In mice, dosage compensation of X‐linked gene expression is achieved through the inactivation of one of the two X‐chromosomes in XX female cells. The complex epigenetic process leading to X‐inactivation is largely controlled by Xist and Tsix, two non‐coding genes of opposing function. Xist RNA triggers X‐inactivation by coating the inactive X, while Tsix is critical for the designation of the active X‐chromosome through cis‐repression of Xist RNA accumulation. Recently, a plethora of trans‐acting factors and cis‐regulating elements have been suggested (...) to act as key regulators of either Xist, Tsix or both; these include ubiquitous factors such as Yy1 and Ctcf, developmental proteins such as Nanog, Oct4 and Sox2, and X‐linked regulators such as Rnf12. In this paper we summarise recent advances in our knowledge of the regulation of Xist and Tsix in embryonic stem (ES) and differentiating ES cells. (shrink)

"My interest in [Max] Scheler's critique of Kant runs back nearly a decade.... The more I read of Scheler, the more I began to see the value of a project dealing with his critique of Kant in _Der Formalismus in der Ethik und die Materiale Wetethik_, which would possess the virtue of focusing in a single project three important strands of philosophical interest: phenomenology, Kantianism, and ethics.... "The study is divided into six chapters and two appendices. Each of the chapters (...) constituting the body of the work contains a brief analysis of the Kantian position or discussion of the basic questions at issue in it, an exposition of Scheler's critique of the Kantian position and its presuppositions, and a detailed appraisal of Scheler's critique." -- from the introduction by the author. (shrink)

Sartre attacks the "illusion" that mental images are "immanent" in consciousness. After comparing sartre with husserl, I develop his view that mental images are non-Perceptual phenomena involving a relationship with something non-Present. From the impoverished, Unworldly view that results, I suggest that sartre's own view is still too attached to the perceptual analogy and conclude with the richer, Alternative view of ricoeur that imaginal fiction has a constructive role in shaping reality.

In lieu of an abstract, here is a brief excerpt of the content:Reviewed by:A Historical Commentary on Arrian’s History of Alexander. Vol. II. Commentary on Books IV–VPhilip A. StadterBosworth, A. B. A Historical Commentary on Arrian’s History of Alexander. Vol. II. Commentary on Books IV–V. Oxford: Clarendon Press, 1995.In books 1–3, Arrian’s Alexander rushed from the Hellespont to Babylon, Susa, and Persepolis. In books IV and V the story changes: Alexander finds himself on the frontier, and beyond. No longer is (...) he confronting the enormous armies of the Persian king in set battles, but pushing beyond the frontiers of empire, seizing impregnable heights, and most important, struggling with his own Macedonians while defining himself.Bosworth, continuing his commentary after a fifteen-year interval, brings an exceptional background of historical, source critical, and literary studies. B. notes that his evaluation is “perhaps more sympathetic” than in his first volume, in part because the quality of the work “improves as it progresses” (v). The thoroughness [End Page 140] of the discussion (360 pages on the two books) is justified by the importance and complexity of the material. The reader is well served by an excellent subject index, a Greek index, ten maps, and four figures. An appendix on Nearchus suggests that that author may have reported much more than the journey from the Indus to the Persian Gulf found in the Indike, and may be a significant source for Arrian in the last four books of the Alexander history. Like the first volume, the commentary has Greek lemmata, translated only when there is a specific difficulty, but even Greekless readers can use it with the help of Brunt’s new Loeb text.Although the commentary deals frequently with textual questions, it focuses on elucidating the historical, geographical, stylistic, and interpretative problems of the text. B. ably notes the constant verbal reminiscences of Herodotus, Thucydides, and Xenophon, especially in the more elaborate passages, e.g., the speeches at the Hyphasis. Still more are undoubtedly to be found, such as the echo of Thucydides (1.110.1, 3.112.8, 87.87.6) in 5.27.6, ¹l¼goi ¨k poll©n. His elucidation of Arrian’s use of Megasthenes, Nearchus, and Eratosthenes in the digressions at the beginning of book 5 is a model of clarity and precision. Here as elsewhere he stresses Arrian’s purposeful blending of his sources: e.g., on 5.6.3–8: “It is an elaborately contrived passage, and the source material is carefully selected to fit the scheme of the argument. Arrian is not merely rewriting a passage of Eratosthenes.” Throughout, his comments on sources are precise and thoughtful.B.’s notes follow wherever the text leads, but he devotes special attention to the major focuses of Arrian’s attention: the great digression on Alexander’s orientalism, the murder of Cleitus, proskunesis, and the page’s conspiracy (4.7.4–14.4 5 45–101), the march to the Indus, with the siege of Massaga and the capture of Aornus (4.22.3–30.9 5 141–96), the series of digressions which begin book 5, (5.1.1–8.1 5 197–259), the battle on the Hydaspes against Porus (5.8.4–19.4 5 262–311), and the mutiny on the Hyphasis (5.24.8–29.5 5 337–60).Bosworth’s commentary on book 5 encompasses the multiple levels of the narrative: the reworking of Eratosthenes, Megasthenes, and Nearchus in the preliminary section; the topographical and tactical problems of the battle with Porus, and the rhetorical and stylistic subtleties of the debate at the Hyphasis. Throughout the book, Arrian shows Alexander going beyond his predecessors. By crossing the Indus he passes the limits of the Persian Empire. At Nysa he surpasses the mythical conquests of Dionysus (5.2.1). The digression on the Indus bridges recalls the bridges (and defeats) of Xerxes and Darius, as well as Roman imperial engineering (5.7.1–2). The crossing of the Hydaspes and great battle contrast with Cyrus’ disastrous battle with the Massagetae in Herodotus 1.204–14 (cf. 5.4.5). The description of the river systems of the Punjab (5.4.1–2) evokes Herodotus’ account... (shrink)

