Luigi Sacco (1769–1863) was the main protagonist of early vaccination campaign in Italy. He found a native source of vaccine lymph: with that, he personally vaccinated more than 500,000 people and furnished all Italy and some Middle East countries too. Starting from the pictures of his books, Sacco proposed to create wax models of real and spurious smallpox pustules in human, cow, sheep and horse; just to permit, not only to doctors, but also to all other health operators, the identification (...) of the right pustules from where to extract active lymph for vaccination. In the Museum of Pathological Anatomy of the Padua University Medical School, we have four anatomical waxes which corresponded exactly to the explicative pictures in 1809 Sacco’s treatise on Vaccine. We have found the same models also at the University of Milan, Pavia and Bologna—the main cities of Cisalpine Republic , the state of North Italy formed at the epoch of Sacco following the Napoleon conquest. The history of the diffusion of these models presented in this text will be a starting point to develop wider questions. In particular, this history could be useful to improve our understanding of the birth of scientific and experimental medicine through XIX and XX Century. (shrink)

The rise of molecular epigenetics over the last few years promises to bring the discourse about the sociality and susceptibility to environmental influences of the brain to an entirely new level. Epigenetics deals with molecular mechanisms such as gene expression, which may embed in the organism “memories” of social experiences and environmental exposures. These changes in gene expression may be transmitted across generations without changes in the DNA sequence. Epigenetics is the most advanced example of the new postgenomic and context-dependent (...) view of the gene that is making its way into contemporary biology. In my article I will use the current emergence of epigenetics and its link with neuroscience research as an example of the new, and in a way unprecedented sociality of contemporary biology. After a review of the most important developments of epigenetic research, and some of its links with neuroscience, in the second part I reflect on the novel challenges that epigenetics presents for the social sciences for a re-conceptualization of the link between the biological and the social in a postgenomic age. Although epigenetics remains a contested, hyped, and often uncritical terrain, I claim that especially when conceptualized in broader non-genecentric frameworks,. (shrink)

An analysis of how capitalism today produces subjectivity like any other “good,” and what would allow us to escape its hold. “Capital is a semiotic operator”: this assertion by Félix Guattari is at the heart of Maurizio Lazzarato's Signs and Machines, which asks us to leave behind the logocentrism that still informs so many critical theories. Lazzarato calls instead for a new theory capable of explaining how signs function in the economy, in power apparatuses, and in the production of (...) subjectivity. Moving beyond the dualism of signifier and signified, Signs and Machines shows how signs act as “sign-operators” that enter directly into material flows and into the functioning of machines. Money, the stock market, price differentials, algorithms, and scientific equations and formulas constitute semiotic “motors” that make capitalism's social and technical machines run, bypassing representation and consciousness to produce social subjections and semiotic enslavements. Lazzarato contrasts Deleuze and Guattari's complex semiotics with the political theories of Jacques Rancière, Antonio Negri and Michael Hardt, Paolo Virno, and Judith Butler, for whom language and the public space it opens still play a fundamental role. Lazzarato asks: What are the conditions necessary for political and existential rupture at a time when the production of subjectivity represents the primary and perhaps most important work of capitalism? What are the specific tools required to undo the industrial mass production of subjectivity undertaken by business and the state? What types of organization must we construct for a process of subjectivation that would allow us to escape the hold of social subjection and machinic enslavement? In addressing these questions, Signs and Machines takes on a task that is today more urgent than ever. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:FÉLIX MaRTÍNEZ-?????? TOWARDS A FORMAL ONTOLOGY OF FICTIONAL WORLDS In this discussion ' I propose a few concepts for the description and classification of fictional "worlds." The variety of fictional systems of"reality" can be understood, I diink, as an aspect ofthe phenomenon of style in literary imagination.2 But styles of imagination or of vision, and die style of literary works, are more than simply kinds of fictional worlds. To (...) put in some perspective my attempt at classification of literary works according to their systems of reality, I will make first a few remarks on the notion of style. It is a well-known preliminary problem when speaking of style diat this word seems to have more than one meaning in ordinary usage. I think that some ofits current meanings are rich and important, and that literary knowledge would profit if we could reconstruct them in abstract and defined concepts, so that the notions involved were somewhat clarified. I doubt diat diis is possible with current conceptual tools. We can see what is meant, say, when we hear diat a certain person we know "has style"; and we certainly distinguish diis attribute from others such as elegance, good manners, character, taste, originality, mannerisms, or idiosyncracies. Thus, we occasionally perceive in personal behavior a phenomenon called style. A conceptual description or a satisfactory definition of such a given, however, seems very difficult. Speaking of matters of art and literature, "style" has been used, among other things, to designate both the conventional forms of traditional expression (as in "manuals of style") and the anomalous, convention-breaking forms of highly individuated creation (as in die classic conception of Vosslerian-Spitzerian Stylistics, or in Buffon's "Le style c'est l'homme même," as usually understood). Style, dien, as conformity and style as singularity and deviance; style as impersonal decorum and as presence of a unique personal essence in the work. This perplexing ambiguity may be reducible though. Whether conventional and common or personal and innovative, style appears to be a form that characterizes and holds together a creation or a phenomenal entity. Indeed, the fact that 182 Félix Martínez-Bonati183 singular innovations of style often become the common trait of a school or current and sometimes a part of general tradition seems to indicate that neither singularity nor general acceptance are the most basic elements of die notion of style. On first reflection, we may conceive of style as a formal principle that consistently determines the constitution of die pertinent objects. Nonetíieless, constitutive form is too weak a definition for style, since it would also apply to what is called "technique" and even to genre. We must look for a more specific determination. There is anodier ambiguity in everyday uses of die word "style" diat deserves attention. We speak often of "good style" and "bad style." But sometimes we speak as if no style is bad and the thing that matters is to have style at all and as much of it as possible. Thus, we condemn a work because of its having no style or only a weak one. This contradiction probably derives from the confusion of a particular normative, a general normative, and a merely descriptive notion of style. We should keep, if possible, to a merely descriptive notion. Still another uncertainty of usage, in literary matters, relates to the (not universally accepted) restriction of the notion of style to a linguistic one; style, in this restricted usage, is seen as primarily an attribute of diction. The most numerous of literary studies of die style of singular works have been, so far as I can see, descriptions of idiolects. In many cases, the linguistic peculiarity is taken as an index of the world-view or die style of imagination diat is supposed to have produced the work. Alternative to this approach, indeed complementary, is the study of literary style as an attribute of die fictional entities to which literary discourse refers. We find the latter kind of approach mostly in characterizations of genres or of periods ("the naturalist novel," "romance," "classicism," etc.). One may suppose that an exhaustive analysis of the idiolect of a work... (shrink)

