Cell line immortalisation is a growing component of African genomics research and biobanking. However, little is known about the factors influencing consent to cell line creation and immortalisation in African research settings. We contribute to addressing this gap by exploring three questions in a sample of Xhosa participants recruited for a South African psychiatric genomics study: First, what proportion of participants consented to cell line storage? Second, what were predictors of this consent? Third, what questions were raised by participants during (...) this consent process? 760 Xhose people with schizophrenia and 760 controls were matched to sex, age, level of education and recruitment region. We used descriptive statistics to determine the proportion of participants who consented to cell line creation and immortalization. Logistic regression methods were used to examine the predictors of consent. Reflections from study recruiters were elicited and discussed to identify key questions raised by participants about consent. Approximately 40% of participants consented to cell line storage. The recruiter who sought consent was a strong predictor of participant’s consent. Participants recruited from the South African Eastern Cape, and older participants, were more likely to consent; both these groups were more likely to hold traditional Xhosa values. Neither illness nor education were significant predictors of consent. Key questions raised by participants included two broad themes: clarification of what cell immortalisation means, and issues around individual and community benefit. These findings provide guidance on the proportion of participants likely to consent to cell line immortalisation in genomics research in Africa, and reinforce the important and influential role that study recruiters play during seeking of this consent. Our results reinforce the cultural and contextual factors underpinning consent choices, particularly around sharing and reciprocity. Finally, these results provide support for the growing literature challenging the stigmatizing perception that people with severe mental illness are overly vulnerable as a target group for heath research and specifically genomics studies. (shrink)

Persons with dementia often prefer to participate in decisions about their health care, but may be prevented from doing so because healthcare decision-making law facilitates use of advance directives or surrogate decision makers for persons with decisional impairments such as dementia. Federal and state disability law provide alternative decision-making models that do not prevent persons with mild to moderate dementia from making their own healthcare decisions at the time the decision needs to be made. In order to better promote autonomy (...) and wellbeing, persons with dementia should be accommodated and supported so they can make their own healthcare decisions. (shrink)

Discussion of supported decision making has been dominated by legal scholars, philosophers, and advocates for persons with disabilities. Peterson et al.’s primary contribution is introducing...

This paper provides an analysis of U.S. farmland owners, operators, and workers by race, ethnicity, and gender. We first review the intersection between racialized and gendered capitalism and farmland ownership and farming in the United States. Then we analyze data from the 2014 Tenure and Ownership Agricultural Land survey, the 2012 Census of Agriculture, and the 2013–2014 National Agricultural Worker Survey to demonstrate that significant nation-wide disparities in farming by race, ethnicity and gender persist in the U.S. In 2012–2014, White (...) people owned 98% and operated 94% of all farmland. They generated 98% of all farm-related income from land ownership and 97% of income from farm owner-operatorship. Meanwhile, People of Color farmers were more likely to be tenants rather than owners, owned less land, and generated less farm-related wealth per person than their White counterparts. Hispanic farmers were also disproportionately farm laborers. In addition to racial and ethnic disparities, there were disparities by gender. About 63% of non-operating landowners, 86% of farm operators, and 87% of tenant farmers were male, and female farmers tended to generate less income per farmer than men. This data provides evidence of ongoing racial, ethnic and gender disparities in agriculture in the United States. We conclude with a call to address the structural drivers of the disparities and with recommendations for better data collection. (shrink)

BackgroundCommunity engagement within biomedical research is broadly defined as a collaborative relationship between a research team and a group of individuals targeted for research. A Community Advisory Board is one mechanism of engaging the community. Within genomics research CABs may be particularly relevant due to the potential implications of research findings drawn from individual participants on the larger communities they represent. Within such research, CABs seek to meet instrumental goals such as protecting research participants and their community from research-related risks, (...) as well as intrinsic goals such as promoting the respect of participants and their community. However, successful community engagement depends on the degree to which CABs legitimately represent and engage with communities targeted for research. Currently, there is little literature describing the use of CABs in genomics research taking place in developing countries, and even less in the field of genomics research relating to mental illness. The aim of this article is to describe and consider the contributions made by a researcher-driven, population-specific CAB in a genomics of schizophrenia research project taking place in South Africa, from the perspective of the research team.DiscussionFour broad discussion topics emerged during the CAB meetings namely: 1) informed consent procedures, 2) recruitment strategies, 3) patient illness beliefs and stigma experiences, and 4) specific ethical concerns relating to the project. The authors consider these discussions in terms of their contributions to instrumental and intrinsic goals of community engagement.SummaryThe CAB gave valuable input on the consent processes and materials, recruitment strategies and suggested ways of minimizing the potential for stigma and discrimination. All of these contributions were of an instrumental nature, and helped improve the way in which the research took place. In addition, and perhaps more importantly, the CAB made a unique and important contribution relating to intrinsic functions such as promoting the respect and dignity of research participants and their community. This was particularly evident in ensuring sensitivity and respect of the community’s traditional beliefs about schizophrenia and its treatment, and in this way promoting a respectful relationship between the research team and the participants. (shrink)

