Childhood adversity is associated with altered or dysregulated stress reactivity; these altered patterns of physiological functioning persist into adulthood. Evidence from both preclinical animal models and human neuroimaging studies indicates that early life experience differentially influences stressor-evoked activity within central visceral neural circuits proximally involved in the control of stress responses, including the subgenual anterior cingulate cortex (sgACC), paraventricular nucleus of the hypothalamus (PVN), bed nucleus of the stria terminalis (BNST) and amygdala. However, the relationship between childhood adversity and the (...) resting-state connectivity of this central visceral network remains unclear. To this end, we examined relationships between childhood threat and childhood socioeconomic deprivation, the resting-state connectivity between our regions of interest (ROIs), and affective symptom severity and diagnoses. We recruited a transdiagnostic sample of young adult males and females (n= 100; mean age = 27.28,SD= 3.99; 59 females) with a full distribution of maltreatment history and symptom severity across multiple affective disorders. Resting-state data were acquired using a 7.2-min functional magnetic resonance imaging (fMRI) sequence; noted ROIs were applied as masks to determine ROI-to-ROI connectivity. Threat was determined by measures of childhood traumatic events and abuse. Socioeconomic deprivation (SED) was determined by a measure of childhood socioeconomic status (parental education level). Covarying for age, race and sex, greater childhood threat was significantly associated with lower BNST-PVN, amygdala-sgACC and PVN-sgACC connectivity. No significant relationships were found between SED and resting-state connectivity. BNST-PVN connectivity was associated with the number of lifetime affective diagnoses. Exposure to threat during early development may entrain altered patterns of resting-state connectivity between these stress-related ROIs in ways that contribute to dysregulated neural and physiological responses to stress and subsequent affective psychopathology. (shrink)

I attempt to get as clear as possible on the chain of reasoning by which irreversible macrodynamics is derivable from time-reversible microphysics, and in particular to clarify just what kinds of assumptions about the initial state of the universe, and about the nature of the microdynamics, are needed in these derivations. I conclude that while a “Past Hypothesis” about the early Universe does seem necessary to carry out such derivations, that Hypothesis is not correctly understood as a constraint on the (...) early Universe’s entropy. (shrink)

Practical reason is the general human capacity for resolving, through reflection, the question of what one is to do. Deliberation of this kind is practical in at least two senses. First, it is practical in its subject matter, insofar as it is concerned with action. But it is also practical in its consequences or its issue, insofar as reflection about action itself directly moves people to act. Our capacity for deliberative self-determination raises two sets of philosophical problems. For one thing, (...) there are questions about how deliberation can succeed in being practical in its issue. What do we need to assume—both about agents and about the processes of reasoning they engage in—to make sense of the fact that deliberative reflection can directly give rise to action? Can we do justice to this dimension of practical reason while preserving the idea that practical deliberation is genuinely a form of reasoning? For another, there are large issues concerning the content of the standards that are brought to bear in practical reasoning. Which norms for the assessment of action are binding on us as deliberating agents? Do these norms provide resources for critical reflection about our ends, or are they exclusively instrumental? Under what conditions do moral norms yield valid standards for reasoning about action? The first set of issues is addressed in sections §§1–3 of the present article, while sections §§4–6 cover the second set of issues. (shrink)

"Cornell Paperback." Includes index. Bibliography: p. 163-165.

This book investigates the potential role that states can play in cosmopolitan thinking and how states could be agents for the advancement of cosmopolitan responsibilities.

A common strategy unites much that philosophers have written about the virtues. The strategy can be traced back at least to Aristotle, who suggested that human beings have a characteristic function or activity, and that the virtues are traits of character which enable humans to perform this kind of activity excellently or well. The defining feature of this approach is that it treats the virtues as functional concepts, to be both identified and justified by reference to some independent goal or (...) end which they enable people to attain. Some recent philosophers seem to have hoped that by following this perfectionist strategy, we might attain a more convincing account of our moral practices than rule-based theories of ethics have been able to provide. (shrink)

We propose, following Clark, that generative models also play a central role in the perception and interpretation of linguistic signals. The data explanation approach provides a rationale for the role of prediction in language processing and unifies a number of phenomena, including multiple-cue integration, adaptation effects, and cortical responses to violations of linguistic expectations.