Questo saggio affronta la dottrina politica di S.N.H. Linguet, analizzando l’uso sistematico dei paradossi al suo interno. La critica dell’ideologia fisiocratica consente a Linguet di individuare il nesso tra scienza e politica quale fondamento dell’ideologia della società e della sua critica. La costellazione concettuale formata da proprietà, appropriazione, patrimonialismo e patriarcato stabilisce le coordinate della sua teoria politica dei concetti sociali. La categoria di rapporto sociale non esprime la coordinazione tra soggetti indifferenti, ma la subordinazione di alcuni individui al potere (...) sociale dei proprietari. La critica di Montesquieu, del suo concetto di legge e di dispotismo asiatico, conduce Linguet ad affermare la necessità di uno Stato burocratico che, grazie al suo diritto positivo sia in grado di governare i movimenti della proprietà che per Linguet è il centro reale del sistema politico. (shrink)

The debtor-creditor relation, which is at the heart of this book, sharpens mechanisms of exploitation and domination indiscriminately, since, in it, there is no distinction between workers and the unemployed, consumers and producers, working and non-working populations, between retirees and welfare recipients. They are all "debtors," guilty and responsible in the eyes of capital, which has become the Great, the Universal, Creditor.--from The Making of the Indebted Man Debt -- both public debt and private debt Has become a major concern (...) of economic and political leaders. In The Making of the Indebted Man, Maurizio Lazzarato shows that, far from being a threat to the capitalist economy, debt lies at the very core of the neoliberal project. Through a reading of Karl Marx's lesser-known youthful writings on John Mill, and a rereading of writings by Friedrich Nietzsche, Gilles Deleuze, Felix Guattari, and Michel Foucault, Lazzarato demonstrates that debt is above all a political construction, and that the creditor/debtor relation is the fundamental social relation of Western societies.Debt cannot be reduced to a simple economic mechanism, for it is also a technique of "public safety" through which individual and collective subjectivities are governed and controlled. Its aim is to minimize the uncertainty of the time and behavior of the governed. We are forever sinking further into debt to the State, to private insurance, and, on a more general level, to corporations. To insure that we honor our debts, we are at once encouraged and compelled to become the "entrepreneurs" of our lives, of our "human capital." In this way, our entire material, psychological, and affective horizon is upended and reconfigured. How do we extricate ourselves from this impossible situation? How do we escape the neoliberal condition of the indebted man? Lazzarato argues that we will have to recognize that there is no simple technical, economic, or financial solution. We must instead radically challenge the fundamental social relation structuring capitalism: the system of debt. (shrink)

