Adult stem cell populations must coordinate their own maintenance with the generation of differentiated cell types to sustain organ physiology, in a spatially controlled manner and over long periods. Quantitative analyses of clonal dynamics have revealed that, in epithelia, homeostasis is achieved at the population rather than at the single stem cell level, suggesting that feedback mechanisms coordinate stem cell maintenance and progeny generation. In the central nervous system, however, little is known of the possible community processes underlying neural stem (...) cell maintenance. Recent work, in part based on intravital imaging made possible in the adult zebrafish, conclusively highlights that homeostasis in neural stem cell pools may rely on population asymmetry and long‐term spatiotemporal coordination of neural stem cell states and fates. These results suggest that neural stem cell assemblies in the vertebrate brain behave as self‐organized systems, such that the stem cells themselves generate their own intrinsic niche. (shrink)

Our discussion of the commentaries begins, at the evolutionary level, with issues raised by our account of the evolution of morality in terms of partner-choice mutualism. We then turn to the cognitive level and the characterization and workings of fairness. In a final section, we discuss the degree to which our fairness-based approach to morality extends to norms that are commonly considered moral even though they are distinct from fairness.

Pour yourself glass of Three Wizard's Chardonnay, Winkle's Old Peculiar, or Soggy Mountain Dew, pull up a three-legged chair, and for Om's sake, stay out of the bathtub! Keep and eye open for the octarine flashes that would indicate magic is trying to escape from the pages and be ready to grab something made of copper in order to ground uncontrolled magic without harmful incident (Some would Consider the Copper Safeguard Unnecessary) You are now ready to dive into Discworld and (...) Philosophy and join a group of philosophical Discworld fans as they explore truth, history, death, luck, morality, and reality in the magical inverse of the Disc. (shrink)

In order to describe the logic of morality, "contractualist" philosophers have studied how individuals behave when they choose to follow their moral intuitions. These individuals, contractualists note, often act as if they have bargained and thus reached an agreement with others about how to distribute the benefits and burdens of mutual cooperation. Using this observation, such philosophers argue that the purpose of morality is to maximize the benefits of human interaction. The resulting "contract" analogy is both insightful and puzzling. On (...) one hand, it captures the pattern of moral intuitions, thus answering questions about human cooperation: why do humans cooperate? Why should the distribution of benefits be proportionate to each person's contribution? Why should the punishment be proportionate to the crime? Why should the rights be proportionate to the duties? On the other hand, the analogy provides a mere as-if explanation for human cooperation, saying that cooperation is "as if" people have passed a contract-but since they didn't, why should it be so? To evolutionary thinkers, the puzzle of the missing contract is immediately reminiscent of the puzzle of the missing "designer" of life-forms, a puzzle that Darwin's theory of natural selection essentially resolved. Evolutionary and contractualist theory originally intersected at the work of philosophers John Rawls and David Gauthier, who argued that moral judgments are based on a sense of fairness that has been naturally selected. In this book, Nicolas Baumard further explores the theory that morality was originally an adaptation to the biological market of cooperation, an arena in which individuals competed to be selected for cooperative interactions. In this environment, Baumard suggests, the best strategy was to treat others with impartiality and to share the costs and benefits of cooperation in a fair way, so that those who offered less than others were left out of cooperation while those who offered more were exploited by their partners. It is with this evolutionary approach that Baumard ultimately accounts for the specific structure of human morality. (shrink)

The contemporary discussion of modesty has focused on whether or not modest people are accurate about their own good qualities. This essay argues that this way of framing the debate is unhelpful and offers examples to show that neither ignorance nor accuracy about the good qualities related to oneself is necessary for modesty. It then offers an attention-based account, claiming that what is necessary for modesty is to direct one’s attention in certain ways. By analyzing modesty in this way, we (...) can best explain the distinct features of modesty, keep much of what is intuitive in contemporary accounts, and better understand why modesty is a virtue at all. (shrink)

Whether on the theoretical level or by analyzing specific cases, this collection examines the different ways of experiencing and dealing with precarity. Its goal is to elucidate the uses of rhetoric so as to grasp to what extent the "minus" may (sometimes) represent a "plus".

A scholarly edition of Nicolas Malebranche's Treatise on Nature and Grace by Patrick Riley. The edition presents an authoritative text, together with an introduction, commentary notes, and scholarly apparatus.

