The unfertilized sea urchin egg is a metabolically quiescent cell. Fertilization results in the activation of a variety of metabolic and biosynthetic pathways, including a 20‐ to 40‐fold increase in the rate of protein synthesis by 2 h after fertilization. This increase is regulated at a purely translational level without the need for new transcription. The greatest part of this increase is due to the translation of stored maternal mRNAs which were not translated in the egg. There is also a (...) 2‐to 3‐fold increase in the peptide elongation rate. The molecular and physiological mechanisms responsible for this activation process are beginning to be understood, and turn out to be much more complex than was anticipated. (shrink)

Considering The Third Man as an “entertainment” with “serious religious and ethical engagement,” this essay suggests the novel’s ultimate discrediting of the despair indicated by the desolate setting, postwar Vienna, and by Jansenist determinism. Two thematically crucial scenes address this despair: the visit to the office of Dr. Winkler, the cynical relic collector; and the interview between the protagonist and the charlatan Harry Lime, who has faked his own death, as they ride on the Great Wheel. “Both Lime’s speech (...) atop the Wheel and Winkler’s dismissal of the relics point the reader to the same interpretive enigma: bodies are nothing more than charnel or they are significant spiritual ‘clues.’” A comparison to the story “A Visit to Morin” shows how The Third Man forces a confrontation with the possibility of grace. (shrink)

This book addresses a range of relevant theoretical issues, including the possibility of an interpersonally comparable measure of well-being, or “utility” metric; the moral value of equality, and how that bears on the form of the social welfare function; social choice under uncertainty; and the possibility of integrating considerations of individual choice and responsibility into the social-welfare-function framework. This book also deals with issues of implementation, and explores how survey data and other sources of evidence might be used to calibrate (...) both a utility metric and a social welfare function, and whether distributive goals are ever best pursued through regulation rather than the tax system. In working through this range of theoretical and practical issues, the book draws from a wide variety of literatures, including philosophical scholarship on equality, responsibility, the nature of well-being, and personal identity over time; the social choice literature within economics; applied economic literatures concerning the measurement of inequality and poverty; legal and policy-analysis scholarship on cost-benefit analysis, environmental justice, and the choice between regulation and taxation; and the burgeoning field of “happiness studies”. (shrink)

This book explores how ancient philosophers, particularly Plato, Aristotle, the Stoics, and Sextus Empiricus, understood relativity and how their theories of the phenomenon affected, and were affected by, their broader philosophical outlooks.

'The men of culture are the true apostles of equality.' Matthew Arnold's famous series of essays, which were first published in book form under the title Culture and Anarchy in 1869, debate important questions about the nature of culture and society that are as relevant now as they have ever been. Arnold seeks to find out 'what culture really is, what good it can do, what is our own special need of it' in an age of rapid social change (...) and increasing mechanization. He contrasts culture, 'the study of perfection', with anarchy, the mood of unrest and uncertainty that pervaded mid-Victorian England. How can individuals be educated, not indoctrinated, and what is the role of the state in disseminating 'sweetness and light'? This edition reproduces the original book version and enables readers to appreciate its immediate historical context as well as the reasons for its continued importance today, in the face of the challenges of multi-culturalism and post-modernism. ABOUT THE SERIES: For over 100 years Oxford World's Classics has made available the widest range of literature from around the globe. Each affordable volume reflects Oxford's commitment to scholarship, providing the most accurate text plus a wealth of other valuable features, including expert introductions by leading authorities, helpful notes to clarify the text, up-to-date bibliographies for further study, and much more. (shrink)

In this paper I respond to Robert Taylor's argument that a Rawlsian framework does not support strong affirmative action programs. The paper makes three main arguments. The first disputes Taylor's claim that strong AA would not be needed in ideal conditions. Private racial discrimination, I suggest, might still exist in such conditions, so strong AA might be needed there. The second challenges Taylor's claims that pure procedural justice constrains Rawlsian nonideal theory. I argue that this rests on a fetishizing of (...) pure procedural justice that is absent from Rawls's work. I also show that a revised formulation of Taylor's concern here also fails. My third argument makes a positive Rawlsian case for strong AA in nonideal conditions that builds on a Taylor concession. Taylor suggests that the goal of nonideal theory is to create a world in which ideal theory can be applied. My argument begins by showing that another permissible goal of Rawlsian nonideal theory is to ameliorate injustice. I then argue that Rawls's contractualist framework supports the strongest forms of AA when category 3 interventions are blocked. (shrink)