Starting from a historical-juridical study of A. M. de Aldama on the origin and evolution of the reference to the teaching of Christian doctrine to pueri contained in the formula of final vows of all priests in the Society of Jesus, the author investigates the meaning of this ministry and its importance today. In an analytic section, the article traces the historical development of the ministry of education in Christian doctrine to pueri and rudes in the experience of Ignatius and (...) his first companions and in the foundational texts. The theme is treated above all in the light of some questions brought up by the historical data of the past and present. In conclusion the author seeks to reply synthetically to the questions, by showing some essential elements in the significance of the ministry of teaching Christian doctrine to children for an apostle in today's world. (shrink)

Résumé La généalogie du capitalisme amorcée par Foucault à la fin des années 70 ébranle ce que nous croyons savoir du libéralisme. Le constat d’Adam Smith conserve toute sa force : le politique (droits) et l’économie (intérêts) ne sont ni superposables, ni réconciliables. Le gouvernement libéral se propose d’y répondre. Englober et « passer par l’extérieur », telles sont ses tâches, et elles connaissent deux modalités d’application depuis lors, qui sont aussi deux techniques de normalisation. La première, prédominante, s’occupe du (...) gros : la discipline. La seconde, active et souterraine, s’occupe des détails : la sécurité. Elle cerne de plus près les multiplicités, la vie, les conduites. Une véritable politique des multiplicités supposerait, bien davantage encore, de passer « par l’extérieur » des agents que nous tenons pour naturels ou spontanés, mais qui sont l’objet d’un souci et d’une ré-institution constants : le marché, l’entreprise, le travailleur. (shrink)

In this paper I explore the heuristic limits ofhuman genetics, in particular the claim that itis possible to manipulate human germcells in a pre-ordinate way (Gordon, 1999). I arguethat this claim is unrealistic based ongenetic reductionism and a wrong concept ofgenetic diseases.

Nationalism and patriotism are two of the most powerful forces shaping world history. In this paperback edition of a highly successful, wide-ranging study, Maurizio Viroli shows exactly why patriotism is a political virtue and nationalism a political vice.

Sex robots are already a reality: in this provocative text, Maurizio Balistreri explores the fascinating world of future sex, exploring the ethical questions raised by the existence of a sex robot industry.

Our understanding of body–world relations is caught in a curious contradiction. On one side, it is well established that many concepts that describe interaction with the outer world – ‘plasticity’ or ‘metabolism’- or external influences on the body - ‘environment’ or ‘milieu’ – appeared with the rise of modern science. On the other side, although premodern science lacked a unifying term for it, an anxious attentiveness to the power of ‘environmental factors’ in shaping physical and moral traits held sway in (...) nearly all medical systems before and alongside modern Europe. In this article, I build on a new historiography on the policing of bodies and environments in medieval times and at the urban scale to problematize Foucault’s claim about biopolitics as a modern phenomenon born in the European eighteenth-century. I look in particular at the collective usage of ancient medicine and manipulation of the milieu based on humoralist notions of corporeal permeability (Hippocrates, Galen, Ibn Sīnā) in the Islamicate and Latin Christendom between the 12th and the 15th century. This longer history has implications also for a richer genealogy of contemporary tropes of plasticity, permeability and environmental determinism beyond usual genealogies that take as a starting point the making of the modern body and EuroAmerican biomedicine. (shrink)

Chapter 1st of the book. This chapter explores the fundamental ambiguity of the concept of plasticity – between openness and determination, change and stabilization of forms. This pluralism of meanings is used to unpack different instantiations of corporeal plasticity across various epochs, starting from ancient and early modern medicine, particularly humouralism. A genealogical approach displaces the notion that plasticity is a unitary phenomenon, coming in the abstract, and illuminates the unequal distribution of different forms of plasticities across social, gender, and (...) ethnic groups. Taking a longer view of the plastic body as a ubiquitous belief in traditions predating and coexisting with modern medicine will help contextualize the seeming radicalism of today’s turn to permeability and the exceptionalism of Western findings. By highlighting the complex biopolitical usages of plasticity in the past, the chapter warns against simplistic appropriations of the term in contemporary body/world configurations driven by findings in neuroscience, epigenetics and microbiomics. (shrink)

This book studies a central but hitherto neglected aspect of Rousseau's political thought: the concept of social order and its implications for the ideal society which he envisages. The antithesis between order and disorder is a fundamental theme in Rousseau's work, and the author takes it as the basis for this study. In contrast with a widely held interpretation of Rousseau's philosophy, Professor Viroli argues that natural and political order are by no means the same for Rousseau. He explores the (...) differences and interrelations between the different types of order which Rousseau describes, and shows how the philosopher constructed his final doctrine of the just society, which can be based only on every citizen's voluntary and knowing acceptance of the social contract and on the promotion of virtue above ambition. The author also shows the extent of Rousseau's debt to the republican tradition, and above all to Machiavelli, and revises the image of Rousseau as a disciple of the natural-law school. (shrink)