The picture of moral development defended by followers of Aristotle takes moral cultivation to be like playing a harp; one gets to be good by actually spending time playing a real instrument. On this view, we cultivate a virtue by doing the actions associated with that virtue. I argue that this picture is inadequate and must be supplemented by imaginative techniques. One can, and sometimes must, cultivate virtue without actually performing the associated actions. Drawing on strands in Buddhist philosophy, I (...) explain several methods of moral development that rely on imagination and visualization rather than overt action. These techniques are essential in cases where cultivating virtue the way one practices the harp is impossible. In particular, I focus on single-event virtues, first-time virtuous acts, and morally dangerous situations. (shrink)

How might a human communication system be bootstrapped in the absence of conventional language? We argue that motivated signs play an important role (i.e., signs that are linked to meaning by structural resemblance or by natural association). An experimental study is then reported in which participants try to communicate a range of pre-specified items to a partner using repeated non-linguistic vocalization, repeated gesture, or repeated non-linguistic vocalization plus gesture (but without using their existing language system). Gesture proved more effective (measured (...) by communication success) and more efficient (measured by the time taken to communicate) than non-linguistic vocalization across a range of item categories (emotion, object, and action). Combining gesture and vocalization did not improve performance beyond gesture alone. We experimentally demonstrate that gesture is a more effective means of bootstrapping a human communication system. We argue that gesture outperforms non-linguistic vocalization because it lends itself more naturally to the production of motivated signs. (shrink)

This paper compares two explanations of the process by which human communication systems evolve: iterated learning and social collaboration. It then reports an experiment testing the social collaboration account. Participants engaged in a graphical communication task either as a member of a community, where they interacted with seven different partners drawn from the same pool, or as a member of an isolated pair, where they interacted with the same partner across the same number of games. Participants’ horizontal, pair‐wise interactions led (...) “bottom up” to the creation of an effective and efficient shared sign system in the community condition. Furthermore, the community‐evolved sign systems were as effective and efficient as the local sign systems developed by isolated pairs. Finally, and as predicted by a social collaboration account, and not by an iterated learning account, interaction was critical to the creation of shared sign systems, with different isolated pairs establishing different local sign systems and different communities establishing different global sign systems. (shrink)

We provide a translation of Binet and Henri’s pioneering 1894 paper on the influence of suggestibility on memory. Alfred Binet is famous as the author who created the IQ test that bears his name, but he is almost unknown as the psychological investigator who generated numerous original experiments and fascinating results in the study of memory. His experiments published in 1894 manipulated suggestibility in several ways to determine effects on remembering. Three particular modes of suggestion were employed to induce false (...) recognitions: indirect suggestion by a preconceived idea; direct suggestion; and collective suggestion. In the commentary we suggest that Binet and Henri’s paper written over 115 years ago is still highly relevant even today. In particular, Binet’s legacy lives on in modern research on misinformation effects in memory, in studies of conformity, and in experiments on the social contagion of memory. (shrink)

_ _ Nick Bostrom popularizó y difundió las intuiciones básicas del movimiento transhumanista desde una perspectiva filosófica. Sin embargo, hoy en día sus ideas pueden considerarse auto contradictorias respecto a su pretensión de superar al humanismo. De hecho, se podría marcar el pensamiento de Bostrom como de ultrahumanista e incluso de materialista ingenuo (Gabriel 2018, 2019). No obstante, admitiendo que la filosofía progresa en cuanto disciplina, es posible identificar pensadores transhumanistas de segunda generación, es decir, pensadores transhumanistas capaces de comprender (...) los límites y presupuestos de las intuiciones presentadas por Bostrom. Consideraremos la actividad filosófica de James Hughes y Stefan L. Sorgner como un transhumanismo de segunda generación en tanto que sus propuestas de transhumanismo son coherentes respecto de sus propios presupuestos. El caso de Hughes refleja la posibilidad de un transhumanismo democrático y consistente con las exigencias morales de nuestros tiempos, mientras que el caso de Sorgner es una invitación a edificar un transhumanismo desde presupuestos no humanistas, a saber, desde la filosofía dinámica de Nietzsche. De este modo, el transhumanismo de segunda generación sería el producto de una reflexión respecto a la coherencia de las propias condiciones de posibilidad del transhumanismo. Palabras clave: Bostrom - Materialismo ingenuo - Filosofía Dinámica - Transhumanismo democrático - Filosofía del transhumanismo. (shrink)

The claim that the observation of a violation of a Bell inequality leads to an alleged alternative between nonlocality and non-realism is annoying because of the vagueness of the second term.

