Plants from a handful of species provide the primary source of food for all people, yet this source is vulnerable to multiple stressors, such as disease, drought, and nutrient deficiency. With rapid population growth and climate uncertainty, the need to produce crops that can tolerate or resist plant stressors is more crucial than ever. Traditional plant breeding methods may not be sufficient to overcome this challenge, and methods such as highOthroughput sequencing and automated scoring of phenotypes can (...) provide significant new insights. Ontologies are essential tools for accessing and analysing the large quantities of data that come with these newer methods. As part of a larger project to develop ontologies that describe plant phenotypes and stresses, we are developing a plant disease extension of the Infectious Disease Ontology (IDOPlant). The IDOPlant is envisioned as a reference ontology designed to cover any plant infectious disease. In addition to novel terms for infectious diseases, IDOPlant includes terms imported from other ontologies that describe plants, pathogens, and vectors, the geographic location and ecology of diseases and hosts, and molecular functions and interactions of hosts and pathogens. To encompass this range of data, we are suggesting inOhouse ontology development complemented with reuse of terms from orthogonal ontologies developed as part of the Open Biomedical Ontologies (OBO) Foundry. The study of plant diseases provides an example of how an ontological framework can be used to model complex biological phenomena such as plant disease, and how plant infectious diseases differ from, and are similar to, infectious diseases in other organism. (shrink)

Beginning in 1989, the breakup of the Soviet Bloc disrupted trade and cut off Cuba's source of subsidized fuel oil, making many modern agricultural practices impossible, including the wide use of pesticides. Among Cuba's responses was an emphasis on biological control of plant diseases. Research into biological control began in the 1930s, and after the revolution many scientists maintained an unofficial interest. When the 1989 economic crisis occurred, the government placed a high priority on biocontrol, and researchers were in (...) a position to begin immediate implementation. For example, the construction of factories for the mass production of biological agents had been approved in 1988, and are currently in operation. Disease monitoring was undertaken before the current crisis, with more than 90% of Cuban agriculture using it to some extent. Such monitoring has allowed a reduction in pesticide use. Since the 1989 onset of economic crisis the monitor system has not been greatly modified for use with biological control techniques, but an example of a successful transition from chemical treatment to biocontrol in Cuba is in banana plantations.At the various research centers, research is being conducted in the biocontrol of vegetable diseases, tobacco root diseases, nematodes, and pasture weeds. Technical research is being done on mass production of inoculum, the production of application formulations, and storage of biocontrol products. Because wide use of biocontrol agents was urgently desired, the government cooperated at every step of research, including in regulatory matters. Obstacles to successful biocontrol mentioned by Cuban scientists were the lack of taxonomic knowledge and the need for strict quality control.There are few economic studies of biocontrol agents despite the importance of such studies. Cuban scientists are in an excellent position to do such research. Forced by the economic crisis to act, Cuba has made a major change in national agronomic policy that may represent a significant and new direction for “modern” agricultural practices. (shrink)

Early diagnosis of leaf diseases is a fundamental tool in precision agriculture, thanks to its high correlation with food safety and environmental sustainability. It is proven that plant diseases are responsible for serious economic losses every year. The aim of this work is to study an efficient network capable of assisting farmers in recognizing pear leaf symptoms and providing targeted information for rational use of pesticides. The proposed model consists of a multioutput system based on convolutional neural networks. The (...) deep learning approach considers five pretrained CNN architectures, namely, VGG-16, VGG-19, ResNet50, InceptionV3, MobileNetV2, and EfficientNetB0, as feature extractors to classify three diseases and six severity levels. Computational experiments are conducted to evaluate the model on the DiaMOS Plant dataset, a self-collected dataset in the field. The results obtained confirm the robustness of the proposed model in automatically extracting the discriminating features of diseased leaves by adopting the multitasking learning paradigm. (shrink)

Cornell University and Zamorano (ThePanamerican School of Agriculture) facilitatedworkshops that provided Honduran and Nicaraguanfarmers new experience with plant diseases and helpedfarmers assimilate information and identify diseasemanagement alternatives. After learning about thebiology of plant diseases, farmers were able toidentify disease problems in their field, enablingthem to use pesticides more selectively. Furthermore,participants of seven courses conceived 273 pathogen-specificmanagement alternatives, and they identifiedon average 66 percent of the common recommendations by plantpathologists for the control of general disease types.Many ideas (...) were novel and may represent newopportunities for improving the practice of diseasemanagement. (shrink)

The world is experiencing a cataclysmically increasing burden from chronic illnesses. Chronic diseases are on the advance worldwide and treatment strategies to counter this development are dominated by symptom control and polypharmacy. Thus, chronic conditions are often considered irreversible, implying a slow progression of disease that can only be hampered but not stopped. The current plant-based movement is attempting to alter this way of thinking. Applying a nutrition-first approach, the ultimate goal is either disease remission or reversal. (...) Hereby, ethical questions arise as to whether physicians’ current understanding of chronic illness is outdated and morally reprehensible. In this case, physicians may need to recommend plant-based diets to every patient suffering from chronic conditions, while determining what other socioecological factors and environmental aspects play a role in the chronic disease process. This article provides insights to aspects of diet and chronic illness and discusses how the plant-based movement could redefine current understanding of chronic disease. The ethical justifications for recommending of a plant-based diet are analyzed. The article concludes that not advocating for plant-based nutrition is unethical and harms the planet and patients alike. (shrink)

A class of maize mutants, collectively known as disease lesion mimics, display discrete disease‐like symptoms in the absence of pathogens. It is intriguing that a majority of these lesion mimics behave as dominant gain‐of‐function mutations. The production of lesions is strongly influenced by light, temperature, developmental state and genetic background. Presently, the biological significance of this lesion mimicry is not clear, although suggestions have been made that they may represent defects in the plants' recognition of, or response to, (...) pathogens. One feature that is common to all lesion mimics is their association with cell death. In plants, as in animals, a number of developmental and pathological processes exist where controlled cell death, whether programmed or triggered in response to physiological or environmental stimuli, constitutes the normal aspect of life. Might disease lesion mimic mutations represent variants where regulation of desirable cell death has gone awry? In this paper we argue that this might be the case, and further conjecture that these mutants offer a unique opportunity for studying the genetic and cellular mechanisms of cell death in plants. (shrink)