What did Thomas Jefferson look like? How did he carry himself? Such questions, reasonable to ask as we look back on a person who lived in an era before photography, are the starting point for this boldly original new work. Maurizio Valsania considers all aspects of Jefferson’s complex conception of "the body," from eighteenth-century clothing and fashion to manners, adornment, posture, gesture, and visual and material culture. Drawing also from the fields of medical science, psychology, and cultural anthropology, the (...) author conjures a vivid and detailed re-creation of the third president as a living, breathing--and pondering--human being. Having situated Jefferson in his own body, Valsania looks at the embodied Jefferson in the world of his fellow humans. Any one of the other people in Jefferson’s society--whether that other person was male or female, free or enslaved, African American or Native American--was a critical counterexample for the eighteenth-century Virginian to define himself against, and Valsania’s explorations here lead to numerous insightful discoveries about race, gender, and structures of power. The first comprehensive exploration of Jefferson’s corporeal world, Jefferson’s Body brings the man vividly to life for the modern reader while deepening our understanding of what it meant to Jefferson to be alive. (shrink)

In this article I defend two theses. The first is that the centrality of recording in the social world is manifested through the production of documents, a phenomenon which has been present since the earliest phases of society and which has undergone an exponential growth through the technological developments of the last decades. The second is that the centrality of documents leads to a view of normativity according to which human beings are primarily passive receptors of rules manifested through documents. (...) We are not intentional producers of values. The latter, as I shall suggest in my conclusion, should be viewed as being ‘socially dependent’ rather than ‘socially constructed’. (shrink)

This article sets the stage for a genealogy of the postgenomic body. It starts with the current transformative views of epigenetics and microbiomics to offer a more pluralistic history in which the ethical problem of how to live with a permeable body – that is plasticity as a form of life – is pervasive in traditions pre-dating and coexisting with modern biomedicine (particularly humoralism in its several ramifications). To challenge universalizing narratives, I draw on genealogical method to illuminate the unequal (...) distribution of plasticity across gender and ethnic groups. Finally, after analysing postgenomics as a different thought-style to genomics, I outline some of its implications for notions of plasticity. I argue that postgenomic plasticity is neither a modernistic plasticity of instrumental control of the body nor a postmodernist celebration of endless potentialities. It is instead closer to an alter-modernistic view that disrupts clear boundaries between openness and determination, individual and community. (shrink)

A history of colonization inflicts psychological, physical, and structural disadvantages that endure across generations. For an increasing number of Indigenous Australians, environmental epigenetics offers an important explanatory framework that links the social past with the biological present, providing a culturally relevant way of understanding the various intergenerational effects of historical trauma. In this paper, we critically examine the strategic uptake of environmental epigenetics by Indigenous researchers and policy advocates. We focus on the relationship between epigenetic processes and Indigenous views of (...) Country and health—views that locate health not in individual bodies but within relational contexts of Indigenous ontologies that embody interconnected environments of kin/animals/matter/bodies across time and space. This drawing together of Indigenous experience and epigenetic knowledge has strengthened calls for action including state-supported calls for financial reparations. We examine the consequences of this reimagining of disease responsibility in the context of “strategic biological essentialism,” a distinct form of biopolitics that, in this case, incorporates environmental determinism. We conclude that the shaping of the right to protection from biosocial injury is potentially empowering but also has the capacity to conceal forms of governance through claimants’ identification as “damaged,” thus furthering State justification of biopolitical intervention in Indigenous lives. (shrink)

There is a growing body of scholarship that is addressing the ethics, in particular, the bioethics of space travel and colonisation. Naturally, a variety of perspectives concerning the ethical issues and moral permissibility of different technological strategies for confronting the rigours of space travel and colonisation have emerged in the debate. Approaches ranging from genetically enhancing human astronauts to modifying the environments of planets to make them hospitable have been proposed as methods. This paper takes a look at a critique (...) of human bioenhancement proposed by Mirko Garasic who argues that the bioenhancement of human astronauts is not only functional but necessary and thus morally permissible. However, he further claims that the bioethical arguments proposed for the context of space do not apply to the context of Earth. This paper forwards three arguments for how Garasic’s views are philosophically dubious: (1) when he examines our responsibility towards future generations he refers to a moral principle (which we will call the principle of mere survival) which, besides being vague, is not morally acceptable; (2) the idea that human bioenhancement is not natural is not only debatable but morally irrelevant; and (3) it is not true that the situations that may arise in space travel cannot occur on Earth. We conclude that not only is the (bio)enhancement of humans on Earth permissible but perhaps even necessary in certain circumstances. (shrink)

In this book, Esposito presents a historiography of organicist and holistic thought through an examination of the work of leading biologists from Britain and America. He shows how this work relates to earlier Romantic tradition and sets it within the wider context of the history and philosophy of the life sciences.