Male sexual arousal (SA) has been known as a multidimensional experience involving closely interrelated and coordinated neurobehavioral components that rely on widespread brain regions. Recent functional neuroimaging studies have shown relation between abnormal/altered dynamics in these circuits and male sexual dysfunction. However, alterations in the topological1 organization of structural brain networks in male sexual dysfunction are still unclear. Here, we used graph theory2 to investigate the topological properties of large-scale structural brain networks, which were constructed using inter-regional correlations of cortical (...) thickness between 78 cortical regions (subcortical regions were not included due to the used cortical surface model) in 40 patients with psychogenic erectile dysfunction (pED) and 39 normal controls. Compared with normal controls, pED patients exhibited a less optimal global topological organization with reduced global and increased local efficiencies. Our results suggest disrupted neural integration among distant brain regions in pED patients, consistent with previous reports of impaired white matter structure and abnormal functional integrity in pED. Additionally, disrupted global network topology in pED was observed to be primarily relevant to altered subnetwork and nodal properties within the networks mediating the cognitive, motivational and inhibitory processes of male SA, possibly indicating disrupted integration of these networks in the whole brain networks and might account for pED patients’ abnormal cognitive, motivational and inhibitory processes for male SA. In total, our findings provide evidence for disrupted integrity in large-scale brain networks underlying the neurobehavioral processes of male SA in pED and provide new insights into the understanding of the pathophysiological mechanisms of pED. (shrink)

Ben shu tong guo li shi shang de yi ge ge xiao gu shi lai shuo li,Rang du zhe kan dao le yi ge zhong min ai min,Shou min ai dai de yan zi,Yi ge qin zheng lian jie,Chi shen li jie de yan zi,Yi ge chong shang jie jian,Fan dui she hua de yan zi.

Background: Gender makes a difference in health and physical activity. This research aimed to identify the gender difference in the relationship of PA and subjective happiness among Chinese university students.Methods: A cross-sectional survey was conducted in Shanghai Jiao Tong University from July 7 to 17 in 2021, using an anonymous online self-report questionnaire. The questionnaire included the Chinese version of the International Physical Activity Questionnaire-Short Form, the Subjective Happiness Scale, the Depression Anxiety Stress Scale-21. The demographic and health-related factors were (...) also reported. Linear regression was carried out to identify the relationship of PA and subjective happiness.Findings: In total, 1,512 students from three comprehensive schools completed the survey. The SHS score was 17.20 ± 3.44, and it was 17.00 ± 3.23 in males, and 17.75 ± 3.93 in females, respectively. There was no gender difference in vigorous, moderate PA, or walk min/week, while female students had longer sedentary behavior hours/day than males. Male students scored higher in each subscale of DASS-21. After controlling for confounders, vigorous PA min/week and sedentary behavior hours/day were significantly positively associated with happiness in male students. In contrast, walk min/week was significantly positively associated with happiness in female students.Interpretation: This research demonstrated a significant gender difference in the association between PA and happiness. Policymakers and college management should pay more attention to PA programs to promote students’ happiness and mental health status. (shrink)