Multiple acoustic dimensions signal speech categories. However, dimensions vary in their informativeness; some are more diagnostic of category membership than others. Speech categorization reflects these dimensional regularities such that diagnostic dimensions carry more “perceptual weight” and more effectively signal category membership to native listeners. Yet perceptual weights are malleable. When short-term experience deviates from long-term language norms, such as in a foreign accent, the perceptual weight of acoustic dimensions in signaling speech category membership rapidly adjusts. The present study investigated whether (...) rapid adjustments in listeners’ perceptual weights in response to speech that deviates from the norms also affects listeners’ own speech productions. In a word recognition task, the correlation between two acoustic dimensions signaling consonant categories, fundamental frequency and voice onset time, matched the correlation typical of English, and then shifted to an “artificial accent” that reversed the relationship, and then shifted back. Brief, incidental exposure to the artificial accent caused participants to down-weight perceptual reliance on F0, consistent with previous research. Throughout the task, participants were intermittently prompted with pictures to produce these same words. In the block in which listeners heard the artificial accent with a reversed F0 × VOT correlation, F0 was a less robust cue to voicing in listeners’ own speech productions. The statistical regularities of short-term speech input affect both speech perception and production, as evidenced via shifts in how acoustic dimensions are weighted. (shrink)

In 1460 Karl von Seckendorf sent the following note along with a manuscript that included a biblical commentary, the Postilla super epistulas dominicales by Matthias de Liegnitz, to an acquaintance.

I have vigorously absorbed the negative element of the age in which I live, an age that is, of course, very close to me, which I have no right ever to fight against, but as it were a right to represent. The slight amount of the positive, and also of the extreme negative, which capsizes into the positive, are something in which I have had no hereditary share. I have not been guided into life by the hand of Christianity – (...) admittedly now slack and failing – as Kierkegaard was, and have not caught the hem of the Jewish prayer shawl – now flying away from us – as the Zionists have. I am an end or a beginning.1. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Journal of the History of Philosophy 39.4 (2001) 603-604 [Access article in PDF] Irving Singer. George Santayana, Literary Philosopher. New Haven: Yale University Press, 2000. Pp. xiii + 217. Cloth, $25.00. In a prefatory comment, Irving Singer affirms that George Santayana, Literary Philosopher is "an introduction to the part of Santayana's philosophy that has meant the most to me" (xii). The locus of this personal interest, he goes on (...) to say, is in the "humanistic relevance" of Santayana's work. Singer's fruitful reflections on Santayana's literary genius, as well as the great philosopher's depth of critical insight with regard to aesthetics, literature, and love, all testify to this humanistic interest.Singer's examinations of Santayana's critical and fictional works are as accessible as they are interesting, a characteristic which alone recommends the book for readers interested in gaining an introductory understanding. Equally important however is the fact that Singer's reflections lend themselves to a much larger academic audience as well. Santayana's work is revealed, correctly, to be not only relevant to the philosophical community, but to contain contributional elements that are of interest to criticism in both literature and art.This does not mean that Singer avoids criticizing Santayana's philosophy. To the contrary, he levels a key criticism that begs response. Singer believes Santayana is incapable of accounting for interpersonal love. According to Singer, Santayana's deficiency in this regard is due to his belief that "[other] individuals are merely the vehicle [End Page 603] to some cherished ideal" (124). More specifically, Singer holds that Santayana's account of the realization of interpersonal love is restricted by an unnecessary dualism: the gratification of material desires (like Freud), and the distanced contemplation of an ideal (like Plato).This familiar dualism might be referred to as the "desire-renunciation" formula Santayana employs throughout his work in an attempt to pay equal respect to the material ground, and the contrasting ideal groundlessness of all things. For Santayana, the oscillation between desire and renunciation is so obviously reflected in individual aspirations, and in the general course of every human life that, for the philosopher, the task is not to attempt to justify one or the other, but to reconcile them. For Singer however, Santayana ultimately fails in this attempt: "...[Santayana's] attempt to unify Platonism and naturalism fails as philosophy..." (x). He charges that the structure of Santayana's philosophy "fails to show us how people can overcome the split between matter and spirit." Thus, Singer's divergence from Santayana derives from an overall rejection of the philosophical soundness of his work (favoring its humanistic appeal), and from his feeling that Santayana's philosophy never achieves the reconciliation it sets out as its goal. But these charges are unjust, and they seem to arise from an insufficient account of Santayana's doctrine of essence as it relates to his understanding of love.For Singer, "persons" rather than essences (or ideals) are the irreducible themes of human interest: "...loving is not the same as desiring. We desire things or persons for what they can give us, for satisfactions we hope they will provide. In loving anyone, however, we take an interest in that person, as a person and not just as a vehicle to something else" (91). But the implicit charge of this claim, namely, that Santayana's preference for essences as the irreducible themes of human interest results in the view that humans are incapable of loving persons-qua-persons (but only qua-essences), is simply wrong; and, importantly, reflective of a misunderstanding of Santayana's doctrine of essence.Santayana is consistent in his affirmation that in youth, when the demand to act is acute, it is sane to cry and to beat one's fists against the world, while with time and experience, such heated displays become tragic and even unbecoming. The same is true for Santayana with respect to love. It is wisdom reflective of the love of all things to laugh (ironically) at what was in youth an irremediable demand for the love of particular... (shrink)

