“Neural coding” is a popular metaphor in neuroscience, where objective properties of the world are communicated to the brain in the form of spikes. Here I argue that this metaphor is often inappropriate and misleading. First, when neurons are said to encode experimental parameters, the neural code depends on experimental details that are not carried by the coding variable. Thus, the representational power of neural codes is much more limited than generally implied. Second, neural codes carry information only by reference (...) to things with known meaning. In contrast, perceptual systems must build information from relations between sensory signals and actions, forming an internal model. Neural codes are inadequate for this purpose because they are unstructured and therefore unable to represent relations. Third, coding variables are observables tied to the temporality of experiments, whereas spikes are timed actions that mediate coupling in a distributed dynamical system. The coding metaphor tries to fit the dynamic, circular, and distributed causal structure of the brain into a linear chain of transformations between observables, but the two causal structures are incongruent. I conclude that the neural coding metaphor cannot provide a valid basis for theories of brain function, because it is incompatible with both the causal structure of the brain and the representational requirements of cognition. (shrink)

Inner speech has been shown to vary in form along several dimensions. Along condensation, condensed inner speech forms have been described, that are supposed to be deprived of acoustic, phonological and even syntactic qualities. Expanded forms, on the other extreme, display articulatory and auditory properties. Along dialogality, inner speech can be monologal, when we engage in internal soliloquy, or dialogal, when we recall past conversations or imagine future dialogs involving our own voice as well as that of others addressing us. (...) Along intentionality, it can be intentional (when we deliberately rehearse material in short-term memory) or it can arise unintentionally (during mind wandering). We introduce the ConDialInt model, a neurocognitive predictive control model of inner speech that accounts for its varieties along these three dimensions. ConDialInt spells out the condensation dimension by including inhibitory control at the conceptualization, formulation or articulatory planning stage. It accounts for dialogality, by assuming internal model adaptations and by speculating on neural processes underlying perspective switching. It explains the differences between intentional and spontaneous varieties in terms of monitoring. We present an fMRI study in which we probed varieties of inner speech along dialogality and intentionality, to examine the validity of the neuroanatomical correlates posited in ConDialInt. Condensation was also informally tackled. Our data support the hypothesis that expanded inner speech recruits speech production processes down to articulatory planning, resulting in a predicted signal, the inner voice, with auditory qualities. Along dialogality, covertly using an avatar’s voice resulted in the activation of right hemisphere homologs of the regions involved in internal own-voice soliloquy and in reduced cerebellar activation, consistent with internal model adaptation. Switching from first-person to third-person perspective resulted in activations in precuneus and parietal lobules. Along intentionality, compared with intentional inner speech, mind wandering with inner speech episodes was associated with greater bilateral inferior frontal activation and decreased activation in left temporal regions. This is consistent with the reported subjective evanescence and presumably reflects condensation processes. Our results provide neuroanatomical evidence compatible with predictive control and in favor of the assumptions made in the ConDialInt model. (shrink)

The neural coding metaphor is so ubiquitous that we tend to forget its metaphorical nature. What do we mean when we assert that neurons encode and decode? What kind of causal and representational model of the brain does the metaphor entail? What lies beneath the neural coding metaphor, I argue, is a bureaucratic model of the brain.

Dans le contexte de la réaction romaine aux guerres de religions françaises, Giovanni Botero, premier théoricien de la raison d'État, effectue une opération originale : il place la question économique au cœur même de la pensée politique et de la théorie de l'État. L'enjeu est de définir une pensée de l'État entièrement fondée sur une idée de puissance qu'il oppose explicitement au concept de souveraineté. Contre la nouvelle théorisation juridico-politique d'origine française qui ne cesse de se répandre en Europe, Botero (...) propose ainsi un modèle politique qui allie l'analyse machiavélienne des rapports de forces et l'étude des conditions du développement économique des États. (shrink)

Integrated information theory postulates that a conscious experience depends on a repertoire of hypothetical experiences. This makes consciousness depend on the context that constrains the set of possibilities and on the scenarios imagined by the external observer, and not only on the system itself.

Essai général sur le philosophe et prosateur chinois Tchouang-Tseu dont l'oeuvre se situe à l'origine du taoïsme philosophique et religieux. Ses leçons métaphysiques, son ironie contre toute forme d'autorité s'épanouissent sous forme de dialogues, fables et historiettes que l'auteur interprète et commente pour en dégager les enjeux.

