesidad de ‘hacerse bálsamo sobre las heridas’ de sus hermanos judíos. Etty es una mística de ojos abiertos. Benjamín González Buelta ha profundizado en la comprensión de la mística, describiéndola y analizándola desde la experiencia de Dios en el contexto latinoamericano. Su reflexión permite hoy leer a Etty Hillesum desde la perspectiva del místico de ojos abiertos. (shrink)

Traditionally the study of chemical elements has been limited to well-known concepts like the periodic properties and chemical families. However, current information shows a new and rich language that allows us to observe relations in the elements that are not limited to their positions in the table. These relations are evident when reactions are represented through networks, as in the case of similar reactivity of organic compounds sharing functional groups. For the past two decades, it has been argued that network (...) reactions may be considered the core of chemistry. This network, which constitutes the basic set of chemical knowledge, provides the basis for classification and delivers routes to obtain new and known substances. In order to provide an example, we constructed and analyzed a network of chemical elements from the formation of stoichiometric binary compounds, providing to the chemistry, a formal structure of extracting the chemical knowledge. Thus, we explored all possible presence of relationships among elements. Concepts like degree centrality and centralization, the relationships among metals, semimetal and nonmetal classes, blocks, and chemical families were analyzed. We observed that the network structure had a small core set of elements of high reactivity and also a peripheral set of elements of low reactivity. The classes, blocks and families show the following increasing order of reactivity: nonmetals > semimetals > metals; p > s > d > f; and families: boron, carbon, pnictogens, chalcogens, halogens, lanthanoids > other families. This example shows, from the network perspective, that the elements and their classifications exhibit properties such as the reactivity, order, and similarity. (shrink)

In this paper I argue that the debate between the so-called “presentists” – according to whom only the present is real – and the “eternalists”, according to whom past present and future are equally real, has no ontological significance. In particular, once we carefully distinguish between a tensed and a tenseless sense of existence, it is difficult to find a single ontological claim on which the two parties could disagree. Since the choice of using a tense or a tenseless language (...) is dictated by purely pragmatic reasons, we should abstain from bringing to bear pseudo-debates generated by the “tensed” or the “tenseless theories” of time on the question of understanding the philosophical implications of contemporary spacetime theories, or notions like becoming, change and persistence in time. (shrink)

Ontologies play a vital role in organizing and constructing knowledge across various domains, enabling effective knowledge management and sharing. The development of domain-specific ontologies, such as the ONTO-TDM ontology for teaching domain modeling, is essential for providing a comprehensive and standardized representation of knowledge within a given discipline. However, to maximize the usefulness and relevance of such ontologies, it is crucial to automate their population with domain-specific information, reducing manual work and ensuring scalability. This paper presents a novel method for (...) ontology population by extracting and integrating relevant information from diverse sources. The method combines the TextRank algorithm with Word2Vec to enhance keyword extraction, capturing both semantic meaning and textual importance. Keywords are then annotated and used to train a machine learning classifier, which aids in integrating new instances into the ontology. Experiments show that the proposed method achieves a precision of 63.33%, a recall of 61.29% and an F1-score of 62.28%, significantly improving keyword extraction and ontology population accuracy compared to existing methods. This validates the method’s effectiveness in semi-automatically extracting relevant instances from diverse data sources, enhancing the efficiency and accuracy of ontology population, and advancing automated knowledge management in domain-specific contexts. (shrink)

“Voluntas ut ratio. Sullo statuto della volontà nel diritto penale” è una monografia di diritto penale rivolta agli studiosi della materia, agli avvocati, ai magistrati e ai pratici del diritto. Dopo avere recuperato le radici della “volontà” e della “libertà” nel pensiero occidentale ed avere esaminato la curvatura riduzionistica tipica della filosofia e della criminalistica moderne, l’Autore di Voluntas ut ratio affida al penalista di oggi alcune riflessioni circa i dogmi del comportamentismo psicologico e la successiva riemersione della volontà e (...) della libertà nella psicologia contemporanea. All’esito dell’indagine, Mauro Ronco formula alcune originali conclusioni sul ruolo della libertà nel diritto penale, sull’imputazione come presupposto di responsabilità, sulla c.d. “colpevolezza normativa” (nozione sottoposta a serrata critica dogmatica), sulla capacità di imputazione e sul carattere essenzialmente deficitario della volontà e della libertà umane, con alcune proposte conclusive in chiave construens. (shrink)