Associations between cardiorespiratory fitness and brain health in healthy older adults have been reported using a variety of cardiorespiratory fitness estimates. Using commonly used methods to determine CRF, we assessed the relationship between CRFe and executive function performance. Healthy older adults, underwent three CRF tests: a Maximal Graded Exercise Test performed on a cycle ergometer, the Rockport Fitness Walking Test, and a Non-Exercise Prediction Equation. Executive function was assessed by a computerized cognitive assessment using an N-Back task and a Stroop (...) task. Multiple hierarchical regression analyses were conducted to assess the relationship between different CRFe and executive function performance. Regardless of age and education, cardiorespiratory fitness estimated from the Maximal Graded Exercise Test and the Rockport Fitness Walking Test was significantly associated with the global switch cost. All CRFe were associated with the interference cost. No association was observed between CRFe and local switching costs or the updating costs. In the present study, not all subcomponents of executive function were related to CRFe. Interestingly, the executive functions that were associated with CRFe are those that are known to be the most affected by aging. (shrink)

Adult stem cell populations must coordinate their own maintenance with the generation of differentiated cell types to sustain organ physiology, in a spatially controlled manner and over long periods. Quantitative analyses of clonal dynamics have revealed that, in epithelia, homeostasis is achieved at the population rather than at the single stem cell level, suggesting that feedback mechanisms coordinate stem cell maintenance and progeny generation. In the central nervous system, however, little is known of the possible community processes underlying neural stem (...) cell maintenance. Recent work, in part based on intravital imaging made possible in the adult zebrafish, conclusively highlights that homeostasis in neural stem cell pools may rely on population asymmetry and long‐term spatiotemporal coordination of neural stem cell states and fates. These results suggest that neural stem cell assemblies in the vertebrate brain behave as self‐organized systems, such that the stem cells themselves generate their own intrinsic niche. (shrink)

Whether on the theoretical level or by analyzing specific cases, this collection examines the different ways of experiencing and dealing with precarity. Its goal is to elucidate the uses of rhetoric so as to grasp to what extent the "minus" may (sometimes) represent a "plus".

Las reflexiones que conforman el presente artículo intentan brindar un aporte a la cuestión de la naturaleza y de la problemática medioambiental desde el punto de vista de lo que denominaremos una filosofía del suelo. Se emprenderá dicha tarea a través de los planteos de una serie de autores y autoras pertenecientes a la contemporaneidad filosófica, que se han preocupado, en distinta medida y de modos muy diferentes, por la problemática de la tierra o el suelo: Donna Haraway, Tim Ingold (...) y Bruno Latour. Para esto, nos serviremos de una serie de elementos que extraeremos de la experiencia visual y táctil de las Líneas de Nazca, legado de nuestro pasado amerindio en el desierto peruano. El trabajo se dividirá en tres partes, dedicada cada una de ellas a explicitar ciertas reflexiones de los autores que puedan asociarse a una filosofía como la que pretendemos mentar. El enfoque priorizará los entrelazos entre los mismos y el desarrollo de elementos que nos permitan un entrecruzamiento de sus respectivas teorías. (shrink)

_ _ Nick Bostrom popularizó y difundió las intuiciones básicas del movimiento transhumanista desde una perspectiva filosófica. Sin embargo, hoy en día sus ideas pueden considerarse auto contradictorias respecto a su pretensión de superar al humanismo. De hecho, se podría marcar el pensamiento de Bostrom como de ultrahumanista e incluso de materialista ingenuo (Gabriel 2018, 2019). No obstante, admitiendo que la filosofía progresa en cuanto disciplina, es posible identificar pensadores transhumanistas de segunda generación, es decir, pensadores transhumanistas capaces de comprender (...) los límites y presupuestos de las intuiciones presentadas por Bostrom. Consideraremos la actividad filosófica de James Hughes y Stefan L. Sorgner como un transhumanismo de segunda generación en tanto que sus propuestas de transhumanismo son coherentes respecto de sus propios presupuestos. El caso de Hughes refleja la posibilidad de un transhumanismo democrático y consistente con las exigencias morales de nuestros tiempos, mientras que el caso de Sorgner es una invitación a edificar un transhumanismo desde presupuestos no humanistas, a saber, desde la filosofía dinámica de Nietzsche. De este modo, el transhumanismo de segunda generación sería el producto de una reflexión respecto a la coherencia de las propias condiciones de posibilidad del transhumanismo. Palabras clave: Bostrom - Materialismo ingenuo - Filosofía Dinámica - Transhumanismo democrático - Filosofía del transhumanismo. (shrink)