「法律系最讓人景仰的人格」「不上他的課會後悔一輩子」 開課三十年屹立不搖 人氣爆棚 學生零負評感動推薦 臺大法律系教授黃榮堅 暢談獨到的法學人生經驗 當法律淪為以口說形式取代心靈的真實感覺和冷靜的思考， 當公平正義的概念變成擴大對立的口號， 不懂得思考，別說你知道法律是什麼 全民共讀法律、建構獨立思維的必備書 法律對人在內心究竟選擇自己要做天使或做魔鬼，天生無能為力。 靈魂可能背叛法律，也可能超越法律， 在一樣的法律概念底下， 是人心中的善念或惡念決定了法律意義的質與量。 ——黃榮堅 ---------------------------------------------------------------------------------------------------- 今日社會裡的每個人或多或少都是一個法律人，一個好的法律人要知道人的一百種不一樣的快樂跟一百種不一樣的痛苦，這些快樂與痛苦就是法律學理上每一個原則背後的故事。 黃榮堅教授以數十年的研究經驗，敘述法律規範與自由之心的關係。書中先從法律觀點說明法律的基本作用、法律的理想與現實，以及認識法律的方法。接著跳脫法律說法，從帶著理想色彩的整體生命意會說出對法律及其現實文 化的思想與疑慮，並呈現法律在人一旦失去靈魂時可能陷入的困境。最後則提出，只有透過一顆具存在意義、能夠自由思考的人心，法律才可能呈現宜人風貌。 本書讓法律人重新認識自我的原始圖像，也讓非法律人探索規範世界的意義，除鋪陳作者幾十年來看待法律的心情轉折，亦帶有一種「遠離法律看法律」的意思。 ------------------------------------------------------------------------------------- ◎好的法學教師，讓人學會解題；優秀的法學教授，讓人渴望創造改變；頂級的法學者，讓人換一種角度看世界。黃榮堅教授，正是難得的頂級法學者之一。而這樣的法學者，願意寫一本通俗讀物，將是台灣公共討論深化的契機 。我至今記得，初學法律時，在台大舊法學院圖書部翻閱《刑罰的極限》一書序文，內心的感動與震撼。我相信本書不僅適合所有非法律人閱讀，更值得內心有所迷惘的法律人細細品味。 ——苗博雅，《阿苗帶風向》主持人 ◎本書談的是法律、法哲學等嚴肅命題，但為文如行雲流水，予人自然開朗，洗鍊通達的感覺。文中涉及較抽象的法律概念時，亦每能舉重若輕，就近取譬，不經意間穿插自己有趣的人生小體驗，或各國古今文哲著作小故事，讓 人在莞爾中豁然開朗。 ——高瑞錚，福田法律事務所負責人、福田文教基金會董事長 ◎不需要懂法律也看得懂的好書！ ——徐自強，司改會工作人員，徐自強案當事人 ◎大師出手的經典法普著作。作者以其敏銳觀察力與深邃的人文法律素養，用素樸卻富魔力的語言，配上令人或揪心或莞爾的案例，深入淺出，刺激你進行一次次的正義的思辨，認識「人生有多難，法律就有多難」的法律世界。 ——許宗力，國立臺灣大學法律系兼任教授 ◎這本書讀完之後，我一直問自己：如果我在開始當法官之前就讀過它，如果我早一點讀過它，這一條法官的路我會不會走得比較不坎坷一點？我會不會有更多的勇氣、更堅定的念頭去面對過往圈內的光怪陸離？我會不會早一點 開始進行實務圈不鼓勵的獨立思考？我能不能早一些擺脫年輕的銳氣和氣盛？會不會讓我冤枉被告的可能性低一點？ ——陳欽賢，台南地方法院法官 ◎艱深法律知識透過作者堅實學術素養轉譯為公眾可以理解的啟發性內容，是值得最高度推薦的法律知識普及性專書。 ——陳東升，台灣大學社會學系教授 ◎這本書好像是在談法律，其實是在說人生。 ——張娟芬，作家 ◎從人民的生活常識出發，帶領讀者進入法律與正義的思辨殿堂。 ——黃國昌，立法委員 出版社 商周出版 (城邦).

Ben shu nei rong bao kuo:zhong hua min zu dao de sheng huo zong lun,Yuan gu zhi zhan guo dao de sheng huo de ji ben zhuang kuang,Dao de guan xi ji wu zhong ji ben lun chang de que li,Li yi gui fan he li wen hua de xing qi yu hong yang,De hua tian xia yu dao de jiao yu zhi kai zhan deng.

Ben shu shi cai yuan pei xian sheng guan yu gong min dao de xiu yang fang mian de dai biao zuo, Zhu yao shou lu ta zui wei zhong yao de dao de si xiang dai biao zuo pinzhong xue xiu shen jiao ke shu hehua gong xue xiao jiang yi, Bing shou lu cai yuan pei qi ta you guan dao de xiu yang de ling san wen zhang, Chong fen ti xian le cai yuan pei (...) xian sheng dui yu xian dai zhong guo ren ying ju you de dao de su yang de zong ti gou xiang. (shrink)

Ben shu tong guo dui Kang Youwei zhi "qun" yu"du" guan nian de kao cha, lai ba wo Kang Youwei dui ge ren, guo jia nai zhi tian xia zhi xu de shen ke si kao. Zhu yao nei rong you: yi, Jin dai"qun-du" guan nian de chu xian ji qi zou xiang, er, Kang Youwei "qun-du" guan nian chan sheng de si xiang bei jing, san, "Du ren" yu Kang Youwei dui xian dai xing ge ti (...) sheng cun zhi ling hui, si, "Qun" yu guo jia wei xin, wu, "qun-du" guan lian yu chong tu: min quan yu guo jia guan nian zhi jian de zhang li, liu, Shi jie fan wei zhi "du" yu "qun" : guo jia yu "da tong"deng. (shrink)

Ben shu bi jiao yan jiu liang shu ming he hu kuo de wen hua qu xiang, zheng zhi qu xiang, xue shu zhi qu, zhong xi wen hua guan, ke xue yu min zhu guan dui chuan tong wen hua de tai du he dui zhong guo wen hua chu lu de xuan ze deng wen ti.

