In this review, we will focus on the role played by transcription factors of the E2F/DP family in controlling the expression of genes that carry out important cell‐cycle control functions, thereby ensuring ordered progression through the mammalian cell division cycle. The emerging picture is that cell‐cycle progression depends on the execution of a regulatory cascade of gene expression, driven by E2F/DP transcription factors, which are in turn regulated by the products of some of these genes. That E2F factors are potent (...) regulators of cell‐cycle checkpoints in mammalian cells is supported by experiments demonstrating that ectopic expression of individual E2F family members is sufficient to modulate cell proliferation and apoptosis. It is also clear that deregulation of E2F activity will result in the loss of particular checkpoint controls, thereby predisposing cells to malignant conversion. BioEssays 21:221–230. 1999. © 1999 John Wiley & Sons, Inc. -/- . (shrink)

Il saggio indaga il rapporto fra impresa e società fra ottocento e novecento così come si esprime nelle società per azioni e nelle imprese cooperative. Nella seconda metà dell’Ottocento i codici di commercio europei introducono la deregolamentazione delle public company e codificano per la prima volta l’impresa cooperativa. Entrambe le novità rappresentano una riposta ai problemi centrali di quella fase dello sviluppo industriale: il finanziamento delle iniziative economiche, la questione sociale e la governance dell’impresa. Si delineano così due forme di (...) impresa, la public company e l’impresa cooperativa, che per tutto il Novecento alimenteranno il dibattito sul rapporto fra società e impresa e contribuiranno alla crescita delle economie occidentali. (shrink)

Starting from the concept and definition of littera in the Grammar treatises of the Late Antiquity and the Early Middle Ages, the contribution analyzes common graphic elements which were used by the scribes to create initials, ornamental patterns and the layout of the manuscript page. These elements and their functions were partly described in encyclopaedic works, e. g. of Isidor of Sevilla and Martianus Capella in the chapters about Geometry. Not only were these features well known through the study of (...) the Artes, they also represented useful tools for the invention and production of medieval diagrams. (shrink)

As Malinowsky states, myth is closely related to rite, presenting the social and moral values that rite asserts in each cyclical repetition. Rite marks the threshold between the sacred and profane, allowing access to myth as an art form, as a narrative expression both of the sacred – in the extension of meaning Emile Durkheim introduced with the term ‘collective consciousness’ – and of the ‘collective unconscious’ as Jung defined it. If it is true that the rite of passage to (...) the adult world, the initiation rite, is one of the most archaic rites in aiming to protect society against the risk of cultural innovation inherent in the younger generations, then it is legitimate to ask what our new myths are regarding education. When technology accelerates the mechanisms eroding collective memory, which rites renew educational myths in everyday practice? When technology dematerializes the devices on which rite and its inherent techniques of control are based, what new forms does mythological narration assume? What roles do new media play in creating a direct channel between the collective consciousness and individual experience, between the nervous system and our environment, enveloping individuals in the telematic embrace Roy Ascott described in 2003, and which not only explains the concept of the Global Village that Marshall McLuhan introduced in 1966, but also delineates the space – time of students in contemporary learning processes? Reading the contemporary educational system through the lens of myth and rite, where new technologies play a central role, allows us to follow a path that traces the progressive impact of media on cognitive processes from the initial emergence of the concept ‘collective consciousness’ onwards, and that offers one of the most interesting interpretations of the ‘open school’ experience in Derrick de Kerkhove’s concept of ‘connective intelligence’ (analysed in my Ph.D. thesis). But myth also allows us to observe those cracks, breaks and discontinuities that mark the places in which contemporary knowledge is created, which is why we find Nietzsche (who dedicated much of his work to myth), Michel Foucault and Ivan Illich at the centre of International Debate on Education for the last decade due to their critical approach to institutions. (shrink)