Résumé L’étude porte sur la représentation d’un enfer chinois. Les espaces plastiques et l’équivoque domaine du textuel y sont interrogés. Fruit d’une imagination complexe, liée aux syncrétismes religieux et païens, l’image engendre des formes vivantes inattendues, notamment grâce à la facture de l’imagier. Condamné par les sages chinois comme la source du mal, l’esprit de démesure semble gagner, jusque dans les moindres détails, ces enfers aux châtiments hallucinants.

Au fil de cet ouvrage, le lecteur rencontrera souvent l'« Économie politique » avec un É majuscule. La minuscule en fait le nom commun d'une supposée réalité, la majuscule le nom propre d'une discipline déconnectée du réel. Il existe des politiques économiques, mais il n'existe pas d'économie politique. L'économie est avant tout un caractère du vivant en relation avec son environnement naturel. Ses particularités, certes, ne sont pas négligeables et méritent une étude spécifique, mais sans jamais oublier qu'elle est avant (...) tout un échange entre l'espèce et l'écosystème, contrairement à ce que prétend l'Économie politique. On a longtemps affirmé que les ressources naturelles étaient gratuites et illimitées, et que l'Économie politique ne devait s'intéresser qu'aux rapports et aux transactions au sein du corps social. Si ce dogme n'est plus explicitement formulé, il demeure implicitement la base axiomatique de l'Économie politique centrée sur le « marché ». Tous les économistes patentés sont coupables de cette imposture, véritable fantasme de la toute-puissance de l'innovation technologique et du pouvoir politique. Pourtant la course à la productivité est en conflit permanent avec les cycles naturels et détruit les ressources renouvelables. C'est en intégrant ces contingences que la science économique devrait être un outil au service de la société et de l'écologie. (shrink)

The stratum-specific treatment effect function is a random variable giving the average treatment effect (ATE) for a randomly drawn stratum of potential confounders a clinician may use to assign treatment. In addition to the ATE, the variance of the stratum-specific treatment effect function is fundamental in determining the heterogeneity of treatment effect values. We offer a non-parametric plug-in estimator, the targeted maximum likelihood estimator (TMLE) and the cross-validated TMLE (CV-TMLE), to simultaneously estimate both the average and variance of the stratum-specific (...) treatment effect function. The CV-TMLE is preferable because it guarantees asymptotic efficiency under two conditions without needing entropy conditions on the initial fits of the outcome model and treatment mechanism, as required by TMLE. Particularly, in circumstances where data adaptive fitting methods are very important to eliminate bias but hold no guarantee of satisfying the entropy condition, we show that the CV-TMLE sampling distributions maintain normality with a lower mean squared error than TMLE. In addition to verifying the theoretical properties of TMLE and CV-TMLE through simulations, we highlight some of the challenges in estimating the variance of the treatment effect, which lack double robustness and might be biased if the true variance is small and sample size insufficient. (shrink)

Whereas Western moral philosophy has mainly accounted for recurrent failed or irrational actions through the concept of weakness of will, many early Chinese texts on self-cultivation, notably the Zhuangzi, stand for a philosophical position that explains our frustrations and failures as an "excess of the will." Leaving aside external factors such as accidents or mistakes, this essay explores the sources of thwarted plans and frustrated expectations that are due to factors internal to the individual—more precisely, to the nature of intentional (...) conscience. Such a view was generally inadmissible in Western moral philosophy, which revolves around the paradigm of a causal agent endowed with a 'muscular ethics' for which all that is desired, and indeed all that is achieved, may only be a direct effect of the will. In striking contrast to this orientation, the Zhuangzi presents a variety of situations in which things do not happen as planned because we were too aware of the plan that guided us. Here, I will use Jon Elster's concept of by-product states in order to explore this contrast between two contending models of action that, far from being culturally rooted, express an inner criticism in both traditions, European and Chinese. (shrink)

Graphical AbstractThe ACcess to Transparent Statistics (ACTS) call to action assembles four measures that are rapidly achievable by journals and funding agencies to enhance the quality of statistical reporting. The ACTS call to action is an appeal for concrete actions from institutions that should spearhead the battle for reproducibility.

