Nucléaire, clonage, OGM, sang contaminé : sans cesse invoqué en matiére d'environnement, de santé, d'alimentation, le principe de précaution est l'objet de multiples controverses. De quoi s'agit-il? Trop de précaution ne risque-t-il pas de bloquer des avancées scientifiques ou techniques cruciales pour l'avenir? Une clarification était nécessaire. Car l'important aujourd'hui est de donner à ce principe un contenu positif, c'est-à -dire une définition assortie d'un mode d'emploi qui puisse être compris de tous et servir à tous. Philippe Kourilsky (...) est directeur général de l'Institut Pasteur, professeur au Collége de France et membre de l'Académie des sciences. Il est notamment l'auteur des Artisans de l'hérédité et de La Science en partage. (shrink)

Innovating new experiences is an innovation strategy that increases product differentiation and the perceived value of offers for future autonomous cars. Young Chinese customers are a relevant target group of lead users to co-create those experiences. We address the co-creation of memorable and engaging experiences with targeted potential users and the building of the meaning of experiential imaginary that results from innovations (based on digital media) echoing the need for sensory atmospherics while strolling in the city. We aim at understanding (...) how customers can co-create meaningful experiences. We analyze the narrative structures of the experiential imaginaries, considering the narratives as a major component of ambiance experiences and imaginary. With an empirical approach that associates projective techniques to semiotic analysis of the corresponding narratives, we describe the structural system of the experiential imaginary of young Chinese customers when imagining driving in the city in tomorrow’s cars. Semiotics offers a novel contribution to innovation marketing and idea generation of experiential innovations. This theoretical stance valorizes the outside-in paradigm of future lead-users as co-creators of innovative experiences, whose imaginary narratives are raw materials for creativity. This approach is an alternative to brainstorming and its limits for creating disruptive innovations. (shrink)

Following a previous elaboration of the concept of weak individuality and some examples of its instances in ecology and biology, the article focuses on general features of the concept, arguing that in any ontological field individuals are understood on the basis of our knowledge of interactions, through the application of these general formulas for extracting individuals from interactions. Then, the specificities of the individuality in the sense of this weak concept are examined in ecology; I conclude by addressing the differences (...) between ecosystems and organisms as they appear in the viewpoint of such concept. (shrink)

In several sign languages, plurals can be realized with unpunctuated or punctuated repetitions of a noun, with different semantic implications; similar repetition-based plurals have been described in some homesigns and silent gestures. Unpunctuated repetitions often get approximate ‘at least’ readings while punctuated repetitions typically correspond to ‘exactly’ readings. The prevalence of these mechanisms could be thought to be a case in which Universal Grammar does not just specify the abstract properties of grammatical elements, but also their phonological realization, at least (...) in the visual modality. We explore an alternative in which punctuated and unpunctuated repetitions arise from general properties of iconic representations. On an empirical level, we argue that in ASL, punctuated and unpunctuated repetitions are unlikely to be an exclusively grammatical mechanism, as they can be found with purely iconic representations. On a theoretical level, we argue for a modular account with three components. First, repetition-based plurals can create a simplified pictorial representation. Second, unpunctuated repetitions give rise to pictorial vagueness, resolved by way of quantification over precisifications. Third, a pragmatic process involving strategic reasoning maps these vague representations onto a set of candidate linguistic meanings, including some ‘at least’ plural readings that are best expressed by unpunctuated repetitions. (shrink)

Long before his last book, The Gift Relationship: From Human Blood to Social Policy, was published in early 1971, Richard M. Titmuss , a professor of social administration at the London School of Economics, had been a major figure in the debates over the welfare state. The Gift Relationship was the culmination of an eventful relationship with the Institute of Economic Affairs, a think tank that advocated the extension of rational pricing to social services. By arguing that the British system (...) of blood procurement and distribution, based on free giving within the National Health Service, was more efficient than the partly commercialized American system, Titmuss intended to signal the dangers of the increasing commercialization of society. What made for the impact of his book, however, was not merely its argument that transfusion‐transmitted infections were much more common with paid than with voluntary donors, but also its reflections on what it is that holds a society together. And here Titmuss argued that a “socialist” social policy, by encouraging the sense of community, played a central role. The eclecticism of Titmuss’s work, together with its strong ethical and political flavor, makes it a rich and original account of the “social” at a time when heated debates over social policy, both in Britain and in the United States, raised the question of the division of labor among the social sciences. (shrink)

In the ordinary modal language, KD is the modal logic determined by the class of all serial frames. In this paper, we demonstrate that KD is nullary.