In order to describe the logic of morality, "contractualist" philosophers have studied how individuals behave when they choose to follow their moral intuitions. These individuals, contractualists note, often act as if they have bargained and thus reached an agreement with others about how to distribute the benefits and burdens of mutual cooperation. Using this observation, such philosophers argue that the purpose of morality is to maximize the benefits of human interaction. The resulting "contract" analogy is both insightful and puzzling. On (...) one hand, it captures the pattern of moral intuitions, thus answering questions about human cooperation: why do humans cooperate? Why should the distribution of benefits be proportionate to each person's contribution? Why should the punishment be proportionate to the crime? Why should the rights be proportionate to the duties? On the other hand, the analogy provides a mere as-if explanation for human cooperation, saying that cooperation is "as if" people have passed a contract-but since they didn't, why should it be so? To evolutionary thinkers, the puzzle of the missing contract is immediately reminiscent of the puzzle of the missing "designer" of life-forms, a puzzle that Darwin's theory of natural selection essentially resolved. Evolutionary and contractualist theory originally intersected at the work of philosophers John Rawls and David Gauthier, who argued that moral judgments are based on a sense of fairness that has been naturally selected. In this book, Nicolas Baumard further explores the theory that morality was originally an adaptation to the biological market of cooperation, an arena in which individuals competed to be selected for cooperative interactions. In this environment, Baumard suggests, the best strategy was to treat others with impartiality and to share the costs and benefits of cooperation in a fair way, so that those who offered less than others were left out of cooperation while those who offered more were exploited by their partners. It is with this evolutionary approach that Baumard ultimately accounts for the specific structure of human morality. (shrink)

We provide a translation of Binet and Henri’s pioneering 1894 paper on the influence of suggestibility on memory. Alfred Binet is famous as the author who created the IQ test that bears his name, but he is almost unknown as the psychological investigator who generated numerous original experiments and fascinating results in the study of memory. His experiments published in 1894 manipulated suggestibility in several ways to determine effects on remembering. Three particular modes of suggestion were employed to induce false (...) recognitions: indirect suggestion by a preconceived idea; direct suggestion; and collective suggestion. In the commentary we suggest that Binet and Henri’s paper written over 115 years ago is still highly relevant even today. In particular, Binet’s legacy lives on in modern research on misinformation effects in memory, in studies of conformity, and in experiments on the social contagion of memory. (shrink)

A scholarly edition of Nicolas Malebranche's Treatise on Nature and Grace by Patrick Riley. The edition presents an authoritative text, together with an introduction, commentary notes, and scholarly apparatus.

The picture of moral development defended by followers of Aristotle takes moral cultivation to be like playing a harp; one gets to be good by actually spending time playing a real instrument. On this view, we cultivate a virtue by doing the actions associated with that virtue. I argue that this picture is inadequate and must be supplemented by imaginative techniques. One can, and sometimes must, cultivate virtue without actually performing the associated actions. Drawing on strands in Buddhist philosophy, I (...) explain several methods of moral development that rely on imagination and visualization rather than overt action. These techniques are essential in cases where cultivating virtue the way one practices the harp is impossible. In particular, I focus on single-event virtues, first-time virtuous acts, and morally dangerous situations. (shrink)

Many of us, even on our happiest days, struggle to quiet the constant buzz of anxiety in the background of our minds. All kinds of worries--worries about losing people and things, worries about how we seem to others--keep us from peace of mind. Distracted or misled by our preoccupations, misconceptions, and, most of all, our obsession with ourselves, we don't see the world clearly--we don't see the world as it really is. In our search for happiness and the good life, (...) this is the main problem. But luckily there is a solution, and on the path to understanding it, we can make use of the rich and varied teachings that have developed over centuries of Buddhist thought. With clarity and compassion, Nicolas Bommarito explores the central elements of centuries of Buddhist philosophy and practice, explaining how they can improve your life and teach you to live without fear. Mining important texts and lessons for practical guidance, he provides a friendly guide to the very practical goals that underpin Buddhist philosophy. After laying out the basic ideas, Bommarito walks readers through a wide range of techniques and practices we can adopt to mend ingrained habits. Rare for its exploration of both the philosophy that motivates Buddhism and its practical applications, this is a compassionate guide to leading a good life that anyone can follow. (shrink)