Cost-benefit analysis is a widely used governmental evaluation tool, though academics remain skeptical. This volume gathers prominent contributors from law, economics, and philosophy for discussion of cost-benefit analysis, specifically its moral foundations, applications and limitations. This new scholarly debate includes not only economists, but also contributors from philosophy, cognitive psychology, legal studies, and public policy who can further illuminate the justification and moral implications of this method and specify alternative measures. These articles originally appeared in the Journal of Legal Studies. (...) Contributors: - Matthew D. Adler - Gary S. Becker - John Broome - Robert H. Frank - Robert W. Hahn - Lewis A. Kornhauser - Martha C. Nussbaum - Eric A. Posner - Richard A. Posner - Henry S. Richardson - Amartya Sen - Cass R. Sunstein - W. Kip Viscusi. (shrink)

Contenu : Analyse des faits de société (famille, emploi, justice, liberté, amour et amitié, démocratie, violence, institutions...) - Recherche de raisons et de critères, causes et conséquences - Moyens de remédiation - Qualité du dialogue, du jugement.

Recently, many philosophers of religion have sought to defend the rationality of religious belief by shifting the burden of proof onto the critic of religious belief. Some have appealed to extraordinary religious experience in making their case. Religious Experience, Justification, and History restores neglected explanatory and historical considerations to the debate. Through a study of William James, it contests the accounts of religious experience offered in recent works. Through reflection on the history of philosophy, it also unravels the philosophical use (...) of the term justification. Matthew Bagger argues that the commitment to supernatural explanations implicit in the religious experiences employed to justify religious belief contradicts the modern ideal of human flourishing. (shrink)

Acts of interpersonal moral address depend upon a shared space of social visibility in which human beings can both display themselves and perceive others as morally important. This raises questions that have gone largely undiscussed in recent philosophical work on moral address. How does the social mediation of interpersonal perception by forces such as ideology shape and limit the possibilities for moral address? And how might creative acts of putting oneself on display make possible unanticipated forms of moral address, especially (...) under ideological conditions? In this paper, I propose that we can make progress towards answering such questions by treating moral address as a fundamentally aesthetic phenomenon. I begin by drawing examples from literature that invite the idea that humans and animals possess ethically value-laden features that are open to empirical view, and argue that approaches to moral address that do not avail themselves of this idea face serious limits, focusing on Stephen Darwall’s The Second-Person Standpoint. I then illustrate the role of the aesthetic in moral address by offering a reading of the “Capitol Crawl,” a 1990 direct action in which people with disabilities left behind assistive devices in order to ascend the stairs leading to the US Capitol. Drawing from some ideas in Iris Murdoch, I argue that the aesthetically striking features of this collective act of moral address are inseparable from the moral demands it expresses, and that, read as an aesthetic whole, its morally expressive power extends beyond the discursive while nevertheless remaining a part of the space of reasons. (shrink)