Chuan bo Zhuzi jia li, xuan jiang Tai zu sheng yu, shi Ming chao zai di fang tui xing de zui zhu yao de liang zhong she hui li jiao xing shi, xian shi chu li zhi shi zhong shi wang chao zheng zhi de yi ge he xin li nian he shou dao te bie qiang diao de she hui zhi li fang shi. Jia li shi wang chao zheng zhi wen hua de yi bu fen, Ming chao wei (...) le tui guang jia li, jian li qi duo qu dao, duo ceng ji de jia li chuan bo: ji you guan fang chang dao ye you min jian zi wei, ji you li shu, li tu deng wen ben xing shi, yi you shi ren shi fan, zhi dao deng fei wen ben xing shi. (shrink)

Ben shu wei "Song Ming shi qi Chang Jiang zhong you de ru xue yan jiu" cong shu zhi yi: ben cong shu shi ren wen she hui ke xue chong dian yan jiu ji di-Wuhan da xue Zhongguo chuan tong wen hua yan jiu zhong xin tou biao, jing jiao yu bu zu zhi zhuan jia ping shen tong guo, zheng shi pi zhun de jiao yu bu ren wen she hui ke xue 2001 nian du zhong da yan (...) jiu xiang mu, xiang mu pi zhun hao shi 01JAZJD720008, ding yu 2004 nian qian hou wan cheng. ke ti zu zhu chi ren wei Guo Qiyong jiao shou, "Jiangxi zhi xue"shi Zhu Xi ti chu de yi ge gai nian, zhu yao zhi chu zi yu Jiangxi Jinxi Lu shi jia zu yi men de xue shuo, qi nei he shi Lu Jiuyuan de xin xue; di 2 quan ze shi you "Song Yuan xue an" suo zai zhi Xiangshan xiong Zhangfu, Suoshan de xue shuo; di 3 quan wei Xiangshan xiong di de di zi men de si xiang. Ben shu quan mian kao cha Jiangxi zhi xue zai Song dai Chang Jiang zhong you xing qi de xue mo yuan yuan, zhu yao xue shuo, yu Luo xue Min xue Zhejiang zhu xue zhe (Lü Zuqian, Yong Shangsi xian sheng deng) zhi jian de guan xi, yi ji qi dui Wang (Yangming) xue xing qi de nei zai guan lian xing, bing yan ji dui xian dai xin ru xue de tan tao. ben shu de xie zuo jiang zhu zhong si xiang kao gu de fang fa, zai quan mian yan jiu you guan dian ji de ji chu shang, dui you guan ren wu de chu sheng di, huo dong de di qu (ru jia zu suo zai cun luo, xue zhe shu xin wang lai, jiang xue, hui jiang, shu yuan deng) jin xing shi di de kao cha, guang fan di yun yong fang zhi, nian pu, shu yuan zhi, jia pu deng cai liao, ba si xiang jia huan yuan yu ju ti huan jing zhi zhong, zai ju ti she hui de li shi de jia zu de bei jing xia kao cha qi si xiang de nei han, jie shi qi jing shen suo zai, bing jin er yin shen chu qi yi yi yu jia zhi. (shrink)

The interocular suppression technique termed continuous flash suppression (CFS) has become an immensely popular tool for investigating visual processing outside of awareness. The emerging picture from studies using CFS is that extensive processing of a visual stimulus, including its semantic and affective content, occurs despite suppression from awareness of that stimulus by CFS. However, the current implementation of CFS in many studies examining processing outside of awareness has several drawbacks that may be improved upon for future studies using CFS. In (...) this paper, we address some of those shortcomings, particularly ones that affect the assessment of unawareness during CFS, and ones to do with the use of ‘visible’ conditions that are often included as a comparison to a CFS condition. We also discuss potential biases in stimulus processing as a result of spatial attention and feature-selective suppression. We suggest practical guidelines that minimize the effects of those limitations in using CFS to study visual processing outside of awareness. (shrink)