Transcranial alternating-current stimulation in the frequency range of 1–100 Hz has come to be used routinely in electroencephalogram studies of brain function through entrainment of neuronal oscillations. It turned out, however, to be highly non-trivial to remove the strong stimulation signal, including its harmonic and non-harmonic distortions, as well as various induced higher-order artifacts from the EEG data recorded during the stimulation. In this paper, we discuss some of the problems encountered and present methodological approaches aimed at overcoming them. To (...) illustrate the mechanisms of artifact induction and the proposed removal strategies, we use data obtained with the help of a schematic demonstrator setup as well as human-subject data. (shrink)

Depuis près de cent cinquante ans, l’essai du mathématicien William Kingdon Clifford intitulé The Ethics of Belief est au centre de la plupart des discussions sur les rapports entre éthique et épistémologie, plus précisément sur les questions d’épistémologie et d’éthique de la croyance religieuse car, même si la croyance religieuse n’est jamais la cible exclusive de Clifford, le contexte de sa rédaction ainsi que la quasi-totalité des exemples pris par Clifford portent sur la religion. On opp...

Cavaillès is an enigmatic figure which raises, more than any other, the question of the relation between intellectual activity and resistance. Is there a link between his demanding philosophy of mathematics and his exemplary commitment in the information and action network he has contributed to form, and which he has lead and sustained with great courage? We will try to demonstrate that in his case, the commitment derives from the philosophical theses he defends and that one must search in his (...) conception of mathematics and their necessity the determinant cause of his action. (shrink)

The practice of philosophy of mathematics requires the level of textual sources being adjusted to fit with the level of concepts. Yet the relationship between these levels is not frequently thematized by philosophers of mathematics, and when it is considered, even partial, problems which are epistemologically significant are often neglected. We will study three philosophers who indulge in such thematization, to determine what remains problematic in their use of mathematical texts. In Husserl’s work, we will examine how taking the linguistic (...) flesh of idealities into account is nevertheless intrinsically linked to the exclusion of mathematical texts from philosophical consideration. In Cavaillès’ work, we will try to clarify what governs his use of abundant textual sources to question the methodological choice of retrospective reading. Finally, in Desanti’s work we will focus on the methodological principle of installation inside theories to question the exact nature of the internal movements observed by the philosopher. This analysis will not disqualify these practices of philosophy of mathematics but will highlight the interest of an investigation of the functional relationship between a practice and the philosophical options it produces. (shrink)

Written in the early 1990s by a winner of the Nobel Prize in Literature.

The development of art marketing as a new field of management occurs in a context of great confusion as to what constitutes the very definition of art, one aspect of this confusion being nothing else but the confusion between art and marketing itself. This confusion leads to conflicts between those who consider that art should be defined by a clear aesthetic criterion and those who accept the absence of such a criterion as a legitimate consequence of the principle of freedom (...) which applies both to the creation of the artist and to the taste of the public. This state of confusion does not seem to be experienced in the same way in France where it has tended to be considered as a symptom of crisis in the world of art and in the United States where it has raised as a dominant force in contemporary art. Hence the confusion of art and marketing varies as a function of time (as shown by the emergence of a new field of management) and of space (as shown by the comparison of the French and American cases). It will be proposed that it is possible to account for these historical fluctuation thanks to an institutional approach based on the notion of system of legitimacy. We shall propose the essentially dynamic institutional foundations of modernity leading to the proliferation of innovations which consequences are ever more difficult to anticipate as a reason why, in America, philosophers coming from the analytic tradition found it meaningful to address questions such as “What is art” (Arthur Danto) or “When is there art” (Nelson Goodman”) expressing the need to go beyond pragmatism as expressed by John Dewey’s Art as Experience to promote a positive attitude towards contemporary art, while, in France confusion between art and marketing has been commonly considered negatively as the sign of the triumph of the most radical form of rhetoric, i.e. sophism. (shrink)

Résumé Cette étude cherche à établir entre Maître Eckhart et Fichte une commune nécessité structurelle d’un principe d’unité s’articulant à partir d’une commune réflexion sur la place accordée à l’être, qui engendre une proximité d’intérêt marquée pour une doctrine de l’image qui peut trouver une interprétation théologique. Ensuite, nous montrons que la Doctrine de la Science entretient avec la théologie négative un rapport privilégié quoique implicite en ce que l’Absolu se veut au fond insaisissable au concept et à la conscience. (...) Cette contribution s’achève sur une tentative critique d’ouverture vers l’occasion d’un dialogue entre Maître Eckhart et Fichte en accentuant les subtiles différences qui les séparent notamment sur les figures du Soll, de la lumière et de la révélation. (shrink)

