The recent withdrawals of Vioxx, Celebrex, and other drugs from the market have spurred high-profile hearings in Congress and increased concern over the state of drug regulation in consumer protection and academic circles. This renewed focus on national drug safety has translated ineluctably into new legislation designed to mitigate that outcry. The most notable example, the passage of the Food and Drug Administration Amendments Act this past September, is at least partly intended as a response to an apparent lack of (...) public confidence in existing drug safety practices.Of the many provisions in the FDAAA, perhaps none carries greater implications for drug safety than the reauthorized Prescription Drug User Fee Act. Now in its fourth iteration, the newest PDUFA differs in important respects from the statute it supersedes. (shrink)

This book compares Butler's and Wang's moral vision and conception of conscience. It seeks to advance our ongoing inquiry into the complex encounter between Christianity and Confucianism. The study shows that in both thinkers' treatises are profound consonances that could serve as framework for a constructive interaction between these two civilizations.

Histories of philosophy frequently depict the later eleventh century as the scene of a series of bouts between dialecticians and anti-dialecticians — Berengar vs. Lanfranc, Roscelin vs. Anselm — preliminaries to the twelfth century welterweight contest between Abelard and St. Bernard and — dare one say? — the thirteenth century heavy-weight championship between St. Thomas and St. Bonaventure.The bouts took place — no question about that — but whether the contestants can properly be characterized as dialecticians and anti-dialecticians is less (...) certain. Dialectics is logic, the third part of the trivium, and increasingly cultivated in the eleventh century; men like Berengar and Roscelin were plainly eager to apply the logical tools with which they had been equipped to the solution of intellectual problems. In particular they undertook the solution of certain central problems of theology — Berengar that of the Eucharist and Roscelin that of the Trinity — and it was this, we are told, that aroused the ire of the anti-dialecticians: if the aim of the dialecticians was to lay bare the mysteries of faith to the light of reason that of the anti-dialecticians was to protect those same mysteries from profanation. (shrink)

Theories of consciousness have a long and controversial history. One well-known proposal — integrated information theory — has recently been labeled as ‘pseudoscience’, which has caused a heated open debate. Here we discuss the case and argue that the theory is indeed unscientific because its core claims are untestable even in principle.

Descartes's works are often treated as a unified, unchanging whole. But in Descartes's Changing Mind, Peter Machamer and J. E. McGuire argue that the philosopher's views, particularly in natural philosophy, actually change radically between his early and later works--and that any interpretation of Descartes must take account of these changes. The first comprehensive study of the most significant of these shifts, this book also provides a new picture of the development of Cartesian science, epistemology, and metaphysics. No changes in (...) Descartes's thought are more significant than those that occur between the major works The World and Principles of Philosophy. Often seen as two versions of the same natural philosophy, these works are in fact profoundly different, containing distinct conceptions of causality and epistemology. Machamer and McGuire trace the implications of these changes and others that follow from them, including Descartes's rejection of the method of abstraction as a means of acquiring knowledge, his insistence on the infinitude of God's power, and his claim that human knowledge is limited to that which enables us to grasp the workings of the world and develop scientific theories. (shrink)

This article outlines how conceptual spaces theory applies to modeling changes of scientific frameworks when these are treated as spatial structures rather than as linguistic entities. The theory is briefly introduced and five types of changes are presented. It is then contrasted with Michael Friedman’s neo-Kantian account that seeks to render Kuhn’s “paradigm shift” as a communicatively rational historical event of conceptual development in the sciences. Like Friedman, we refer to the transition from Newtonian to relativistic mechanics as an example (...) of “deep conceptual change.” But we take the communicative rationality of radical conceptual change to be available prior to the philosophical meta-paradigms that Friedman deems indispensable for this purpose. (shrink)

