Specific inhibition of gene expression by antisense agents provides the basis for rational drug discovery based on molecular targets. Due to the specificity of Watson‐Crick base‐pair hybridization, antisense oligodeoxynucleotides have been used extensively in attempts to inhibit gene expression in both in vitro and in vivo models. Analogues modified from normal phosphodiester oligodeoxynucleotides have entered clinical trials against diseases including AIDS and cancer. Although the precise mechanism of action of these drugs has not been clarified, these oligodeoxynucleotides offer considerable promise (...) as novel molecular therapeutics. We review the recent attempts to harness the therapeutic potential of these oligodeoxynucleotides and appraise the near‐term prospects for antisense technology. (shrink)

Contributed research papers on various aspects of Hindu philoosphy.

In this paper, using Ambedkar’s pioneering vision for engaged Buddhism, we developed the notion of radical interdependence, which consists of four interrelated processes: dialogical recognition; negating invisibilities; dignity as an embodied praxis; ordinary cosmopolitanism. Our research primarily focused on women janitors’ lives in a Mumbai Mall using this conception. Our participants experienced four different kinds of dignity injuries. They used various strategies to preserve personal, intersubjective, and processual dignities. We also found horizontal and vertical ordinary cosmopolitanism strategies to bridge social (...) boundaries between colleagues and mall customers. We further discuss the implications of radical interdependence for organizational research. (shrink)

ABSTRACT:In this qualitative study we examine the role of caste, class, and Dalit janitorial labor in the aftermath of floods in Chennai, India, in 2015. Drawing from a variety of sources including interviews, social media, and news coverage, we studied how Dalit janitors were treated during the performance of janitorial labor for cleaning the city. Our study focuses on two theoretical premises: caste-based social relations reproduce inequalities by devaluing Dalit labor as ‘dirty work’; and Dalit subjectivities, labor, and sufferings including (...) occupational hazards become invisible and ungrievable forcing Dalits to provide a counter narrative to preserve the memory of their trauma and dignity injuries. We find that the discursive construction of janitorial labor as dirty work forced Dalit janitors to work in appalling and unsafe working conditions. Janitors suffered several dignity injuries in terms of social exclusion and a lack of recognition for their efforts and accomplishments. Specifically, we examine various ways through which caste, dirty work, and dignity intersected in the narrative accounts of Dalit janitors. We also explore memory and how processes of remembering and forgetting affected the dignity claims of Dalit janitors. (shrink)

Many traditions in the East have proposed that consciousness without content is possible and could be achieved with mental training. However, it is not clear whether such a state is possible given that intentionality is a critical property of mentality and consciousness in many theories of consciousness. A prominent recent attempt to account for such states of “minimal phenomenal experience” is the ascending reticular arousal system (ARAS) model, which proposes a specific type of non-conceptual representational content to address such a (...) state. Consciousness without content can also be understood by studying related or similar states of minimal phenomenal experience and this paper discusses such findings from such states including dreamless sleep experience and their implications. One way to argue for the need for proposing consciousness without content is to locate a property of consciousness that would necessitate postulating it. A continuous state of consciousness without content may be needed to understand continuity of conscious experience. Finally, I discuss the implications of consciousness without content for current theories of consciousness. (shrink)

Unconscious thought theory (UTT) states that all information is taken into account and the attributes are weighted optimally resulting in better decisions in complex decision problems during unconscious thought. Very few studies have investigated the actual amount of information processed in the unconscious thought condition. We hypothesized that only a small subset of information might be considered during unconscious thought (like conscious thought). To test this possibility and to explore the way attribute information is selected and combined, we performed computer (...) simulations on the datasets used by previous researchers. The simulations showed that considering a small subset (3-4) of attributes, yields results comparable to previous studies. There is no need to posit infinite capacity in the unconscious thought condition. The results also suggest that weight information is used for attribute selection that could potentially explain the difficulties in replicating the deliberation-without-attention effect. (shrink)

This article presents an overview of the single-channel dereverberation methods suitable for distant speech recognition application. The dereverberation methods are mainly classified based on the domain of enhancement of speech signal captured by a distant microphone. Many single-channel speech enhancement methods focus on either denoising or dereverberating the distorted speech signal. There are very few methods that consider both noise and reverberation effects. Such methods are discussed under a multistage approach in this article. The article concludes with a hypothesis that (...) the methods that do not require an a priori reverberation impulse response is desirable in varying the environmental conditions for DSR applications such as intelligent home and office environments, humanoid robots, and automobiles rather than the methods that require an a priori reverberation impulse response. (shrink)