Moral distress has been characterised in the nursing literature as a major problem affecting nurses in all healthcare systems. It has been portrayed as threatening the integrity of nurses and ultimately the quality of patient care. However, nursing discourse on moral distress is not without controversy. The notion itself is conceptually flawed and suffers from both theoretical and practical difficulties. Nursing research investigating moral distress is also problematic on account of being methodologically weak and disparate. Moreover, the ultimate purpose and (...) significance of the research is unclear. In light of these considerations, it is contended that the notion of moral distress ought to be abandoned and that concerted attention be given to advancing inquiries that are more conducive to improving the quality and safety of moral decision-making, moral conduct and moral outcomes in nursing and healthcare domains. (shrink)

Reductionism is a central issue in the philosophy of biology. One common objection to reduction is that molecular explanation requires reference to higher-level properties, which I refer to as the context objection. I respond to this objection by arguing that a well-articulated notion of a mechanism and what I term mechanism extension enables one to accommodate the context-dependence of biological processes within a reductive explanation. The existence of emergent features in the context could be raised as an objection to the (...) possibility of reduction via this strategy. I argue that this objection can be overcome by showing that there is no tenable argument for the existence of emergent properties that are not susceptible to a reductive explanation. (shrink)

The New Testament documents represent a variety of perceptions about the church, showing that the early church was not unitary in practise or theology. How do we explain the diversity in the early church? Existential phenomenological hermeneutics can shine insightful light on this question by utilising Heidegger’s concept of Dasein in an interpretation model. The model used the pre-structure of Dasein and its interactive circular dynamic with the hermeneutical concepts of world and phenomena to table aspects of the hermeneutic situation (...) and the resultant Dasein types as self-understanding developed from various groups’ interpretations of Jesus. In this way, the hermeneutic dynamic explains the variety of pre- and post-Easter groups. The results show that there is no objective, standard view of Jesus and no objective set of Jesus’ teachings available; no ideal Dasein type is presented for faith communities. The kerygma of the Crucified and Risen One as God’s act of salvation is the central presupposition of the church’s Dasein. The historical nature of hermeneutics cannot be denied. Historical–critical exegesis and its circular dynamic of understanding is a legitimate and sound hermeneutic model. Unhistorical hermeneutics have definite limitations and should be deemed insufficient. There is no plain meaning of any phenomenon or text, only the text or phenomenon as it is understood. Faith communities consciously partake in the hermeneutic dynamic and recognise the influence of their pre-understandings, presuppositions and prejudices which constantly be questioned and adjusted to facilitate their authentic Dasein.Contribution: This historical hermeneutical study explains that different hermeneutical situations lead to different Dasein types as various self-understandings developed according to Jesus groups’ interpretations of Jesus varied. No ideal Dasein type for faith communities is presented. These findings resonate with HTS Theological Studies focus and scope regarding historical thought in research. (shrink)

Within the Reformed tradition, 'calling' is a core concept. Often, this biblical verse is cited when a pastor is installed or a new candidate is ordained, 'The one who calls you is faithful and he will do it'. It is also confessed within this tradition that all Christians are called to be faithful ministers of the graces of God in whatever profession they may serve. In some Presbyterian congregations, it is a practice to say at the baptism of a child, (...) 'This is your ordination to ministry'. This article focuses on what is meant by calling when we use it in so many ways and with so many meanings. The first part explores the use of the concept in church history by different scholars and leaders - like in the Reformation. The second part briefly explores the implications and impact of the calling of someone into full-time congregational ministry. (shrink)