Résumé Le formalisme relève d’une vision unilatérale et dualiste qui lutte contre les formes. La forme est vivante comme désir conscient et inconscient, matière, couleur, rythme, métamorphose, Gestaltung énergétique et érotique au sens de Klee. Ces perspectives semblent échapper à nombre de théoriciens qui la figent dans ses oppositions traditionnelles avec le contenu et la matière. Refoulant l’événement sensible et corporel qu’elle constitue, les uns l’assimilent au formalisme, les autres élaborent un concept d’informe, tous s’avérant incapables de distinguer la forme (...) du formalisme. (shrink)

In these three Indian biographies dating from the 1920s, Romain Rolland introduces the French reader to Gandhi's political struggle and to the spiritual careers of Ramakrishna and his disciple Vivekananda, while revealing the deep meaning of his attraction to Hindu India at this time of his life.

Romain Rolland (1866-1944), écrivain, dramaturge, historien et musicologue, est l'auteur d'une oeuvre considérable et variée. La Grande Guerre fut pour lui l'occasion d'une méditation sur la violence et la haine, et le désastre qui s'abattit sur l'Europe, méditation qui aboutira à la rédaction d'Au-dessus de la mêlée (1914). Ce manifeste pacifiste, lucide et passionné, contribua à l'obtention, par l'auteur déjà célèbre de Jean-Christophe, Beethoven, La vie de Tolstoï, Danton, Les Loups, etc, du prix Nobel de littérature (1915). Son oeuvre (...) se caractérise par la recherche d'une harmonie universelle, de paix et de justice. Empédocle (1918) et L'éclair de Spinoza (1924) sont une expression "enthousiaste" de gratitude envers deux immenses penseurs, compagnons de route de Rolland, qui en a subi la profonde et durable influence. Il s'y révèle un styliste de grande classe, poète original en même temps que rigoureux penseur et pédagogue. (shrink)

Alors même qu'elle n'y est que rarement définie, la question de la censure est à l'arrière plan d'une large part de la pensée politique italienne de l'époque dite de la Contre-Réforme (Botero, Fracchetta, Ammirato, Albergati, Possevino). Elle constitue toutefois une pierre de touche permettant de contester l'idée, aujourd'hui répandue, d'une homogénéité de pensée entre tous les théoriciens de la raison d'État. Alors que certains d'entre eux acceptent le modèle ancien de la censure politique romaine, réactualisé par la théorie juridique bodinienne, (...) les principaux représentants de la raison d'État catholique semblent la rejeter, ou du moins l'ignorer, au profit d'un autre modèle, celui de la censure ecclésiastique. Directement opposés à Bodin, ces auteurs développent cependant le programme que celui-ci expose dans son chapitre De la censure (République, VI, 1) : un contrôle social de la population pensé sur le modèle de la vision panoptique et omnisciente. Mais ils prétendent à une efficacité majeure, grâce à la multiplication des outils et des occasions du contrôle. Il ne s'agit plus simplement de dénombrer les sujets et leurs biens, mais d'épier directement leurs actions et leurs pensées : la figure du censeur fait place à celle de l'espion. Tel qu'il est formulé par tous ces auteurs, l'enjeu principal du contrôle social est bien de connaître les opinions des hommes et de soumettre les consciences ; or la force de la proposition des penseurs catholiques consiste à confier cette tâche ' politique ' à la seule autorité légitime en matière de gouvernement des âmes : le clergé, chargé de la confession et de la direction des consciences. De la sorte, la raison d'État catholique prétend à une efficacité politique supérieure à toute théorie qui détache l'État de sa bride confessionnelle. (shrink)

For naturalism, fed on recent cosmological speculations, mankind is in a position similar to that of a set of people living on a frozen lake, surrounded by cliffs over which there is no escape, yet knowing that little by little the ice is melting, and the inevitable day drawing near when the last film of it will disappear, and to be drowned ignominiously will be the human creature’s portion. The merrier the skating, the warmer and more sparkling the sun by (...) day, and the ruddier the bonfires at night, the more poignant the sadness with which one must take in the meaning of the total situation. —William James, The Varieties of Religious Experience1. (shrink)

