This collection provides a complete version of Shelley's masterpiece Frankenstein as well as her short fiction and letters.

This article considers why individuals take beyond their own needs at the cost of others. Within the context of negotiations, a story is employed in framing an examination of the advancement of self–interest over connections of interdependence and civic membership. Forces of natural predisposition and environment are juxtaposed to formulate an understanding of the struggle involved in acting ethically. Notions of distributive and procedural justice are discussed with respect to claims of American citizenship, religious right, and the centrality of (...) happiness, resulting in a call for the substantive justice of interest–based negotiation. (shrink)

Scientists of the Human Genome Project tend to rely on three metaphors to describe their work, each of which implicitly tells much the same story. Whether they claim to interpret the ultimate "book," to fix a flawed "machine," or to map a mysterious "wilderness," they invariably cast the researcher as one who dominates and exploits the Other. This essay, which explores the ways such a story conflicts with feminist values, proposes an alternative.

The essentialism story is a version of the history of biological classification that was fabricated between 1953 and 1968 by Ernst Mayr, who combined contributions from Arthur Cain and David Hull with his own grudge against Plato. It portrays pre-Darwinian taxonomists as caught in the grip of an ancient philosophy called essentialism, from which they were not released until Charles Darwin's 1859 Origin of Species. Mayr's motive was to promote the Modern Synthesis in opposition to the typology of idealist (...) morphologists; demonizing Plato served this end. Arthur Cain's picture of Linnaeus as a follower of 'Aristotelian' (scholastic) logic was woven into the story, along with David Hull's application of Karl Popper's term, 'essentialism', which Mayr accepted in 1968 as a synonym for what he had called 'typological thinking'. Although Mayr also pointed out the importance of empiricism in the history of taxonomy, the essentialism story still dominates the secondary literature. The history of the first telling of the essentialism story exposes its scant basis in fact. (shrink)

"Jada's working on her science project. She's finding out whether plants grow best in water, milk, juice, or soda. There's just one problem--she keeps getting interrupted. From her cousin texting and her friends stopping by to her little brother playing with the plants, Jada runs into one obstacle after another. Find out how [she] relies on grit to keep on going"--Back cover.

So in literature we have two (perhaps identical) syntactically articulate vocabularies, the terms of each taking the terms of the other as referents, with both of the resultant systems — the one a system of denotation, the other of exemplification — being syntactically articulate and semantically dense. Thus, even though a literary work is articulate and may exemplify or express what is articulate, endless search is always required here as in other arts to determine precisely what is exemplified or expressed.

This issue of Business & Society contains the transcripts of 12 oral history interviews with founders of and early contributors to the business and society/social issues in management field. The publication of these interviews is the culmination of a very long-term project, with the first interview having been conducted in 1993 with Lee Preston and the most recent interview having been conducted in 2011 with Jim Post. This project has been very much of a team effort with Sandra Waddock, John (...) Steiner, Mary Mallott, Ariane Berthoin Antal, and, of course, our interviewees all playing important roles. (shrink)

Stories represent lived experiences as they have happened or as they could have happened. According to Paul Ricoeur, the difference between historical and fictional stories is narratively speaking not very significant; all stories follow a plot. The construction of the plot, selects, values, and connects different events – whether factual or fictional – in such a way that they follow a logical line towards a meaningful end. The line of events gathers together the different actors, times, places, figures, and themes (...) in the story. The story-teller and listener follow that line. In that receptive act, however, other stories will resonate with this story, which will add to the meaning of... (shrink)

Mary Midgley argues in her powerful new book that far from being the opposite of science, myth is a central part of it. In brilliant prose, she claims that myths are neither lies nor mere stories but a network of powerful symbols that suggest particular ways of interpreting the world.

