Genetic studies have revealed that the antagonistic interplay between PcG and TrxG/MLL complexes is essential for the proper maintenance of vertebrate Hox gene expression in time and space. Hox genes must be silenced in totipotent embryonic stem cells and, in contrast, rapidly activated during embryogenesis. Here we discuss some recently published articles1-4 that propose a novel mechanism for the induction of Hox gene transcription. These studies report a new family of histone demethylases that remove H3K27me3/me2 repressive marks at Hox promoters (...) during differentiation of stem cells. Though the overall importance of these enzymes for proper embryogenesis was demonstrated, their precise role in Hox gene epigenetic regulation during development still remains to be firmly established. BioEssays 30:199–202, 2008. © 2008 Wiley Periodicals, Inc. (shrink)

La tesis principal de este trabajo es que el principio con el que Kant comprende el origen de la cultura o de la historia humana en la tesis cuarta de I dea de una historia universal desde el punto de vista cosmopolita, la insociable sociabilidad, no implica “conceptualmente” el mal moral. Defiendo así, contra una larga tradición de lectura que sostiene lo contrario, que la cultura es producto de dos disposiciones diferentes de la especie humana que son originarias e independientes (...) de su carácter moral y, por lo tanto, también son independientes de su propensión inmoral. Esto significa, específicamente, que si hubiera unos seres racionales que fueran como nosotros, sociables e insociables, pero que no tuvieran noticia, a diferencia de nosotros, de la ley moral, esto es, que fueran moralmente inocentes, producirían, sin embargo, cultura. Como tesis secundarias muestro que se pueden establecer otras relaciones de implicación entre los conceptos de insociable sociabilidad y mal moral: por un lado, inversamente, el mal moral puede implicar “conceptualmente” la insociable sociabilidad; por otro lado, este último principio implica “contingentemente” el mal moral cuando es referido a la especie humana. (shrink)

The aim of this research is to find a relationship between organizational commitment and Organizational Citizenship Behavior (OCB) on Call Centre employee. Organizational commitment is degree which is the employee identify and internalize the organizational values, which makes the employee wants to stay in organization. OCB is employee’s voluntary behavior, beyond job’s description, and contribute toward organizational efectivity. This research is using Spearman-rank order coefficients of correlations formula. The finding reveals that there is a relationship between organizational commitment and OCB (...) r s (86) = 0,441, p < 0,01. This finding shows that there is positive and significant relationship between organizational commitment and OCB.  . (shrink)

We consider application of the structural approximation method to research information flow in social networks. The notations of potential, interparticle flux and energy are considered in terms of social networks. The basic notations of society functioning related to the communication and information transfer processes are modeled by means of multidimensional potentials and the corresponding interactions arisen in networks. A graph associated to the network is considered in the high dimensional space R^d when d is comparable with the number of vertices (...) in graphs. (shrink)

The present article aims to explore the complex relation between global and European Pentecostalism and politics. The self-evident scarcity of studies on this particular topic, despite the global prominence and the dynamic growth of Pentecostalism, and the tendency to collapse strikingly opposing tendencies under a generic terminology call for a serious examination of the approaches Pentecostalism adopts in relation to political involvement. Throughout the three main sections of this paper, political, historical, cultural and theological concepts will be employed in order (...) to: firstly, provide a qualitative and quantitative overview of global Pentecostalism; secondly, explore worldwide different political preferences of Pentecostal churches and denominations that range from apolitism, to full-fledged political involvement, or to the preference for an alternative polis; thirdly, to analyse European Pentecostalism and the particularities of its relation with politics. (shrink)

In this article, we address the case of self-tracking as a practice in which two meaningful backgrounds (physical world and technological infrastructure) play an important role as the spatial dimension of human practices. Using a (post)phenomenological approach, we show how quantification multiplies backgrounds, while at the same time generating data about the user. As a result, we can no longer speak of a unified background of human activity, but of multiple dimensions of this background, which, additionally, is perceived as having (...) no pivotal role in the process, often being hidden, situated beyond human consciousness, or taken for granted. Consequently, the phenomenological experience of the background turns into a hermeneutic practice focused on the interpretation of representations and descriptions. By adopting a (post)phenomenological approach, we show the problems and limitations of quantification of human activities occurring in self-tracking and the theoretical problems associated with the scheme of human-technology relations. (shrink)

