A gene's “expression profile” denotes the number of transcripts present relative to all other transcripts. The overall rate of transcript production is determined by transcription and RNA processing rates. While the speed of elongating RNA polymerase II has been characterized for many different genes and organisms, gene‐architectural features – primarily the number and length of exons and introns – have recently emerged as important regulatory players. Several new studies indicate that rapidly cycling cells constrain gene‐architecture toward short genes with a (...) few introns, allowing efficient expression during short cell cycles. In contrast, longer genes with long introns exhibit delayed expression, which can serve as timing mechanisms for patterning processes. These findings indicate that cell cycle constraints drive the evolution of gene‐architecture and shape the transcriptome of a given cell type. Furthermore, a tendency for short genes to be evolutionarily young hints at links between cellular constraints and the evolution of animal ontogeny. (shrink)

Chapter One: Constructions. Entities, constructions, and functions When one travels from Los Angeles to New York, going, say, by way of St. Louis, Chicago, ...

The article offers a rigorous explication of the intuitive notion of verisimilitude, I.E., Of the distance of a theory from the truth. The proposal is defended against charges of material inadequacy made by popper, Niniluoto, And miller.

I. The framework. 1, Aristotle's project and methods. 2, The perceptual capacity of the soul. 3, The sensory apparatus. 4, The common sense and the related capacities -- II. The terminology. 1, Overlooked occurrences of the phrase 'common sense'. 2, De anima III.1 425a27. 3, De partibus animalium IV.10 686a31. 4, De memoria et reminiscentia 1 450a10. 5, De anima III.7 431b5. 6, Conclusions on the terminology -- III. Functions of the common sense. 1, Simultaneous perception and cross-modal binding. 2, (...) Perceptual discrimination. 3, Waking, sleep, and control of the senses. 4, Perceiving that what we see and hear, and monitoring of the senses. 5, Other roles of the common sense -- Conclusion. (shrink)

In this paper, I would like to present Aristotle’s attitude to sense-perception. I will refer to this attitude as “perceptual optimism”. Perceptual optimism is, very briefly, the position that the senses give us full access to reality as it is. Perceptual optimism entails perceptual realism, the view that there is a reality out there which is accessible to our senses in some way or other, and the belief that our senses are veridical at least to some extent, but it is (...) more comprehensive than that. For instance, a perceptual optimist does not admit such things as qualities which are perceptible in principle but not by us or bodies too small to be perceptible. In this paper I argue that Aristotle is a perceptual optimist, since he believes that reality, at least in the sublunary sphere, is indeed fully accessible to our senses. In the first and largest part of this paper, I will show, in seven distinct theses, what Aristotle’s perceptual optimism entails. In the second and shorter part, I will put Aristotle’s position in a wider context of his epistemology and show why it was important for him to be a perceptual optimist. (shrink)

Ordinary consciousness is viewed as a variety of practically spiritual attitude to life, as an element of socially-transformational activity in its various manifestations as characteristics of life itself as syncretic phenomenon, performing a function of integral reality mastering on a level of everyday life. Direct contact with life, a pragmatic mood and practical orientation of ordinary consciousness clear up its ontological status and make it possible to speak about its eternal role in the social and private life of man; about (...) relative independence concerning specialized forms and levels of social consciousness, which came out of the ordinaryconsciousness and later separated from it. In the XX century the stake of society on pragmatism of ordinary consciousness while increasing the supremacy of utilitarian relations above human relations (a man becomes one of the material things) against a background of globalization and postmodernism led culture to the spiritual crisis, into the oblivion of spiritual values by contemporary man. Of course, globalization brings a number of advantages creating a sense of identity all over the world. It lowers trade barriers, shipping costs, telecommunication and computing costs, improves communication among peoples. However, there is debate about whether the power of international capital and the supposed homogenization of taste worldwide are good things or not. Globalization imposes a common standard of living on states and peoples, which belittles their cultural and national originality. Such a standard of living (mainly founded on principles of practicism) hinders mankind’s and man’s development. For the collective life is dialectical unity of diversity. The world must be smile and multipolar simultaneously. Unstable equilibrium between the whole and its parts leads to spiritual crisis. The social production of «useful» man closed up practically the possibility of bringing up man as the personality. That is why it so important today to recognize the necessity and possibility of moral and spiritually–religioustransformation of ordinary consciousness. The Eastern Wonder of the XX century (the South Korea, China and Japan) in the sphere of economics is based on the synthesis of national and human laws of being. (shrink)

2 Popper's Logical Definition of Verisimilitude. 3 Popper's Probabilistic Definition of Verisimilitude. 4 Conclusion.

The paper deals with the semantics of mathematical notation. In arithmetic, for example, the syntactic shape of a formula represents a particular way of specifying, arriving at, or constructing an arithmetical object (that is, a number, a function, or a truth value). A general definition of this sense of "construction" is proposed and compared with related notions, in particular with Frege's concept of "function" and Carnap's concept of "intensional isomorphism." It is argued that constructions constitute the proper subject matter of (...) both logic and mathematics, and that a coherent semantic account of mathematical formulas cannot be given without assuming that they serve as names of constructions. (shrink)

The article offers a rigorous truth condition for subjunctively conditional statements. The theory is framed in the system of transparent intensional logic and takes connections (especially the cause-Effect relation) as basic. Counterexamples are given to rival theories based on the notion of world similarity.