It is frequently demanded that AI-based Decision Support Tools (AI-DSTs) ought to be both explainable to, and trusted by, those who use them. The joint pursuit of these two principles is ordinarily believed to be uncontroversial. In fact, a common view is that AI systems should be made explainable so that they can be trusted, and in turn, accepted by decision-makers. However, the moral scope of these two principles extends far beyond this particular instrumental connection. This paper argues that if (...) we were to account for the rich and diverse moral reasons that ground the call for explainable AI, and fully consider what it means to “trust” AI in a descriptively rich sense of the term, we would uncover a deep and persistent tension between the two principles. For explainable AI to usefully serve the pursuit of normatively desirable goals, decision-makers must carefully monitor and critically reflect on the content of an AI-DST’s explanation. This entails a deliberative attitude. Conversely, calls for trust in AI-DSTs imply the disposition to put questions about their reliability out of mind. This entails an unquestioning attitude. As such, the joint pursuit of explainable and trusted AI calls on decision-makers to simultaneously adopt incompatible attitudes towards their AI-DST, which leads to an intractable implementation gap. We analyze this gap and explore its broader implications: suggesting that we may need alternate theoretical conceptualizations of what explainability and trust entail, and/or alternate decision-making arrangements that separate the requirements for trust and deliberation to different parties. (shrink)

This book discusses major milestones in Rohit Jivanlal Parikh’s scholarly work. Highlighting the transition in Parikh’s interest from formal languages to natural languages, and how he approached Wittgenstein’s philosophy of language, it traces the academic trajectory of a brilliant scholar whose work opened up various new avenues in research. This volume is part of Springer’s book series Outstanding Contributions to Logic, and honours Rohit Parikh and his works in many ways. Parikh is a leader in the realm of ideas, offering (...) concepts and definitions that enrich the field and lead to new research directions. Parikh has contributed to a variety of areas in logic, computer science and game theory. In mathematical logic his contributions have been in recursive function theory, proof theory and non-standard analysis; in computer science, in the areas of modal, temporal and dynamic logics of programs and semantics of programs, as well as logics of knowledge; in artificial intelligence in the area of belief revision; and in game theory in the formal analysis of social procedures, with a strong undercurrent of philosophy running through all his work.This is not a collection of articles limited to one theme, or even directly connected to specific works by Parikh, but instead all papers are inspired and influenced by Parikh in some way, adding structures to and enriching “Parikh-land”. The book presents a brochure-like overview of Parikh-land before providing an “introductory video” on the sights and sounds that you experience when reading the book. (shrink)

This Collection Of Twenty Essays Dealing With A Wide Variety Of Authors And Texts Concentrates On The Concept Of Self.

The notion of epistemic injustice has become an important topic of inquiry in recent times. It refers to the injustice committed to a person when her claim to knowledge is not given due consideration. This article argues that there are two major sources of epistemic injustice: One is the dominating tendencies present in us, and the other is susceptibility to cognitive biases and distortions. When societies become more complex, injustice increases and one can see countless instances of epistemic injustice in (...) everyday life. To reduce epistemic injustice, one has to tackle both sources. Increasing cooperative behaviour is the key in this regard which, in turn, may require revisiting the way the self is automatically understood. (shrink)

25 years ago, when AI & Society was launched, the emphasis was, and still is, on dehumanisation and the effects of technology on human life, including reliance on technology. What we forgot to take into account was another very great danger to humans. The pervasiveness of computer technology, without appropriate security safeguards, dehumanises us by allowing criminals to steal not just our money but also our confidential and private data at will. Also, denial-of-service attacks prevent us from accessing the information (...) we need when we want it. We are being dehumanised not by the technology but by criminals who use the ubiquity of the technology and its lack of security to steal from us and prevent us from doing what we want. What is more interesting is that this malevolent use of the technology doesn’t come from monolithic corporate structures eager to control our lives but mainly from individuals keen to demonstrate their knowledge of the technology for social networking purposes. The aim of this paper is to turn the clock back 25 years and present an alternative perspective: the single, biggest threat of dehumanisation is not the pervasiveness and ubiquity of computers but the lack of ensuring that humans are provided with the basic security they need for using the technology safely and securely. Cyberspace is not a safe space to be. This was something that even far-sighted researcher colleagues in the 1970s and 1980s overlooked. The paper will explore where we went wrong 25 years ago in our predictions and concerns. We will also present a scenario that allows future generations to have a safer cyberworld. (shrink)