Reading the Shape of Nature vividly recounts the turbulent early history of the Museum of Comparative Zoology at Harvard and the contrasting careers of its founder Louis Agassiz and his son Alexander. Through the story of this institution and the individuals who formed it, Mary P. Winsor explores the conflicting forces that shaped systematics in the second half of the nineteenth century. Debates over the philosophical foundations of classification, details of taxonomic research, the young institution's financial struggles, and (...) the personalities of the men most deeply involved are all brought to life. In 1859, Louis Agassiz established the Museum of Comparative Zoology to house research on the ideal types that he believed were embodied in all living forms. Agassiz's vision arose from his insistence that the order inherent in the diversity of life reflected divine creation, not organic evolution. But the mortar of the new museum had scarcely dried when Darwin's Origin was published. By Louis Agassiz's death in 1873, even his former students, including his son Alexander, had defected to the evolutionist camp. Alexander, a self-made millionaire, succeeded his father as director and introduced a significantly different agenda for the museum. To trace Louis and Alexander's arguments and the style of science they established at the museum, Winsor uses many fascinating examples that even zoologists may find unfamiliar. The locus of all this activity, the museum building itself, tells its own story through a wonderful series of archival photographs. (shrink)

This qualitative study explores how business leaders narrate their personal ways of recognizing, reasoning, and resolving moral conflicts and what these stories reveal about their moral identity processes within organizational contexts. Based on interviews with 25 business leaders, 4 moral identity statuses were identified: achievement, moratorium, foreclosure, and diffusion. The moral identity statuses were based on how leaders approached and interpreted moral conflicts and what the influence of the organizational context was in their moral decision-making processes. Some remained steadfast in (...) adhering to their previous value commitments, while others tried to avoid taking any clear moral standpoint. Still others experienced moral conflicts as disequilibrating events that triggered reflective processes and developmental cycles of moral identity change. These moral identity statuses hold implications for facilitating moral identity development among business leaders in the context of work. (shrink)

The current picture of the history of taxonomy incorporates A. J. Cain's claim that Linnaeus strove to apply the logical method of definition taught by medieval followers of Aristotle. Cain's argument does not stand up to critical examination. Contrary to some published statements, there is no evidence that Linnaeus ever studied logic. His use of the words “genus” and “species” ruined the meaning they had in logic, and “essential” meant to him merely “taxonomically useful.” The essentialism story, a narrative (...) that has most pre-Darwinian biologists steeped in the world view of Plato and Aristotle, is ill-founded and improbable. (shrink)

In Helen Bannerman’s Little Black Sambo, the text describes its main character as witty, brave, and resourceful. The drawings of the story’s main character which accompany this text, however, present a unique kind of harm that only becomes clear when the work is read as a collection of single-panel comics rather than an illustrated book. In this chapter, I show what happens when we read drawings in books as textless comics, and, based on how things turn out from this (...) reading, motivate why we have some substantive reason to read both Little Black Sambo and other books with drawings-as-comics. (shrink)

This paper is primarily an attempt to study the Homeric evidence on houses, particularly on the , in relation to the relevant remains. The reverse procedure, illuminating the archaeological evidence by references to Homer, is a hazardous one, as we shall see. It is often unclear just what is represented by the descriptions in the poems, and what period, if any, the things described belong to. I shall be concerned with these questions here. Are the houses in the poems Mycenaean: (...) genuine traditions from the period in which the stories are set? Or are they Geometric: contemporary? Or a memory of some time in between? Or a mixture? We know so little about the development of the epic tradition that any possible source of information is worth pursuing. (shrink)

Liana Badr's The Eye of the Mirror explores the historical trauma of the 1975–6 siege of the Palestinian refugee camp Tal el–Zaatar in Beirut and the massacre of thousands of its inhabitants by Christian militias. Analogous to Holocaust writing, Badr's fictionalized history, grounded in actual survivor testimonies, enacts a complex politics of cultural memory, but does so from a specifically female perspective. Collapsing the personal and political, private and public, inside and outside through figured violations of bodies and psyches, Badr (...) repositions women at the centre of the Palestinians’ struggle for and story of survival. Badr's novel traces the annihilation of the possibility of address, accompanied by self–loss and the ability to witness, and the laborious recreation of address. Claiming authority on the basis of the emotional, visceral truth of suffering, she seeks to break the endless cycle of an oppressive and impotent masculine history, constructing an alternative history which at least attempts to address the voice of cultural, national, and gender difference. (shrink)

