Biobanking activities for genetic research purposes have recently undergone nothing short of a small revolution. Many biobanks have left their traditional home of a small refrigerator in a laboratory to reach the unprecedented proportion of large, sophisticated storage centers containing DNA samples from whole populations. As we turn our attention to research on complex diseases and show great interest in human genetic variation and genetic epidemiology, we need to base our research not only on the DNA of small family cohorts, (...) but on larger sample collections, coupled with geographic location, genealogical information, and environmental and medical data. Population genetic research projects are underway around the world. Setting up such large-scale population biobanks is a challenge for any researcher. Population genetic research projects raise legal, ethical, and social issues that need to be addressed properly in order to maintain the trust of the population, an absolute requirement for the success of such research endeavour. (shrink)

Diversity is an undeniable fact of nature, and there is now evidence that nature did not stop generating diversity just before “designing” the human brain :15,468–15,473. https://doi.org/10.1073/pnas.1509654112, 2015). If neurodiversity is a fact of nature, what about neurodivergence? Although the terms “neurodiversity” and “neurodivergence” are sometimes used interchangeably, this is, we believe, a mistake: “neurodiversity” is a term of inclusion whereas “neurodivergence” is a term of exclusion. To make the difference clear, note that everyone can be said to be neurodiverse, (...) but that it is almost impossible for everyone to be neurodivergent. Neurodivergence is, we claim here, a fact of society. Neurodivergent individuals are those whose cognitive profile diverges from an established cognitive norm, a norm that is not an objective statistical fact of human neurological functioning but a standard established and maintained by socio-political processes. In this paper, we describe the socio-political mechanisms that build neurodivergence out of neurodiversity which, inspired by Mihai :395–416. https://doi.org/10.1057/s41296-017-0186-z, 2018), we call “epistemic and cognitive marginalization”. First, we extend the traditional concept of neurodiversity, which we believe too closely tied to a neuroreductionist conception of cognition, to that of “extended neurodiversity,” thereby viewing neurodiversity through the lens of 4E cognition. Considering that human cognition depends on epistemic resources, both for their construction and their online dynamic expression, we hypothesize that the differential access to epistemic resources in society, a form of epistemic injustice, is an overlooked mechanism that turns neurodiversity into neurodivergence. In doing so, we shed light on a type of epistemic injustice that might be missing from the epistemic injustice literature: cognitive injustices. (shrink)

I aim here to confront texts of Levinas and Sartre in an attempt to rethink the relation of the poIitical to the ethical in the early eighties in France. The method is essentially to try to think a passage from one domain into the other without privileging poIitics over ethics or vice versa while uncovering their organic and dialectical interaction, a subject that an only be touched upon via the bridging metaphor of a Visage that can liberate oneself from the (...) totalization of egoity. My purpose, thus, is not to confront Levinas and Sartre but to allow them to embark on a dialogue constructed around the paradigm of the question of the Other. (shrink)

How do René Girard’s theories apply to a context of double colonization? Through a new interpretation of Alexis Wright’s novel Plains of Promise, this paper aims to show the crosscultural relevance of mimetic theory. The study will highlight the way in which the scapegoat mechanism is represented in the Australian colonial context. It also offers a Girardian analysis of the predicament of female characters of Aboriginal descent who are victims of sexual violence.

This article reads with Michi Saagiig Nishnaabe writer and independent scholar Leanne Betasamosake Simpson, and Nêhiyaw legal scholar and novelist Tracey Lindberg. The practice of reading with involves heeding textual instructions and prioritising narrative terms of engagement. Indigenous bodies layered with resurgent potential in Lindberg’s and Simpson’s fictions refuse to re-centre the legacy of white settler coloniality. Attending to the process of reading with, as a relational undertaking, involves re-apprising cross-generational legacies and re-membering collective responsibilities.