Las reflexiones que conforman el presente artículo intentan brindar un aporte a la cuestión de la naturaleza y de la problemática medioambiental desde el punto de vista de lo que denominaremos una filosofía del suelo. Se emprenderá dicha tarea a través de los planteos de una serie de autores y autoras pertenecientes a la contemporaneidad filosófica, que se han preocupado, en distinta medida y de modos muy diferentes, por la problemática de la tierra o el suelo: Donna Haraway, Tim Ingold (...) y Bruno Latour. Para esto, nos serviremos de una serie de elementos que extraeremos de la experiencia visual y táctil de las Líneas de Nazca, legado de nuestro pasado amerindio en el desierto peruano. El trabajo se dividirá en tres partes, dedicada cada una de ellas a explicitar ciertas reflexiones de los autores que puedan asociarse a una filosofía como la que pretendemos mentar. El enfoque priorizará los entrelazos entre los mismos y el desarrollo de elementos que nos permitan un entrecruzamiento de sus respectivas teorías. (shrink)

(in press, under contract with MIT Press, accepted on June 30th, 2006). Attention, Information and Epistemic Perception. In Terzis, G. & Arp, R. (Eds) Information and the Living Systems: Essays in the Philosophy of Biology. The MIT Press. (14,000 words).

Interest in the computational aspects of modeling has been steadily growing in philosophy of science. This paper aims to advance the discussion by articulating the way in which modeling and computational errors are related and by explaining the significance of error management strategies for the rational reconstruction of scientific practice. To this end, we first characterize the role and nature of modeling error in relation to a recipe for model construction known as Euler’s recipe. We then describe a general model (...) that allows us to assess the quality of numerical solutions in terms of measures of computational errors that are completely interpretable in terms of modeling error. Finally, we emphasize that this type of error analysis involves forms of perturbation analysis that go beyond the basic model-theoretical and statistical/probabilistic tools typically used to characterize the scientific method; this demands that we revise and complement our reconstructive toolbox in a way that can affect our normative image of science. (shrink)

Dieu, le temps, la liberte: trois manieres de poser le probleme des rapports du fini et de l'infini. Comment un etre fini peut-il etre tellement hante par l'idee de l'infini, qu'elle soit la plus originaire et l'horizon de toutes ses pensees? Si Dieu a tout cree sans ordre ni raison, l'infinite de sa puissance n'est-elle pas son unique perfection? Comment une creature finie peut-elle desirer acquerir les perfections infinies qu'elle concoit en Dieu sans s'assigner ainsi une tache infinie? Pour deduire (...) l'infinite des verites creees du petit nombre d'idees et d'axiomes qui sont innes a son entendement, ne lui faudrait-il pas un temps infini? Mais, faute d'en disposer jamais, peut-elle s'eprouver assignee a une tache infinie sans eprouver ce mauvais infini comme l'echec d'un perpetuel inachevement? En confrontant les analyses de Descartes a celles de Malebranche et de Leibniz, c'est a ces problemes que les six etudes ici reunies tentent d'apporter quelque lumiere. (shrink)

Written seven years after publication of his Search after Truth, Malebranche's Treatise on Ethics develops a detailed, experimental science of ethics in two parts - the ethics of virtue and the ethics of duty.

In Study 1, we examined the moderating impact of alexithymia (i.e., a difficulty identifying and describing feelings to other people and an externally oriented cognitive style) on the automatic processing of affective information. The affective priming paradigm was used, and lower priming effects for high alexithymia scorers were observed when congruent (incongruent) pairs involving nonverbal primes (angry face) and verbal target were presented. The results held after controlling for participants' negative affectivity. The same effects were replicated in Studies 2 and (...) 3, with trait anxiety and depression entered as additional covariates. In Study 3, no moderating impact of alexithymia was found for verbal-facial pairs suggesting that the results cannot be merely explained in terms of transcoding limitations for high alexithymia scorers. Overall, the present results suggest that alexithymia could be related to a difficulty in processing and automatically using high arousal emotional information to respond to concomittant behavioural demands. (shrink)