The objective of this study—a substudy to a phase I bioequivalence study—was to compare the effect of standard and concise consent forms on research volunteers’ comprehension of and satisfaction with consent forms, as well as to assess the effect of select volunteer characteristics, such as financial motivations to participate in research, on their comprehension. A 36-item questionnaire measured volunteers’ comprehension, satisfaction, and motivations for participation. Volunteers were randomized to the standard Pfizer consent form or a concise, easier-to-read form. We approached (...) 139 volunteers to participate, and 138 completed the questionnaire . The cohorts did not differ in sociodemographic characteristics. We found that the average comprehension scores for the standard consent form cohort and the concise consent cohort were about the same, and that satisfaction with the consent form was high in both cohorts. Surprisingly, volunteers with a financial motivation had significantly greater comprehension of the study. (shrink)

It is argued that future research capacity building for the social sciences needs to incorporate methods to accelerate the acquisition by researchers of holistic expertise relevant to their roles as researchers and as developers of others. An agenda is presented, based on a model of learning that highlights missing elements of current provision, and two approaches currently under development are described.

Challenging the paradigm in ethics -- The spirit of the enterprise -- Social artifacts and ethical criticism -- General and particular in practical knowledge -- Virtues of benevolence and justice.

Previous research on the conversation analytic phenomenon of ‘repair’ has focused on its design and function in spoken interaction. Conversely, research on written text or writing rarely focuses on interaction. In this article, we examine repair in written discourse; specifically in online settings. The data corpus comprises one-to-one quasi-synchronous Facebook ‘chat’. First, we show that, as in spoken interaction, repair happens. This basic observation supports conversation analytic arguments that features of talk, like repair and laughter, do not ‘leak randomly’ into (...) interaction but are precision-timed and designed to accomplish action. Second, we report on two types of repair: visible repair which can be seen and oriented to by both participants in the interaction, and message construction repair, which is available only to the message’s writer. While the practice of message construction repair is made possible through the affordances of the online medium, it nevertheless shows how participants in written interaction are oriented to the same basic contingencies as they are in spoken talk: building sequentially organized courses of action and maintaining intersubjectivity. We suggest that assumptions about differences between spoken and online interaction are premature. Rather, we argue that online interaction should be treated as an adaptation of an oral speech-exchange system. (shrink)

This book, translated into English from Japanese and revised, argues that cultural diversity is a treasure for humanity, and we must realize that it is a necessary condition for a fully human existence. By realizing the deep connectedness of all human beings, we send a positive message to humanity.

Together, their work signals a new direction in the field and offers refreshingly original insights into a broad spectrum of texts.

The North American environmental movement has historically sought to redress the depletion and degradation of natural resources that has been the legacy of the industrial revolution. Predominant in this approach has been the preservation of wilderness, conservation of species biodiversity and the restoration of natural ecosystems. While the results of such activity have often been commendable, several scholars have pointed out that the environmental movement has inherited an unfortunate bias against urban environments, and consequently, a blind spot to ways in (...) which densely populated built spaces can serve to enhance rather than degrade efforts to achieve sustainability. After exploring this concern we argue that environmental architecture can serve as a counter-balance to this bias, focused, as it is, on the ways in which the construction and organisation of built spaces for humans can help or hinder the pursuit of environmental priorities. But if environmental architecture is to take this role then it must be understood in a broader context, one which does not exclude other moral, political and aesthetic values in the production of human environments. We will highlight several examples of how environmental architecture has combined success and failure at taking a broader view of environmental questions, with a specific focus on one green skyscraper that may be good for the natural environment but not necessarily for the human environment of the city. (shrink)