"Charming, interesting, thought-provoking and a great read." Rosalind Hursthouse The daughter of a pacifist rector who answered "No!" when his congregation asked him "Is everything in the bible true?", perhaps Mary Midgley was destined to become a philosopher. Yet few would have thought this inquisitive, untidy, nature-loving child would become "one of the sharpest critical pens in the west." This is her remarkable story. Probably the only philosopher to have been in Vienna on the eve of its invasion (...) by Nazi Germany in 1938 and dance in Trafalgar Square on VE day seven year later, she studied philosophy at Oxford in the same year as Iris Murdoch, Elizabeth Anscombe and Philippa Foot, all of whom became close friends. Midgley tells us in vivid and humorous fashion how they cut a swathe through the arid landscape of 1950s British philosophy, writing and arguing - often with each other - about the grand themes of character, beauty and the meaning of rudeness while the spectral figure of Ludwig Wittgenstein hovered in the background. She also charts the highs and lows of philosophy and academia in Britain. On joining the Reading philosophy department on £400 a year in 1949, she doubled its staff complement. But her many years at Newcastle University - where Mike Brearley, who later captained England at cricket, also used to teach - were rewarded with the closure of the philosophy department in the 1980s. The mother of three children, her journey is also one of a woman who in the 1950s and 1960s was fighting to combine a professional career with raising a family. In startling contrast to many of the academic stars of her generation, we learn that Midgley nearly became a novelist and started writing philosophy only when in her fifties, suggesting that Minerva's owl really does fly at dusk. Plainly told like her philosophy, this is an elegiac and moving account of friendships found and lost, bitter philosophical battles and of a profound love of teaching all too rarely acknowledged today. (shrink)

The principles of the Earth Charter and the cosmological story of Journey of the Universe provide a unique synergy for rethinking a sustainable future. The Great Story inspires the Great Work of the transformation of the political, social, and economic orders. Such a synergy can contribute to the broadened understanding of sustainability as including economic, ecological, social, and spiritual well-being. This integrated understanding may be a basis for creating biodemocracies, which will involve long-term policies, programs, and practices for (...) a planetary future that is not only ethically sustainable, but also sustaining for human energies. (shrink)

Cresp, Mary; Tranter, Janice Entanglements were part of Julian Edmund Tenison Woods' life from the time of his birth in London on 15 November 1832. His mother, Henrietta Tenison, daughter of a Church of Ireland rector, had several relatives in the Anglican clergy, including Thomas Tenison, Archbishop of Canterbury, and Edmund Tenison, Bishop of Ossory. Julian's father, James Dominic, was the son of a Cork businessman and studied law in Ireland. He was Catholic, but not practising during his working (...) years. James and Henrietta married in London, raising their family there. James joined 'The Times' as parliamentary reporter; their home was a centre for Irish writers, newspaper men and those in the medical and legal professions. His brother, Nicholas, following duty as surgeon with the East India Company Civil Service, joined the Woods household with his two daughters after his wife's death. Stories of India and his uncle's collections of 'curiosities of various kinds' fascinated Julian and 'served to form [his] taste for natural history'. (shrink)

Being diagnosed with a disease is like being thrust onto a new path, a biographical bifurcation akin to a mourning process, bringing in its wake a shattering of the social self. The passage from an ideal of perfect health to a state of illness introduces various fractures into the individual's life course, leading to a process of biographization. To illustrate this, the life story of a diabetic person is used to analyze various biographical turning points. The analysis of the (...) subjectivation process highlights different reconstructions of the self through the experience of therapeutic education, seen as a relational space of in-between identities. (shrink)