This article aims at conceptualising the notion of embarrassment as a negativistic figure of thought that takes the experience of one’s own non-sovereignty as a starting point and emphasises an engagement with situations of not-knowing. This consideration is clarified in discussion with the figure of Socrates or with the philosophical attitude of Socrates. Because the negativistic thrust of the conceptualisation undertaken is reminiscent of irony, the paper then addresses the question of what distinguishes embarrassment understood as a figure of thought (...) from irony. For this purpose, Kierkegaard’s reading of Socratic irony is drawn upon. It is shown that irony is inherently a negativism, which in the last consequence aims at a retention of rights; but this is exactly what embarrassment avoids, because, as the article shows, it is not a negativism of strength, but of weakness. (shrink)

Autistic people continue to face considerable stigmatization. Much work remains to be done to identify and tackle the causes of this stigmatization. We identify two related assumptions that generate and perpetuate this stigmatization: one ontological; one epistemic. We argue that breaking the stigma around autism requires addressing these twin assumptions. The ontological assumption presupposes the pathologization of autism as a disorder. Addressing this first assumption requires taking neurodiversity seriously and moving away from neuronormativity. The epistemic assumption posits that “allistics-know-best” and (...) prevents allistics from acknowledging the epistemic limits of their own perspective. Addressing this second assumption requires centering Autistics’ perspectives and experiences in the production, dissemination, and use of knowledge about Autistics. To make our case against these two problematic assumptions, we draw on the key epistemological notions of standpoint, ignorance, and epistemic injustice—which have implications for all fields that concern minoritized groups and the contents produced about or with them. Fruitfully connecting our original pluralist conception of epistemic agency (which centers crucial experiential knowledge beyond mere propositional knowledge) to 4E cognition (embodied, embedded, extended, enacted), we identify a new category of epistemic injustice: ecological epistemic injustice. We then illustrate the importance of addressing the widespread yet problematic ontological and epistemic assumptions underlying the stigmatization of autism by turning to the case of applied behavioral analysis (ABA), which instantiates both neuronormativity and epistemic injustice. (shrink)

Cet article se propose de montrer que le langage en traduction joue un rôle performatif parce que les termes qu’il emploie retraduisent des normes sociales et des positions institutionnelles construites dans une autre culture, avec d’autres conditions historiques. Dans le cas de la naissance des sciences de la communication en Chine, des concepts américains sur la communication sont venus par leur traduction à la rencontre des normes et positions chinoises sur le journalisme et la propagande, engendrant une reconfiguration mutuelle des (...) actants, qu’ils soient sociaux ou langagiers. Nous étudions comment le système socio-culturel de la Chine a recréé un ordre local propre sous la forme d’une discipline spécifique à ce pays, xinwen chuanboxue .This article sets out to show that language in translation plays a performative role, because the terms it uses effectively retranslate social norms and institutional positions that were built up in a different culture and in different historical circumstances. In the case of the emerging communication sciences in China, American concepts on communication, which arrived in translation, came to encounter Chinese norms and positions on journalism and propaganda, and this caused a mutual reconfiguration of the actants, both social and linguistic. We look here at how the Chinese socio-cultural system re-created its own local order in the form of a discipline which is specific to the country, “xinwen chuanboxue”. (shrink)

Le but de la recherche est de construire une base de données fonctionnant sur les principes de l’informatique décisionnelle. L’objet de la communication est de décrire la hiérarchie des diverses dimensions de la base de données. Elle permettra d’observer la diversité des relations temporelles dans des textes enfantins. L’analyse s’appuie sur un corpus de 200 récits d’élèves de cycle 3 de l’école élémentaire française. La communication questionne : - le découpage séquentiel du texte - l’analyse interne des séquences - la (...) normalité des productions des élèves. (shrink)

This paper introduces a novel method to control the operation of the active suspension system. In this research, a quarter-dynamic model is used to simulate the vehicle’s vibrations. Besides, the sliding mode-PID-integrated algorithm with five state variables is proposed to be used. This is a completely original and novel algorithm. The process of establishing the control algorithm is clearly described. The simulation is performed by the MATLAB software. The results of the paper have shown the advantages of the sliding mode-PID (...) algorithm used in this research. Accordingly, the displacement and acceleration of the sprung mass were significantly reduced when this algorithm was used. The maximum and average values of the displacement of the sprung mass are only 1.31% and 1.29%, respectively, compared with the situation of the vehicle using a passive suspension. Similarly, the value of the acceleration is 6.98% and 2.94%, respectively. In addition, the phenomenon of “chattering” has also been significantly reduced when using this controller. In the future, some more complex algorithms can be proposed. (shrink)