The literature on deep brain stimulation (DBS) and adaptive DBS (aDBS) raises concerns that these technologies may affect personality, mood, and behavior. We conducted semi-structured interviews with researchers (n = 23) involved in developing next-generation DBS systems, exploring their perspectives on ethics and policy topics including whether DBS/aDBS can cause such changes. The majority of researchers reported being aware of personality, mood, or behavioral (PMB) changes in recipients of DBS/aDBS. Researchers offered varying estimates of the frequency of PMB changes. A (...) smaller majority reported changes in personality specifically. Some expressed reservations about the scientific status of the term ‘personality,’ while others used it freely. Most researchers discussed negative PMB changes, but a majority said that DBS/aDBS can also result in positive changes. Several researchers viewed positive PMB changes as part of the therapeutic goal in psychiatric applications of DBS/aDBS. Finally, several discussed potential causes of PMB changes other than the device itself. (shrink)

This paper offers a novel way of reconstructing conceptual change in empirical theories. Changes occur in terms of the structure of the dimensions—that is to say, the conceptual spaces—underlying the conceptual framework within which a given theory is formulated. Five types of changes are identified: (1) addition or deletion of special laws, (2) change in scale or metric, (3) change in the importance of dimensions, (4) change in the separability of dimensions, and (5) addition or deletion of dimensions. Given this (...) classification, the conceptual development of empirical theories becomes more gradual and rationalizable. Only the most extreme type—replacement of dimensions—comes close to a revolution. The five types are exemplified and applied in a case study on the development within physics from the original Newtonian mechanics to special relativity theory. (shrink)

History reveals how civilisations can be decimated by changes in climate. More recently modern methods of warfare have exposed the vulnerability of the artefacts of civilisation. Bringing together a range of subjects - from science, energy and sustainability to aesthetics theory and civilization theory - this book uniquely deals with climate change and the ensuing catastrophes in relation to cultural factors, urbanism and architecture. It links the evolution of civilisation, with special emphasis on the dynamics of beauty as displayed in (...) architecture and urbanism, to climate change. It then considers both the historic and predicted impacts of climate change and the threat it poses to the continued viability of human civilisation when survival is the top priority. This book gives students, researchers and professionals in architecture and sustainable design as well as anyone interested in the threat of global warming to civilisation, new insights as to what could be lost if action is not taken at a global level. (shrink)

Climate change is an ethical issue, because it involves the distribution of a scarce resource – the capacity of the atmosphere to absorb our waste gases without producing consequences that no one wants. Various principles might be used to decide what distribution is just. This commentary argues that on any plausible principle, the industrialised nations should be doing much more than they are doing now, and much more than they are required to do by the Kyoto protocol, to reduce their (...) greenhouse gas emissions. The commentary also responds specifically to some issues raised by MacCracken, Toman and Gardiner, including feasibility, the discount rate, and grounds for pessimism. (shrink)

In Jackendoff's Parallel Architecture, the well-formed expressions of a language are licensed by correspondences between phonology, syntax, and conceptual structure. I show how this architecture can be used to make sense of the existence of parasitic gap constructions. A parasitic gap is one that is rendered acceptable because of the presence of another gap in the same sentence. Compare *a person whoi everyone who talks to ti likes Chris, which shows an illicit extraction from a relative clause, and a person (...) whoi everyone who talks to pgi likes ti, which shows a parasitic gap in the relative clause. Languages differ in terms of the range of configurations in which they allow parasitic gaps; these configurations appear to form a hierarchy. These observations raise some fundamental questions: Why do parasitic gaps exist at all? Why are different syntactic configurations possible for P-gaps and why just these configurations? Why is there a parasitic gap hierarchy? The answers that I propose make crucial use of constructional overgeneralization of across-the-board extraction in coordinate constructions, formulated straightforwardly in the framework of Jackendoff's Parallel Architecture. (shrink)

In this special edition of his award-winning bestseller, visionary scientist Peter Russell updates his classic manifesto for awakening to the mounting planetary crisis while deepening the connection to inner tranquility. Amid fears of ecological catastrophe and political chaos, this book stands out for its message of sanity and hope.