When membership of the faith community gets separated from Biblical concepts for us Christians the church is gradually and slowly getting into trouble. This is especially true when membership and discipleship are separated. In the first article, I have mentioned that discipleship may have become unpopular because of mainly two reasons: the wrong association with confrontational evangelism and secondly for the inconvenience of the radical nature of discipleship, especially in a situation where churches are still monocultural and still prefer the (...) ‘convenience’ of a culturally constituted and dominated church. In this article, the focus will be on the role of the church in seeking the ‘Kingdom and his righteousness’ and on what seeking might entail, with special reference to continuing formation of the membership on this journey of following the Christ. The background to my research problem and question is that the ‘we’ can just not afford that people, because of the church, not being serious about herself, turn away from the church – but turn to God: ‘Everyday people are straying away from the church and going back to God’. This is just not normal. (shrink)

The source texts for Ovid's Heroides often contain precedents for his heroines as message senders at moments in their tradition especially ripe for elegiac refashioning. The first part of this paper suggests that the disputed first word of Heroides 1, a hanc with no apparent referent, signals Penelope's penchant for composing messages, both in Ovid's elegiac letter and in Homer's epic, and functions as a programmatic opening to the collection. The second part more briefly treats letters 4, 5, 6, 7, (...) 9, and 13 to show how their authors' previous mythographical correspondence also provides points of origin for the Heroides. (shrink)

Business Ethics: A European Review, EarlyView.

According to the Gospel of Matthew, disciplemaking seems to be the signature mark of faithful disciples of Jesus the Christ. Van Aarde refers to this, with reference to Von Harnack and Lohmeyer as the manifesto of the church, being on the same level of meaning as Deuteronomy 6 in the Old Testament. It may be fair to say that this 'natural' way of being and doing was in more than one way exchanged for evangelism practices that did nothing to show (...) forth that following the Christ is a better or best way of living life, here already, to its fullest. These practices even reflected negatively on disciplemaking as such. A personal conviction is that 'discipling' may even be one of the missing links in the so-called missional conversation. This article will reflect on current theory on discipling and the natural necessity thereof. It will also draw upon findings in empirical research conducted by the National Church Life Surveys during 2014 in South Africa that may give an indication whether discipling is a common praxis among selected South African denominations and congregations. The focus will be on 'Faith-Sharing' as a core quality among adult attenders and includes several measures of the involvement of attenders in the outreach of the congregation. (shrink)

This work provides a mindset for leadership to deal with the problem of unethical transgressions in South African communities and buisness. It provides a thorough and comprehensive diagnosis of leadership and morality, from an analysis of causes, to the compilation of remedies.

Despite recent empirical interest, the links between optimism and pessimism with pro-environmental behavior remain equivocal. This research is characterized by a reliance on cross-sectional data, a focus on trait-level at the neglect of state-level optimism–pessimism, and assessments of retrospective self-reported ecological behavior that are subject to response bias. To attend to these gaps, 140 North American adults were experimentally primed with bogus optimistic or pessimistic environmental news articles, and then asked to report their levels of state optimism–pessimism, intentions to purchase (...) green products, in vivo PEB, and support for geoengineering technologies. Results confirmed that optimistic environmental messaging enhanced the expression of state optimism, which then contributed to PEB and support for geoengineering. These results have important implications for the framing of environmental messaging intended to promote ecologically conscious behavior. (shrink)

A currently popular proposal for fairly distributing emission quotas is the equal shares view, which holds that that emission quotas should be distributed to all human beings globally on an equal per capita basis. In this paper I aim to show that a number of arguments in favour of equal shares are based on a misleading analysis of climate change as a global commons problem. I argue that a correct understanding of the way in which climate change results from the (...) overuse of a global commons shows those who defend equal shares using commons arguments to be harbouring more controversial commitments than might at first appear. I then discuss two options for equal shares theorists who wish to maintain the view in the face of my critique, and attempt to show that one approach holds more promise than the other. (shrink)