The introduction of genes into plants encoding potent antibacterial proteins, derived from insects, may significantly augment the level of their resistance to bacterial disease. Using modern techniques, genes of choice can be introduced into plant tissue and this tissue can be manipulated to produce viable plants. The potato has been chosen as the model system, not only because of its plasticity of development, which allows for the relatively easy regeneration of whole plants from transformed tissue, but also because (...) the potato ranks among the top four plants in the world in terms of economic importance. (shrink)

I discuss the two different responses from the angiosperms to the specific molecular mechanisms of the tumor-inducing agent contained in the bacteriumAgrobacterium tumefaciens. This is done in terms of the collective variables for expressing genetic response to a continuously varying supply of energy from metabolic pathways. We are led to the conjecture that the expression of the recessive oncogenes may not be restricted to humans (retinoblastoma and osteosarcoma), but may also occur in plants (crown gall), and be expressed through a (...) heat-shock. (shrink)

There is no doubt that custard apple diseases are among the important reasons that destroy the Custard Apple plant and its agricultural crops. This leads to obvious damage to these plants and they become inedible. Discovering these diseases is a good step to provide the appropriate and correct treatment. Determining the treatment with high accuracy depends on the method used to correctly diagnose the disease, expert systems can greatly help in avoiding damage to these plants. The expert system (...) correctly diagnoses Custard Apple disease to make it easier for farmers to find the right treatment based on the appropriate diagnosis. Objectives: A specialized syllable language system was established for the diagnosis of Custard Apple plant disease. (shrink)

This is an article in Thomas J.J. McCloughlin (Ed.) The Nature of Science in Biology: A Resource for Educators. Graphikon Teo, Dublin. -/- Abstract: Philosophers usually tend to think of animals when they think about life, plants often only appear in their works as on the margins, in the background; they are rarely in the centre. However, plant life involves unique processes, including remarkable modes of interaction between plants and their environments. Needless to say, plants are vital parts of (...) ecosystems. Serious attention to plants provides novel and interesting perspectives on many topics in philosophy of biology, including individuality, organisation and disease. Plant biology should have a substantial part in philosophy education. To support this assertion, this paper briefly describes three topics related to plant-environment interaction and explains some of their philosophical implications. These topics are growth, plant hormones and plant-plant microbiota interactions, all of which present crucial aspects related to some prevalent topics in philosophy of biology such as individuality, systems thinking, and holobiont. (shrink)

MicroRNAs are non‐coding regulators of gene expression and key factors in development, disease, and targets for bioengineering. Consequently, microRNAs have become essential elements of already burgeoning draft plant genome descriptions where their annotation is often particularly poor, contributing unduly to the corruption of public databases. Using the Citrus sinensis as an example, we highlight and review common failings of miRNAome annotations. Understanding and exploiting the role of miRNAs in plant biology will be stymied unless the research community (...) acts decisively to improve the accuracy of miRNAome annotations. We encourage genome annotation teams to do it right or not at all. (shrink)

Plant protection problems are simulated by a system of ordinary differential equations with given initial conditions. The sensitivity and resistance of pathogen subpopulations to fungicide mixtures, fungicide weathering, plant growth, etc. are taken into consideration. The system of equations is solved numerically for each set of initial conditions and parameters of the disease and fungicide applications. Optimization algorithms were investigated and a computer program was developed for optimization of these solutions. 14 typical cases of the disease (...) were simulated and optimized in order to determine optimal fungicide treatments. The optimized strategy for fungicide application differs considerably from the commonly used method and seems to be an important new principle in plant protection. The approach developed in this study may be useful for a wide spectrum of purposes in the simulation of leaf diseases. It may also help the biologist to decrease or pinpoint experimental work and analyze its results and is perspective for plant disease control. (shrink)

This paper reports on action research that evaluated local perceptions and knowledge of indigenous tree planting and management in the Romwe catchment, Chivi District, southern Zimbabwe. The species tested were the overexploited Afzelia quanzensis, important for timber and carvings of sculptures and utensils; Sclerocarya birrea, the marula tree used for wood, bark, and fruit; and Brachystegia glaucescens, the dominant miombo tree species, used for firewood, fiber, and fodder. Participants volunteered to plant and manage the test seeds, while a research (...) team monitored their activities and results for 26 months. For Afzelia quanzensis, the germination rate was 81%, and 69% of the seedlings were still alive after one year. In the case of Sclerocarya birrea, the germination rate was 69%, and the one-year survival rate was 50%. For Brachystegia glaucescens, the germination rate was only 30%, and the survival rate was 31%. The main reasons for planting were to provide shade, to serve as a windbreak, and to conserve and gain individual control over dwindling natural resources, particularly Afzelia quanzensis. Women were generally more active and innovative than men. For instance, they searched for their own seeds or seedlings in the bush when there weren’t sufficient plants. Some participants tried out various indigenous methods of pest and disease control, water conservation, and moisture retention. Group feedback sessions and informal interactions provided the opportunity to share experiences. The participants learned that indigenous trees can be purposefully planted and were not simply a gift from God. Despite the droughts and political instability of recent years, a growing number of people became involved in tree planting during 2002–2003. As a result, there is now greater awareness among the local population of dwindling resources and their future potential. (shrink)

Background: The castor bean is a large grassy or semi-wooden shrub or small tree. Any part of the castor plant parts can suffering from a disease that weakens the ability to grow and eliminates its production. Therefore, in this paper will identify the pests and diseases present in castor culture and detect the symptoms in each disease. Also images is showing the symptom form in this disease. Objectives: The main objective of this expert system is to (...) obtain appropriate diagnosis of the disease. Methods: In this paper, the expert system is designed for the ability of agricultural engineers to detect and diagnose disease of castor like as: seeding blight, alternaria blight, cercospora leaf spot, powdery mildew and wilt. This system presents the disease symptoms, survival and spread, favorable conditions and image for each disease. Clips and Delphi expert system languages are used for designing and implementing the proposed expert system. Results: The expert system in the diagnosis of castor diseases was assessed by farmers and agricultural engineers and they were satisfied and accepted with its quality of performance. Conclusions: The expert system is easy for farmers and people have experience in the plant of castor to detect and diagnosis the symptoms that may face this plant from several disease. (shrink)