When Saint Thomas Aquinas makes claims such as “that which is not just seems to be no law at all” it is a bit difficult to discern what he means. Some think that Aquinas is defending what is now called the Strong Natural Law Thesis: for all X, X is a law only if X is just. Others think that Aquinas is defending what is now called the Weak Natural Law Thesis: for all X, X is a non-defective law only (...) if X is just. In this paper, focusing on Aquinas’s metaphysics, I argue that both of these interpretations are mistaken. Aquinas is primarily defending what we can call The Metaphysical Natural Law Thesis: since being and goodness are convertible, legal validity comes in degrees—and this entails that the justice of a law literally increases the amount of being a law possesses, while the injustice of a law literally decreases the amount of being a law possesses. On this interpretation, then, the injustice of a law entails an ontological attenuation of the law without entailing an ontological annihilation of the law. (shrink)

This paper stages an argument in five premises:1. That the insight to which post-structuralist ethics responds—which is that there is an 'unmistakableparticularity of concrete persons or social groups'—leads theorists who base their moral theory upon itinto a problematic parallel to that charted by Kant in his analysis of the sublime.2. That Kant's analysis of the sublime divides its experience into what I call two 'moments', the secondof which involves a reflexive move which the post-structuralists are unwilling to sanction in theontological (...) and/or ethical realm, even if they are performatively committed to doing it.3. That, drawing on the parallel established in 1, it could be argued that the same reflexive move asKant describes in the second 'moment' of the sublime is also at the heart of our moral experience,wherein we are faced by the Otherness of concrete Others. This amounts to the argument that askingOthers to follow an impersonal or 'dumb' law which fails to do justice to their noumenal Otherness is atthe same time the only possible way to respect this Otherness.4. That what game theory shows us is that, at thelimits of our ability to calculatively predict the conduct of other subjects, the only 'rational' thing to dois precisely to presume the pre-existence of impersonal social norms regulating our own conduct andthat of others.5. That, accordingly, to borrow a formulation from Slavoj Zizek, respect for theOther is always respect for their ‘castration’—that is, respect for their capacity to follow norms that do not directly do justice to their concrete particularity but which, in this very 'dumbness', let this Otherness indirectly show itself.In the conclusion, I reflect on what this argument does, and upon its limits—that is, what it does not. (shrink)

Taxonomy is undeniably central to science — indeed, some see taxonomy as prerequisite to scientific theorizing. But what are taxonomies about? Are taxonomies discoveries or inventions? Has the world an objective, monistic structure — natural kinds or, to use Plato’s metaphor, joints along which true scientific theories carve? Controversy surrounding these issues has been at the heart of important debates in the philosophy of science, metaphysics, and the philosophy of language.

This paper argues for a rehabilitation of philosophical engagement with the question of whether revolution can be justified. Such a renewed engagement with the problem of revolution appears to be stymied by the intuition that we have strong moral arguments ruling out revolution in almost every case. I aim to show that we should abandon this intuition. I will argue that standard arguments against revolution are not strong enough to warrant the relative inattention the question of the justifiability revolution has (...) recently suffered, especially given the emergence of new potential justifications for revolution (appeals to principles of distributive justice, appeals to the international human rights regime) and the subtle but important shifts that we ought to make in our conceptions of sovereignty and revolution. Accordingly, this paper sketches six forms of argument against the justifiability of revolution. I assess each form of argument and I conclude that none of them are strong enough to makes further philosophical inquiry into the justification of revolution pointless. (shrink)

Stage theory is the metaphysical view that everyday objects like you and the Eiffel tower are stages—instantaneous temporal parts. Existing defenses of stage theory by Katherine Hawley and Ted Sider quite explicitly include certain semantic claims. Thus Sider says that stages are.

The general issue addressed in this dissertation is: what do the models of formal model-theoretic semantics represent? In chapter 2, I argue that those of first-order classical logic represent meaning assignments in possible worlds. This motivates an inquiry into what the interpretations of first-order quantified model logic represent, and in Chapter 3 I argue that they represent meaning assignments in possible universes of possible worlds. A possible universe is unpacked as one way model reality might be. The problem arises here (...) as to how we are to understand the distinction between the actual and the possible as it relates to modal reality. ;Along with the development of the main arguments in Chapters 2 and 3, the dissertation assesses the status of semantic accounts or logical properties and relations. Specifically, what does the model-theoretic account of a logically possible situation add to the syntactic account ? ;Proofs of invalidity in terms of the models of formal semantics do not establish that it is possible for the premises to be true and the conclusion false, since a formal model is merely given by a consistent set of sentences. Unless there is some way to generate a non-formal model from a formal one, such proofs do not really go beyond syntactic notions. The dissertation ends by concluding that there is no way to generate a non-formal model from a formal one without relying on logical intuitions that are syntactical. ;Hence efforts to construct a semantic basis for model logic independent of syntactic commitments are misguided. However, in classical logic the independence of the semantic account from the syntactic one is grounded on the intuition that it is metaphysically possible for there to be a denumerably infinite totality of objects. (shrink)