The problem of unification in a normal modal logic $L$ can be defined as follows: given a formula $\varphi$, determine whether there exists a substitution $\sigma$ such that $\sigma $ is in $L$. In this paper, we prove that for several non-symmetric non-transitive modal logics, there exists unifiable formulas that possess no minimal complete set of unifiers.

Corporate social responsibility (CSR) has repeatedly been described as an “essentially contested concept,” which means that its signification is subject to continuous struggle. We argue that the “CSR institution” (CSRI; i.e., the set of standards and rules regulating corporate conduct under the banner of CSR) is legitimized by narratives which “decontest” the underlying concept of CSR in a manner that safeguards the CSRI from calls for alternative institutional arrangements. Examining several such narratives from a structuralist perspective, we find them to (...) be permeated with six recurrent ambiguities that we show to be reflective of three deep-set taboos: the taboo of the noncongruency between corporate profit objectives and societal needs, the taboo of multinational firms’ continued contribution to the emergence of global socioenvironmental issues, and the taboo of the CSRI’s moderate results in solving these problems. We contend that the perpetuation of these taboos contributes to inhibiting substantial change in the way of doing business, and we sketch out possibilities for initiating a “recontestation” of CSR’s meaning. (shrink)

There are two main approaches to the problem of donkey anaphora (e.g. If John owns a donkey , he beats it ). Proponents of dynamic approaches take the pronoun to be a logical variable, but they revise the semantics of quantifiers so as to allow them to bind variables that are not within their syntactic scope. Older dynamic approaches took this measure to apply solely to existential quantifiers; recent dynamic approaches have extended it to all quantifiers. By contrast, proponents of (...) E-type analyses take the pronoun to have the semantics of a definite description (with it ≈ the donkey, or the donkey that John owns ). While competing accounts make very different claims about the patterns of coindexation that are found in the syntax, these are not morphologically realized in spoken languages. But they are in sign language, namely through locus assignment and pointing. We make two main claims on the basis of ASL and LSF data. First, sign language data favor dynamic over E-type theories: in those cases in which the two approaches make conflicting predictions about possible patterns of coindexation, dynamic analyses are at an advantage. Second, among dynamic theories, sign language data favor recent ones because the very same formal mechanism is used irrespective of the indefinite or non-indefinite nature of the antecedent. Going beyond this debate, we argue that dynamic theories should allow pronouns to be bound across negative expressions, as long as the pronoun is presupposed to have a non-empty denotation. Finally, an appendix displays and explains subtle differences between overt sign language pronouns and all other pronouns in examples involving ‘disjunctive antecedents’, and suggests that counterparts of sign language loci might be found in spoken language. (shrink)

The comprehension of living organisms in all their complexity poses a major challenge to the biological sciences. Recently, systems biology has been proposed as a new candidate in the development of such a comprehension. The main objective of this paper is to address what systems biology is and how it is practised. To this end, the basic tools of a systems biological approach are explored and illustrated. In addition, it is questioned whether systems biology ‘revolutionizes’ molecular biology and ‘transcends’ its (...) assumed reductionism. The strength of this claim appears to depend on how molecular and systems biology are characterised and on how reductionism is interpreted. Doing credit to molecular biology and to methodological reductionism, it is argued that the distinction between molecular and systems biology is gradual rather than sharp. As such, the classical challenge in biology to manage, interpret and integrate biological data into functional wholes is further intensified by systems biology’s use of modelling and bioinformatics, and by its scale enlargement. (shrink)