To address climate change fairly, many conflicting claims over natural resources must be balanced against one another. This has long been obvious in the case of fossil fuels and greenhouse gas sinks including the atmosphere and forests; but it is ever more apparent that responses to climate change also threaten to spur new competition over land and extractive resources. This makes climate change an instance of a broader, more enduring and - for many - all too familiar problem: the problem (...) of human conflict over how the natural world should be cared for, protected, shared, used, and managed. -/- This work develops a new theory of global egalitarianism concerning natural resources, rejecting both permanent sovereignty and equal division, which is then used to examine the problem of climate change. It formulates principles of resource right designed to protect the ability of all human beings to satisfy their basic needs as members of self-determining political communities, where it is understood that the genuine exercise of collective self-determination is not possible from a position of significant disadvantage in global wealth and power relations. These principles are used to address the question of where to set the ceiling on future greenhouse gas emissions and how to share the resulting emissions budget, in the face of conflicting claims to fossil fuels, climate sinks, and land. It is also used to defend an unorthodox understanding of responsibility for climate change as a problem of global justice, based on its provenance in historical injustice concerning natural resources. (shrink)

In an effort to address healthcare disparities in lesbian, gay, bisexual, transgender, and queer populations, many hospitals and clinics institute diversity training meant to increase providers’ awareness of and sensitivity to this patient population. Despite these efforts, many healthcare spaces remain inhospitable to LGBTQ patients and their loved ones. Even in the absence of overt forms of discrimination, LGBTQ patients report feeling anxious, unwelcome, ashamed, and distrustful in healthcare encounters. We argue that these negative experiences are produced by a variety (...) of subtle, ostensibly insignificant features of healthcare spaces and interpersonal interactions called microaggressions. Healthcare spaces and providers often convey heteronormative microaggressions, which communicate to LGBTQ—and, we suggest, intersex and asexual —people that their identities, experiences, and relationships are abnormal, pathological, unexpected, unwelcome, or shameful. We identify heteronormative microaggressions common to healthcare settings and specify how they negatively impact LGBTQIA patients. We argue that standard diversity training cannot sufficiently address heteronormative microaggressions. Despite these challenges, healthcare institutions and providers must take responsibility for heteronormative microaggressions and take steps to reduce their frequency and mitigate their effects on LGBTQIA care. We conclude by offering strategies for problem-solving at the level of medical education, institutional culture and policy, and individual awareness. (shrink)

Richard Stanley Peters appreciates the centrality of concepts for everyday life, however, he fails to recognize their pedagogical dimension. He distinguishes concepts employed at the first-order (our ordinary language-use) from second-order conceptual clarification (conducted exclusively by academically trained philosophers). This distinction serves to elevate the discipline of philosophy at the expense of our ordinary language-use. I revisit this distinction and argue that our first-order use of concepts encompasses second-order concern. Individuals learn and teach concepts as they use them. Conceptual understanding (...) is an obligation that all individuals, and not just academically trained philosophers, must fulfil. I conclude that the role of philosophy in education is to provide a conversational context for the pedagogical dimension of concepts. I draw upon the philosophies of Cora Diamond, Stephen Mulhall, Iris Murdoch and Rush Rhees. (shrink)

Land is becoming increasingly scarce relative to the demands of the global economy; a problem significantly exacerbated by climate change. In response, some have suggested that land should be conceptualised as a global commons. This framing might seem like an appealing way to promote sustainable and equitable land use. However, it is a poor fit for the worldʼs land because global commons are generally understood as resources located beyond state borders. I argue that land can be seen to fit the (...) definition of a global commons, if viewed in a particular way; namely, as a biogeochemical resource system that sequesters carbon emissions. The question then arises whether land should be conceptualised as a global commons. I consider this question by reference to three contemporary problems of land justice (land grabbing, forced displacement, and unfairness in land-based climate mitigation); arguing that the global-commons framing will not be conducive to understanding or responding to these problems. I leave the question of how the global community should conceptualise land in the context of climate change open, claiming that any answer must include the voices and perspectives of those whose livelihoods and identities are closely connected to the land. (shrink)

Volume 25, Issue 2, February 2025, Page 61-64.

Shavelson and colleagues (2023) describe how medical aid-in-dying laws in the United States prohibit assistance in administering aid-in-dying medication. This prohibition distinguishes aid in dying...

