Here we review concepts related to an ensemble description of G-protein-coupled receptors. The ensemble is characterized by both inactive and active states, whose equilibrium populations and exchange rates depend sensitively on ligand, environment, and allosteric factors. This review focuses on the adenosine A2 receptor, a prototypical class A GPCR. 19F Nuclear Magnetic Resonance studies show that apo A2AR is characterized by a broad ensemble of conformers, spanning inactive to active states, and resembling states defined earlier for rhodopsin. In keeping with (...) ideas associated with a conformational selection mechanism, addition of agonist serves to allosterically restrict the overall degrees of freedom at the G protein binding interface and bias both states and functional dynamics to facilitate G protein binding and subsequent activation. While the ligand does not necessarily “induce” activation, it does bias sampling of states, increase the cooperativity of the activation process and thus, the lifetimes of functional activation intermediates, while restricting conformational dynamics to that needed for activation. GPCRs represent a ubiquitous class of transmembrane receptors, responsible for cell signaling and cell homeostasis. Their activation gives rise to conformational changes that allow the receptor to engage downstream partners. Activation can be thought of in terms of a free energy landscape associated with distinct conformers, responsible for the process. Here, the action of ligands is seen to alter this landscape by enabling transitions between key intermediates. (shrink)

The dominance of capitalism, through the hegemony of neoliberal ideology, is maintained as an illusion through the use of four main strategies. In order to obtain the consent of the population, mass schooling tends to produce graduates who accept this illusion because they are vulnerable to these strategies and cannot imagine a post-capitalist world. However, through education, people can better appreciate the problematic reality of unbridled capitalism, such as the degradation of the global ecosystem. It is argued here that programs (...) which are designed to address these problems, such as Education for Sustainable Development, are dependent upon citizens developing a critical consciousness. This consciousness is firstly able to confront the four strategies maintaining capitalism’s dominance. It is argued that an education which engages with spiritual ideals and values regarding how a good life is understood in an aspirational sense, enables people to engage with the dominance of capitalism and to envision other possibilities for society in which capitalism is harnessed to serve the greater public good. This requires education’s ontology – as the character of students – to critically read the world, imagine possibilities which can constitute a good life, and are courageous to enact the social actions required to make these ideals a reality. This is made possible by an education which returns to the spiritual roots of ideals. (shrink)

In this analysis, I employ Husserl’s three-part description of intentionality to show how a player/play act/play object model for consciousness helps us see play more clearly. I review Suits’ logic-based attempts to amend Huizinga’s overly inclusive characterization of play. However, I do so on what I see as stronger phenomenological grounds by describing four kinds of experience embedded in Suits’ work-play dichotomy. I analyze two species of play-fortified work – namely, work that requires intrinsic enhancement and work that does not. (...) I also describe two species of play – namely, play that is compromised and play that is unfettered. I conclude by summarizing advantages of phenomenological analyses and underlining the important distinctions this philosophic method uncovers within traditional work and play categories. (shrink)

Volume I. Metaphysics and sport -- volume II. Ethics of sport -- volume III. Sport and the good life -- volume IV. Sport and education.

Though William Lane Craig believes his anti-Platonism is compatible with objective, Christian morality, I argue that it is not. First, I survey the main contours of his nominalism. Second, I discuss how he sees those points in relation to objective, Christian morality. Then, I argue that his view cannot sustain the qualitative aspects of moral virtues or principles, or even human beings. Moreover, Craig’s view loses any connection between those morals and humans, thereby doing great violence to objective, Christian morals. (...) Finally, I sketch two advantages of a Platonic realism in regards to Christian morals. (shrink)

Volume 47, Issue 2, July 2020, Page 318-321.

The article examines the surprising role of Rousseau in the revival of liberal and humanist thought in contemporary French political thought. The choice of Rousseau as an inspiration and source of humanism is an illuminating indication of a shift in French thought. The authors concentrate on the natural- rights republicanism of Luc Ferry and Alain Renaut and the critical humanism of Tzvetan Todorov. While these thinkers all appeal to Rousseau's definition of humanity in terms of freedom, they draw on different (...) aspects of his thought and his relationship to the philosophic tradition. Their different receptions of Rousseau reveal tensions in the humanist revival and provoke reflection on the relationships among republicanism, liberalism and humanism in contemporary France. (shrink)