This contribution takes the notion of herbal landscape (a mental field associated with plants used to cure or prevent diseases and established within specific cultural and climatic zones) as a starting point. The authors argue that the features by which a person recognises the plant in the natural growing environment is of crucial importance for the classification and the use of plants within the folk tradition. The process of perception of the plant can be divided into analytical categories (...) according to the sign concept of Charles Sanders Peirce. Whereas the plant can be seen as the object, the feature(s) the plant is recognised by is (are) the representamen(s), and the image of the plant within the herbal landscape can be understood as the interpretant. Different methods of perception of the signs within the herbal landscape are demonstrated comparing the herbal knowledge acquired from the herbals with the method of plant recognition learned in the traditional way. The first can be looked at with the terms of Tim Ingold as transportation, using plant features to go across, leaving all other signs present in the landscape unnoticed. The wayfarer, guided by signs learned within the context of surroundings, walks along and perceives the plant as a part of the herbal landscape. Although the examples analysed come from Estonian ethnobotany, the method of analysis can be applied in ethnobotanical research worldwide. (shrink)

The Uddevalla Volvo plant represents a different paradigm for automotive assembly. In parallel-flow work, self-managed work groups assemble entire automobiles with comparable productivity as conventional series-flow assembly lines. From the perspective of the demand-control model, operators at the Uddevalla plant have low physical and timing demands, high psychological demands because of increased duties and high-decision latitude due to varied and complex skills utilized, the two latter characterizing active work. Operators at standard assembly lines have higher levels of physical (...) and timing demands, lower levels of psychological demand, and lower control, characterizing high-strain work. Active work is related to lower incidence of heart disease than high-strain work. (shrink)

Anton de Bary is best known for his elucidation of the life cycle of Phytopthora infestans, the causal organism of late blight of potato and the crop losses that caused famine in nineteenth-century Europe. But while practitioner histories often claim this accomplishment as a founding moment of modern plant pathology, closer examination of de Bary’s experiments and his published work suggest that his primary motiviation for pursing this research was based in developmental biology, not agriculture. De Bary shied away (...) from making any recommendations for agricultural practice, and instead focused nearly exclusively on spontaneous generation and fungal development – both concepts promoted through prize questions posted by the Académie des Sciences in the 1850s and 1860s. De Bary’s submission to the Académie’s 1859 Alhumbert prize question illustrates his own contributions to debates about spontaneous generation and demonstrates the practical applications of seemingly philosophical questions – such as the origin of life. (shrink)

Nearly all contemporary people subsist on cultivated plants, most of which are vulnerable to diseases. Yet, there have been few studies of what traditional people know – and do not know – about crop disease. Agricultural scientists in general are becoming aware of the potential contribution of social scientists and farmers in developing integrated management of crop diseases. The International Potato Center (CIP) has focused on stimulating farmer-scientist collaboration in developing management of late blight, a major fungal disease (...) of potatoes and other plants. Understanding farmers' knowledge of this and other plant diseases is an important element in furthering such collaboration. Although not all agricultural scientists recognize the value of social science, this literature search shows that some agricultural scientists now actively collaborate with farmers, in ways that cross the boundary into social science research. During this search, much of the work we found was written by plant pathologists and entomologists. We found over fifty publications on farmer knowledge of crop disease, and we have annotated the material that we thought most relevant to farmer- scientist collaboration for research of crop diseases, especially late blight. (shrink)

Anthropogenic climate change is causing temperature rise in temperate zones resulting in climate conditions more similar to subtropical zones. As a result, rising temperatures increase the range of disease-carrying insects to new areas outside of subtropical zones, and increased precipitation causes flooding that is more hospitable for vector breeding. State governments, the federal government, and governmental agencies, like the Animal and Plant Health Inspection Service of USDA and the National Notifiable Disease Surveillance System of the U.S. Centers (...) for Disease Control and Prevention, lack a coordinated plan for vector-borne disease accompanying climate change. APHIS focuses its surveillance primarily on the effect of illness on agricultural production, while NNDSS focuses on the emergence of pathogens affecting human health. This article provides an analysis of the current framework of surveillance of, and response to, vector-borne infectious diseases, the impacts of climate change on the spread of vector-borne infectious diseases, and recommends changes to federal law to address these threats. (shrink)

Central African highland farmers' perceptions of common bean disease were investigated using both phytopathology and anthropological techniques. Farmers rarely mentioned diseases as production constraints in formal questionnaires. More participatory research showed farmers often related disease symptoms to the effects of rain and soil depletion for fungal diseases, or to varietal traits for bean common mosaic virus. Rain or moisture is divided into numerous forms through which it can damage plants, both physically and through putrefaction. Most conditions associated with (...) putrefaction appear to be linked to pathogens. Farmers have an understanding of plant health closely related to their concept of human health. In plants, this understanding is based on the prior state of plant health. Conceptually, local disease management strategies are based on prevention by managing the conditions that promote good plant health rather than by treating disease symptoms. Intervention strategies that build on local knowledge are encouraged. (shrink)

European animal disease policy seems to find its justification in a “harm to other” principle. Limiting the freedom of animal keepers—e.g., by culling their animals—is justified by the aim to prevent harm, i.e., the spreading of the disease. The picture, however, is more complicated. Both during the control of outbreaks and in the prevention of notifiable, animal diseases the government is confronted with conflicting claims of stakeholders who anticipate running a risk to be harmed by each other, and (...) who ask for government intervention. In this paper, we first argue that in a policy that aims to prevent animal diseases, the focus shifts from limiting “harm” to weighing conflicting claims with respect to “risks of harm.” Therefore, we claim that the harm principle is no longer a sufficient justification for governmental intervention in animal disease prevention. A policy that has to deal with and distribute conflicting risks of harm needs additional value assumptions that guide this process of assessment and distribution. We show that currently, policies are based on assumptions that are mainly economic considerations. In order to show the limitations of these considerations, we use the interests and position of keepers of backyard animals as an example. Based on the problems they faced during and after the recent outbreaks, we defend the thesis that in order to develop a sustainable animal disease policy other than economic assumptions need to be taken into account. (shrink)

