In multicellular organisms, cells are frequently programmed to die. This makes good sense: cells that fail to, or are no longer playing important roles are eliminated. From the cell’s perspective, this also makes sense, since somatic cells in multicellular organisms require the cooperation of clonal relatives. In unicellular organisms, however, programmed cell death poses a difficult and unresolved evolutionary problem. The empirical evidence for PCD in diverse microbial taxa has spurred debates about what precisely PCD means in the case of (...) unicellular organisms. In this article, we survey the concepts of PCD in the literature and the selective pressures associated with its evolution. We show that definitions of PCD have been almost entirely mechanistic and fail to separate questions concerning what PCD fundamentally is from questions about the kinds of mechanisms that realize PCD. We conclude that an evolutionary definition is best able to distinguish PCD from closely related phenomena. Specifically, we define “true” PCD as an adaptation for death triggered by abiotic or biotic environmental stresses. True PCD is thus not only an evolutionary product but must also have been a target of selection. Apparent PCD resulting from pleiotropy, genetic drift, or trade-offs is not true PCD. We call this “ersatz PCD.”. (shrink)

This first English-language translation captures the excitement of the original text-already a contemporary classic, and will likely become a standard reference in the history of eighteenth-century thought, politics, and society, and in the ...

We study the role of meeting numbers in pcf theory. In particular, Shelah's Strong Hypothesis is shown to be equivalent to the assertion that for any singular cardinal σ of cofinality ω, there is a size collection Q of countable subsets of σ with the property that for any infinite subset a of σ, there is a member of Q meeting a in an infinite set.

Let$\kappa $be a regular uncountable cardinal, anda cardinal greater than or equal to$\kappa $. Revisiting a celebrated result of Shelah, we show that ifis close to$\kappa $and(= the least size of a cofinal subset of) is greater than, thencan be represented (in the sense of pcf theory) as a pseudopower. This can be used to obtain optimal results concerning the splitting problem. For example we show that ifand, then no$\kappa $-complete ideal onis weakly-saturated.

« Ma seconde maxime était d’être le plus ferme et le plus résolu en mes actions que je pourrais, et de ne suivre pas moins constamment les opinions les plus douteuses, lorsque je m’y serais une fois déterminé, que si elles eussent été très assurées. Imitant en ceci les voyageurs qui, se trouvant égarés en quelque forêt, ne doivent pas errer en tournoyant, tantôt d’un côté, tantôt d’un autre, ni encore moins s’arrêter en une place, mais marcher toujours le plus (...) droit qu’ils peuvent vers un mêm.. (shrink)

Abstract This paper compares Heidegger's conception of time with more prevalent physical and broadly psychological analyses of time. The ?vulgar? notion of time, as Heidegger understands it, is based on the assumption that time, regardless of whether it is identified with tense or not, is something that is essentially measurable by clocks. Heidegger maintains that the vulgar notion of time is a distortion of his own preferred conception of temporality. I show how temporality may be understood as the non?sequential tensed (...) structure underlying tensed discourse. I argue against any straightforward reduction of this tensed structure and the direction of time to physical occurrences. Nevertheless I argue that temporality can be distinguished from purely psychological analyses of temporal experience and from traditional conceptions of time as tensed experience. The selectiveness of demonstrative discourse provides the basis for Heidegger's critique and reconstruction of time understood as tensed discourse about things. Heidegger's scepticism about the interpretation of time as a sequence of nows that underlies the dominant interpretation of tense is due to his appropriation of the relativity of simultaneity from special relativity. But his interpretation of physical theory leads him to the thesis that time is pre?supposed but not completely analysed in physical theory. The meta?language of physical theory makes covert use of temporal notions, for entities can themselves only be understood in covertly temporal ways. I show how this claim may be understood and defended in the light of current physical theory. Heidegger's analysis gives us some basis for thinking that his own notion of temporality is built into an understanding of temporal experience. But I argue that Heidegger fails to make the case that physical time is ontologically dependent on human existence. (shrink)

Attributing the creation of new features to categorization requirements implies that the exemplars displayed are correctly assigned to their category. This constraint limits the scope of Schyns et al.'s proposal to supervised learning. We present data suggesting that this constraint is unwarranted and we argue that feature creation is better thought of as a byproduct of the attentional, on-line processing of incoming information.