This article focuses on the following three novel and original philosophical approaches to classical liberalism: Den Uyl and Rasmussen’s perfectionist argument from meta-norms, Gaus’s justificatory model, and Kukathas’s conscience-based theory of authority. None of these three approaches are utilitarian or consequentialist in character. Neither do they appeal to the notion of a rational bargain as it is typical within contractarianism. Furthermore, each of these theory rejects the idea that classical liberalism should be grounded on considerations of interpersonal justice such as (...) those that are central to the Lockean tradition. It is argued that these three theories, despite their many attractive features, fail to articulate in a convincing manner some central classical liberal concerns. (shrink)

Written seven years after publication of his Search after Truth, Malebranche's Treatise on Ethics develops a detailed, experimental science of ethics in two parts - the ethics of virtue and the ethics of duty.

This article examines HIV-positive patients’ experiences of treatments within a context characterized by the multiplicity of opinions expressed both by specialists and the public domain. It is based upon a survey of 63 patients encountered in a Paris hospital. The authors demonstrate the contrasts between these patients in terms of two main dimensions: the degree of the patients’ proximity to specialist knowledge, and the level of homogeneousness that the patients attribute to medical know-how. At the point where these two dimensions (...) meet, the article distinguishes between three forms of patient attitude towards treatment; in other words, three ways of simultaneously positioning oneself with regard to the media, associations, doctors and family circles/entourage: resorting to exteriority; self-integration into biomedical institutions; arranging heterogeneous actors. It analyses the transformations relating to the main experience profiles highlighted by sociological studies of other pathologies. (shrink)

Se aborda la polémica entre Leibniz y Malebranche en torno a la relación entre las sustancias. Se plantean cuatro hipótesis para explicar esta interacción: la influencia física, la asistencia divina inmediata, la identidad y la armonía previa. Se explica la posición crítica de Leibniz respecto a las otras tres. En relación con la primera hipótesis Leibniz y Malebranche están de acuerdo en que no es viable. Se explican la crítica de Leibniz al ocasionalismo de Malebranche y al monismo sustancialista de (...) Spinoza. Y finalmente se analiza, desde la hipótesis de la armonía previa, el modo en que Leibniz aprovecha la disputa con el ocasionalismo, tanto en la versión de Malebranche como en la de Pierre Bayle, para reivindicar la autonomía de la razón en el ámbito de las causas segundas. En ello juegan un papel fundamental la noción de naturaleza de las cosas, el principio de diversidad y el principio de razón suficiente. (shrink)

¿Es posible que el arte progrese al mismo ritmo que la filosofía racional? ¿No existe algún tipo de incompatibilidad constitutiva entre ambos modos de interpretar la realidad, de manera tal que, siempre, la mayor precisión de la última implica una menor intensidad del primero? Tales preguntas constituyeron un vital eje de preocupación para los pensadores de la Ilustración francesa. En este artículo, nos concentramos en la respuesta que Denis Diderot intenta dar al dilema. Mostramos, en primer lugar, cómo el editor (...) de la Encyclopédie diferencia ambas áreas de la producción humana a la hora de trazar su historia: si bien es necesario destacar el progreso de la razón, lo es también el reconocer la decadencia de las artes como una de sus consecuencias. En segundo lugar, mostramos cómo, elaborado este diagnóstico, Diderot procura, a través de propuestas pictóricas, poetológicas y dramatúrgicas, salvar la potencia estética del arte para un siglo ilustrado. (shrink)

"Philosophe polémiste, souvent apostrophé par ses commentateurs, Zénon d'Elée fait l'objet depuis l'antiquité d'un " procès de parole " sans précédent dans l'histoire des idées : Cruel Zénon, Palamède d'Elée, Amphotéroglôsse... Invectives, louanges et blâmes prolifèrent autour de Zénon d'Elée, dessinant en creux la réception d'une pensée atypique, toujours fortement investie. C'est le récit de ce traitement singulier que, de surnom en surnom, ce livre entreprend de retracer.".

Le dispositif des groupes multifamiliaux favorise l’expression et l’élabora-tion des conflits psychiques chez chaque participant, notamment à partir d’une approche originale dite « de confrontation intergénérationnelle ». À travers le cas de trois adolescentes enclines aux actings et aux manifestations comportementales, les auteurs montrent comment ces groupes thérapeutiques conduisent non seulement à l’élaboration de conflits réels intersubjectifs entre les adolescents et leurs parents tels qu’ils se les présentent dans la réalité, mais aussi au renforcement de leur activité fantasmatique et in (...) fine au réaménagement des liens intergénérationnels. (shrink)