Central banks have become the go-to institution of modern economies. In the wake of the 2007 financial crisis, they injected trillions of dollars of liquidity – through a process known as quantitative easing – first to prevent financial meltdown and later to stimulate the economy. The untold story behind these measures, and behind the changing roles of central banks generally, is that they have come at a considerable cost. Central banks argue we had no choice. This book offers a powerfully (...) original examination of why this claim is false. Using examples from Europe and the US, the authors present and analyse three specific concerns about the way central banks in developed economies operate today. Firstly, they show how unconventional monetary policies have created significant unintended negative consequences in terms of inequalities in income and wealth. They go on to argue that central banks may have become independent of governments, but have instead become worryingly dependent on financial markets. They then proceed to analyse how central bankers, despite being the undisputed experts on monetary policy, can still err and suffer from multiple forms of bias. This book is a sobering and urgent wake-up call for policy-makers and anyone interested in how our monetary and financial system really works. (shrink)

Demography plays a large role in cultural evolution through its effects on the effective rate of innovation. If we assume that useful inventions are rare, then small isolated societies will have low rates of invention. In small populations, complex technology will tend to be lost as a result of random loss or incomplete transmission (the Tasmanian effect). Large populations have more inventors and are more resistant to loss by chance. If human populations can grow freely, then a population-technology-population positive feedback (...) should occur such that human societies reach a stable growth path on which the rate of growth of technology is limited by the rate of invention. This scenario fits the Holocene to a first approximation, but the late Pleistocene is a great puzzle. Large-brained hominins existed in Africa and west Eurasia for perhaps 50,000 years with, at best, slow rates of technical innovation. The most sophisticated societies of the last glacial period appear after 50,000 years ago and were apparently restricted to west and north-central Eurasia and North Africa. These patterns have no simple, commonly accepted explanation. We argue that increased high-frequency climate change around 70,000–50,000 years ago may have tipped the balance between humans and their competitor-predators, such as lions and wolves, in favor of humans. At the same time, technically sophisticated hunters would tend to overharvest their prey. Perhaps the ephemeral appearance of complex tools and symbolic artifacts in Africa after 00,000 years ago resulted from hunting inventions that allowed human populations to expand temporarily before prey overexploitation led to human population and technology collapse. Sustained human populations of moderate size using distinctively advanced Upper Paleolithic artifacts may have existed in west Eurasia because cold, continental northeastern Eurasia–Beringia acted as a protected reserve for prey populations. (shrink)

Climate change is one of the greatest challenges that human societies have ever faced. After a late start, it is by now rather intensely debated and analysed also in the social sciences and humanities, though mostly through overly generic explanations in terms of an instrumental relation to nature, of capitalist expansion drives or of the human longing for comfort. In contrast, this article concentrates on the socio-political transformations since the middle of the 20th century, which have been referred to as (...) the ‘Great Acceleration’ in the use of biophysical resources and in environmental degradation. It provides an analysis of the socio-political mechanisms that brought the resource-intensive path of social development about, showing how Western democratic societies tended to ‘solve’ difficult social problems by means of a triple displacement: onto other societies; onto nature and the planet; and into the future. As an unintended consequence, this displacement politics led to the globalization of resource-intensive development and to a planetary situation in which, at least as it appears in much of current debate, no further displacement is possible. The article concludes with insights for a more adequate approach to social phenomena of large scale and long duration in social theory. (shrink)

From the ethicist the_ New Yorker_ calls “the most influential living philosopher,” a new way of thinking about living ethically.

Thousands of people will suffer and die this year because we do not donate enough substances of human origin, including blood plasma. To solve this, some recommend that we allow commercial organizations to assist in collecting these and that we permit donor compensation as a tool to encourage donations. Many object to these proposals, including for semiotic or expressive reasons. But insofar as these objections rely on meanings and these meanings are social constructs, we can revise the meaning of these (...) practices to avoid commodification. Revision may work in principle, but in practice some complain that changing meanings may be too difficult or practically infeasible. This essay attempts to show that this is not so in a wide range of cases and uses the case of commercial compensated blood plasma collection as an illustration. Getting people to conceive of this practice not as payment for blood plasma but as compensation for the time, effort, and inconvenience associated with the giving of plasma is practically feasible and preferable to prohibition. (shrink)