In this paper, we present and defend the theoretical framework of an empirical model to describe people’s fundamental moral attitudes (FMAs) to animals, the stratification of FMAs in society and the role of FMAs in judgment on the culling of healthy animals in an animal disease epidemic. We used philosophical animal ethics theories to understand the moral basis of FMA convictions. Moreover, these theories provide us with a moral language for communication between animal ethics, FMAs, and public debates. We (...) defend that FMA is a two-layered concept. The first layer consists of deeply felt convictions about animals. The second layer consists of convictions derived from the first layer to serve as arguments in a debate on animal issues. In a debate, the latter convictions are variable, depending on the animal issue in a specific context, time, and place. This variability facilitates finding common ground in an animal issue between actors with opposing convictions. (shrink)

This article argues that governments in countries that currently permit intensive animal agriculture - especially but not exclusively high-income countries - are, in principle, morally justified in taking steps to restrict or even eliminate intensive animal agriculture to protect public health from the risk of zoonotic pandemics. Unlike many extant arguments for restricting, curtailing, or even eliminating intensive animal agriculture which focus on environmental harms, animal welfare, or the link between animal source food (ASF) consumption and noncommunicable disease, the (...) argument in this article appeals to the value of protecting populations from future global health emergencies and their broad social, economic, and health impacts, taking the SARS-CoV-2 virus as a particularly salient example. The article begins by identifying how intensive animal agriculture contributes to the outbreak (and risk of future outbreaks) of zoonotic diseases. Next, we explore three specific policy options: 1. Incentivizing plant-based and cell-based ASF alternatives through government subsidies; 2. Disincentivizing intensive ASF production through the adoption of a “zoonotic tax”; and 3. Eliminating intensive ASF production through a total ban. We argue that all three of these measures are permissible, although we remain agnostic as to whether these measures are obligatory. We argue for this conclusion on the grounds that each measure is justified by the same sorts of considerations that justify other widely accepted public health interventions, and each is compatible with a variety of theories of justice. We then address potential objections. Finally, we discuss how our novel argument relates to extant ethical arguments in favor or curtailing ASF production and consumption. (shrink)

Reactive oxygen species (ROS) are known as toxic metabolic products in plants and other aerobic organisms. An elaborate and highly redundant plant ROS network, composed of antioxidant enzymes, antioxidants and ROS-producing enzymes, is responsible for maintaining ROS levels under tight control. This allows ROS to serve as signaling molecules that coordinate an astonishing range of diverse plant processes. The specificity of the biological response to ROS depends on the chemical identity of ROS, intensity of the signal, sites of (...) production, plant developmental stage, previous stresses encountered and interactions with other signaling molecules such as nitric oxide, lipid messengers and plant hormones. Although many components of the ROS signaling network have recently been identified, the challenge remains to understand how ROS-derived signals are integrated to eventually regulate such biological processes as plant growth, development, stress adaptation and programmed cell death. (shrink)

Ecosystem health, as James Nelson argues, must be understood as having both descriptive and normative content; it is in this sense a 'morally thick' concept. The health analogy refers (a) at the similarities between conservation ecology and medicine or plant pathology as normative sciences, and (b) to the ability of ecosystems to 'heal' themselves in the face of disturbances. Nelson, however, goes beyond these two aspects and argues that judgements of illness in ecosystems only support moral obligations to protect (...) them if they are attributed a 'good of their own'. But this latter extension of the analogy flies in the face of ecological science, which has been forced to abandon organicism. If one separates the question of the warranted assertibility of environmentalists' goals from the question of where values in nature are located, the search for an objective realm of value realism can be seen to be unnecessary. (shrink)

Supply chain management is critical for addressing uncertainties caused by random demand and production yield. In this study, a random yield supply chain, in which the production process of fresh agricultural products is easily affected by factors, such as weather, soil, or plant diseases and insect pests, was considered. Therefore, the actual output is typically less than the planned output. A model in which the producer faces yield uncertainty was considered, and the influence of the producer’s fairness concerns on (...) the planned output of the contract-farming supply chain was considered. Methods to motivate the producer to increase planned output through reasonable contracts were investigated. The results revealed that the producer’s fairness concern considerably influences the optimal expected profit. In the case of the random output, the planned output and maximum expected profits reduce when the farmer exhibits fairness concerns. As the degree of the producer’s fairness concern increases, the planned output and expected profit gradually decrease The cost-sharing contract can effectively encourage the producer to increase his planned output and expected utility. Finally, the results were verified numerically. (shrink)

Greece's agricultural economy has undergone a gradual process of adjustment since World War II. While farm numbers have been reduced and average farm size has increased, the relative size of the farm population is still large by European standards. The slow rate of consolidation and adjustment in the agricultural sector of Greece is influenced by the following three factors: (1) lack of developed markets for long term capital; (2) multiple job holding among Greek farmers; and (3) protective agricultural policies.Greece's accession (...) into the European Economic Community in 1981 has shifted her trade patterns towards her European partners. In terms of agricultural trade, Greece exported considerably more agricultural goods to EEC members in 1987 than was imported from EEC countries. Greece's agricultural trade balance with all nations of the world is roughly one to one, i.e., agricultural imports equal agricultural exports in value. Since entry into the EEC, Greece has improved her degree of competitiveness or self-sufficiency in vegetables, citrus, and wine, but has reduced her self-sufficiency or competitiveness in meat and livestock products.Improved competitiveness of Greece's agricultural sector in the 1990s will require adoption of known production technologies, reduction in government bureaucracy, development of new technologies for improving product quality and minimizing plant diseases, reduction in production and marketing costs, and more effective domestic and export group marketing strategies. (shrink)