BackgroundAmidst expanding roles in education and policy making, questions have been raised about the ability of Clinical Ethics Committees (CEC) s to carry out effective ethics consultations (CECons). However recent reviews of CECs suggest that there is no uniformity to CECons and no effective means of assessing the quality of CECons. To address this gap a systematic scoping review of prevailing tools used to assess CECons was performed to foreground and guide the design of a tool to evaluate the quality (...) of CECons.MethodsGuided by Levac et al’s (2010) methodological framework for conducting scoping reviews, the research team performed independent literature reviews of accounts of assessments of CECons published in six databases. The included articles were independently analyzed using content and thematic analysis to enhance the validity of the findings.ResultsNine thousand sixty-six abstracts were identified, 617 full-text articles were reviewed, 104 articles were analyzed and four themes were identified – the purpose of the CECons evaluation, the various domains assessed, the methods of assessment used and the long-term impact of these evaluations.ConclusionThis review found prevailing assessments of CECons to be piecemeal due to variable goals, contextual factors and practical limitations. The diversity in domains assessed and tools used foregrounds the lack of minimum standards upheld to ensure baseline efficacy.To advance a contextually appropriate, culturally sensitive, program specific assessment tool to assess CECons, clear structural and competency guidelines must be established in the curation of CECons programs, to evaluate their true efficacy and maintain clinical, legal and ethical standards. (shrink)

Climate change and decarbonization raise complex justice questions that researchers and policymakers must address. The distributions of greenhouse gas emissions rights and mitigation efforts have dominated justice discourses within scenario research, an integrative element of the IPCC. However, the space of justice considerations is much larger. At present, there is no consistent approach to comprehensively incorporate and examine justice considerations. Here we propose a conceptual framework grounded in philosophical theory for this purpose. We apply this framework to climate mitigation scenarios (...) literature as proof of concept, enabling a more holistic and multidimensional investigation of justice. We identify areas of future research, including new metrics of service provisioning essential for human well-being. [Can be freely read by clicking the ReadCube link below.]. (shrink)

IntroductionDuring the COVID-19 outbreak, many citizens were asked to stay at home in self-quarantine, which can pose a significant challenge with respect to remaining physically active and maintaining mental health. This study aimed to evaluate the prevalence of inadequate physical activity, anxiety, and depression and to explore the relationship of physical activity with anxiety and depression symptoms among Chinese college students during quarantine.MethodUsing a web-based cross-sectional survey, we collected data from 1,396 Chinese college students. Anxiety and depression were assessed with (...) the Self-Rating Anxiety Scale and the Self-Rating Depression Scale, respectively. The data on physical activity were collected by types of physical activity and the International Physical Activity Questionnaire.ResultsDuring the COVID-19 outbreak, about 52.3% of Chinese college students had inadequate physical activity. The rates of anxiety and depression symptoms were 31.0 and 41.8%, respectively. A high level of physical activity was significantly closely associated with low anxiety, while a moderate, or high level of physical activity was significantly closely associated with reduced depression after adjusting confounding demographic factors. Moreover, specific types of physical activity, such as stretching and resistance training, were negatively correlated with both anxiety and depression; doing household chores was negatively correlated with depression.ConclusionOur findings highlight specific levels and types of home-based physical activities that need to be taken into consideration to protect the mental health of college students during the COVID-19 epidemic. (shrink)

BackgroundThe COVID-19 pandemic has changed the healthcare landscape drastically. Stricken by sharp surges in morbidity and mortality with resource and manpower shortages confounding their efforts, the medical community has witnessed high rates of burnout and post-traumatic stress amongst themselves. Whilst the prevailing literature has offered glimpses into their professional war, no review thus far has collated the deeply personal reflections of physicians and ascertained how their self-concept, self-esteem and perceived self-worth has altered during this crisis. Without adequate intervention, this may (...) have profound effects on their mental and physical health, personal relationships and professional efficacy.MethodsWith mentions of the coronavirus pervading social media by the millions, this paper set out to collate and thematically analyse social media posts containing first-person physician reflections on how COVID-19 affected their lives and their coping mechanisms. A consistent search strategy was employed and a PRISMA flowchart was used to map out the inclusion/exclusion criteria.ResultsA total of 590 social media posts were screened, 511 evaluated, and 108 included for analysis. Salient themes identified include Disruptions to Personal Psycho-Emotional State, Disruptions to Professional Care Delivery, Concern for Family, Response from Institution, Response from Society and Coping Mechanisms.ConclusionIt is evident that the distress experienced by physicians during this time has been manifold, multi-faceted and dominantly negative. Self-concepts were distorted with weakened self-esteem and perceived self-worth observed. The Ring Theory of Personhood (RToP) was adopted to explain COVID-19’s impact on physician personhood as it considers existential, individual, relational and social concepts of the self. These entwined self-concepts serve as ‘compensatory’ to one another, with coping mechanisms buffering and fortifying the physician’s overall personhood. With healthcare institutions playing a vital role in providing timely and targeted support, it was further proposed that a comprehensive assessment tool based on the RToP could be developed to detect at-risk physicians and evaluate the presence and effectiveness of established support structures. (shrink)