In her paper Expelled Again from Eden: Facing Difference through Connection, delivered in Plymouth in 1998, Mary Grey said the story of the Garden of Eden was a dilemma for Feminist Theologians. This because it both bears responsibility for the Fall of relationship between God and Man and the misogyny that has ensued through the ages but also underpinning the desire to return to a supposed golden age of matriarchy with the re-emergence of the Goddess and a related (...) ecological and egalitarian epoch of harmony. Grey makes a connection between the Lost Garden myth and the second wave feminist ideal of global sisterhood of the 1960s. Reflecting on her paper and updating it later, Grey concluded she still felt the challenge of years ago: the sense of rightness of connection and mutuality, yet the crucial need to embrace difference. (shrink)

Introduction/Background: Moral distress and related concepts surrounding morality and ethical decision-making have been given much attention in nursing. Despite the general consensus that moral distress is an affective response to being unable to act morally, the literature attests to the need for increased clarity regarding theoretical and conceptual constructs used to describe precisely what the experience of moral distress involves. The purpose of this study is to understand how student nurses experience morally distressing situations when caring for patients with different (...) values and beliefs than their own in the clinical environment -/- Methods: This study is based on secondary analysis of participant data. The stories of eight student nurses who completed the original study were reviewed following Yin’s multiple-case study design. -/- Results: Findings suggest there is a subtle form of moral distress that has been under appreciated in the literature and differs from Jameton’s classic definition. While traditional institutional triggers to moral distress are pervasive, personal conflict as a result of differing value systems may be a moral challenge faced by nursing students working with culturally diverse patients. -/- Conclusion: Ethics education is needed in nursing school to reduce moral distress in the clinical environment. Nursing students need opportunities to develop moral reasoning skills in addition to their clinical skills. A philosophical approach to ethics education may be needed to prevent and alleviate moral distress. (shrink)

In “The Mind Incarnate” Shapiro argues that research in the area of embodied, embedded mind and cognition undermines a functionalist program. In contrast Clark, in “Pressing the Flesh”, argues that embodied, embedded approaches can be viewed as extended functionalistic approaches. In the light of these arguments my thesis is devoted to elucidating the logical relation between functionalism and embodied, embedded approaches. I argue that the functionalist programme is not undermined by embodied and embedded approaches. Shapiro argues that research of embodied, (...) embedded cognition and mind shows that characteristics of embodiment determine characteristics of mind. I label this view the body-detail model. The consequence of this model is that the very same kind of mind cannot exist in bodies with different characteristics. Thus, having a humanlike mind requires a humanlike body. This conflicts with abstract versions of functionalism that endorse multiple realization: the idea that the same mind can exist in different kinds of bodies. I argue against the body-detail model, demonstrating that for each of the research projects presented by Shapiro the strong reading that one has to have a humanlike body to have a human mind is not justified. This paves the way for an alternative reading, represented by Clark, under which the body is recognized as being part of a larger system which overall operating profile determines mind. Arguments for this position involve argumentative extensions of functionalism. On this basis I conclude that functionalism is not undermined by embodied, embedded approaches. (shrink)

The aim of this article is to elucidate how nurses are positioned in Canadian news stories regarding their salaries. While the image of nursing in mass media has been widely studied, few studies explore how nurses are constructed in news stories. Drawing on ideas from institutional ethnography together with discourse analysis, this discussion highlights public textual discourses about nurses’ salaries in Canadian news stories. The media discourse was found to distort the issues by focusing attention on nurses. Recognizing how these (...) textual distortions mediate and construct messages is important in understanding how nurses and their work are constructed in the media. This discussion seeks to inform readers about how nurses are situated within commonly circulated discourses in the media. It also seeks to contribute to the literature about the nurse's image and how nurses and their work are portrayed in the public realm. It concludes by recommending increased awareness about how nurses are talked about in mass communication and the need to disrupt these messages and their underlying assumptions. (shrink)