This study presents the first translation from Latin to English of the Linnaean dissertationMundus invisibilisorThe Invisible World, submitted by Johannes Roos in 1769. The dissertation highlights Linnaeus's conviction that infectious diseases could be transmitted by living organisms, too small to be seen. Biographies of Linnaeus often fail to mention that Linnaeus was correct in ascribing the cause of diseases such as measles, smallpox and syphilis to living organisms. The dissertation itself reviews the work of many microscopists, especially on zoophytes and (...) insects, marvelling at the many unexpected discoveries. It then discusses and quotes at length the observations of Münchhausen suggesting that spores from fungi causing plant diseases germinate to produce animalcules, an observation that Linnaeus claimed to have confirmed. The dissertation then draws parallels between these findings and the contagiousness of many human diseases, and urges further studies of this ‘invisible world’ since, as Roos avers, microscopic organisms may cause more destruction than occurs in all wars. (shrink)

It is important to understandfactors that influence management decisionsthat determine the level of diversificationwithin cropping systems. Because of the widevariety of cropping systems within a region,our study focused on a single county in northwestern Minnesota. This county wasselected because it is in an area where farmerswere reevaluating their cropping practicesduring the 1990s in response to severe plantdisease outbreaks and economic stresses. Asurvey and follow-up interviews of representative farmers in Marshall Countyshowed that they were approaching theircropping systems management decisions underthese conditions (...) through a dominant conceptualframework and two secondaryconceptual frameworks, which we termed “mental causalmodels.” The study illustrates the ways farmersdefine and make decisions affecting theircropping systems diversity under conditions ofagronomic and economic adversity. It alsochallenges agricultural professionals to expandtheir thinking about educational strategiesthat are sensitive to the varied perspectivesof farmers beyond just the scientific mentalcausal model. (shrink)

Biotechnology can provide appropriate new tools for use in solution of specific problems in sustainable agriculture. Its usefulness will depend in large part on the degree to which sustainable agriculturists understand the utility of biotechnology and apply it toward ends they deem important. Biotechnology can give little assistance to sustainable agriculture in the short term. It can be more useful in the medium term, and it could be highly useful in the long term as an integral part of the art (...) and science of plant breeding and other components of sustainable agriculture systems. (shrink)

In precolonial Africa, women were the major authorities in herbal remedies within their own homes and at the community level, where they focused on disease prevention and cure. Such roles were pushed to the periphery of Africa’s health discourse by the introduction of Western modes of healing. Furthermore, missionaries branded African indigenous medicine (AIM) as evil and categorised it within the sphere of witchcraft. However, the emergence of new diseases which conventional medicine has found difficult to cure seems to (...) have caused Africans to rethink their position on AIM. For example, there appears to have been a resurgence of interest in utilising AIMs during the coronavirus disease 2019 (COVID-19) pandemic. Greater utilisation, while positive, may lead to herbs and plants becoming extinct if the harvesting is done haphazardly. Therefore, the intention of this article is to examine the intersections of gender and health in the COVID-19 context. The article seeks to establish the role that was and continues to be played by women in the utilisation of AIM within the context of COVID-19. The focus of the paper is on finding out the ways in which women are safeguarding plants and trees whose leaves, roots and barks are envisioned as effective in preventing infection as well as curing the disease. Data were gathered through informal interviews. Theoretically, the article makes use of gender and Afrocentricity as theories informing the study.Contribution: The article highlights the need for placing women at the centre of both health and environmental discourses for sustainable development. It argues for the recentring of women in Earth discourses. Hence, its contribution is in retrieving women’s voices in health and Earth discourses in Zimbabwe for sustainable development to be achieved. (shrink)

Emerging infectious diseases such as Ebola, Hendra, SARS, West Nile, Hepatitis E and avian influenza have led to a renewed recognition of how diseases in human beings, wildlife and livestock are interlinked. The changing prevalence and spread of such infections are largely determined by human activities and changes in environment and climate—where the latter are often also caused by human activities. Since the beginning of the 21st century, these insights have been brought together under the heading of OneHealth—a concept that (...) calls for interdisciplinary collaboration between various sciences as well as professional practices to promote and protect the health of human and non-human animals and the natural environment. Just as insights from public health have led to a broadened focus for health policy and medical care, from treating individual patients to protecting and promoting population health, OneHealth calls for an even broader perspective, including a concern for the environment and animals, and for social-cultural factors that affect human, animal and environmental health. OneHealth not only covers collaborative work to understand and control zoonotic diseases, but also other ways in which interactions between animals, plants and humans may positively or negatively impact on each other’s health. Thus, studies in veterinary medicine and environmental sciences may lead to new insights in human medicine, and vice versa. Acknowledgment of the links between environmental, animal and social health is of course not a novel insight. Hippocrates already pointed to the importance of a clean environment as a requirement for good health; the early public health movements emphasized hygienic living conditions including good-quality housing, sewage systems and clean air and water; and the founders of modern medicine such as William Osler and Rudolf Virchow promoted …. (shrink)