Music-Dance explores the identity of choreomusical work, its complex authorship and its modes of reception as well as the cognitive processes involved in the reception of dance performance. Scholars of dance and music analyse the ways in which a musical score changes its prescriptive status when it becomes part of a choreographic project, the encounter between sound and motion on stage, and the intersection of listening and seeing. As well as being of interest to musicologists and choreologists considering issues such (...) as notation, multimedia and the analysis of performance, this volume will appeal to scholars interested in applied research in the fields of cognition and neuroscience. The line-up of authors comprises representative figures of today's choreomusicology, dance historians, scholars of twentieth-century composition and specialists in cognitive science and performance studies. Among the topics covered are multimedia and the analysis of performance; the notational practice of choreographers and the parallel attempts of composers to find a graphic representation for musical gestures; and the experience of dance as a paradigm for a multimodal perception, which is investigated in terms of how the association of sound and movement triggers emotions and specific forms of cognition. (shrink)

In Europe the elderly population is projected to increase from 18.5% (93.9 million) in 2014 to 28.7% (149.1 million) by 2080. In the USA it is estimated that by the year 2030 more than 20% of the population will be aged 65 years or over. This specific population is at high risk of unrecognised or untreated psychiatric illnesses and suicide. It is well known that completed suicide rate increases with age in both men and women. Although elderly people attempt suicide (...) less often than other age groups, they show a higher completion rate. Generally the methods chosen by elderly are more lethal, the intent is more serious, they are more determined and they show fewer warning sign than the younger population. A recent systematic review and meta-analysis of psychosocial intervention following self-harm in adults found that cognitive behavioural therapy was the most effective in these patients. Unfortunately there have been few reported trials of other potentially effective interventions. Because the scientific literature on psychosocial suicide prevention interventions in the elderly is still scant we decided to conduct a mini-review in order to take stock of the situation. Studies were identified through electronic searches of the Cochrane library, MEDLINE, Scopus and Web of Science databases. PRISMA guidelines were followed and only 7 articles met the inclusion criteria. No firm conclusions can be drawn about this topic because there is still little data and studies used inconsistent outcome measures and designs. Nonetheless, the existing data suggests that psychosocial interventions are promising. (shrink)

Patrizia Lombardo | : Stendhal et Musil sont les deux écrivains par excellence qui se sont interrogés sur le type de connaissance qui vient de la littérature. Avant Musil et comme Musil, Stendhal répond à cette question fondamentale en montrant que le roman offre une connaissance des émotions humaines et de leur lien avec les valeurs. Il s’agit à la fois de valeurs éthiques — les situations morales dans lesquelles se trouvent les personnages — et des valeurs esthétiques et (...) proprement littéraires — le tragique, le comique, le tragi-comique, le sublime, etc. Surtout, le roman n’est pas simple représentation du réel, mais aussi du possible. L’analyse de quelques phrases hypothétiques, conjectures et expériences de pensée dans Le Rouge et le Noir, confirme la thèse que la littérature propose une connaissance du possible à travers le travail de l’imagination. | : Stendhal and Musil are deeply concerned with the question of theknowledge value of literature. Like Musil and before him, Stendhalanswered this question by showing the potential of the novel :this literary form presents human emotions and their connection tovalues. The characters deal with various situations, therefore conveyethical values, while aesthetic values —such as the comic, thetragic, the tragic-comic, the sublime- emerge from the way in whichhuman actions and emotions are represented. All these values arebrought about by the style of Stendhal, which is both form and content,both ethical and aesthetic. The analysis of some hypotheticalsentences, conjectures and thought experiments in The Red and the Blackconfirms the thesis later endorsed by Musil, that literature allows forthe knowledge of the possible, thanks to the exercise of theimagination. (shrink)

The exponential rise in transgender self-identification invites consideration of what constitutes an ethical response to transgender individuals’ claims about how best to promote their well-being. In this paper, we argue that ‘accepting’ a claim to medical transitioning in order to promote well-being would be in the person’s best interests iff at the point of request the individual is correct in their self-diagnosis as transgender (i.e., the distress felt to reside in the body does not result from another psychological and/or societal (...) problem) such that the medical interventions they are seeking will help them to realise their preferences. If we cannot assume this—and we suggest that we have reasonable grounds to question an unqualified acceptance in some cases—then ‘acceptance’ potentially works against best interests. We propose a distinction between ‘acceptance’ and respectful, in-depth exploration of an individual’s claims about what promotes their well-being. We discuss the ethical relevance of the unconscious mind to considerations of autonomy and consent in working with transgender individuals. An inquisitive stance, we suggest, supports autonomous choice about how to realise an embodied form that sustains well-being by allowing the individual to consider both conscious and unconscious factors shaping wishes and values, hence choices. (shrink)

Name der Zeitschrift: Semiotica Heft: Ahead of print.