Background Performance evaluation is vital for IRB operations. As the number of IRBs and their responsibilities in reviewing and supervising clinical research grow in China, there is a significant need to evaluate their performances. To date, little research has examined IRB performance within China. The aim of this study was to ascertain the perspectives and experiences of IRB employees and researchers to understand the current status of IRBs; compare collected results with those of other countries; and identify shortcomings to improve (...) IRB performance. Methods This study was conducted in China from October 2020 to September 2021, using an online survey with the IRB-researcher assessment tool-Chinese version. Results 757 respondents were included in the analysis and classified into IRB employees, researchers, or those who are both IRB employees and researchers. Overall, the score for an ideal IRB was significantly higher than that of an actual IRB. Compared to the US National Validation study, Chinese participants and American participants both agree and differ in their perspectives on the most and least important ideal items. Conclusion This investigation provides a benchmark of the perceived performance of actual IRBs in China. IRBs in China can be precisely adjusted by targeting identified areas of weakness to improve their performances. (shrink)

This study was conducted to investigate the relationship between posttraumatic growth, resilience, positive coping style, and self-efficacy among the primary caregivers of children with developmental disorders in Chongqing, China. A total of 198 primary caregivers aged from 22 to 66 years old, including 155 females and 43 males, were enrolled. The Posttraumatic Growth Inventory, Connor-Davidson Resilience Scale-10, Simplified Coping Style Questionnaire, and General Self-Efficacy Scale were used for data collection. The results found that PTG could be positively predicted by resilience. (...) Positive coping style and self-efficacy mediated the relationship between resilience and PTG. The different levels of PTG were determined by the resident location, monthly income and education of the primary caregivers. The results suggest that it is critical to improve the mental health of the primary caregivers of children with developmental disabilities. Our results also provide a scientific basis for future research. (shrink)

The meshed control theory assumes that cognitive control and automatic processes work together in the natural attention of experts for superior performance. However, the methods adopted by previous studies limit their capacity to provide in-depth information on the neuromotor processes. This experiment tested the theory with an alternative approach. Twelve skilled golfers were recruited to perform a putting task under three conditions: (1) normal condition, with no focus instruction (NC), (2) external focus of attention condition (EC), and (3) internal focus (...) of attention condition (IC). Four blocks of 10 putts each were performed under each condition. The putting success rate and accuracy were measured and electroencephalographies (EEGs) were recorded. The behavioral results showed that the NC produced a higher putting success rate and accuracy than the EC and IC. The EEG data showed that the skilled golfers’ attentional processes in the NC initially resembled those in the EC and then moved toward those in the IC just before putting. This indicates a switch from more automatic processes to cognitive control processes while preparing to putt. The findings offer support for the meshed control theory and indicate the dynamic nature of neuromotor processes for the superior performance of athletes in challenging situations. (shrink)

Since the COVID-19 pandemic, the tourism economy has been seriously affected. China has implemented a direct traveling management mechanism and recovered from the pandemic faster than the rest of the world. However, the COVID-19 situation is complicated and uncontrollable because of the available unclear information including difficult medical terminologies. This study attempts to find the determinants of the travel intention of China’s tourists in the post-COVID-19 epidemic. Along with information overload and perception risk, an expanded research model of the Theory (...) of Planned Behavior was employed to propose the theoretical framework of this study. A survey was conducted among 518 tourists who spend their holiday in Hainan, which is a popular tourist destination in China. The empirical results show that information overload positively and significantly impacted perceived risk. Furthermore, perceived risk negatively affects the intention to travel. Perceived risk also negatively affected the attitude toward traveling. However, response self-efficacy did not have a significant effect on the intention to travel. Finally, based on the analysis results, this study proposes relevant research contributions and practical recommendations with management implications for the travel industries. (shrink)

This study formulates a two-factor empirical model under the intertemporal CAPM framework to evaluate the cross-sectional implications of socially responsible investments in the US equity market. Our results show that socially responsible investments have no asset pricing impact on the US market. We argue that this ‘no financial impact’ finding indicates that investors will not be disadvantaged financially by investing in socially responsible funds or corporations.