Many have written about trope ontology, but relatively few have considered its implications for some of the ontological conditions needed for us to have knowledge. I explore the resources of trope ontology to meet those conditions. With J. P. Moreland, I argue that, being simple, we can eliminate tropes’ qualitative contents without ontological loss, resulting in bare individuators. Then I extend Moreland’s argument, arguing that tropes undermine some of the needed ontological conditions for knowledge. Yet, we do know many things, (...) and trope nominalists presuppose that too. Therefore, I consider three counter-arguments, starting with David Lewis’s rebuttal based on appeal to brute facts. Second, I explore Jeffrey Brower’s recent proposal as a possible solution. Last, I consider Robert Garcia’s recent distinction between module and modifier tropes, to see if it can be of assistance. I conclude, however, that trope nominalism cannot preserve some of the needed ontology to have knowledge. (shrink)

William Lane Craig has claimed that Platonism is incompatible theologically with Christian theism in that it undermines God’s aseity. He develops three main objections to Platonism, as well as his own nominalist theory of reference, for which he draws from philosophy of language. However, I rebut his arguments. I argue that, unlike on Platonism, his view will not preserve a real essence of intentionality. Without that, his view undermines our abilities to know reality. As an implication, I also will highlight (...) the importance methodologically of approaching this issue from the primacy of the ontology of knowledge, not philosophy of language. (shrink)

The development of the science of economics is closely linked to the structure of capitalism. Even though ancient and medieval thinkers had already stated a certain number of ideas in this domain, the science of economics, in the modern sense of the word, did not truly begin until the 17th Century and the early 18th Century. At that time the methodology for research in the natural sciences was developed, and the first scientific academies and societies were founded (England, France, Prussia, (...) Russia). The initial step in the development of the science of economics occurred in conjunction with this process. Moreover, the ideas of the first economists were, as a general rule, centered on the practical problems and needs of the State. And in that period the prevalent state structure in Europe was the absolute monarchy. Consequently, the first economists were, for the most part, counsellors to the sovereign, authors of studies and reports containing a variety of proposals regarding economic policy. With regard to a great many distinguished economists of the 17th and 18th Centuries, we can speak of them being “men of proposals”. (shrink)

It is with these virile words of the Martinique poet Aimé Сésaire, an expression of assurance regained, testimony to a self-confidence once stolen but then reconquered, that I would like to open my remarks.*Africa was present at the last great international philosophical meeting two years ago in Montreal. I would like here to illustrate the meaning behind this presence and to explain the reasons why we wanted to be present, in order to avoid facile misunderstandings which could have weighty consequences.

It is some 900 years before Christ that we find the most ancient traces of two innovations which were to have incalculable consequences for the future of mankind. The evolution of civilization has, in fact, been marked by a clean break located at the era when man discovered the rudiments of agriculture and animal husbandry and began to produce his own food. Whereas for the three million years during which he had to provide for his needs exclusively through hunting, fishing (...) and gathering, his progress was extremely slow, the adoption of a new way of life based on agriculture and animal husbandry allowed man to transform himself in less than twelve thousand years from deer hunter into astronaut. (shrink)

If we attempt to unify the theoretical efforts that appreciate a specific social activity in play, we can sketch the perspective of an entire anthropology of play into cohesive parts deriving from the knowledge of collective experience. This preoccupation is, in fact, two-fold. On the one hand is the comprehensive description of the relationship between life styles and their stylizations in everyday practices and customs as well as in cultural works, and on the other are social sensitivities and representations that (...) are relatively shared by individuals grouped in human communities. This very general framework encourages situating the presence of play as one of the concrete manifestations of an emotional core, converting primitively negative impulses into attractive forces which, because of this, becomes the seat of all human interaction and agitation, the energetic heart of social power. (shrink)

Though nominalism is a major presupposition in academia and western society, R. Scott Smith shows that nominalism undermines all knowledge whatsoever. In light of the many clear examples of knowledge that we do have, nominalism should be replaced by a realist view of properties.

John Dewey has been portrayed as a sort of villain in Rosenow's (1997) article which appeared in this journal, apparently because he was unfairly opposed to God and to religion, and also because he deliberately usurped religious language to 'camouflage' his secular ideas. By drawing mainly upon similar sources but with some important additions, I wish to challenge the four major concerns raised in Rosenow's article and in doing so aim to offer an alternative interpretation. It is understood here that (...) Dewey's approach to religion was not so much religious as it was 'spiritual' and while developing and changing throughout his writings, his ideas on spirituality nevertheless were thoroughly entwined with his other views, especially those dealing with education, science and democracy. (shrink)

The terms “modem” and “modernity”, like many other terms in common use and of wide extension, are extremely complex. And a theory of modernity should have no other goal initially than to settle this polysemy in the hope of arriving at a sufficiently rigid definition that the “thing” itself can become the object of a clearer consideration. But what is the path toward this greater clarity?