Since its origin in the early 20th century, the modern synthesis theory of evolution has grown to represent the orthodox view on the process of organic evolution. It is a powerful and successful theory. Its defining features include the prominence it accords to genes in the explanation of development and inheritance, and the role of natural selection as the cause of adaptation. Since the advent of the 21st century, however, the modern synthesis has been subject to repeated and sustained challenges. (...) In the last two decades, evolutionary biology has witnessed unprecedented growth in the understanding of those processes that underwrite the development of organisms and the inheritance of characters. The empirical advances usher in challenges to the conceptual foundations of evolutionary theory. Many current commentators charge that the new biology of the 21st century calls for a revision, extension, or wholesale rejection of the modern synthesis theory of evolution. Defenders of the modern synthesis maintain that the theory can accommodate the exciting new advances in biology, without forfeiting its central precepts. The original essays collected in this volume—by evolutionary biologists, philosophers of science, and historians of biology—survey and assess the various challenges to the modern synthesis arising from the new biology of the 21st century. Taken together, the essays cover a spectrum of views, from those that contend that the modern synthesis can rise to the challenges of the new biology, with little or no revision required, to those that call for the abandonment of the modern synthesis. (shrink)

This book addresses several key issues in the biological study of death with the intent of capturing their genealogy, the assumptions and presuppositions they make, and the way that they open specific new research avenues. The book is divided into two sections: the first considers physiology and the second evolutionary biology. Huneman explains that biologists in the late 1950s put forth a research framework that evolutionarily accounts for death in terms of either an effect of the weakness of natural selection (...) or a by-product of natural selection for early reproduction. He illustrates how the biology of death is a central field and that studying it provides insight into the way that the epistemic structure of this knowledge has been constituted, persists until now, and may conflict with some traditional philosophical ideas. (shrink)

Institute for Biomedical Ethics, Geneva University Medical School * Corresponding author: Médecins Sans Frontières (OCG), rue de Lausanne 78, CH-1211 Geneva 21, Switzerland. Tel.: +41 (0)22 849 89 29; Fax: +41 (0)22 849 84 88; Email: philippe_calain{at}hotmail.com ' + u + '@' + d + ' '//--> Abstract Outbreaks of filovirus (Ebola and Marburg) hemorrhagic fevers in Africa are typically the theater of rescue activities involving international experts and agencies tasked with reinforcing national authorities in clinical management, biological diagnosis, sanitation, (...) public health surveillance and coordination. These outbreaks can be seen as a paradigm for ethical issues posed by epidemic emergencies, through the convergence of such themes as: isolation and quarantine, privacy and confidentiality and the interpretation of ethical norms across different ethnocultural settings. With an emphasis on the boundaries between public health investigations and research, this article reviews specific challenges, past practices and current normative documents relevant to the application of ethical standards in the course of outbreaks of filovirus hemorrhagic fevers. Aside from commonly identified issues of informed consent and institutional review processes, we argue for more clarity over the specification of which communities are expected to share benefits, and we advocate for the use of collective definitions of duty to care and standard of care. We propose new elaborations around existing normative instruments, and we suggest some pathways toward more comprehensive approaches to the ethics of research in outbreak situations. CiteULike Connotea Del.icio.us What's this? (shrink)

Farabi et l'école d'Alexandrie, est la première étude consacrée à l'ensemble des thèmes de l'œuvre de celui qui fut l'un des plus grands philosophes arabes.

Machine generated contents note: -- Acknowledgements -- PART I: WHAT HAPPENED? -- Inheriting from Seattle -- What Are We Dealing With? -- Daring to be Pragmatic -- Infernal Alternatives -- Minions -- PART II: LEARNING TO PROTECT ONESELF -- Do You Believe in Sorcery? -- Leaving Safe Ground -- Marx Again... -- To Believe in Progress No Longer? -- Learning Fright -- PART III: HOW TO GET A HOLD? -- Thanks to Seattle? -- The Trajectory of an Apprenticeship -- Fostering (...) New Connections -- Sorry, but we have to -- Reactivating History -- PART IV: NEEDING PEOPLE TO THINK -- A Cry -- Interstices -- Ecosophy -- Political Creation -- Empowerment -- Reclaim -- Above All, Not to Conclude -- Index. (shrink)