Search engines are important contemporary sources of information and contribute to shaping our beliefs about the world. Each time they are consulted, various algorithms filter and order content to show us relevant results for the inputted search query. Because these search engines are frequently and widely consulted, it is necessary to have a clear understanding of the distinctively epistemic role that these algorithms play in the background of our online experiences. To aid in such understanding, this paper argues that search (...) engine algorithms are providers of “bent testimony”—that, within certain contexts of interactions, users act as if these algorithms provide us with testimony—and acquire or alter beliefs on that basis. Specifically, we treat search engine algorithms as if they were asserting as true the content ordered at the top of a search results page—which has interesting parallels with how we might treat an ordinary testifier. As such, existing discussions in the philosophy of testimony can help us better understand and, in turn, improve our interactions with search engines. By explicating the mechanisms by which we come to accept this “bent testimony,” our paper discusses methods to help us control our epistemic reliance on search engine algorithms and clarifies the normative expectations one ought to place on the search engines that deploy these algorithms. (shrink)

Objective tests of olfaction are widely available to aid in the assessment of olfaction. Their clearest role is in the characterization of olfactory changes, either reported by or suspected in a patient. There is a rapidly growing literature concerned with the association of olfactory changes with certain neuropsychiatric conditions and the use of olfactory testing to supplement conventional assessments in clinical and research practice is evolving. Neural pathways important for olfactory processing overlap extensively with pathways important for cognitive functioning, and (...) especially those important for executive functioning, many of which are concentrated in the frontal lobes. Previous work has identified associations between performance on certain olfactory tests and executive functioning and behavioral measures. More recently, similar associations have also been identified in non-clinical samples, raising new questions as to the utility of olfactory test scores as proxy measures for non-olfactory phenomena. In this systemic review, we sought to identify studies, both clinical and non-clinical, that investigated the associations of olfaction with performance on tasks sensitive to frontal lobe functioning. Our search criteria led to the identification of 70 studies published in English. We examined in detail and tabulated the data from these studies, highlighted each study's key findings, and critically evaluated these studies. We use the results of this review to reflect on some of the current and future challenges concerning the use of olfactory testing in clinical neuropsychiatric practice and research and speculate on the potential benefits of administering phonemic fluency in combination with olfactory testing to enhance its predictive value. (shrink)

The September 2006 military coup against the Thaksin government in Thailand has had a profound impact on Thai politics. It has arrested the process of democratic consolidation that was set in motion in the country in the 1990s. Although many of Thaksin's policies lacked the spirit of democratic governance, he was democratically elected and was ousted from power unconstitutionally. The entire tenure of Thaksin has brought to the fore two deep cleavages in Thailand. The first of these is the deep (...) divide between the rural and urban electoral constituencies. The former provided a major vote bank with little bearing on the dispersion of power and resources that was effectively dominated by the latter. Thaksin and his populist policies effectively undermined the urban electorate and strengthened the rural constituency. The second and perhaps structurally more significant tension is that which has developed between the new business elite and the old establishment elite that comprise the monarchy, military, and the bureaucracy. This old elite has been at the forefront of displacing Thaksin through its fear of loss of control over the domestic political process. The drawn out confrontation that has spawned two social movements has significantly raised the country's political temperature and there is the real potential for the situation to deteriorate into violence. Despite these changes, a number of continuities unique to the Thai political situation continue to obtain as well. (shrink)

The paper seeks to argue that the feeling of being part of a larger whole, considered to be a major feature of spiritual experience in some traditions, amounts to a change in the way the self is pre-reflectively understood. Further, the paper argues that some recent developments in the study of cognition support the case for such a revision in self-conception, and this can be used to build up a secular understanding of spirituality. The paper proceeds by making use of (...) Abraham Maslow's account of peak experience along with some accounts of both ancient and contemporary forms of spirituality to argue that the feeling of being part of a larger whole amounts to a significant shift from the separative self-conception implicit in everyday behavior. Subsequently, it is argued that some extant theories on cognition point at the illusory nature of separative self-conception. (shrink)