There is a view, expressed by some research ethics committees and health care professionals, that research should not, under any circumstance, be performed on dying patients. This paper begins to explore current attitudes towards palliative care research, although it becomes clear that the issues discussed apply to all fields of bio-medical research. Indeed the underlying principles of autonomy, non-maleficence, beneficence and justice should apply to all groups of human subjects involved across all areas of research. The ethical principles should apply (...) equally to healthy individuals as well as to those suffering from ill health, whether this be inherited or acquired, curable or terminal. (shrink)

Excerpt from The Dynamic Foundation of Knowledge It is now a long time since the writer of the following pages first thought of a dynamical interpretation of the concept of Matter. After some years of consideration and discussion he expressed his views in print in an essay entitled Matter and Energy: Are there two Real Things in the Physical Universe? This essay was published in 1887. A second essay was published in 1897 under the title, The Doctrine of Energy: A (...) Theory of Reality. In these essays he maintained that the scientific concept of energy adequately explains the phenomena of nature, and that the inconsistent concept of material reality should be finally abandoned. The question referred to has made great apparent progress since the date first mentioned above. The foolish abuse with which in certain quarters such ideas were then greeted has disappeared. They might now almost be called popular. In philosophical journals they are constantly referred to, whilst as integral parts of scientific theory they are accepted and employed by many high authorities. The successors of some who looked upon them with dislike and derision seem even disposed to claim them as their own. About the Publisher Forgotten Books publishes hundreds of thousands of rare and classic books. Find more at www.forgottenbooks.com This book is a reproduction of an important historical work. Forgotten Books uses state-of-the-art technology to digitally reconstruct the work, preserving the original format whilst repairing imperfections present in the aged copy. In rare cases, an imperfection in the original, such as a blemish or missing page, may be replicated in our edition. We do, however, repair the vast majority of imperfections successfully; any imperfections that remain are intentionally left to preserve the state of such historical works. (shrink)

In this book a non-realist philosophy of mathematics is presented. Two ideas are essential to its conception. These ideas are (i) that pure mathematics--taken in isolation from the use of mathematical signs in empirical judgement--is an activity for which a formalist account is roughly correct, and (ii) that mathematical signs nonetheless have a sense, but only in and through belonging to a system of signs with empirical application. This conception is argued by the two authors and is critically discussed by (...) three philosophers of mathematics. (shrink)

This thesis is concerned with Immanuel Kant's mature philosophy as a whole. My aim is to show the systematic relationship among Kant's three Critiques, and the continuity of these with the Inaugral Dissertation. I use recent interpretations of Kant's projects in the Critique of Pure Reason and I offer my own interpretation of the Critique of Judgment, in which I highlight the importance of the final Appendix in that work, to argue that the goal of these three works taken together (...) is to replace traditional metaphysics with a new approach entirely. In place of the traditional approach in which the principles of metaphysics are supposed to be principles of the objective order of things quite apart from the way they appear to us, Kant argues in favour of a system of subjective principles that he believes will nevertheless allow us to achieve the goals of metaphysics. The new metaphysics will not be knowledge-based, as traditional metaphysics had been. Rather Kant's system is primarily ethics-based. That is, the primary principles of Kant's metaphysical system are those of his rational ethics, which have the function of regulating our activity in, and organization of, the world. Instead of knowledge, ethics, and theology being uneasily coordinated parts of philosophy, as they are in traditional metaphysical systems, all three become integrated within an ethical, and essentially teleological, framework in Kant's system. Showing the role of the Critique of Judgment in bringing about this change, as well as showing the importance of teleology for Kant's philosophy, are both important goals of the thesis. (shrink)

In this volume of the Dictionary of Literary Biography, early philosophers of the classical period, the "golden age," are represented as well as a number of other figures whose contributions gave shape and direction to philosophy in America in the nineteenth and twentieth century.