Van Heijenoort's main contribution to history and philosophy of modern logic was his distinction between two basic views of logic, first, the absolutist, or universalist, view of the founding fathers, Frege, Peano, and Russell, which dominated the first, classical period of history of modern logic, and, second, the relativist, or model-theoretic, view, inherited from Boole, Schröder, and Löwenheim, which has dominated the second, contemporary period of that history. In my paper, I present the man Jean van Heijenoort (Sect. 1); then (...) I describe his way of arguing for the second view (Sect. 2); and finally I come down in favor of the first view (Sect. 3). There, I specify the version of universalism for which I am prepared to argue (Sect. 3, introduction). Choosing ZFC to play the part of universal, logical (in a nowadays forgotten sense) system, I show, through an example, how the usual model theory can be naturally given its proper place, from the universalist point of view, in the logical framework of ZFC; I outline another, not rival but complementary, semantics for admissible extensions of ZFC in the very same logical framework; I propose a way to get universalism out of the predicaments in which universalists themselves believed it to be (Sect. 3.1). Thus, if universalists of the classical period did not, in fact, construct these semantics, it was not that their universalism forbade them, in principle, to do so. The historical defeat of universalism was not technical in character. Neither was it philosophical. Indeed, it was hardly more than the victory of technicism over the very possibility of a philosophical dispute (Sect. 3.2). (shrink)

Ecology in principle is tied to evolution, since communities and ecosystems result from evolution and ecological conditions determine fitness values. Yet the two disciplines of evolution and ecology were not unified in the twentieth-century. The architects of the Modern Synthesis, and especially Julian Huxley, constantly pushed for such integration, but the major ideas of the Synthesis—namely, the privileged role of selection and the key role of gene frequencies in evolution—did not directly or immediately translate into ecological science. In this paper (...) I consider five stages through which the Synthesis was integrated into ecology and distinguish between various ways in which a possible integration was gained. I start with Elton’s animal ecology, then consider successively Ford’s ecological genetics in the 1940s, the major textbook Principles of animal ecology edited by Allee et al., and the debates over the role of competition in population regulation in the 1950s, ending with Hutchinson’s niche concept and McArthur and Wilson’s Principles of Island Biogeography viewed as a formal transposition of Modern Synthesis explanatory schemes. I will emphasize the key role of founders of the Synthesis at each stage of this very nonlinear history. (shrink)

À la pensée de l'infini, il nous vient une idée de Dieu; c'est une élaboration de notre entendement fini, imparfait. Nous avons appris, par ceux qui nous ont précédés, combien profonde et difficile est cette idée. Toute notre civilisation s'est édifiée sur le fondement que nous nommons judéo-chrétien, mais hellène aussi, quoiqu'en ce temps qui est nôtre nous en sommes venus à rejeter cette expérience. D'ailleurs, le triomphe de la civilisation marchande a recouvert d'un manteau d'oubli une longue accoutumance, au (...) point qu'une pensée de l'absolue désespérance a gagné nos esprits, résolus à oublier le divin. C'est précisément ce que nous ne pouvons, parce qu'il est en nous une obligation d'éprouver, en dépit de notre imperfection et à cause d'elle, ce qui nous appelle vers l'infini, présent en l'âme et notre boussole en ce monde. Le présent écrit n'est pas un traité; tout au plus une patiente exploration."--Page 4 of cover. (shrink)

La bonne nouvelle (l'évangile), c'est que tous les hommes, sans distinction de culture ou de religion, sont en tant qu'êtres de la Nature dotés de raison et d'intuition et sont, de ce fait, capables d'acquérir une connaissance vraie de cette Nature dont ils font partie et donc de leur propre nature. Ils sont déterminés par cette Nature à être heureux. Cet ouvrage démontre comment Spinoza a conçu et la métaphysique de la Substance et l'éthique, en vue de nous introduire à (...) cette connaissance du bonheur qui en découle. (shrink)

In topological spaces, the relation of extended contact is a ternary relation that holds between regular closed subsets A, B and D if the intersection of A and B is included in D. The algebraic counterpart of this mereotopological relation is the notion of extended contact algebra which is a Boolean algebra extended with a ternary relation. In this paper, we are interested in the relational representation theory for extended contact algebras. In this respect, we study the correspondences between point-free (...) and point-based models of space in terms of extended contact. More precisely, we prove new representation theorems for extended contact algebras. (shrink)