Thomist solution to the problem of love -- Remarks on the elements of the Thomist solution in Greek and medieval thought -- Two medieval sketches of the physical theory -- First characteristic : duality of the lover and the beloved -- Second characteristic : the violence of love -- Third characteristic : irrational love -- Fourth characteristic : love as the final end -- Appendix 1: The postulation of the problem of love in the first scholastics -- Appendix 2: The (...) formal identification of love and understanding in William of St. Thierry. (shrink)

The importance given by historian and philosopher of science Georges Canguilhem to the role of practice, techniques, and experimentation in concept-formation was largely overlooked by commentators. After placing Canguilhem’s contributions within the larger history of historical epistemology in France, and clarifying his views regarding this expression, I re-evaluate the relation between concepts and experimental practices in Canguilhem’s philosophy of science. Drawing on his early writings on the relations between science and technology in the 1930s, on the Essai sur quelques problèmes (...) concernant le normal et le pathologique , and on La formation du concept de réflexe aux XVIIe et XVIIIe siècles , I argue that the formation and rectification of concepts in Canguilhem’s sense are intrinsically bound with the experimental, material, technical, and cultural contexts in which concepts are operationalized. (shrink)

This chapter contains sections titled: Hippocrates With and Against Philosophy Alexandrian Medicine and the Hellenistic Philosophical Schools The Theoretical Audacity of the Medical Schools Medicine and Skepticism Ethics and Medicine Bibliography.

Gaining momentum during the last third of the twentieth century, the philosophy of biology is now a distinct field with its own debates, journals, audiences, and professional societies. This professionalization came along with the forging of an intellectual identity based on the existence of disciplinary frontiers that demarcated philosophy of biology from neighboring disciplines such as philosophy of medicine, history of biology, or general philosophy of science. Here, I argue that the identity of this emerging philosophy of biology also excluded (...) Continental traditions often called “biological philosophy” or “historical epistemology of the life sciences”. Going back to the 60s and 70s, I explore the emergence of the philosophy of biology at a time when its identity was still in flux and its analytic orientation debated. To do so, I focus primarily on the works of David Hull and Marjorie Grene, and I draw on their unpublished correspondence. Although Grene’s intellectual contribution to the philosophy of biology has been widely acknowledged, her coming from a different philosophical universe created tensions with the identity Hull and others sought to establish. Overall, this chapter raises a question about the historical conditions that make fields such as the philosophy of biology possible, and calls attention to the exclusions that permeated the philosophy of biology from its inception and what this involves in terms of the proper relation between philosophy and science, especially biology. (shrink)

This paper shows that the Clauser–Horne–Shimony–Holt test of locality of correlations which was originally designed to be used with binary observables can actually be used for any couples of quantum-like bounded continuous observables, and then for any experimental situation describable within the mathematical framework of quantum theory.

Our main results are: (A) It is consistent relative to a large cardinal that holds but fails. (B) If holds and are two infinite cardinals such that and λ carries a good scale, then holds. (C) If are two cardinals such that κ is λ‐Shelah and, then there is no good scale for λ.