Natalia Carrillo and Tarja Knuuttila claim that there are two traditions of thinking about idealization offering almost opposite views on their functioning and epistemic status. While one tradition views idealizations as epistemic deficiencies, the other one highlights the epistemic benefits of idealization. Both of them treat idealizations as deliberate misrepresentations, however. They then argue for an artifactual account of idealization, comparing it to the traditional accounts of idealization, and exemplifying it through the Hodgkin and Huxley model of the nerve (...) impulse. From the artifactual perspective, the epistemic benefits and deficiencies introduced by idealization frequently come in a package due to the way idealization draws together different resources in model construction. Accordingly, idealization tends to be holistic in that it is not often easily attributable to some specific parts of the model. They conclude that the artifactual approach offers a unifying view into idealization in that it is able to recover several basic philosophical insights motivating both the deficiency and epistemic benefit accounts, while being simultaneously detached from the idea of distortion by misrepresentation. (shrink)

Is it possible to explicate tolerant principles in the philosophy-political discourse of Kant? It seems the answer to this question is positive. And it is the philosophical project of Kant “Perpetual Peace”, which is the most representative in this respect, for it is based on the principles of tolerance. This project is included in ethic-legal (liberal) system and is connected with such notions as civil society, legal state, duty, moral law. Tolerance exists, on the one hand, as a result of (...) moral effort and choice, and on the other, as legal obligation. In Kantian conception tolerance appears as a multi-aspect phenomenon: firstly, as a natural deposit of the human race, developing as a result of the influence of antagonistic nature of the human society; secondly, as a demand of the moral law; thirdly, as a means of peace attaining; fourthly, as a principle of peaceful state, a universal civic alliance and eternal peace. The dynamic development of the world society, the acceleration of processes of globalization and intercultural communication dictate new strategies of the world development, make the problem of political responsibility the topic of today. According to Kant’s logic, it is necessary to be tolerant in the modern world. (shrink)

El artículo ilumina los modos rivales de articular el modernismo estético y socialismo propuestos hacia fines del siglo XIX por Rubén Darío, Leopoldo Lugones y Manuel Ugarte. Tomando como hilo conductor las disímiles acepciones del término “burgués” por las que parecen haber optado estos escritores, reconstruimos el deslindamiento que intenta Darío entre las dos tendencias modernizadoras, luego analizamos la conexión entre modernismo y socialismo revolucionario que realiza Lugones en el periódico La Montaña (1897), para finalmente explorar los cuestionamientos del joven (...) Ugarte al “esteticismo descomprometido” de Darío y al “socialismo aristocratizante” de Lugones, así como su alianza con el “socialismo pedagógico” de Juan B. Justo. The article focuses on the rival ways of linking aesthetic modernism and socialism that were proposed by Rubén Darío, Leopoldo Lugones and Manuel Ugarte at the end of the 19th century. Taking as a thread the dissimilar meanings of the term “bourgeois”, we rebuild the intent of Darío to mark the boundaries of the two modernizing tendencies; then we analyze the connection between modernism and revolutionary socialism that Lugones proposes in the newspaper La Montaña (1897); finally we explore Ugarte’s arguments with Darío’s “uncompromising aestheticism” and Lugones’ “aristocratizing socialism”, as well as the alliance of Ugarte with the “pedagogical socialism” of Juan B. Justo. (shrink)

En este trabajo ofrecemos la traducción del latín al castellano del Prólogo al Liber disputationum contra Symonem iudeum de Pedro de Cornwall, única sección del texto que se encuentra actualmente editada gracias a la labor de Richard W. Hunt. A ella se le suma, a modo de anexo, el breve intercambio final entre los personajes de Pedro y Simón que Hunt transcribió en la introducción a dicha edición. Ambas traducciones están precedidas por la presentación del autor y de la obra (...) en su conjunto, y de un breve estudio crítico del texto tanto en sí mismo como en relación con su contexto de producción: los diálogos literarios de disputas interreligiosas que florecieron entre finales del siglo XI y principios del XIII. (shrink)