Bien que les approches basées sur les déficits soient encore prédominantes en formation à l’enseignement, on reconnaît de plus en plus l’apport potentiel des approches basées sur les forces, afin de développer une identité professionnelle positive. Conséquemment, nous avons expérimenté une activité innovante d’écriture réflexive, basée sur la psychologie positive, auprès de 50 stagiaires en enseignement préscolaire/primaire au Québec. L’analyse de ces empreintes offre de dégager divers aspects constitutifs de l’identité professionnelle des stagiaires, de décrire l’évolution du processus de construction (...) identitaire, ce qui permet d’apprécier la contribution de ce type d’activité pour rendre ce processus plus explicite. (shrink)

Computational drug repositioning has been proven as a promising and efficient strategy for discovering new uses from existing drugs. To achieve this goal, a number of computational methods have been proposed, which are based on different data sources of drugs and diseases. These methods approach the problem using either machine learning- or network-based models with an assumption that similar drugs can be used for similar diseases to identify new indications of drugs. Therefore, similarities between drugs and between diseases are usually (...) used as inputs. In addition, known drug-disease associations are also needed for the methods as prior information. It should be noted that those associations are still not well established due to the fact that many of marketed drugs have been withdrawn and this could affect the outcome of the methods. In this study, we propose a novel method named RLSDR to find new uses of drugs. More specifically, it relies on a semi-supervised learning model, Regularized Least Square, thus it does not require definition of non-drug-disease associations as previously proposed machine learning-based methods. In addition, the similarity between drugs measured by chemical structures of drug compounds and the similarity between diseases which share phenotypes can be represented in a form of either similarity network or similarity matrix as inputs of the method. Moreover, instead of using a gold-standard set of known drug-disease associations, we construct an artificial set of the associations based on known disease-gene and drug-target associations. Experiment results demonstrate that RLSDR achieves better prediction performance on the artificial set of drug-disease associations than that on the gold-standard ones in terms of area under the Receiver Operating Characteristic curve. In addition, it outperforms two representative network-based methods irrespective of the prior information of drug-disease associations. Novel indications for a number of drugs are also identified and validated by evidences from a different data resource. (shrink)

In air traffic control, the airspace is divided into several smaller sectors for better management of air traffic and air traffic controller workload. Such sectors are usually managed by a team of two air traffic controllers: planning controller and executive controller. D-side controller is responsible for processing flight-plan information to plan and organize the flow of traffic entering the sector. R-side controller deals with ensuring safety of flights in their sector. A better understanding and predictability of D-side controller actions, for (...) a given traffic scenario, may help in automating some of its tasks and hence reduce workload. In this paper, we propose a learning model to predict D-side controller actions. The learning problem is modeled as a supervised learning problem, where the target variables are D-side controller actions and the explanatory variables are the aircraft 4D trajectory features. The model is trained on six months of ADS-B data over an en-route sector, and its generalization performance was assessed, using crossvalidation, on the same sector. Results indicate that the model for vertical maneuver actions provides highest prediction accuracy. Besides, the model for speed change and course change action provides predictability accuracy of 80% and 87%, respectively. The model to predict the set of all the actions for each flight achieves an accuracy of 70% implying for 70% of flights; D-side controller’s action can be predicted from trajectory information at sector entry position. In terms of operational validation, the proposed approach is envisioned as ATCO assisting tool, not an autonomous tool. Thus, there is always ATCO discretion element, and as more ATCO actions are collected, the models can be further trained for better accuracy. For future work, we will consider expanding the feature set by including parameters such as weather and wind. Moreover, human in the loop simulation will be performed to measure the effectiveness of the proposed approach. (shrink)