Dynamic Consent is both a model and a specific web-based tool that enables clear, granular communication and recording of participant consent choices over time. The DC model enables individuals to know and to decide how personal research information is being used and provides a way in which to exercise legal rights provided in privacy and data protection law. The DC tool is flexible and responsive, enabling legal and ethical requirements in research data sharing to be met and for online health (...) information to be maintained. DC has been used in rare diseases and genomics, to enable people to control and express their preferences regarding their own data. However, DC has never been explored in relationship to historical collections of bioscientific and genetic heritage or to contexts involving Aboriginal and Torres Strait Islander people.In response to the growing interest by First Peoples throughout Australia in genetic and genomic research, and the increasing number of invitations from researchers to participate in community health and wellbeing projects, this article examines the legal and ethical attributes and challenges of DC in these contexts. It also explores opportunities for including First Peoples' cultural perspectives, governance, and leadership as a method for defining DC on cultural terms that engage best practice research and data analysis as well as respect for meaningful and longitudinal individual and family participation. (shrink)

The task of designing an ontology through reuse is difficult, and a major challenge in this effort is choosing between different ontologies that are candidates for reuse. To address this challenge,...

Unrecognized conventions—practices that are conventional even though their participants do not recognize them as such—play central roles in shaping our lives. They range from the indispensable (e.g. unrecognized linguistic conventions) to the insidious (e.g. some of our gender conventions). Unrecognized conventions pose a challenge for accounts of conventions because it is difficult to incorporate the distinctive arbitrariness of conventions—the fact that conventions always have alternatives—without accidentally excluding many unrecognized conventions. I develop an Accessibility Requirement that allows us to account for (...) both arbitrariness and unrecognized conventions. Specifically, I argue that a conventional practice must have at least one alternative that is at least approximately as good and at least approximately as accessible as the conventional practice itself, independent of the dominance the practice gained as it became conventional. In the course of arguing for this requirement, I also show that two prominent accounts of conventions, David Lewis’s and Ruth Garrett Millikan’s, run into problems with capturing the arbitrariness of conventions. The Accessibility Requirement opens the door to improved accounts of conventions by precisely identifying the way in which conventions are arbitrary. (shrink)

Here are two widely held positions on the ethics of dating: First, people are generally morally justified in excluding people they don’t find attractive from their dating pool. Second, people are not justified in maintaining a dating pool that is racially exclusive, even on grounds like attraction. In this paper, we demonstrate how these positions are consistent. To do so we differentiate our attitudes in dating and our dating behavior. Then we show how existing criticisms of racialized attitudes in dating (...) are incomplete as practical criticisms of our behavior. Finally, we give our account of the moral reasons whites have to change their dating preferences when they exclude people of color. In doing so, we supplement existing discussions of race-based discrimination in dating. (shrink)

Video‐recording healthcare interactions provides important opportunities for research and service improvement. However, this method brings about tensions, especially when recording sensitive topics. Subsequent reflection may compel the researcher to engage in ethical and moral deliberations. This paper presents experiences from a South African genetic counselling study which made use of video‐recordings to understand communicative processes in routine practice. Video‐recording as a research method, as well as contextual and process considerations are discussed, such as researching one's own field, issues of trust (...) and anonymity, the challenge of providing true informed consent and capturing details which may cause psychological harm. Several recommendations for research practice in diverse healthcare settings are made. This includes the value of reflective pieces, the importance of retrospective consent, disclosure of the limitations to anonymity, as well as the collective responsibility of those involved to produce ethical research. These recommendations have value for genetic counselling and other healthcare fields. (shrink)

SUMMARYContemporary scholars seeking to advance the study of political phenomena identify their inquiry as a ‘science' that attains success through rigorous method. Thus the ‘methodological anarchism' of Paul Feyerabend's philosophy of science might seem an inauspicious place to find a fruitful disciplinary vision. Nonetheless, it echoes a longstanding conception of the ‘science' of politics articulated by Niccolò Machiavelli. Looking to Feyerabend, we propose to surmount the impasse between Machiavelli's account of politics and the demands of modern science and recover his (...) contribution to the scientific study of politics. In doing so, Machiavelli illustrates the potential of a Feyerabendian political science. (shrink)