This paper draws from critical data studies and related fields to investigate police officer-involved homicide data for Los Angeles County. We frame police officer-involved homicide data as a rhetorical tool that can reify certain assumptions about the world and extend regimes of power. We highlight the possibility that this type of sensitive civic data can be investigated and employed within local communities through creative practice. Community involvement with data can create a countervailing force to powerful dominant narratives and supplement activist (...) projects that hold local officials accountable for their actions. Our analysis examines four Los Angeles County police officer-involved homicide data sets. First, we provide accounts of the semantics, granularity, scale and transparency of this local data. Then, we describe a “counter data action,” an event that invited members of the community to identify the limits and challenges present in police officer-involved homicide data and to propose new methods for deriving meaning from these indicators and statistics. (shrink)

In mass democracies, voting—in elections or referendums—is the main way in which most citizens can publicly express their political preferences. And yet this means of expression is sometimes perceived by them as highly frustrating, partly because it does not allow for much expression. Dominant voting methods lead to a reduction of options, pressure citizens to vote tactically at the cost of expressing their genuine preferences, and fail to convey what they really think about different candidates, parties, or options. Yet citizens (...) do not merely have a right to vote; they have a more fundamental right to political expression from which one can derive a right to a voting method that offers the most opportunities for expression among those satisfying other important requirements. The aim of this article is therefore to add this consideration about the importance of political expression to debates about voting methods that have mainly been conducted from the perspective of social choice theory. To illustrate what is at stake, it introduces evaluative voting methods (allowing voters to grade all of the candidates, parties, or options) as a promising way of honoring the right to political expression without jeopardizing other important properties of voting methods. (shrink)

The first theory of confirmation that Carnap developed in detail is to be found in "Testability and Meaning". In this paper, he addressed the issue of a definition of empiricism, several years after abandoning the quest for a unique and universal logical framework supposed to be the basis of a clear distinction between the meaningful sentences of science and the pseudo-sentences of metaphysics. The principle of tolerance (according to which everyone is free to build up his own form of language (...) as he wishes) had been adopted near the end of 1932, at a time when it was already obvious to Carnap that a strictly verificationist criterion of meaning was inadequate. He therefore considered a variety of empiricisms and a variety of choices for the language of science. As Carnap put it, "there are many different possibilities in framing an empiricist language" and, correspondingly, several degrees of liberalization of the criterion of meaning. It was in this context that Carnap provided both a logical (syntactical) and an empirical analysis of confirmation (and of testing), before distinguishing requirements of different strengths which served the purpose of defining several versions of empiricism. (shrink)

Dans le traité De la divination dans le sommeil, Aristote entend réfuter la thèse d’une origine divine des rêves qui semblent annoncer les événements futurs. Pour cela, il ne se contente pas de soutenir une thèse différente. Il dénonce également la faiblesse épistémologique de la pratique divinatoire, en proposant un modèle scientifique alternatif : une méthode de classification des rêves et de division par épuisement, qui exclut les rêves inspirés. Cette méthode conduit à souligner le caractère irréductible des faits de (...) hasard et à admettre le caractère inexplicable d’un grand nombre de rêves « véridiques ». La notion de coïncidence ( sumptôma ) joue sur ce point un rôle essentiel. Ce rôle est à la fois descriptif et critique : il permet de définir la classe des rêves dont la dimension véridique est absolument fortuite, et il dénonce l’illusion commune qui les relie à des événements réels. De ce point de vue, le chapitre 1 du De divinatione apporte une contribution, modeste mais spécifique, à la théorie des modalités physiques. (shrink)

This article deals with the links between the enaction paradigm and artificial intelligence. Enaction is considered a metaphor for artificial intelligence, as a number of the notions which it deals with are deemed incompatible with the phenomenal field of the virtual. After explaining this stance, we shall review previous works regarding this issue in terms of artificial life and robotics. We shall focus on the lack of recognition of co-evolution at the heart of these approaches. We propose to explicitly integrate (...) the evolution of the environment into our approach in order to refine the ontogenesis of the artificial system, and to compare it with the enaction paradigm. The growing complexity of the ontogenetic mechanisms to be activated can therefore be compensated by an interactive guidance system emanating from the environment. This proposition does not however, resolve that of the relevance of the meaning created by the machine (sense-making). Such reflections lead us to integrate human interaction into this environment in order to construct relevant meaning in terms of participative artificial intelligence. This raises a number of questions with regards to setting up an enactive interaction. The article concludes by exploring a number of issues, thereby enabling us to associate current approaches with the principles of morphogenesis, guidance, the phenomenology of interactions and the use of minimal enactive interfaces in setting up experiments which will deal with the problem of artificial intelligence in a variety of enaction-based ways. (shrink)