Philosophy in Vietnam is defined as a system of the most universal points of view on the world and the place of man in this world. Philosophy often plays a key role it plays in one’s worldview and methodology. The question is: on what problems should philosophy focus in order to successfully carry out its worldview andmethodological role in the present context? Firstly, if international philosophers are focusing their research on problems caused by globalization, Vietnamese philosophers should orient their research (...) on the practical problems raised by building and developing our country in the context of globalization and international economic integration. Secondly, one of the important tasks for Vietnamese philosophers is to research the philosophical thought of Vietnam. Thirdly, one of the no less important tasks for people engaging in research and teaching of philosophy in Vietnam is to investigate the trends and ideas of preeminent world philosophers, both in the East as well as in the West. (shrink)

The recent availability of multiple avian genomes has laid the foundation for a huge variety of comparative genomics analyses including scans for changes and signatures of selection that arose from adaptions to new ecological niches. Nocturnal adaptation in birds, unlike in mammals, is comparatively recent, a fact that makes birds good candidates for identifying early genetic changes that support adaptation to dim‐light environments. In this review, we give examples of comparative genomics analyses that could shed light on mechanisms of adaptation (...) to nocturnality. We present advantages and disadvantages of both “data‐driven” and “hypothesis‐driven” approaches that lead to the discovery of candidate genes and genetic changes promoting nocturnality. We anticipate that the accessibility of multiple genomes from the Genome 10K Project will allow a better understanding of evolutionary mechanisms and adaptation in general. -/- . (shrink)

This research investigates the factors influencing the disparity between domestic gold prices (SJC gold and 9999 gold) and global gold prices in Vietnam from January 2011 to December 2023. Using the Autoregressive Distributed Lag (ARDL) model, we identify key macroeconomic determinants impacting this price spread, including interest rates, oil prices, and consumer demand. Our findings reveal that higher interest rates are associated with larger price spreads, suggesting that monetary policy plays a significant role in the domestic gold market. Oil prices (...) exhibit a negative relationship with the price spread for 9999 gold, indicating that rising oil prices tend to align domestic gold prices more closely with global trends. Consumer demand notably affects the SJC_Global price spread but not the 9999_Global spread, reflecting the different market dynamics of finished goods versus raw materials. Additionally, the error correction terms in both models indicate a robust mechanism for long-term equilibrium, demonstrating the Vietnamese gold market’s resilience. These insights highlight the need for policymakers to reconsider existing regulations, such as Decree 24, to ensure a stable and efficient gold market. The study concludes that while the Vietnamese gold market exhibits sustainable practices, regulatory revisions are necessary to support both market growth and community development. Future research should consider additional macroeconomic variables and the impact of regulatory changes over time to further understand the dynamics of gold price disparities in Vietnam. (shrink)

Il s’agit d’approfondir la comparaison de l’ « activité d’immobilité » [Χν≅ργεια 3κινησBας] au repos en Éthique à Nic. VII 15, 1154 b 21-31, et en cela de montrer en quoi ils sont identiques et en quoi ils sont différents. Le point de départ est que Aristote vise avant tout l’activité du premier moteur et qu’il a conçu tout d’abord l’ « activité d’immobilité » pour expliquer la continuité éternelle du mouvement du ciel. Cela conduit naturellement à la Physique où (...) le premier moteur et le repos sont définis. Le passage le plus important est certainement VI 8, 239 a 23 - b 4 où les deux sont également traités. Mais c’est aussi un des passages les plus litigieux, car la lecture proposée dans cet article n’est pas celle qui est proposée généralement par les traducteurs et commentateurs qui ne rattachent pas ce passage à ce qui précède, mais le considère comme une préfiguration du chapitre 9 où se trouvent exposés les problèmes de Zénon. Une grande part de l’article est consacrée à l’analyse de leur lecture, afin de redonner à ce passage la position clé qu’il mérite comme un jalon sur le chemin qui conduit à poser l’éternelle immobilité du premier moteur à la fin de la Physique. Ce passage est crucial, car Aristote y distingue l’activité du premier moteur immobile du repos en l’affirmant « dans l’instant » comme il l’avait fait d’ailleurs en Éthique à Nic. X 3, 1174 b 9 en distinguant l’ « activité d’immobilité » du mouvement. L’une des thèses avancées dans cet article est que seule l’instantanéité permet à cette activité d’être principe d’éternité. (shrink)