Although scientific images have begun to receive significant attention from philosophers, one type of image has thus far been ignored: moving images. As techniques such as live cell imaging and videomicroscopy are becoming increasingly important in many areas of biology, however, this oversight needs to be corrected. Biologists often claim that there are relevant differences between video and static images. Most interesting is the idea that video images allow us to see causal relationships. By identifying the conditions that would be (...) required for this to be true and showing that they are not satisfied at the micro level, I will show that videomicroscopy does not provide us with special access to causal information. †To contact the author, please write to: Department of Philosophy, University of Calgary, 2500 University Dr. NW, Calgary, Alberta T2N 1N4; e-mail: mdelehan@ucalgary.ca. (shrink)

The topic of fake news has received increased attention from philosophers since the term became a favorite of politicians (Habgood-Coote 2016; Dentith 2016). Notably missing from the conversation, however, is a discussion of fake news and conspiracy theory media as a market. This paper will take as its starting point the account of noxious markets put forward by Debra Satz (2010), and will argue that there is a pro tanto moral reason to restrict the market for fake news. Specifically, we (...) begin with Satz’s argument that restricting a market may be required when i) that market inhibits citizens from being able to stand in an equal relationship with one another, and ii) this problem cannot be solved without such direct restrictions. Our own argument then proceeds in three parts: first, we argue that the market for fake news fits Satz’s description of a noxious market; second, we argue against explanations of the proliferation of fake news that are couched in terms of “epistemic vice”, and likewise argue against prescribing critical thinking education as a solution to the problem; finally, we conclude that, in the absence of other solutions to mitigate the noxious effects of the fake news market, we have a pro tanto moral reason to impose restrictions on this market. At the end of the paper, we consider one proposal to regulate the fake news market, which involves making social media outlets potentially liable in civil court for damages caused by the fake news hosted on their websites. (shrink)

In this target article by Morain and Largent (2023), the authors focus on an investigator’s duty to patient-subjects specifically regarding incidental or collateral findings within the context of e...

Nietzsche writes a preface to _The Gay Science_ in 1886, four years after its first four books were in print. In this address, he explains that he has _been ill_ and is _in recovery_. He diagnoses himself as having suffered from “romanticism.” Nietzsche warns that he will henceforth vent his malice on the sort of lyrical romantic sentimentalism from which he suffered. Nietzsche then undertakes to write an additional fifth book to the corpus, which he added in 1887—a year after (...) the above-referenced preface, thereby providing a _new_ end in departure from his previous romantic excursions of the initial four books of _GS_. I wish to trace how these claims—of illness and convalescence are related to what I argue is a major philosophical turn in Nietzsche’s thinking on the nature of reality and how reality matters to us—as value. In this essay, I will locate Nietzsche’s turn. To do so, I explain (1) what Nietzsche describes as “romantic pessimism,” that is, an epistemological dualism (i.e., assertion of an irresolvable appearance versus reality distinction). I will first explain and then show how Nietzsche suffers from this illness in the early books of _GS_, using textual examples to demonstrate his epistemological presuppositions and romantic-pessimistic preferences (which manifest as a defiant claim that fictions are preferred to reality, thereby still crediting an appearance-reality distinction); (2) how by his later book five of _GS_ Nietzsche plays a different tune by which prior dualisms dissolve in his affirmation of a co-implication of fiction and truth, such that (a) neither are wholly separate from the other, and (b) it becomes difficult if not impossible to distinguish between them. (shrink)

Object-oriented ontology (OOO) is a philosophy that asks us to step outside the human-centric view of the world to recognize that objects have realities of their own. Although we cannot directly access a thing-in-itself, we can still come to know something about it through an indirect access that Graham Harman suggests is provided by aesthetics, specifically the metaphor. In the metaphor, we step into the place of the object-in-itself (that withdraws) and experience a taste of its reality. This main purpose (...) of this article is to show that the visual arts—specifically Haim Steinbach’s art works—offer a different way to know objects. Steinbach “arranges” found objects on shelves; this emphasis on “arrangement” raises questions about the nature of the space between objects. I argue that it is this space between objects (rather than the indirect contact with objects) that grants us some access to the thing-in-itself. By relating the spaces between objects to silence, I show that it is in these spaces that objects speak. In other words, the theatricality of the metaphor Harman privileges for understanding the object only exists in a silence that emerges from the spaces between objects. (shrink)