In this paper we argue that Aristotle operates with a particular theoretical model in his explanation of animal locomotion, what we call the ‘centralized incoming and outgoing motions’ model. We show how the model accommodates more complex cases of animal motion and how it allows Aristotle to preserve the intuition that animals are self-movers, without jeopardizing his arguments for the eternity of motion and the necessary existence of one eternal unmoved mover in Physics VIII. The CIOM model helps to elucidate (...) Aristotle’s two central yet problematic claims, namely that the soul is the efficient cause of animal motion and that it is the internal supporting-point necessary for animal motion. Moreover, the CIOM model helps us to explain the difference between voluntary, involuntary and non-voluntary motions, and to square Aristotle’s cardiocentrism with his hylomorphism, but also, more generally, it provides an interesting way of thinking about the place of intentionality in the causal structure of the world. (shrink)

Traxler, Pickering, and Clifton found that ambiguous sentences are read faster than their unambiguous counterparts. This so-called ambiguity advantage has presented a major challenge to classical theories of human sentence comprehension because its most prominent explanation, in the form of the unrestricted race model, assumes that parsing is non-deterministic. Recently, Swets, Desmet, Clifton, and Ferreira have challenged the URM. They argue that readers strategically underspecify the representation of ambiguous sentences to save time, unless disambiguation is required by task demands. When (...) disambiguation is required, however, readers assign sentences full structure—and Swets et al. provide experimental evidence to this end. On the basis of their findings, they argue against the URM and in favor of a model of task-dependent sentence comprehension. We show through simulations that the Swets et al. data do not constitute evidence for task-dependent parsing because they can be explained by the URM. However, we provide decisive evidence from a German self-paced reading study consistent with Swets et al.'s general claim about task-dependent parsing. Specifically, we show that under certain conditions, ambiguous sentences can be read more slowly than their unambiguous counterparts, suggesting that the parser may create several parses, when required. Finally, we present the first quantitative model of task-driven disambiguation that subsumes the URM, and we show that it can explain both Swets et al.'s results and our findings. (shrink)

This article provides an ethical analysis of the moral conflict over access to premium audio-visual online content, which is currently regulated by geo-blocking in the domain of digital film distri...

Out of the broad variety of Cusanus' work, this book discusses six of his writings, careful not to isolate them from the whole of his work. It instead presents them against the maturation of Cusanus' thinking as it developed from his first sermons up to his shortest philosophical text De apice theoriae. The texts in question are De docta ignorantia, De coniecturis, Idiota de mente, De beryllo, Trialogus de possest and De apice theoriae. In the search for God, or rather (...) in Cusanus' lifetime eff orts to have his spirit touch the fi rst principle and the basis of all things, new perspectives on the world and man within would open up for Cusanus. Respecting this basic intention of Cusanus' thinking, the author primarily deals with Cusanus' ontotheological (metaphysical) claims and, in their context, turns his attention to the cosmological, or anthropologico-gnoseological opinions. (shrink)

The paper «Situation as concrete entity» dedicated to ontological opposition of abstract being and concrete being. Main idea of this paper – situation as concrete being was rejected, ignored by philosophic and religious systems for thousands of years, because situation was associated with false being, being of things (Plato), life distress, illusion (Hinduism, Buddhism). But culture of XX century includes «reanimation» of situation as concrete being by existentialphilosophy and modern art, and now we can speak about new approach to problem (...) of human being, practice and cognition – situative method. This approach has high humanitarian potential and wide perspectives of development. (shrink)

Intensions feature prominently among the entities we talk about.

_ Source: _Volume 48, Issue 2, pp 265 - 285 This article examines the development of Heidegger’s thought directly following _Being and Time_, a period that is significant both in its own right and in its capacity to shed light on the problems driving Heidegger’s later works. I assess Crowell’s thesis that Heidegger’s aim was to develop a metontology along the lines of a pre-critical _metaphysica specialis_ based on a reassessment of Kant’s transcendental dialectic. I show that such a reading (...) misrepresents the nature of Heidegger’s project in this period and argue that Heidegger was instead attempting to develop a distinctively critical metaphysics in a post-Kantian vein. (shrink)

This Festschrift is in honour of Professor Marie Duzí, VSB - Technical University of Ostrava. The 16 contributions, authored by 24 colleagues, run the gamut from foundations in logic and theoretical computer science through philosophical logic, multi-agent systems and theory of communication to personal recollections. Marie Duzí is best known for her profound and extensive work on both the foundations and multiple applications of Transparent Intensional Logic, originally developed by Pavel Tichý in the late 1960s. Her work, whether single-authored (...) or co-authored, has appeared in various high-level journals. In 2008 the Rector of her home university granted Marie the award Outstanding Results in the Development of Science and Research. The 2010 monograph Procedural Semantics for Hyperintensional Logic earned Marie and her coauthors the prestigious Award for Outstanding Results of Major Scientific Importance from the Academy of Sciences of the Czech Republic. The major achievements of Transparent Intensional Logic that Marie has been involved in over the last decade have been compiled into the volume Transparent Intensional Logic: Selected Recent Essays, also published by College Publications. (shrink)