ObjectivePrevious studies have demonstrated altered brain activity in strabismic amblyopia. In this study, low-frequency repetitive transcranial magnetic stimulation was applied in children with strabismic amblyopia after they had undergone strabismus surgery. The effect of rTMS was investigated by measuring the changes of brain features using the amplitude of low-frequency fluctuation.Materials and MethodsIn this study, 21 SA patients were recruited based on their age, weight, and sex. They all had SA in their left eyes and they received rTMS treatment one month (...) after strabismus surgery. Their vision before and after surgery were categorized as pre-rTMS and post-rTMS. All participants received rTMS treatment, underwent magnetic resonance imaging, and their data were analyzed using the repeated measures t-test. The team used correlation analysis to explore the relationship between logMAR visual acuity and ALFF.ResultsPre- versus post-rTMS values of ALFF were significantly different within individuals. In the POT group, ALFF values were significantly decreased in the Angular_R, Parietal_Inf_L, and Cingulum_Mid_R while ALFF values were significantly increased in the Fusiform_R and Frontal_Inf_Orb_L compared to the PRT stage.ConclusionOur data showed that ALFF recorded from some brain regions was changed significantly after rTMS in strabismic amblyopes. The results may infer the pathological basis of SA and demonstrate that visual function may be improved using rTMS in strabismic amblyopic patients. (shrink)

Synchronization of biological neurons is not only a hot topic, but also a difficult issue in the field of bioelectrical physiology. Numerous reported synchronization algorithms are designed on the basis of neural model, but they have deficiencies like relatively complex and poor robustness and are difficult to be realized. Morris-Lecar neuron is considered, and linear active disturbance rejection control is designed. Only one control input signal is utilized to synchronize membrane potentials of biological neurons. Meanwhile, in order to verify the (...) robustness of synchronization, sinusoidal signal and parameter perturbations are introduced in numerical simulations. LADRC can still achieve satisfactory synchronization. Both theoretical and numerical simulation results show that LADRC is capable of estimating and cancelling disturbances and uncertainties. Neither accurate neural models nor concrete disturbance signal models are indispensable. A more practical and effective thought is provided to address the synchronization between neurons. (shrink)

Students often face difficulties and experience negative emotions toward second language learning. The affective tutoring system is a next-generation learning approach that can detect the affective status of learning to increase performance. Therefore, for the purposes of this study, an innovative affective mobile language tutoring system was designed to support Japanese language learning. The effects of AMLTS, along with asynchronous discussion, that were intended to improve performance, were examined using a triangulation method. To investigate the effect on emotion, the proposed (...) AMLTS provides a virtual emotion agent that can interact with users and record emotional events, learning assessments, and the results of the interaction into a database. Learning effectiveness evaluations were conducted via two experiments: prototype evaluation and final evaluation. Sixty-three students, all beginners, were invited to use the AMLTS to learn Japanese. The research results show that the proposed AMLTS affective interaction design significantly improves learner engagement and performance. In the emotion feedback analysis and learning process, AMLTS helped students deepen their understanding of the content, enabled them to clearly understand the content, and to engage in peer interaction and experience positive emotions. In the evaluation of system usability, AMLTS reveals good usability for foreign language acquisition. (shrink)

Both glycemic control and handgrip strength affect microvascular function. Multiscale entropy of photoplethysmographic pulse amplitudes may differ by diabetes status and hand activity. Of a middle-to-old aged and right-handed cohort without clinical cardiovascular disease, we controlled age, sex, and weight to select the unaffected,the well-controlled diabetes, and the poorly controlled diabetes groups. MSEs were calculated from consecutive 1,500 PPG pulse amplitudes of bilateral index fingertips. Thesmall-, medium-,and large-scale MSEs were defined as the average of scale 1, scales 2–4, and scales (...) 5–10, respectively. Intra- and intergroups were compared by one- and two-samplet-tests, respectively. The dominant handMSE5–10was lower in the poorly controlled diabetes group than the well-controlled diabetes and the unaffected groups, whereas the nondominant handMSE5–10was lower in the well- and poorly controlled diabetes groups than the unaffected group. TheMSE1of dominant hand was higher than that of nondominant hand in the well-controlled diabetes. In conclusion, diabetes status and hand dominance may affect the MSE of PPG pulse amplitudes. (shrink)