The use of socially learned information (culture) is central to human adaptations. We investigate the hypothesis that the process of cultural evolution has played an active, leading role in the evolution of genes. Culture normally evolves more rapidly than genes, creating novel environments that expose genes to new selective pressures. Many human genes that have been shown to be under recent or current selection are changing as a result of new environments created by cultural innovations. Some changed in response to (...) the development of agricultural subsistence systems in the Early and Middle Holocene. Alleles coding for adaptations to diets rich in plant starch (e.g., amylase copy number) and to epidemic diseases evolved as human populations expanded (e.g., sickle cell and G6PD defi- ciency alleles that provide protection against malaria). Large-scale scans using patterns of linkage disequilibrium to detect recent selection suggest that many more genes evolved in response to agriculture. Genetic change in response to the novel social environment of contemporary modern societies is also likely to be occurring. The functional effects of most of the alleles under selection during the last 10,000 years are currently unknown. Also unknown is the role of paleoenvironmental change in regulating the tempo of hominin evolution. Although the full extent of culture-driven gene-culture coevolution is thus far unknown for the deeper history of the human lineage, theory and some evidence suggest that such effects were profound. Genomic methods promise to have a major impact on our understanding of gene-culture coevolution over the span of hominin evolutionary history. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Self-Culture in Emerson’s Schellingian Solution to FateNicholas L. Guardiano (bio)Professor of English literature, President of Yale University, and Commissioner of Major League Baseball, Angelo Bartlett Giamatti (1938–1989), delighted in saying that Emerson “is as sweet as barbed wire.”1 Giamatti understood the full range of Emerson’s thought, which spans the highs and lows of the human condition. Writings such as “Experience,” “Illusions,” “The Tragic,” and “Fate” demonstrate the transcending of (...) Emerson’s transcendentalism beyond any soft Romanticism or naïve idealism. They consistently assert the reality of antagonistic forces pervading human experience and nature. “The Tragic” opens with the lines: “He has seen but half the universe who never has been shown the House of Pain. As the salt sea covers more than two thirds of the surface of the globe, so sorrow encroaches in man on felicity” (CW 10:334).2 “Fate” similarly insists: “We cannot trifle with this reality [of fate], this cropping-out in our planted gardens of the core of the world. No picture of life can have any veracity that does not admit the odious facts” (CW 6:11; my emphasis). Emerson was made intimately aware of the House of Pain by his own personal hardships. To name only a few, there was the death of his first wife Ellen at age 19 from tuberculosis, a rheumatic eye disease that left Emerson nearly blind for months, the terrible loss of his five-year old son Waldo to scarlet fever, the untimely deaths of his two brothers Charles and Edward in their 20s, a fire that partially destroyed the Emerson family home, and the inexorable mental decline into aphasia afflicting Emerson in his final years. Emerson further bore sympathetic witness to the hardships of his friends, family, and community. In addition, he lived through the national crisis of the American Civil War, and was a committed abolitionist willing to face head on the real evils of slavery. These experiences and others were a discipline in the tragic [End Page 28] constitution of the world. Furthermore, they provided hints on how to make one’s way through it.3In this essay, I aim to do some justice to Emerson’s mature transcendentalism by examining his metaphysical-ethical co-principles of fate and freedom, or necessity and power. These co-principles are the central topic of the essay “Fate,” which appeared as the opening chapter of the book The Conduct of Life (1860). There, Emerson somewhat paradoxically admits both principles as opposing forces, and attempts to show their compatibility using a Schellingian dialectic. After presenting Emerson’s understanding of fate and an interpretation of his metaphysical solution to it, I follow up on the primary ethical concern that opens the essay and book, namely “How shall I live?” (CW 6:1). To that end, I attempt to flesh out the ethical character of a life that embraces fate in terms of an Emersonian project of self-culture. My methodological approach throughout evolves progressively from the interpretation to the expansion of Emerson’s ideas. Its first section examines his philosophy as an offshoot of the world-historical line of thought extending from Plato to the Neoplatonists, Eriugena, Spinoza, Goethe, and Schelling, among others. Later philosophers, scientists, and artists who took inspiration from Emerson’s transcendentalism, including Charles Peirce, the Hudson River School painters, Wallace Stevens, and Loren Eiseley, follow the same intellectual trajectory.4 Further taking up the torch, my second section creatively amplifies Emerson’s insights for an ethics of self-culture, and in this way argues for the truth of his Schellingian form of freedom.I. The Problem and Its SolutionFor Emerson, fate is real. It consists in the “immovable limitations” and necessary “laws of the world” (CW 6:2). These limits or laws occur in the conduct of life not so much as theoretical abstractions or remote chains of efficient [End Page 29] causality but as impositions on our will, both from within and without. On the one hand, we are confronted by the rough and tumble of nature, the outside environment in which we live. Serious in Emerson’s nineteenth century and remaining so today are... (shrink)

In lieu of an abstract, here is a brief excerpt of the content:I Listen Like Nausicaa to NPR KATIE HARTSOCK “Kwame wants to show me the Pru River... Young girls and women wash clothes along the banks.” —“River Blindness Robbed Him of His Sight But Not His Independence,” Morning Edition As if we stood with no one between us, not your translator or my handmaidens. Why should a young thing like me want a man oceans older, trailing a goddess who (...) gussies him up to take the years off. I’ll go online to read the radio story, posted with pictures of your cloudy face. “The trick,” you say, “to gardening blind is planting in straight lines.” Your hands in dirt, knowing by feel the cardinal directions, work alone. I’m rinsing the silks of my soaped-up trousseau for an abstract husband, in the river you reel your fish from, waters that breed the black fly whose parasitic bite pricked you, quick as a paper cut from a book of murder ballads, before you reached the age to marry. I could have brought cloths, those last days you could see, when you saw worms swim across your eyes, to swathe your itching, long ago, beyond all laws, before a state-mandated pill ended the disease. “I sleep and wake on my own.” But that is just what a king would say, washed up naked at my feet arion 26.3 winter 2019 and hiding histories of desire with a leaf. Our separate selves stay separate. No one suspects a thing as we walk, at a distance I decide, away from the river that rose to our thighs with its necessities, like laundry or longing, and its cataracts of other lives, disrobing. 34 i listen like nausicaa to npr... (shrink)

Collecting seeds and specimens was an integral aspect of botany and natural history in the eighteenth century. Historians have until recently paid less attention to the importance of collecting, trading and compiling knowledge of their cultivation, but knowing how to grow and maintain plants free from disease was crucial to agricultural and botanical projects. This is particularly true in the case of food security. At the close of the eighteenth century, European diets (particularly among the poor) began shifting from (...) wheat- to potato-dependence. In Britain and Ireland during these decades, extensive crop damage was caused by diseases like ‘curl’ and ‘dry rot’ – leading many agriculturists and journal editors to begin collecting data on potato cultivation in order to answer practical questions about the causes of disease and methods that might mitigate or even eliminate their appearance. Citizens not only produced the bulk of these data, but also used agricultural print culture and participation in surveys to shape and direct the interpretation of these data. This article explores this forgotten scientific ambition to harness agricultural citizen science in order to bring stability and renewed vitality to the potato plant and its cultivation. I argue that while many agriculturists did recognize that reliance upon the potato brought with it unique threats to the food supplies of Britain and Ireland, their views on this threat were wholly determined by the belief that the diseases attacking potato plants in Europe had largely been produced or encouraged by erroneous cultivation methods. (shrink)