. Speaker recognition has been an active research area for many years. Methods to represent and quantify information embedded in speech signal are termed as features of the signal. The features are obtained, modeled and stored for further reference when the system is to be tested. Decision whether to accept or reject speakers are taken based on parameters of the data modeling techniques. Real world offers various degradations to the signal that hamper the signal quality. The degradations may be due (...) to ambient background noise, reverberation or multispeaker scenario. This paper presents a survey of various feature extraction, data modeling methods, metrics that are used to take the decisions and methods that can be used to preprocess the degraded data that have been used to perform the task of speaker recognition. (shrink)

Embodied approach to cognition has taken roots in cognitive studies with developments in diverse fields such as robotics, artificial life and cognitive linguistics. Taking cue from the metaphor of a Watt governor, this approach stresses on the coupling between the organism and the environment and the continuous nature of the cognitive processes. This results in questioning the viability of computational–representational understanding of mind as a comprehensive theory of cognition. The paper, after giving an overview of embodied approach based on some (...) examples from conceptual metaphor theory, looks into a special case of Orwell’s problem in cognitive science. The problem is that there is so much evidence for embodiment to be true, yet there is little understanding of the same. I shall try to solve this problem by pointing out that it is our inveterate habits of perceiving ourselves that makes the embodied approach appear implausible. Studies on free will as well as the importance of the unconscious in overall cognitive processing raise challenging questions on our self-conception. A revision in the self-conception in the light of these findings will pave the way for a better appreciation of the embodied approach to cognition. (shrink)

Study of the Nyāyasāra, aphoristic work on Hindu logic and epistemology by Bhāsarvajña, 10th century Kashmiri scholar; includes complete Sanskrit text with Padabhañjikā commentary of Vāsudevasūri.

A detailed guide to Samkhya Vedic philosophy and how to break free from the cycles of rebirth.

We investigate the semantics of messages, and argue that the meaning ofa message is naturally and usefully given in terms of how it affects theknowledge of the agents involved in the communication. We note thatthis semantics depends on the protocol used by the agents, and thus not only the message itself, but also the protocol appears as a parameter in the meaning. Understanding this dependence allows us to give formal explanations of a wide variety of notions including language dependence, implicature, (...) and the amount of information in a message. (shrink)

Epistemic injustice is a matter of not doing justice to the knowledge claims of a person, and it is pervasive in our everyday interactions. It can be traced to the susceptibility of the human mind to cognitive biases and distortions. The paper discusses some ways proposed to mitigate epistemic injustice and suggests that this endeavor requires efforts in more dimensions. The paper tries to demonstrate that the existing efforts to combat epistemic injustice need to be complemented by looking into the (...) very manner in which the self is automatically conceptualized. A shift from the remembering or narrative mode of understanding oneself to the experiential or episodic one will help contain misleading biases and reduce epistemic injustice. Practices such as mindfulness can help enormously in this task. (shrink)

This article argues that there is no performative self-contradiction involved in reports of selfless consciousness, at least in the non-pathological sense of the term. This is because what is central to the experience of selfless consciousness is a different kind of relation of the self with the rest of the world and, therefore, it is not a case of dissolution or decimation of the self. Such an understanding of selflessness can easily distinguish spiritual selflessness from pathological forms such as depersonalisation. (...) This article seeks to provide an explanation for why reports are made of there being no self or subjectivity by appealing to the notion of attentional saliency. (shrink)

The Hindu ethic of cow protectionism is legislatively interpreted in many Indian states through the criminalisation of cow slaughter, and beef consumption, obscuring dairying’s direct role in the butchery of spent female and unproductive male bovines. Cow milk, however, is celebrated as sacred in scriptural and ritual Hinduism, and mobilised by commercial dairying, as well as by right-wing Hindu groups to advance the idea of a Hindu Indian nation. In order to fully protect cows from the harms of human exploitation, (...) it is vital to problematise milk as a benign, rightful product for humans to consume, including its use in Hindu beliefs, rituals and identity. The paper applies feminist vegan critiques to two Hindu legends commonly invoked to promote milk consumption: the boy-god Krishna’s great love for butter and the mythology of the gods and demons churning the Ocean of Milk to attain ambrosia. These critiques unsettle the core relationship of the Hindu to the cow as a lactating mother and provoke the idea that the original sacred milk in Hinduism in fact is plant-based and vegan. (shrink)