This chapter argues that central banks find themselves between a rock and a hard place when it comes to green central banking. Either they endorse the project, exposing them to the charge that they lack the input legitimacy to do so, or they eschew taking into account climate concerns, thus undermining their output legitimacy. Our discourse analysis of central bankers’ speeches shows that disagreements among officials from the same institution regarding green central banking are grounded on issues outside their core (...) expertise. Furthermore, neither the conservative nor the progressive central bankers defend positions that have the potential to overcome the legitimacy dilemma we formulate. (shrink)

Unnatural States is a radical critique of international theory, in particular, of the assumption of state agency--that states act in the world in their own right. Peter Lomas argues that since the universal states system is inequitable and rigid, and not all states are democracies anyway, this assumption is unreal, and to adopt it means reinforcing an unjust status quo. Looking at the concepts of state, nation, and agency, Lomas sees populations struggling to find an agreed model of the (...) state, owing to inherited material differences; and unsurprisingly, among theorists of the nation, only controversy and a great confusion of terms. Meanwhile, the functional incarnations of the state agent are caricatures: the mandarin state, the lawyer state, the landlord state, the heir-to-history state, and the patriot state. Yet recent developments in international theory (constructivism, scientific realism, postmodernism) sacrifice state agency only at the price of an unhelpful abstraction. The states system is dysfunctional and obsolete, Lomas contends, and international theory must be recast, with morality as central, to inspire and to guide historic change. He focuses in his conclusion on prescriptions for change, led by four moral concerns: human rights, weapons of mass destruction, relations between rich and poor societies, and the environment. "I begin this book," writes Lomas, "with the commonest commonplace of international theory, to expose it as a meaningless cliche. In the masterly hands of Hobbes, it was elaborated into a shock formula for organized society, a reading of history as civilization's failure. Kant sought to rescue morality from Hobbes and create the structures of modernity, but Kant's influence is coming to an end. In the Cold War, politicians disagreeing over another philosopher almost brought the world to an end. Hence the challenges of our time. These are primary and profound. Philosophers have done much to define the modern world. The point of international theory is to change it.". (shrink)

Most Americans today view mines as little more than ugly scars on the landscape, places with no connection to an American way of life. This creative new work will force many to rethink that impression: after an introduction to the history of mining in America, the authors present eight visual and historical essays about diverse sites across the nation, each of which reveals mines not simply as physical degradations but as evolving cultural artifacts of the American landscape.

Changing Ideals in Modern Architecture revolutionized the understanding of modernism in architecture, pushing back the sense of its origin from the early twentieth century to the 1750s and thus placing architectural thought within the a broader context of Western intellectual history. This new edition of Peter Collins's ground-breaking study includes all seventy-two illustrations of the original hard cover edition, which has been out of print since 1967, and restores the large format.

Outlining the characteristics of “wicked” and “super‐wicked” problems, climate change is considered as a global super‐wicked problem that is primarily about the future. Being global‐ and future‐oriented makes climate change something we have to learn to live with but cannot expect to solve. Because the Institute on Religion in an Age of Science (IRAS) is a multidisciplinary society that yokes the natural and social sciences with values, it is in a position to explore strategies for living with climate change—exemplified by (...) the articles in this section. Finally, asking “who/what is in charge,” it is suggested that in a dynamically interrelated and evolving world no one is. It is important to distinguish between good that is already created and the creative interactions that give rise to new good. In order to live with climate change, our primary orientation should be to live with the creativity that has created and continues to create our life on Planet Earth—since we are not able to know what the future holds. (shrink)

The dominant world civilization today is based on the pursuit of more and more material wealth. With the loss of faith in religion and in communism, there are few counter-models to the view that this is the goal of our existence. But this pursuit of material wealth is coming into conflict with the capacity of our global ecosystem to remain stable. Energy consumption is linked with the production of green house gases, and this will lead to changes in climate that (...) will be disastrous for many people. At the same time, we have good evidence that the pursuit of material wealth does not lead to happiness, either individually or collectively. For these reasons it is time to reconsider our fundamental values. I argue that we can live in a way that is both more meaningful and fulfilling for ourselves, and more sustainable for the world, if we abandon the pursuit of affluence and consciously adopt the living of an ethical life as a goal. (shrink)