Onofri [Onofri, A. 2018. ‘The Publicity of Thought.’ Philosophical Quarterly 68 (272): 521–541.] proposes an individuation criterion for thoughts that purports to satisfy both shareability (the notion that different thinkers, or a single thinker at different times, can and generally do think type-identical thoughts) and Frege's constraint (according to which two thoughts are different if it is possible for a rational subject to endorse one while rejecting the other). I argue that his proposal fails to satisfy Frege's constraint. Then I (...) propose a modification to Onofri's proposal to fix the problem. (shrink)

"Saturne, c'est ici l'Absolu de Hegel, un Absolu pensé si seul qu'il ne vit que de la perpétuelle dévoration de ses propres enfants, craignant d'être détrôné de son absoluité s'il n'absorbe pas, à mesure qu'il la produit, sa propre altérité. C'est cette solitude de Dieu qui est ici interrogée, en suivant au sein de l'oeuvre hégélien l'évolution, puis le plein déploiement conceptuel de la notion de Singularité, qui n'est autre que le nom divin par excellence. Si Dieu, l'Absolu, est pour (...) Hegel la Singularité même, ce n'est que parce qu'il est le mouvement de réflexion réciproque de l'Universel et du Particulier : l'Esprit est la réflexion du Logique dans la Nature, et de la Nature dans le Logique. Hegel ou Le Festin de Saturne se présente alors comme une enquête destinée à dévoiler le meurtre rituel dont la Singularité est le nom dans le Système hégélien. Or, cette Singularité, que nous sommes habitués à entendre individuelle, s'y révèle être boulimique ou, justement, saturnienne. S'ouvrant sur la faillite spéculative des singuliers sensibles au début de la Phénoménologie de l'Esprit, le présent ouvrage ne pourra se conclure qu'avec le triomphe de la Singularité dialectique ne laissant rien - pas même ou surtout pas son Autre - hors d'elle-même, lorsque ce triomphe sera mesuré à l'aune de la conceptualité chrétienne dont se revendique le protestant Hegel, mais qu'il trahit sur un point capital en voulant l'accomplir. Mais Saturne, c'est aussi le "soleil noir" des alchimistes, que l'on a pu associer au soleil obombré au moment de la mort du Christ : quoi de plus naturel, dès lors, que d'en faire l'astre tutélaire d'un système qui se construit tout entier autour d'un "Vendredi saint spéculatif"? Car, comme Dante dut traverser les neuf cercles de l'Enfer avant d'espérer pouvoir s'élever au Purgatoire, puis au Paradis, l'homme pensant doit traverser le Système de la Science, en subir peut-être les glaçantes tentations, en méditer en tous cas la fascinante rigueur conceptuelle, pour pouvoir ensuite espérer voir scintiller devant lui les lueurs matinales d'un inattendu "dimanche de Pâques spéculatif"."--Page 4 of cover. (shrink)

The question of a pragmatist justification of religious beliefs appeared in James’s writing in 1898, as an alternative to Royce’s theory of the absolute. This pragmatist justification was repeated in The Varieties of Religious Experiences in 1902 but it failed to give a proper account of the truth of religious beliefs based on private religious experiences and ultimately failed to answer Royce’s arguments. James knows that any possible pragmatist justification of religious belief based on the practical consequences of religious belief (...) must be completed by a metaphysical theory of the non-natural causality of religious experiences. But that would require going beyond the dualistic and naturalistic account of the Varieties. Nevertheless, the difficulties of the monistic theories of the Essays in Radical Empiricism pushed James to defend, in A Pluralistic Universe, a pantheistic theory in which the Absolute is accepted as a logical possibility, which in turn supposes to accept the composition theory of consciousness that he had rejected in The Principle of Psychology. Therefore, James’s final theory isn’t very different to Royce’s theory, since Royce’s theory is not a theory of the necessity of the Absolute but rather a theory of its possibility. (shrink)