Sometimes physicians lie to third-party payers in order to grant their patients treatment they would otherwise not receive. This strategy, commonly known as gaming the system, is generally condemned for three reasons. First, it may hurt the patient for the sake of whom gaming was intended. Second, it may hurt other patients. Third, it offends contractual and distributive justice. Hence, gaming is considered to be immoral behavior. This article is an attempt to show that, on the contrary, gaming may sometimes (...) be a physician's duty. Under specific circumstances, gaming may be necessary from the viewpoint of the internal morality of medicine. Moreover, the objections against gaming are examples of what we call the idealistic fallacy, that is, the fallacy of passing judgments in a nonideal world according to ideal standards. Hence, the objections are inconclusive. Gaming is sometimes justified, and may even be required in the name of beneficence. (shrink)

It is commonly assumed that moral deliberation requires that the alternatives available in a choice situation are evaluatively comparable. This comparability assumption is threatened by claims of incomparability, which is often established by means of the small improvement argument (SIA). In this paper I argue that SIA does not establish incomparability in a stricter sense. The reason is that it fails to distinguish incomparability from a kind of evaluative indeterminacy which may arise due to the vagueness of the evaluative comparatives (...) ‘better than,’ ‘worse than,’ and ‘equally as good as.’. (shrink)

High and low alexithymia scorers were confronted with a modified visual oddball task that allowed the study of categorical perception of emotional expressions on faces. Participants had to quickly detect a deviant (rare) morphed face that shared or did not share the same emotional expression as the frequent one. Expected categorical perception effects, which were also neurophysiologically indexed, showed that rare stimuli were detected faster if they depicted a different emotional expression compared to rare stimuli depicting the same emotional expression (...) than the frequent one. Even if no differences were observed at a behavioural level, high alexithymia scorers evidenced overall delayed neurophysiological responses in components related to the attentional processing of rare emotional faces. Moreover, the categorical perception effects for event-related components associated with the attentional processing were smaller in high alexithymia scorers and were even absent for anger. These results show that high alexithymia scorers present discrimination delays that are already observed at the attentional level. (shrink)

We present a new proof of soundness/completeness of tableaux with respect to dialogical games in Classical First-Order Logic. As far as we know it is the first thorough result for dialogical games where finiteness of plays is guaranteed by means of what we call repetition ranks.

In the past decade, experiments on altruistic punishment have played a central role in the study of the evolution of cooperation. By showing that people are ready to incur a cost to punish cheaters and that punishment help to stabilise cooperation, these experiments have greatly contributed to the rise of group selection theory. However, despite its experimental robustness, it is not clear whether altruistic punishment really exists. Here, I review the anthropological literature and show that hunter-gatherers rarely punish cheaters. Instead, (...) they avoid dealing with them and switch to other partners. I suggest that these data are better explained by individual selection, and in particular by partner choice models, in which individuals are in competition to be recruited by cooperative partners. I discuss two apparent problems for partner choice theories: large-scale cooperation and punishments in economic games. I suggest that rather than favouring group selection theory, these two phenomena provide evidence in favour of individual selection: (1) people produce large-scale cooperation through institutions in which punishment is not altruistic but rewarded on an individual basis; (2) punishment in experimental games can be explained without altruism and is indeed often better explained by individual interests. (shrink)

Recently, swimming-style colour synaesthesia was introduced as a new form of synaesthesia. A synaesthetic Stroop test was used to establish its genuineness. Since Stroop interference can occur for any type of overlearned association, in the present study we used a modified Stroop test and psychophysiological synaesthetic conditioning to further establish the genuineness of this form of synaesthesia. We compared the performance of a swimming-style colour synaesthete and a control who was trained on swimming-style colour associations. Our results showed that behavioural (...) aspects of swimming-style colour synaesthesia can be mimicked in a trained control. Importantly, however, our results showed a psychophysiological conditioning effect for the synaesthete only. We discuss the theoretical relevance of swimming-style colour synaesthesia according to different models of synaesthesia. We conclude that swimming-style colour synaesthesia is a genuine form of synaesthesia, can be mimicked behaviourally in non-synaesthetes, and is best explained by a re-entrant feedback model. (shrink)