In the present research, we examine the relation between leader mindfulness and employee performance through the lenses of organizational justice and leader-member relations. We hypothesize that employees of more mindful leaders view their relations as being of higher leader-member exchange quality. We further hypothesize two mediating mechanisms of this relation: increased interpersonal justice and reduced employee stress. In other words, we posit that employees of more mindful leaders feel treated with greater respect and experience less stress. Finally, we predict that (...) LMX quality serves as a mediator linking leader mindfulness to employee performance—defined in terms of both in-role and extra-role performance. Across two field studies of triadic leader-employee-peer data and dyadic leader–employee data, we find support for this sequential mediation model. We discuss implications for theorizing on leadership, organizational justice, business ethics, LMX, and mindfulness, as well as practical implications. (shrink)

PurposeThe paper seeks to explore the interrelation among the phenomena of wandering mind, free-floating self and intuitive dualism. Further, the paper aims at looking at the possibility of revising the self-conception by changing the wandering nature of mind.MethodThe paper proceeds by demonstrating the existence of the wandering mind and the presence of a particular kind of reflexive self-conception and then contends that reflexive self-conception, characterised in terms of free-floating nature of the self, can be understood to be the result of (...) intuitive dualism along with the wandering mind.Result and DiscussionThe relationship between wandering mind and reflexive self-conception brings out the possibility of revising the reflexive self-conception through practices such as mindfulness because it opens ways to reflexively realise embodiment and reduces the wandering nature of mind. This can possibly give rise to a different kind of self-conception that is more holistic in outlook and is less separative or free-floating. (shrink)

It is generally believed that through one-person one vote the diverse groups within society would be integrated into a shared identity. But the multiculturalists- Kymlicka, Parekh, Taylor, Young- argue that in well established democracies, some groups like African-American, indigenous peoples, ethnic and religious minorities and women feel marginalized and as a remedy, propose measures that the political system could mirror the distinct cultural identity of the different people. The critics of multiculturalism- Miller, Barry- argue that Liberalism accommodates cultural plurality and (...) stresses on the need for shared identity and common public space, which multiculturalism overlooks. (shrink)

We examined proactive and reactive control effects in the context of task-relevant happy, sad, and angry facial expressions on a face-word Stroop task. Participants identified the emotion expressed by a face that contained a congruent or incongruent emotional word. Proactive control effects were measured in terms of the reduction in Stroop interference as a function of previous trial emotion and previous trial congruence. Reactive control effects were measured in terms of the reduction in Stroop interference as a function of current (...) trial emotion and previous trial congruence. Previous trial negative emotions exert greater influence on proactive control than the positive emotion. Sad faces in the previous trial resulted in greater reduction in the Stroop interference for happy faces in the current trial. However, current trial angry faces showed stronger adaptation effects compared to happy faces. Thus, both proactive and reactive control mechanisms are dependent on emotional valence of task-relevant stimuli. (shrink)

This article aims to highlight the importance of organizational climate with both destructive and constructive deviance behaviour in different cultural setting with workplace as a common ground. First, we discuss the need for research in workplace deviance especially destructive and constructive deviance behaviour with the review of previous studies from deviance literature. Next, we present the importance of climate and culture with both destructive and constructive deviance by proposing relationship among them with the help of a framework. The presented theoretical (...) framework can be useful for conducting future empirical research. Finally, we present the conclusion and future research in conducting cross-national research with respect to deviance. (shrink)

The role of holistic or parts-based processing in face identification has been explored mostly with neutral faces. In the current study, we investigated the nature of processing (holistic vs. parts) in recognition memory for faces with emotional expressions. There were two phases in this experiment: learning phase and test phase. In the learning phase participants learned face–name associations of happy, neutral, and sad faces. The test phase consisted of a two-choice recognition test (whole face, eyes, or mouth) given either immediately (...) or after a 24-hour delay. Results indicate that emotional faces were remembered better than neutral faces and performance was better with whole faces as compared to isolated parts. The performance in immediate and delayed recognition interacted with emotional information. Sad eyes and happy mouth were remembered better in the delayed recognition condition. These results suggest that in addition to holistic processing, specific parts–emotion combinations play a critical role in delayed recognition memory. (shrink)