ABSTRACTIn this essay, I defend sport as a hobby in contrast to sport as a ‘mutual quest for excellence through challenge’. With the assistance of ideas found in the novel Don Quixote, I rai...

If educators are to educate they must be accorded some level of trust. Anthony Giddens claims that because trust is not easily created, it is now being replaced with ‘confidence’ because this latter disposition is much easier to give and is more convenient. It is argued in this paper that this shift from trust to confidence stifles education because emphasis is placed solely upon qualifications and competence, and is neglectful of disclosing one’s motives and desires—which are considered to be essential (...) elements for relationships and communities which depend upon trust. Therefore, educators ought to seek to become more trustworthy by going beyond evidence-based practices and codes of ethics, towards articulating a developed personal philosophy of education outlining the ultimate end-purposes to which they aspire. Through such a philosophy, educators identify their ultimate desires and commitments and this self-disclosure can make trust-giving more likely. Demonstrated evidence of achievements and qualifications encourage confidence and this has some value. In addition to these artefacts of evidence, it is argued here that educators must also articulate what they actually desire. This can be understood as John Dewey’s virtue of ‘genuine interest’ which he characterises as being wholehearted, persistent and impartial. For educators, this is often represented in our personal philosophy of education and because it is personal, it is also existential in the sense that it pertains to giving sense, meaning and purpose to all of our activities and way of life for which we are individually responsible and passionately committed to as professionals. As a consequence of being existential, our philosophy and our commitment to it has an intellectual and moral aspect and because it reaches to the very depths of our raison d’être, it pertains to our passion as described by Søren Kierkegaard. This paper shall draw upon Dewey’s notion of wholeheartedness and Kierkegaard’s notion of purity of heart, to make the case that if educators embrace these in their practices, we may become more trustworthy. (shrink)

Many understand intentionality as the ofness or aboutness of mental states yet disagree about it metaphysically. I will argue that (1) intentionality seems best understood as an abstract universal; (2) it is needed to have factual knowledge of reality, yet (3) metaphysical treatments (or uses) of intentionality by several fashionable philosophies land us in constructivism. I will focus on Daniel Dennett’s treatment of intentionality and then extend my findings to other naturalist and physicalist views, postmodern epistemologies, and nominalism. I also (...) will sketch show how we use intentionality to know reality before suggesting an implication for epistemic externalism. (shrink)

In this essay, I revisit my claims about game structures and amend them by adding achievement-regulated games to previously analyzed time- and event-structured activities. In describing achievement formats, I discuss their heavy reliance on the world of work, their strong dependency on Suits’ lusory attitude, and their relative independence from constitutive rules. I argue that achievement-structured games carry disadvantages not shared by time- and event-regulated activities. I speculate that achievement gaming came first in our evolutionary history, but show that it (...) still holds value for modern players and spectators. (shrink)

The article is intended to reveal important similarities between fiction and sport. I build on Jonathan Gottschall’s discussion in The Storytelling Animal: How Stories Make Us Human by celebrating the significance of stories and their ‘witchy power’ and by examining factors that demonstrate similarities between fiction and sport. I suggest that an unmistakable semantic, structural, and cultural kinship exists between the two. This argument requires a discussion of play theory, play resources and constitutive rules, the semantic power of problems and (...) the uncertainty they produce, and the role of ‘frames’ in bringing problems to life. I conclude by noting the unique frame capabilities of ‘the big game’ and zero-sum dichotomous sporting motifs. (shrink)

It is important for educators to recognise that the various calls to decentre the subject—or self—should not be interpreted as necessarily requiring the removal of the subject altogether. Through the individualism of the Enlightenment the self was centred. This highly individualistic notion of the sovereign self has now been decentred especially through post‐structuralist literature. It is contended here however, that this tendency to decentre the subject has been taken to an extreme at times, especially by some designers of school frameworks (...) and curricula, who have eliminated the subject altogether. Such elimination is argued to contribute to the numbers of youth who are dropping out of school. By adopting an existential perspective and by drawing mainly upon Kierkegaard's subjective truth and Dewey's notion of centeredness, the case is made that for education the subject should not only be included but should actually be centred—at least momentarily. (shrink)