Cells are the fundamental building blocks of organisms and their organization holds the key to our understanding of the processes that control Development and Physiology as well as the mechanisms that underlie disease. Traditional methods of analysis of subcellular structure have relied on the purification of organelles and the painstaking biochemical description of their components. The arrival of high‐throughput genomic and, more significantly, proteomic technologies has opened hereto unforeseen possibilities for this task. Recently two reports(1,2) show how much can (...) be gleaned from the combination of analytical centrifugation, mass spectrometry and advanced statistical techniques focused on a high‐throughput analysis of the content and organization of plant and animal cells. The results reveal intriguing possibilities for the future and the possibility of mapping much of the known proteome onto our current map of the cell. BioEssays 28: 780–784, 2006. © 2006 Wiley Periodicals, Inc. (shrink)

In the early twentieth century, viruses had yet to be defined in a material way. Instead, they were known better by what they were not – not bacteria, not culturable, and not visible with a light microscope. As with the ill-defined “gene” of genetics, viruses were microbes whose nature had not been revealed. Some clarity arrived in 1929 when Francis O. Holmes, a scientist at the Boyce Thompson Institute for Plant Research reported that Tobacco mosaic virus could produce local (...) necrotic lesions on tobacco plants and that these lesions were in proportion to dilutions of the inoculum. Holmes’ method, the local lesion assay, provided the first evidence that viruses were discrete infectious particles, thus setting the stage for physicochemical studies of plant viruses. In a field where there are few eponymous methods or diseases, Holmes’ assay continues to be a useful tool for the study of plant viruses. TMV was a success because the local lesion assay “made the virus visible” and standardized the work of virology towards determining the nature of the virus. (shrink)

Many groups of closely related species have reticulate phylogenies. Recent genomic analyses are showing this in many insects and vertebrates, as well as in microbes and plants. In microbes, lateral gene transfer is the dominant process that spoils strictly tree‐like phylogenies, but in multicellular eukaryotes hybridization and introgression among related species is probably more important. Because many species, including the ancestors of ancient major lineages, seem to evolve rapidly in adaptive radiations, some sexual compatibility may exist among them. Introgression and (...) reticulation can thereby affect all parts of the tree of life, not just the recent species at the tips. Our understanding of adaptive evolution, speciation, phylogenetics, and comparative biology must adapt to these mostly recent findings. Introgression has important practical implications as well, not least for the management of genetically modified organisms in pest and disease control. (shrink)

Like most other subjects under discussion today, the theory of nature is largely controlled by considerations of knowledge. Treatment of it is, consequently, incidental to the treatment of these other problems, and is undertaken, in the main, because they compel it. A brief catalogue of characteristic statements about nature will illustrate this. “Nature,” says one writer, “is that which we observe in perception through the senses”; and another writes, “It is not experience which is experienced, but nature—stones, plants, animals, diseases, (...) health, temperature, electricity, and so on.” Nothing is more apparent in these sentences than the fact that it is not nature that the writers are so much concerned with, as with what it is that appears through the senses. The theory of nature, that is, is not so much guided by an analysis of the word's context and usage, as it is by the question: what is the proper object of knowledge? Consequently it is the latter question that is answered and not the question: what is nature? The reason for this is evident in the purpose of these statements and in their history; their purpose: the desire to do away with the separation between experience and nature, and to transform nature into a field familiar and accessible; and their history: the very framework against which they are directed, for they are embedded in the set-up from which they are trying to disentangle themselves. Perhaps something ought to be said to substantiate the thesis that the sentences cited are controlled by the problem of knowledge, especially since their intent seems to be to escape that problem. In any case, their history should serve to clarify them, and render a different approach to the theory of nature more significant. (shrink)

This paper investigates how reticulate evolution contributes to a better understanding of human sociocultural evolution in general, and community formation in particular. Reticulate evolution is evolution as it occurs by means of symbiosis, symbiogenesis, lateral gene transfer, infective heredity, and hybridization. From these mechanisms and processes, we mainly zoom in on symbiosis and we investigate how it underlies the rise of (1) human, plant, animal, and machine interactions typical of agriculture, animal husbandry, farming, and industrialization; (2) diet-microbiome relationships; and (...) (3) host-virome and other pathogen interactions that underlie human health and disease. We demonstrate that reticulate evolution necessitates an understanding of behavioral and cultural evolution at a community level, where reticulate causal processes underlie the rise of synergistic organizational traits. (shrink)

Preserved human remains from ancient Egypt provide an unparalleled opportunity for studies in the history of disease and medical practices. Egyptian medical papyri describe physiological concepts, disease diagnoses and prescribed treatments which include both ‘irrational’, and ‘rational’ procedures. Many previous studies of Egyptian medicine have concluded that ‘irrational’ methods predominated, but this perception is increasingly challenged by results from scientific studies of ancient human remains, and plant materials. This paper demonstrates the significant contribution being made by multidisciplinary (...) studies to our understanding of disease occurrence and medical treatments in ancient Egypt, and considers the feasibility of developing epidemiological comparisons of ancient and modern data sets that will provide acceptable historical contexts for contemporary disease studies. (shrink)

Targeted protein degradation (TPD) has emerged as a highly promising approach for eliminating disease‐associated proteins in the field of drug discovery. Among the most advanced TPD technologies, PROteolysis TArgeting Chimera (PROTAC), functions by bringing a protein of interest (POI) into proximity with an E3 ubiquitin ligase, leading to ubiquitin (Ub)‐dependent proteasomal degradation. However, the designs of most PROTACs are based on the utilization of a limited number of available E3 ligases, which significantly restricts their potential. Recent studies have shown (...) that phytoplasmas, a group of bacterial plant pathogens, have developed several E3‐ and ubiquitin‐independent proteasomal degradation (UbInPD) mechanisms for breaking down host targets. This suggests an alternative approach for substrate recruitment and TPD. Here, we present existing evidence that supports the feasibility of UbInPD in eukaryotic cells and propose candidate proteins that can serve as docking sites for the development of E3‐independent PROTACs. (shrink)