Learner control is an important instructional design in video-based learning. This study assessed two conditions: a full learner control where learners direct their learning path, and a hybrid learner control where learners follow the instructor-set path but still enjoy certain aspects of control. Two groups of university students participated in this study by learning statistics through online video courses. The findings show that the full learner control condition attained higher learning performance than the hybrid learner control condition, but spent more (...) time than the latter. The full learner control condition scored higher than the hybrid condition in the difficult sections of video-based learning; but no significant difference was found in the easy section. There was a significant difference between the two conditions in learning agency, but no differences in cognitive load and affective and cognitive engagement. Hierarchical regression analysis indicated differences between the full and the hybrid learner control conditions in the factors predicting overall scores. The findings carry important contributions and implications for the research and practice of instructional designs in online video-based learning such as MOOCs. (shrink)

Bernard Gert argues that legitimate moral disagreement calls for tolerance and moral humility; when there is more than one morally acceptable course of action, then intolerance and what Gert calls “moral arrogance” would be objectionable. This article identifies some possible difficulties in distinguishing moral arrogance from moral reform and then examines Gert's treatment of abortion as a contemporary example of moral disagreement that he characterizes as irresolvable.

I respond to the frequent objection that structural realism fails to sharply state an alternative to the standard predicate-logic, object / property / relation, way of doing metaphysics. The approach I propose is based on what I call a ‘math-first’ approach to physical theories (close to the so-called ‘semantic view of theories') where the content of a physical theory is to be understood primarily in terms of its mathematical structure and the representational relations it bears to physical systems, rather than (...) as a collection of sentences that attempt to make true claims about those systems (a ‘language-first’ approach). I argue that adopting the math-first approach already amounts to a form of structural realism, and that the choice between epistemic and ontic versions of structural realism is then a choice between a language-first and math-first view of metaphysics; I then explore the status of objects (and properties and relations) in fundamental and non-fundamental physics for both versions of math-first structural realism. (shrink)

A defence of the idea that there are sui generis duties of love: duties, that is, that we owe to people in virtue of standing in loving relationships with them. I contrast this non‐reductionist position with the widespread reductionist view that our duties to those we love all derive from more generic moral principles. The paper mounts a cumulative argument in favour of the non‐reductionist position, adducing a variety of considerations that together speak strongly in favour of adopting it. The (...) concluding section connects this debate with larger issues in moral theory concerning the general idea of obligation. (shrink)

_Wittgenstein, Mind and Meaning_ offers a provocative re-reading of Wittgenstein's later writings on language and mind, and explores the tensions between Wittgenstein's ideas and contemporary cognitivist conceptions of the mental. This book addresses both Wittgenstein's later works as well as contemporary issues in philosophy of mind. It provides fresh insight into the later Wittgenstein and raises vital questions about the foundations of cognitivism and its wider implications for psychology and cognitive science.

This letter responds to a letter by Moti Gorin in the same issue, September‐October 2024, of the Hastings Center Report.

This work offers a comprehensive picture of the dynamic natures of language and consciousness that will interest linguists, psychologists, literary scholars,...

The Moral Nexus develops and defends a new interpretation of morality—namely, as a set of requirements that connect agents normatively to other persons in a nexus of moral relations. According to this relational interpretation, moral demands are directed to other individuals, who have claims that the agent comply with these demands. Interpersonal morality, so conceived, is the domain of what we owe to each other, insofar as we are each persons with equal moral standing. The book offers an interpretative argument (...) for the relational approach. Specifically, it highlights neglected advantages of this way of understanding the moral domain; explores important theoretical and practical presuppositions of relational moral duties; and considers the normative implications of understanding morality in relational terms. The book features a novel defense of the relational approach to morality, which emphasizes the special significance that moral requirements have, both for agents who are deliberating about what to do and for those who stand to be affected by their actions. The book argues that relational moral requirements can be understood to link us to all individuals whose interests render them vulnerable to our agency, regardless of whether they stand in any prior relationship to us. It also offers fresh accounts of some of the moral phenomena that have seemed to resist treatment in relational terms, showing that the relational interpretation is a viable framework for understanding our specific moral obligations to other people. (shrink)