La question de l'identité personnelle, sous ses deux formes : " Qui suis-je? " et " Qu'est-ce que le moi? ", a souvent été traitée par des philosophes qui ont entrepris de la résoudre en empruntant la voie du raisonnement pur. Elle est ici abordée par un autre biais, à partir de trois protocoles expérimentaux qui permettent de la saisir à vif, en situation, et non dans l'abstrait : l'ouvrage que Marc Parmentier a consacré à " la philosophie des sites (...) de rencontre ", le récit fait par Jean Genet d'un étrange épisode vécu au cours d'un chemin de fer, dont les enseignements s'étaient raccordés dans son esprit à la fréquentation de deux peintres, Rembrandt et Giacometti, la série de clichés photographiques réalisés par Cindy Sherman où, en vue de mettre en scène la mythologie de la femme américaine, elle s'est prise elle-même pour modèle. L'examen de ces expériences concrètes illustre la possibilité de faire de la philosophie autrement ; s'en dégage, non une réponse inédite à la question de l'identité personnelle, mais la confirmation du caractère définitivement aporétique des interrogations auxquelles celle-ci renvoie. (shrink)

Contre la critique platonicienne, Aristote a confié au théâtre la charge d’une opération mimétique associant à la valeur épistémique de la fable la fonction politique d’une catharsis collective des passions, produite par la représentation théâtrale. Qu’en est-il de ces thèses aujourd’hui, où aller au théâtre n’est plus un rite politique? En quoi l’art du théâtre peut-il contribuer à l’expérience des spectateurs, comme connaissance du monde et comme formation subjective? En dépit des critiques de Deleuze et de Foucault, on réhabilitera la (...) notion de représentation dans son rapport à l’expérience. On soutiendra la valeur esthétique et politique de la narrativité théâtrale, non pour récuser les gestes de subversion du sens des années 70, mais pour en reprendre l’intention critique par d’autres voies. (shrink)

On a utilisé des raisonnements contrefactuels en histoire dans le but de valider ou de réfuter des relations de causalité. L’exemple le plus connu est celui des travaux de Fogel, sur la question de l’importance du développement des chemins de fer dans l’essor de l’économie américaine. En imaginant des scénarios contrefactuels dans lesquels ce développement n’aurait pas eu lieu, il est arrivé à une conclusion négative : l’essor américain aurait pu avoir lieu même en utilisant d’autres moyens d..

L’article part du contemporain et de ce qui en affecte le religieux, un effondrement des médiations sociales et la montée de religiosités privées vivant d’un rapport direct à la vérité. Il reprend ensuite certains des motifs en cause, décalant les oppositions reçues. Ainsi sur les médiations, à repenser en lien à ce que sont tant le religieux que le social, sur l’extériorité, à repenser en lien à ce qu’est le sujet, sur ce qu’est une tradition, à repenser comme cristallisation culturelle (...) et institutionnelle d’une voie d’accomplissement de l’humain, à investir et valider comme telle, hors système auto-référencié. L’article fait enfin retour sur ce qu’il en est du christianisme, dans sa consistance propre, en principe faite d’une suite d’acculturations au creux des sociétés et des cultures, et vivant d’instances diverses et irréductibles. L’article y reprend le motif de l’expérience dite religieuse et en rapport à ce qui peut être une transcendance, mais cristallisée en corps à corps avec le monde et ce qui s’en éprouve et s’en dit, une expérience alors féconde, mais ainsi seulement. (shrink)