Several initiatives by the Government of Uganda, Research Institutes and CGIAR centers have promoted the use of tissue culture banana technology as an effective means of providing clean planting material to reduce the spread of Banana Xanthomonas wilt but its uptake is still low. We examine factors that constrain uptake of tissue culture banana planting materials in central Uganda by considering the cultural context of banana cultivation. Data were collected using eight focus group discussions involving 64 banana farmers and 10 (...) key informant interviews and subjected to thematic analysis. Results showed that banana cultivars in the study communities were important for food, cultural practices and medicine. Cultivars supplied through TC were based on commercial considerations focusing on market value and household income and insufficient attention was given to their cultural importance. Farmers regard banana from TC planting material to be incompatible with their tastes and preferences for traditional food and drinks, culture and medicine. Furthermore, the plantlets are perceived as complicated to use, and farmers report requiring more knowledge and information on how to plant and maintain the plantlets on-farm. In these aspects, TC planting material does not align with cultural values linked to societal welfare. Future efforts aimed at controlling pests and diseases would benefit from more location-specific and holistic approaches that integrate cultural dimensions alongside planting material hygiene, quality and vigor. (shrink)

This contribution is part of a series on Methodology and Biblical Spirituality. In this, the fourth contribution, the scope is widened; more practical-analytically oriented, three thoroughly different but nevertheless all unusual kinds of interpretations of the Bible are described, characterised and contextualised. Namely: • In order to explain what are perceived as textual anomalies, some Old Testament authors have been described by US-based medical practitioners as having suffered psychiatric dysfunctions. • The Garden of Eden from Genesis 2 and further has (...) been located by a recently diseased Nigerian scholar as having been in her home country, with a Nigerian race having been the predecessors of biblical Adam and Eve. • Rastafarians, primarily Jamaica-based, regard marijuana as a holy herb and find direct support for their religious use of this plant in the Bible. However strange such 'mystifying' interpretations may seem within the theological mainstreams of Judeo-Christianity, there is more to these kinds of interpretations than simple whim. Certain cultural conditions along with personal, particularly spiritual, commitments enable these interpretations, which must be taken seriously in order to come to a fuller understanding of the text-interpreter dynamic. These then can cast at least some form of reflective light on the more usual current biblical-interpretative mainstreams within Judeo-Christianity, posing in a new light the question of what constitutes legitimate interpretations, also within mainstream interpretations, as religiously inclined people try to live their lives in the light of Scripture. (shrink)

The science of the soul exceeds all other parts of philosophy not only in “dignity and exactness”, but also in “usefulness, necessity, charm, and, above all, in difficulty”.1 As the body is the subject of health and disease, so too the soul is the subject of virtue and vice; and just as the physician must devote great effort to knowing the body, anyone who treats morals “must take care to have a clear understanding of things pertaining to the scientia (...) de anima”.2 To be mistaken about the soul, in the way of materialists or the impious Averroes, is to leave “the good without reward, and evil without punishment”, and thus to “uproot all good morals, all laws and Republics”.3 The study of the soul is inescapably a prolegomenon to moral philosophy and to theology. But because it studies what is common to all living things, the science of the soul also prepares the way for the study of particular plants and animals, just as physics precedes the study of elements and mixtures.4 The natural philosopher deals with six kinds of bodies: the simple incorruptible bodies of the heavens, the simple but corruptible terrestrial elements, imperfect mixtures (ice, comets), perfect inanimate mixtures (metals and pre-. (shrink)

This chapter examines biological practice in relation to agricultural management at the Dutch botanical garden at Buitenzorg, Java. Melchior Treub, Buitenzorg’s director from 1880 to 1909, fundamentally transformed the garden by expanding and developing its facilities, partly in response to the need to control diseases of both plants and humans. The Garden attracted foreign scientists from around the world and became a model for biological stations elsewhere. Garden scientists also led in the disciplinary transformation of morphological science around 1900. In (...) response to problems of tropical biology and agriculture, evolutionary morphology developed into a new kind of science that embraced an ecological approach involving both field and laboratory research. This new conception of morphology departed dramatically from the understanding of morphology as the speculative construction of evolutionary trees, the predominant view in the European university. The Garden provides an exceptionally good location to assess the transformations occurring in biological science around 1900. Instead of the idea that there was a “revolt” from morphology at this time, we can see that there was instead a transformation and reinvention of the morphological orientation, one that depended on a cooperative relationship between more academic and corporate approaches to science, parallel to the study of cooperation processes in the environment itself. (shrink)

An idea is a public good. The use of an idea by one person does not hinder others to benefit from the same idea. However in order to generate new life-saving ideas, e.g. inventions in the life sciences, a huge amount of human and material resources are needed. Powerful, but highly criticized tools to speed up the rate of innovation are exclusive rights, most prominently the use of patents and plant breeders’ rights. Exclusive rights leave by nature a number (...) of people empty-handed, with starvation, stuntedness, prevalence of disease and death as preventable and quotidian consequences. To stimulate a human rights compatible use of exclusive rights a wide range of moral frameworks have been developed to condemn current praxes. Most prominent in the debate are theories building on (1) utilitarian calculations of weighing benefits with Peter Singer as a prominent advocate, (2) Pogge’s vindication of compensatory duties for institutional harms, (3) a comprehensive analysis on how the current innovation incentive system fails to secure human rights and human capabilities and lastly (4) showing how the status quo nurtures misrecognition. With help of those theories modest targets as well as a thorough restructure of the innovation incentive system can be justified. Those theories have the mammoth task of restraining well-established ideas supporting the permissibility of a reckless use of property rights that are deeply anchored in the property law discourse. Life sciences raise a range of special problems when justifying pro-poor innovation. Healthy people living in a society with a good sanitary infrastructure need far less resources to tackle health problems than people in places with a poor infrastructure. Patents that involve gene sequences (or part thereof) make inventing around impossible, making the seeking of licenses mandatory for investigators wanting to make follow-up research with the molecule. Speedy sharing of data concerning public health hazards or threats to food security are vital to maintain living standards. (shrink)