In my paper, I propose a certain classification of evaluative expressions. I hypothesize that the basic criterion to distinguish between evaluative and descriptive terms is the faultless disagreement test. Next, I discuss a few kinds of phenomena which seem to render this distinction dubious: context–sensitivity, vagueness and using descriptive terms to express evaluative judgments. Further, I investigate Ch. Kennedy’s proposal according to which gradable adjectives can express two kinds of subjectivity. I modify this account by postulating another sub-class of subjective (...) adjectives which are not subjective due to vagueness and which are not evaluative either as they do not necessarily encode any valence. I propose a linguistic test to identify these expressions. Finally, I check where my classification of adjectives places the predicate of personal taste “tasty”. I suggest that “tasty” is both evaluative and experiential and additionally, it carries a condition of its own use, that is the information that can be used to positively assess the taste of something. This, I argue, makes it similar to thin evaluative terms as it carries no descriptive component at all. (shrink)

У статті проаналізовано стан санаторно-курортної діяльності України. Відзначається, що в останні роки в санаторно-курортній сфері переважає скорочення кількості установ, які спеціалізуються на оздоровленні населення, зниження якості та номенклатури надаваних послуг, кількість оздоровлених людей. Підкреслюється, що у 2014 році Україна втратила значну частину курортного потенціалу в результаті анексії Криму і військових дій на сході країни. Як подальший напрямок розвитку запропоновано реформувати галузь з метою вдосконалення лікувальної та діагностичної баз на основі останніх розробок в області медицини й курортології, розвитку інфраструктури, підвищення якості (...) та номенклатури надаваних послуг, підвищення ефективності та результативності роботи здравниць. (shrink)

У статті висвітлено теоретичну сутність підходів та нових концепцій управління розвитком промислового підприємства, які сьогодні є найбільш затребуваними в практиці господарської діяльності підприємств - TQM, реінжинірингу, ощадливого менеджменту, аутсорсингу, бенчмаркінгу, контролінгу, концепції організації, що навчається тощо. Визначено основні інструменти та механізми їх застосування.

У статті визначено економічний зміст механізму стимулювання соціальної відповідальності підприємства, розроблена концепція його вдосконалення. Сформульовано мету й завдання запропонованого механізму, обґрунтовано принципи його формування. Розроблено інструменти механізму стимулювання соціальної відповідальності підприємства і критерії оцінки його ефективності. Визначено напрями реалізації механізму стимулювання соціальної відповідальності підприємств.

Іn the article the shortcomings of current legislation in corporate governance and shareholder rights are analysed and identificated and possible mechanisms for the protection of shareholder rights and corporate investors are introduced.

The paper deals with the problem of the social construction of the Self in socio-phenomenological perspective. I am trying to explore the idea, that the shortcomings of the so-called classical Self-models can be clearly explicit in the light of socio-phenomenological approach. Heuristic power of transcendentally phenomenological conception of the Ego and Alter Ego is examined as well as its further development in the framework of phenomenological tradition in the social sciences. Turning to postmodern tradition in the social thinking, I am (...) trying to argue, that significance of phenomenological approach to the problem of the social construction of the Self consists in the fact, that it mediates “classic” Self-theories in European social thinking and further developed radical forms of cognitive constructivism which paves the way to postmodern deconstruction. (shrink)

Unlike other Post-Communist countries, Romania displays three clear individual-level trends related to political and religious institutions. The Romanians are the most supportive for the EU and Church, and the most critical towards national political institutions in the region. By conducting an empirical longitudinal study on the Romanian population, we aim to understand the linkages between these two trends and to identify what can explain the high level of trust vested by the Romanian citizens in the Orthodox Church in the post-Communist (...) period. In doing so, we test two alternative explanations and we employ bivariate and multivariate statistics. The results indicate that there is weak evidence for the relationship between trust in political and religious institutions, with a stronger emphasis on the EU aspect. Whenever the attitudes are linked, they are consistent: positive attitudes towards the national government and Parliament trigger positive attitudes towards the Church. (shrink)

In this paper we aim to think systematically about, formulate, and begin addressing some of the challenges to applying theories of moral responsibility to behaviors shaped by a particular subset of unsettling psychological complexities: namely, implicit biases.