According to the principle known as “the principle of present-tense ascription immunity”, “It is impossible for anyone to have or entertain thoughts without being aware—immediately and self-evidently—that he is thinking that thought”. In other words, my thoughts are fundamentally experienced as mine, and I typically have this experience of mineness immediately, that is, without any inference based on evidence about who is the thinker of the thought. Thought insertion reveals instead that, under particular pathological conditions, people can be startlingly in (...) error about who is thinking a thought. How can this happen? In the attempt to specify how the capacity for self-ascription of a thought can.. (shrink)

Name der Zeitschrift: Semiotica Jahrgang: 2015 Heft: 206 Seiten: 89-108.

The new discoveries of QM led to re-assessing, broadening the meanings of many physical concepts, and formulating a new logic that was no longer based on the classical principles of non-contradiction, identity, and causality. Heisenberg considered the classical logic and the conception of language expressed in the Tractatus Logico-Philosophicus inadequate for the understanding of the problems of language with which the physicists of the Copenhagen school had had to deal in order to define the foundations of Quantum Mechanics. On the (...) contrary, he saw in Wittgenstein’s posthumous Philosophical Investigations the key to solving those problems. One may formulate a proportion and state that the use of language described in the Tractatus fits the use of language in Classical Mechanics, as the use of language described in PI fits the use of language in QM. I interpret the reflections of the physicists of the Copenhagen school on the limits of language relative to QM by highlighting how the epistemological revolution of quantum physics shares a conception of language similar to that expressed by late Wittgenstein in PI. I also aim to explain why Heisenberg considered it inappropriate to subsume the propositions and concepts of QM under the rules of the propositional logic of Tractatus. I explain why the philosophy of language expounded in PI, which is based on language games and resemblance families, sheds a light on how and why QM has contributed to renewing existing concepts (such as space, trajectory, observer, etc.) and to formulate a new logic (quantum logic). (shrink)

I thank Dr. Matthew Parrott and Dr. V.Y. Allison-Bolger very much for their valuable comments on my paper. They have given me the chance to reflect further on the account of thought insertion I propose, and I respond to them with enthusiasm. I also thank the Editor of this journal for arranging this discussion and for giving me the opportunity to reply. Both Dr. Parrott and Dr. Allison-Bolger are concerned about whether my account is fundamentally tenable. They suggest that I (...) make two incompatible claims in the paper: I deny that a schizophrenic thinker suffering from thought insertion has the appropriate dispositions to enter the cause/reason-giving practice for the thought that she... (shrink)

This article analyses the relationship of human faces with trauma and death, in particular focalizing on the use of snap shot and ID kinds of photos in site of memory, memorials an public art.

Exploring Textual Action questions how we analyse works of art after the performative turn and shows how the interplay of performativity (textual action), space and topography, and the converging of genres and art forms is essential in modern drama, theatre, prose fiction, poetry and film. The volume also fosters a keen concern for the development of congenial theory. Its 14 detailed essays analyse works of art ranging from Balzac, Melville and George Eliot, to Breton, Kafka, Benjamin, Blixen and Woolf; and (...) from W.C. Williams, Bresson and Scorsese, to Sarraute, Duras, Reygadas, Dumont and Waltz. The approach of these studies discloses the art works as creative and dynamic utterances with active and shaping forces so powerful, and consequential, that they have the potential to transform human perception and blur clear distinctions between art and "real" life. Using an alternative and dynamic method and suggesting a direction towards the detailed analysis of literature, art, media and culture, Exploring Textual Action addresses current debates within the humanities. (shrink)

Offers an accessible reader that combines theory with historical and contemporary case studies that encourage students to apply their theoretical understandings of justice to real world issues.