Silence in court: the devaluation of the stories of nurses in the narratives of health lawThis paper sets out to address one of the major findings from an extensive analysis of case law involving nurses from 1904 to 1999. The 180 cases were collected from the civil, coronial, professional and industrial jurisdictions of Australia, Canada and the UK. It specifically examines the way in which nurses’ voices and experiences are excluded from legislation and case law, and the resultant effect which (...) this has on the status of the nurse in clinical and healthcare decision‐making. It addresses two of the many issues which emerged from the research, but which are particularly problematic for nurses. The first is that doctors are not necessarily required to heed the clinical concerns of nurses, and the second is that nurses are not necessarily expected to intervene to prevent imminent harm to the patient. This paper also suggests some possible solutions to these issues. (shrink)

Increasingly, stories are emerging about businesses that engage in ethical behaviors above and beyond mere compliance with regulations. These positive deviations along the ethical continuum provide an opportunity to explore how some companies’ business philosophy leads them to pursue an array of outcomes beyond the bottom line. This paper presents a case study of Green Mountain Coffee Roasters, the leading ethical company in the U.S. as rated by Forbes magazine, exploring the company culture and operating philosophy from a perspective of (...) the author calls conscientious capitalism, a paradigm based on three interdependent assumptions: interconnectedness, holistic wealth, and multiple generations of time. Considerations discussed for future research. (shrink)

Nick Joaquin, one of the Philippines’ pillars of literature in English, is regrettably known locally for his nostalgic take on the Hispanic aspect of Philippine culture. While Joaquin did spend a great deal of time creatively exploring the Philippines’ Hispanic past, he certainly did not do so simply because of nostalgia. As recent studies have shown, Joaquin’s classic techniques that often echo the Hispanic influence on Philippine culture may also be considered as a form of resistance against both the American (...) neocolonial influence and the nativist brand of nationalism in the 1950s and 1960s. Despite the emergence of Gothic criticism in postcolonial writing, Joaquin’s works have rarely received the attention they deserve in this critical area. In this context, this paper explores the idea of the Gothic in Joaquin’s writing and how it relates to Joaquin being the “most original voice in postcolonial Philippine writing.” In 1972, the University of Queensland Press featured Joaquin’s works in its Asian and Pacific writing series. This “new” collection, Tropical Gothic, contained his significant early works published in Prose and Poems plus his novellas. This collection’s title highlights a specific aspect of Joaquin’s writing, that of his propensity to use Gothic tropes such as the blending of the real and the fantastic, or the tragic and the comic, as shown in most of the stories in the collection. In particular, I examine how his novella interrogates the neurosis of the nation—a disconnection from the past and its repercussions on the present/future of the Philippines. (shrink)

The French botanist Michel Adanson spent five years in precolonial Senegal in the 1750s, under the auspices of the Compagnie des Indes. This essay follows the archival traces of Adanson’s engagement with African indigo, including experiments conducted in an ad hoc “laboratory” near the French fort of Saint Louis. A reconstruction of these experiments exposes the multifarious connections to and from the island garden-laboratory, mediated by materials and different kinds of indigo knowledge, including that of local Wolof informants. A microhistory (...) of encounters in and around a tiny island off the West African coast merges with a transatlantic story connecting Senegal to Paris and to French colonies in the Caribbean (Saint-Domingue and Guyana). The essay explores geographies of knowledge and French imperial ambitions through close attention to the material properties of indigo, the practices associated with its cultivation and transformation from plant to dye, and the material remnants of Adanson’s engagement with it in Africa. These remnants—herbarium sheets, experimental notes, color samples on paper strips, dyed fabric swatches, sketched maps, correspondence, collection catalogues, and plant taxonomies—put various kinds of African knowledge and Caribbean plantation experience into dialogue with European botany and dye chemistry. (shrink)

Growing research evidence on the ethic of care suggests that caring should be an integral part of the pedagogical methods implemented in schools. However, the colour blind ‘community of care’ often described in the literature does not disaggregate lines of ethnicity or race and much of this existing literature concerns elementary‐ and middle‐school students. This phenomenological study examined teacher care for African American secondary students, through a theoretical lens of critical race and care theory, as it was represented through the (...) counter stories of eight ‘successful’ African American teachers. Findings revealed that teachers’ definitions and perceptions of care reflected a blend of traditional care literature, critical race theory and the literature on African American teachers before and after the US Supreme Court’s landmark Brown decision on integration. Findings also reveal the possibility of a pedagogy that I refer to as ‘culturally relevant critical teacher care’. (shrink)