_Published by Taylor & Francis Group for the American Association of Colleges for Teacher Education_ This _Handbook_ addresses the concept and implementation of technological pedagogical content knowledge -- the knowledge and skills that teachers need in order to integrate technology meaningfully into instruction in specific content areas. Recognizing, for example, that effective uses of technology in mathematics are quite different from effective uses of technology in social studies, teachers need specific preparation in using technology in each content area they will (...) be teaching. Offering a series of chapters by scholars in different content areas who apply the technological pedagogical content knowledge framework to their individual content areas, the volume is structured around three themes: What is Technological Pedagogical Content Knowledge? Integrating Technological Pedagogical Content Knowledge into Specific Subject Areas Integrating Technological Pedagogical Content Knowledge into Teacher Education and Professional Development The _Handbook of Technological Pedagogical Content Knowledge for Educators_ is simultaneously a mandate and a manifesto on the engagement of technology in classrooms based on consensus standards and rubrics for effectiveness. As the title of the concluding chapter declares, "It’s about time!" The American Association of Colleges for Teacher Education is a national, voluntary association of higher education institutions and related organizations. Our mission is to promote the learning of all PK-12 students through high-quality, evidence-based preparation and continuing education for all school personnel. For more information on our publications, visit our website at: www.aacte.org. (shrink)

Elliot Eisner notes, “The kinds of nets we know how to weave determine the kinds of nets we cast. These nets, in turn, determine the kinds of fish we catch.”1 Sound studies is a recently emerged interdisciplinary field that draws upon the social sciences and humanities in support of a broad range of inquiry into music and sound. Weaving new approaches that cast interesting questions that yield fascinating catches, sound studies has much to offer those looking to expand or challenge (...) their conceptions of music and sound—particularly educators who wish to hear the world anew while helping others to grow meaningfully with music. This article presents an overview of the field with particular attention to those actual... (shrink)

Aquinas says that faith is belief about things one does not “see” for oneself. But if you do not see it for yourself, what makes your belief reasonable? Recent interpreters have missed a key part of Aquinas’s answer, namely, that faith is believing God (credere Deo). In other words, they have not given sufficient attention to the formal object of faith. As a result, they overemphasize other parts of his answer. Drawing partly on recent epistemology of testimony, I explain how (...) the formal object of faith contributes to the justification of one’s faith. (shrink)

In recent years an increasing number of moral theorists have come to embrace the term "moral pluralism" to describe a particular kind of moral theory. Unfortunately, there has been little consensus regarding what exactly constitutes a pluralistic theory, and what specific commitments such theories involve. My dissertation takes on the task of articulating the underlying schema of pluralist moral theory, and of analyzing the plausibility and implications of pluralism's fundamental commitments. I argue that the most thoroughgoing pluralist theories are shaped (...) by two defining theses; the plurality of the good , and the plurality of the right , and that these are conceptually linked by two additional meta-ethical commitments. My analysis of the plausibility of these commitments is at times friendly to moral pluralism and at times critical of it. For instance, I develop an account of "value incommensurability," an idea upon which pluralism depends, that resists some of more the important attacks within the literature. Yet I also criticize the commitment to the plurality of the right, as held by Susan Wolf and several other pluralists. I argue that this view is less plausible than "limited pluralism"---a view that is pluralistic about the good but monistic about the right. In the final chapter I explore the relationship between moral pluralism and political liberalism, focusing on the role that overriding values play within each type of theory. (shrink)

While it is often thought that pluralism is best accommodated by a liberal state, John Kekes has recently argued that pluralism and liberalism involve inconsistent commitments. He maintains that liberalism is committed to the idea that one or more of the “liberal values” must override all other values, while pluralism is committed to the idea that there are no overriding values whatsoever. In this paper I challenge Kekes' position by arguing that ethical pluralism does not require an absence of overriding (...) values, and that liberalism does not require that one or more of the liberal values must override all others. (shrink)