According to a recent theory of the motivational content of self-deception, the self-deceiver wants to be in a state of mind of belief that p, upon which her want that p be true would be merely contingent. While I agree with Funkhouser that the self-deceiver is considerably moved by an interest in believing that p, which makes it possible for her to relate to reality in a highly prejudiced way, I will argue that it is unlikely that the self-deceiver’s primary (...) want to believe, or interest in believing that p occurs as the result of a merely contingent interest in p being true. I will finally assess various consequences of the view I favor, regarding the self-deceiver’s avoidance behaviour, “twisted” self-deception, and whether we should provide a unifying account of “straight” and “twisted” self-deception. (shrink)

Tobacco, divine, rare superexcellent tobacco, which goes far beyond all panaceas, potable gold and philosopher's stones, a sovereign remedy to all diseases.Although most of the toxicity, including cancerogenicity, of tobacco is related to a mix of components other than nicotine present in cigarettes (U.S. Surgeon General 2010), it is indeed nicotine that causes addiction to smoking (Benowitz 2010; Russo et al. 2011).In 1988, the U.S. Surgeon General's Report concluded that cigarettes and other forms of tobacco are addictive as a result (...) of their nicotine content, and that the processes determining tobacco addiction "are similar to those that determine addiction to drugs such as heroin and cocaine." Previously, in .. (shrink)

Plotinus represent a constant reference in all of Šestov's philosophy. For the Russian philosopher Plotinus is, on the one hand, the one who thought up thesynthesis of Greek philosophy, on the other, the one who first broke with that same tradition precisely when it was at its peak. However, Šestov does lift from the Enneadi certain passages which he marries - as if in a sort of contrapuntal rewriting exercise - to others in which Plotinus seems to contradict himself. What (...) interests Šestov are precisely those discontinuities in the thought of the last great philosopher of old in an anti-Greek function. That of Šestov is once again a marked criticism of Rationalism as creator of an autonomous set of ethics that he judges according to an intellect which everything is subject to. Autonomousethics, affirms Šestov, is a fruit of Greek schools of thought to the extent that it shows distrust for what is mutable, unforeseen and arbitrary, of everything which, in short, is irrational, as it is not inserted in the One/All necessitating, justifying, regulating. In the alternative between Athens and Jerusalem, between the Rationalism and the Bible, Šestov opts to assume a stance, in no uncertain terms, on the side Jerusalem, taking with him the Plotinus of the awakening andheading towards a greater reality capable of overturning the throne occupied for too long by reason. That Plotinus who at a certain point was obliged to say thatin this other dimension "the intellect before God represents a reckless, ungodly apostate" (VI.9.5). That Plotinus, who ultimately, in one of those most particularmoments, realized that he was predestined for something loftier with respect to the world of evil and death. (shrink)

Contemporary international migration is directly related to the construction of the nation-state. The variations in this migration are multiple, depending on the type of mobility, the territories and the characteristics of the people who practice it. One kind of migration that has been particularly important at the end of the twentieth century and so far in the twenty-first century is that of minors who migrate without being accompanied by their parents. The legal definitions, bureaucratic practices and rights of these minors-turned-migrants (...) vary across European states and in the international literature. This paper aims to analyse the terminology used colloquially in the media and academically to refer to this group of people. In the early days of the phenomenon, the acronym MENA (unaccompanied migrant minors) has been the most common in Spain. It was intended to be a “neutral” term used in the legal sphere and migration studies. Still, in recent times, MENA has become more than a descriptive category. It has become a way of criminalising a group of young people who are in national territory and come from another country (usually an African country and, especially, a Maghreb country). However, not everything is determined by the circumstances surrounding us or our lives as social beings. Social pressure, with its narrative, cannot mean leaving aside history, legal culture, and learning. We need a new language to talk about this group of people. Currently, the negative connotation hides the most human aspect of this condition; the term “MENA” is a banner to mystify a fundamental fact: we are talking about children and adolescents who, not being able to count on the protection of an adult or family member, are condemned to social exclusion. This article approaches the migrant child as a critical figure who embodies the paradox of humanitarian reasoning, which is also a legal and political paradox, encapsulating the tension between structural rejection and the individual capacity of the human subject. By focusing on the theoretically productive role of minors without parental guardianship as subjects of ethnographic examination, this paper aims to understand better how current anthropological knowledge redefines the concepts of childhood, adulthood, and migration. The first part of this paper focuses on examining the terminologies used at the European and international levels, with their respective social implications. The second part focuses on the Spanish case, with the different impacts the term produces at the local level. The third and final part focuses on the terminology of refugee children and opens the discussion on scapegoating in Spain. (shrink)