The doyen of living English philosophers, by these reflections, took hold of and changed the outlook of a good many other philosophers, if not quite enough. He did so, essentially, by assuming that talk of freedom and responsibility is talk not of facts or truths, in a certain sense, but of our attitudes. His more explicit concern was to look again at the question of whether determinism and freedom are consistent with one another -- by shifting attention to certain personal (...) rather than moral attitudes, first of all gratitude and resentment. In the end, he arrived at a kind of Compatibilist or, as he says, Optimist conclusion. That is no doubt a recommendation but not the largest recommendation of this splendidly rich piece of philosophy. (shrink)

For thirty years, Peter Singer's Practical Ethics has been the classic introduction to applied ethics. For this third edition, the author has revised and updated all the chapters and added a new chapter addressing climate change, one of the most important ethical challenges of our generation. Some of the questions discussed in this book concern our daily lives. Is it ethical to buy luxuries when others do not have enough to eat? Should we buy meat from intensively reared animals? (...) Am I doing something wrong if my carbon footprint is above the global average? Other questions confront us as concerned citizens: equality and discrimination on the grounds of race or sex; abortion, the use of embryos for research and euthanasia; political violence and terrorism; and the preservation of our planet's environment. This book's lucid style and provocative arguments make it an ideal text for university courses and for anyone willing to think about how she or he ought to live. (shrink)

Adults and infants display a robust ability to perceive the unity of a center-occluded object when the visible ends of the object undergo common motion (e.g. Kellman, P.J., Spelke, E.S., 1983. Perception of partly occluded objects in infancy. Cognitive Psychology 15, 483±524). Ecologically oriented accounts of this ability focus on the primacy of motion in the perception of segregated objects, but Gestalt theory suggests a broader possibility: observers may perceive object unity by detecting patterns of synchronous change, of which common (...) motion is a special case. We investigated this possibility with observations of adults and 4-month-old infants. Participants viewed a center-occluded object whose visible surfaces were either misaligned or aligned, stationary or moving, and unchanging or synchronously changing in color or bright- ness in various temporal patterns (e.g. ¯ashing). Both alignment and common motion con- tributed to adults' perception of object unity, but synchronous color changes did not. For infants, motion was an important determinant of object unity, but other synchronous changes and edge alignment were not. When a stationary object with aligned edges underwent syn- chronous changes in color or brightness, infants showed high levels of attention to the object, but their perception of its unity appeared to be indeterminate. An inherent preference for fast over slow ¯ash rates, and a novelty preference elicited by a change in rate, both indicated that infants detected the synchronous changes, although they failed to use them as information for object unity. These ®ndings favor ecologically oriented accounts of object perception in which surface motion plays a privileged role. Ó 1999 Elsevier Science B.V. All rights reserved. (shrink)

Drosophila males sing a courtship song to achieve copulations with females. Females were recently found to sing a distinct song during copulation, which depends on male seminal fluid transfer and delays female remating. Here, it is hypothesized that female copulation song is a signal directed at the copulating male and changes ejaculate allocation. This may alter female remating and sperm usage, and thereby affect postcopulatory mate choice. Mechanisms of how female copulation song is elicited, how males respond to copulation song, (...) and how remating is modulated, are considered. The potential adaptive value of female signaling during copulation is discussed with reference to vertebrate copulation calls and their proposed function in eliciting mate guarding. Female copulation song may be widespread within the Drosophila genus. This newly discovered behavior opens many interesting avenues for future research, including investigation of how sexually dimorphic neuronal circuits mediate communication between nervous system and reproductive organs. (shrink)

_Elaborates the author’s conception of plasticity by proposing a new way of thinking through Heidegger’s writings on change._.

The concept of mechanism is analyzed in terms of entities and activities, organized such that they are productive of regular changes. Examples show how mechanisms work in neurobiology and molecular biology. Thinking in terms of mechanisms provides a new framework for addressing many traditional philosophical issues: causality, laws, explanation, reduction, and scientific change.