Geht es um die Frage, welche Faktoren zur Akzeptanz und Verbreitung von Verschwörungserzählungen beitragen, so verweist die Forschungsliteratur zur Erklärung oft auf sehr allgemeine Bedürfnisse, die in der Regel als anthropologische Gegebenheiten aufgefasst werden, wie etwa das Bedürfnis nach Sinngebung und Orientierung. Der vorliegende Artikel weist auf die möglichen Probleme einer anthropologischen Verkürzung der Sachlage bei solchen Erklärungsansätzen hin und formuliert einen genealogischen Ansatz, der es erlaubt, jene Bedürfnisse, die den Verschwörungsglauben begünstigen, als Resultat eines historisch voraussetzungsreichen Subjektivierungsprozesses zu begreifen. (...) Zur Beschreibung jenes Prozesses werden in Auseinandersetzung mit Nietzsches Genealogie der Moral insbesondere die Motive des Ressentiments und der Schuld als Triebkräfte herangezogen, die insbesondere unter säkularen Bedingungen Projektionsweisen befördern, auf denen Verschwörungserzählungen beruhen. (shrink)

Ao dai is a typical long dress of Viet Nam used to be worn by both men and women of the Viet and other ethnic peoples. In her shaping and development history, Viet Nam became a place that converged various cultural flows such as the Vietnamese indigenous culture and that of the Chinese, Champa and Indian etc. To the end of the 19th century, especially the 20th, Viet Nam continued to be influenced by the French culture and the American ways (...) of living. The acceptance of cultures from various nationalities and communities from the North to South, East to West made it possible for the Vietnamese fashion designers to harmonize all into an Ao dai for the Vietnamese women. This article will synthesize and analyze three renovation movements of Ao dai in the 20th century. It also discusses about these processes and introduces typical innovators whose contribution has created the Ao dai as it is today, a traditional dress that represents history of the Vietnamese culture, aesthetic sense, art and vitality. (shrink)

This three-volume set—LNAI 13031, LNAI 13032, and LNAI 13033—constitutes the thoroughly refereed proceedings of the 18th Pacific Rim Conference on Artificial Intelligence (PRICAI 2021), held in Hanoi, Vietnam, in November 2021. The 93 full papers and 28 short papers presented in these volumes were carefully reviewed and selected from 382 submissions. -/- PRICAI covers a wide range of topics of social and economic importance for countries in the Pacific Rim, including artificial intelligence, machine learning, natural language processing, knowledge representation and (...) reasoning, planning and scheduling, computer vision, distributed artificial intelligence, and search methodologies. -/- Part I includes the following topical headings: AI Foundations / Decision Theory, Applications of AI, Data Mining and Knowledge Discovery, Evolutionary Computation / Optimization, and Knowledge Representation and Reasoning. -/- . (shrink)

Le De mundi caelestis terrestrisque constitutione liber, attribué à tort à Bède, est un texte curieux, qui, élaboré en milieu monastique au XIe ou XIIe siècle, présente peu de références scripturaires, mais renseigne sur la réception médiévale des textes scientifiques et philosophiques latins d'époque tardive.

Using a sample of US stocks over the period 1991–2019, we test whether stocks with high exposure to a social index exhibit high returns. Using a univariate analysis, our in‐sample results show that stocks with high sensitivities to the MSCI KLD 400 Social Index underperform stocks with low sensitivities by an annual risk‐adjusted performance of 7.02%. The negative premium is also larger in the post‐crisis period of 2007–2019 and is equal to 10.25%. The out‐of‐sample results offer, however, only weak evidence (...) of such a finding, with a risk‐adjusted performance difference of merely −0.84% over the full sample period and no significant differences between the pre‐crisis and post‐crisis periods. In the multivariate regression, we find evidence of a negative relationship between exposure to the social index and stock performance. Moreover, we find that stocks with high exposure to the social index display a low corporate social responsibility score, a high Tobin’s Q, high long‐term debt, a large size, high total risk, a high market beta, a high SMB coefficient, a low HML coefficient, and a small MOM coefficient. (shrink)