We live in a time of moral confusion: many believe there are no overarching moral norms, and we have lost an accepted body of moral knowledge. Alasdair MacIntyre addresses this problem in his much-heralded restatement of Aristotelian and Thomistic virtue ethics; Stanley Hauerwas does so through his highly influential work in Christian ethics. Both recast virtue ethics in light of their interpretations of the later Wittgenstein's views of language. This book systematically assesses the underlying presuppositions of MacIntyre and Hauerwas, finding (...) that their attempts to secure moral knowledge and restate virtue ethics, both philosophical and theological, fail. Scott Smith proposes alternative indications as to how we can secure moral knowledge, and how we should proceed in virtue ethics. (shrink)

For most of the church's history, people have seen Christian ethics as normative and universally applicable. Recently, however, this view has been lost, thanks to naturalism and relativism. R. Scott Smith argues that Christians need to overcome Kant's fact-value dichotomy and recover the possibility of genuine moral and theological knowledge.

This Special Issue [available free online] co-edited by Peg Brand Weiser (University of Arizona) and R. Scott Kretchmar (Pennsylvania State University) is entitled, "The Myles Brand (1942-2009) Era at the NCAA: A Tribute and Scholarly Review." The late Myles Brand was a philosopher (of action theory; social and political applied philosophy, philosophy of sport), former department chair (University of Illinois at Chicago; University of Arizona), dean (Arizona), provost (The Ohio State University), president (University of Oregon; Indiana University), and fourth (...) president of the NCAA (National Collegiate Athletic Association). [An extensive website created in 2020 by Peg Brand Weiser of over 300 entries of his work--speeches, essays, podcasts, and videos--can be found at a website under his name.] This Special Issue includes insightful essays on the legacy of Myles Brand by authors who dig deeply into continuing controversies within higher education, intercollegiate athletics, and the values, principles, and style of Brand's leadership. They take up the gauntlet to dissect and disseminate Brand's lasting influence on the institution of the NCAA in terms of the decisions and policies enacted between 2003 and 2009 that continue to affect the well-being of today's student-athletes, the sustainability of high-cost intercollegiate competition, and now, the "threat to" or "abandonment of" (depending on your point of view) "amateur status" due to students' newfound economic agency and ability to profit from NILs (Name, Image, Likeness) monetary deals. Essays include a co-authored "Editors' Introduction;" an introductory preface by John R. Thelin ("From Chaos to Coherence: Myles Brand and the Balancing of Academics and Athletics"); a short remembrance by Josh Brand ("Myles Brand, My Father"); and essays by Peg Brand Weiser ("Life is an Adventure: From Action Theory to Action"); R. Scott Kretchmar ("President Brand's Gambit: Inviting Scholars Inside the Tent"); Walter Harrison ("Myles Brand and the Responsibility of Leadership"); Heather Reid ("Amateurism, Professionalism and the Value of College Sports"); Lou Mats ("Myles Brand: Intercollegiate Athletics Within the Limits of the Academic Mission Alone'); Welch Suggs and Jennifer Hoffman ("Myles Brand's Collegiate Model and the Post-Amateurism World of College Sports"); David K. Wiggins ("Myles Brand: A Leader Deeply Committed to Diversity, Inclusiveness, and Social Justice"); C. Keith Harrison, Bernard Franklin, and Whitney Griffin ("Myles Brand's Philosophy of the Value of Intercollegiate Athletics: A Collaborative Effort and the Perspective of Two Black Males on Educational Achievement at the NCAA"); and Rodney Fort ("Myles Brand's College Sports Sustainability: 'Amateurism,' Finances, and Institutional Balance. (shrink)

This article looks at social entrepreneurs that operate for-profit and internationally, offering that international for-profit social entrepreneurs (IFPSE) are of a unique type. Initially, this article utilizes the entrepreneurship, social entrepreneurship, and international entrepreneurship literatures to develop a definition of the IFPSE. Next, a proposed model of the IFPSE is built utilizing the dimensions of mindset, opportunity recognition, social networks, and outcomes. Case studies of three IFPSE are then used to examine the proposed model. In the final section, findings from (...) the case studies are used to examine the proposed model and more fully elucidate the dimensions of the IFPSE. (shrink)