As is well know, one of the most impressive mentalities of the Middle Ages was that of scholastic thought. The scholastic, in its true sense, must be understood as a particular type of didactics used to understand the Holy Scriptures and doctrines of the faith. Nevertheless it was specifically the modus operandi of the masters of the medieval universities. It reached its zenith in the 13th century thanks, fundamentally, to two simultaneous phenomena: the return to the West of Aristotle’s works (...) and the creation of the University. However, this forma mentis had already begun to develop in the works of several previous thinkers, perhaps the most significant of which being Sic et Non, by Peter Abelard. Without claiming to be exhaustive, this article will focus on the methodological principles that Abelard introduces in the prologue of his work. This will then allow us to compare the substance of the rupture with, and renovation of, previous thinking as well as to emphasise the contributions that so intimately link it to the first scholastic. (shrink)

Bertrand Russell’s Critique of the Arguments for the Existence of God The paper presents Bertrand Russell’s critique of arguments for the existence of God. I divided the theistic arguments which Russell criticizes into three groups. The first group involves arguments concerning the relation between Universe and God: the First Cause argument, the Natural law argument and the argument from Design. The second group is related to the concept of God as a moral Lawmaker and it contains the argument from morality (...) and the argument from remedy for injustice. The last group of arguments pertains to the relation between God and human beings. Here, I consider Russell's reflections on the validity of the argument from religious experience and his approach to the issue of the foundation of religion. The aim of this article is to consider whether Russellian argumentation against evidence for God's existence is justified. Keywords: Bertrand Russell, existence of God, argument, philosophy of religion, evidence. (shrink)

Different proprietary databases have been used extensively in research to assess the environmental performance and environmental risk of companies. This study explores the convergent validity of the environmental ratings of MSCI ESG STATS, Thomson Reuters ASSET4 and Global Engagement Services. The study shows that the ratings have common dimensions, but on aggregate, they do not converge. On the environmental opportunity side, KLD environmental strengths, and ASSET4 and GES environmental performance metrics correlate highly and provide convergent scores for US companies from (...) 2003–2011. On the environmental risk side, KLD environmental concerns converge with the GES environmental industry risk and company emissions from the ASSET4 database. Further analysis confirms that industry-related risks are drivers of company-specific environmental performance. (shrink)

Russian philosophy has always lived on translations. Difficulties in the process of creating a conceptual language used to be overcome gradually, one by one. Now, in the post-Soviet period after all of the locks had been opened, the accelerated development of Russian culture often causes us to assimilate deconstructivism before constructivism and some newer versions of phenomenology before Husserl. It brings about a cultural paradox which cannot be solved by habitual philosophical means. My point here is that Russian philology is (...) able to contribute toward finding a way out. The paper aims to justify this idea. (shrink)

Nursing is at the same time a vocation, a profession and a job. By nature, nursing is a moral endeavor, and being a ‘good nurse’ is an issue and an aspiration for professionals. The aim of our qualitative research project carried out with 18 nurse teachers at a university nursing school in Brazil was to identify the ethical image of nursing. In semistructured interviews the participants were asked to choose one of several pictures, to justify their choice and explain what (...) they meant by an ethical nurse. Five different perspectives were revealed: good nurses fulfill their duties correctly; they are proactive patient advocates; they are prepared and available to welcome others as persons; they are talented, competent, and carry out professional duties excellently; and they combine authority with power sharing in patient care. The results point to a transition phase from a historical introjection of religious values of obedience and service to a new sense of a secular, proactive, scientific and professional identity. (shrink)

Interview of Amina Kkhelufi, Kseniia Myroshnyk, Nataliia Reva with Natalia Viatkina.

The existence of embodied communication in humans places them among other living systems and helps to differentiate sign patterns that are common to all bioforms from those that are peculiarly human. Despite the fact that the biological roots of communication have been proven, the understanding of human forms of discourse is still far from being clarified. The main question remains: when and why did humans acquire the ability to exchange messages via speech? My thesis is that it became possible only (...) after humans made a shift from on-line to off-line interaction and learned to communicate in the interpersonal mode via externalized analog codes that constitute the various forms of human culture. (shrink)

It behooves us to examine , first, in the work of Rousseau the overlapping of their conception of nature and the foundations of social and political life : it is possible to mention the harmony between man and nature without considerations of politics? Then we examine some aspects of modern subjectivity – feeling of existence , moral conscience , the idea of ​​ happiness, pursuit of the indoor unit.