Many aspects of The Varieties of Religious Experience found their theoretical background in other books of James psychology or philosophy. In this article I try to connect his theory of imagination in The Principle of Psychology with his supernaturalism regarding religious experience. Both suppose a theory of the “feeling of reality” that explains how, under the working of imagination, abstract ideas or remote ideals can be perceived as real and lively, becoming motives for action, although they may not have anything (...) to do with sense experience. Although imagination is not mentioned in James’s doctrine of the will to believe, it is central in both understanding this doctrine as well as the overall vision of James psychology and philosophy of religion. Similarly, imagination is essential to grasp a better understanding of how ideas and ideals unite with reality in Dewey’s thoughts concerning religion. I find it useful, in order to have a better understanding of James position, to compare it with what Dewey has to say about it in A Common Faith. Contrasting their theories will show that James’s understanding of imagination can only be understood if rooted in a kind of realism about the ‘unseen universe’. (shrink)

Ce livre a été publié en 1929. Il est le premier tome de l'Essai sur la mystique et l'action de l'Inde vivante, le deuxième tome étant La vie de Vivekananda et l'évangile universelpublié en 1930. Il présente la vie et la pensée d'un des plus grands sages de l'Inde : Ramakrishna. Ramakrishna est un saint du Bengale né en 1836 à Calcutta et mort dans cette même ville en 1886. Ramakrishna enseignait que toutes les religions recherchent le même but : (...) l'union avec Dieu. Proche de l'Islam, du Christianisme et bien que profondément hindou, il a cherché à faire une synthèse des religions. Son message demeure plus que jamais d'actualité. (shrink)

Psychiatry is becoming a cognitive neuroscience. This new paradigm not only aims to give new ways for explaining mental diseases by naturalizing them, but also to have an influence on different levels of psychiatric norms. We tried here to verify whether a biological paradigm is able to fulfill this normative goal. We analyzed three main normative assumptions that is to say the will of giving psychiatry a valid nosology, a rigorous definition of what is a mental disease, and new tools (...) for destigmatizing mentally ill patients. Although these different kinds of normativity are very heterogeneous, we must conclude that, in all these cases, biological psychiatry is a failure, in part because of a lack of epistemological conceptualization. (shrink)

La 4e de couv. indique : "Depuis quelque temps, il est devenu presque impossible de faire l'impasse sur l'antispécisme. Ses militants, végans ou animalistes, ont fait émerger la question du droit des animaux sur la scène publique. Partout retentit le slogan : égalité entre tous les êtres sensibles! Le but de cet ouvrage est de questionner cet appel à la justice. Il propose d'explorer les fondements théoriques de la pensée animaliste. Il met à jour la vision de l'homme et du (...) monde sous-jacente à l'idée d'une égalité morale entre l'homme et les animaux. L'auteur s'appuie alors sur la tradition philosophique et mène une analyse critique de plusieurs livres majeurs prétendant justifier l'antispécisme. De Platon à Nietzsche en passant entre autres, par Bentham ou le christianisme, l'antispécisme sera évalué à l'aune de l'histoire de la philosophie. Un voyage parfois périlleux, difficile, mais dont la conclusion, fort simple, est étonnante et peut-être inquiétante.". (shrink)

This paper shows that low-level generalisations in argument structure constructions are crucial to understanding the concept of alternation: low-level generalisations inform and constrain more schematic generalisations and thus constructional meaning. On the basis of an analysis of the causative alternation in English, and more specifically of the theme, I show that each construction has its own schematic meaning. This analysis is conducted on a dataset composed of 11,554 instances of the intransitive non-causative construction and the transitive causative construction. The identification (...) of lower-level generalisations feeds into the idea that language acquisition is organic and abstractions are formed only gradually from exposure to input. So far, most of the literature on argument structure constructions has focused on the verb itself, and thus fails to capture these generalisations. I make up for this deficit through an in-depth analysis of the causative alternation. (shrink)

The role of the major histocompatibility complex (MHC) in mate choice in humans is controversial. Nowadays, the availability of genetic variation data at genomic scales allows for a careful assessment of this question. In 2008, Chaix et al. reported evidence for MHC‐dependent mate choice among European American spouses from the HapMap 2 dataset. Recently, Derti et al. suggested that this observation was not robust. Furthermore, when Derti et al. applied similar analyses to the HapMap 3 European American samples, they did (...) not see a significant effect. Although some of the points raised by Derti et al. are relevant, we disagree with the reported absence of evidence for MHC‐dependent mate choice within the HapMap samples. More precisely, we show here that the MHC dissimilarity among HapMap 3 European American spouses is still extreme in comparison to the rest of the genome, even after multiple testing correction. This finding supports the hypothesis of MHC‐dependent mate choice in some human populations. (shrink)