Entre tradiciones y procesos de transformación, asistimos a una poética del pensar del poema extenso en las Antillas hispanas. Desde la “décima”, venida de Europa, se desarrolla una creatividad lingüística por medio de una apertura pragmática, en estrecha relación con la particularidad colonial: entre mito del progreso y mito de la edad de oro. Para entender la inventiva caribeña, recordamos la práctica del Neobarroco, elaborado a base de las confluencias de lo heterogéneo. Vemos como a través de una heteroglosia discursiva, (...) el poema extenso se asienta en este espacio cultural que son las islas antillanas y subrayamos su papel actual en el relato de historias mínimas que alimentan por otro cariz la historia universal. (shrink)

Paul Menzel and Donald Light ("A Conservative Case for Universal Access to Health Care," Jul-Aug 2006) tell a story that is plausible. However, based on my twenty-five years of experience as a policy analyst interested in access to health care, I find it inaccurate for a number of reasons.

Storytelling, art and craft can be considered aesthetic expressions of identities. Kalahari identities are not fixed, but fluid. Research with present-day Kalahari People regarding their artistic expression and places where it has been, and is still, practised highlights that these expressions are informed by spirituality. This article explores this idea via two Kalahari case studies: Water Stories recorded in the Upington, Kakamas area, as well as research on a specific rock engraving site at Biesje Poort near Kakamas. The importance of (...) the Kalahari People’s spiritual beliefs as reflected in these case studies and its significance regarding their identities and influence on social change and/or community development projects is discussed. The article thus highlights ways in which spirituality can be considered in relation to social change projects that are characterised by partnerships between local community, non-government and tertiary education representatives and researchers and that highlight storytelling as an integral part of people’s spirituality. (shrink)

The current widespread belief that taxonomic methods used before Darwin were essentialist is ill-founded. The essentialist method developed by followers of Plato and Aristotle required definitions to state properties that are always present. Polythetic groups do not obey that requirement, whatever may have been the ontological beliefs of the taxonomist recognizing such groups. Two distinct methods of forming higher taxa, by chaining and by examplar, were widely used in the period between Linnaeus and Darwin, and both generated polythetic groups. Philosopher (...) William Whewell congratulated pre-Darwinian taxonomists for not adhering to the rigid ideal of definition used in the mathematical sciences. What he called the method of types is here called the method of exemplars because typology has been equated with essentialism, whereas the use of a type species as the reference point or prototype for a higher category was a practice inconsistent with essentialism. The story that the essentialism of philosophers dominated the development of systematics may prove to be a myth. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Human Gene TherapyMary Carrington Coutts (bio)On September 14, 1990, researchers at the U.S. National Institutes of Health (NIH) performed the first approved gene therapy procedure on a four-year-old girl named Ashanti DeSilva. Born with a rare genetic disease, severe combined immune deficiency (SCID), Ashanti lacked a healthy immune system and was extremely vulnerable to infection. Children with SCID usually develop overwhelming infections and rarely survive to adulthood; even a (...) common childhood illness like chicken pox is life-threatening. Ashanti led a cloistered existence, avoiding contact with people outside her family, remaining in the sterile environment of her home, and battling frequent illnesses with massive amounts of antibiotics.In Ashanti's gene therapy procedure, her own white blood cells were genetically modified and then infused back into her bloodstream. Laboratory tests show that the therapy has strengthened Ashanti's immune system. She no longer has recurrent colds, has been allowed to attend school, and has been immunized against whooping cough. This gene therapy procedure is not a cure, however. The genetically-treated white blood cells only survive for a few months and must then be replaced, but Ashanti's future is much brighter because of the new therapy (VI, Thompson [The First] 1993).Although this simplified description of Ashanti's gene therapy procedure sounds like a happy ending, it is little more than an optimistic chapter in a long story. The road to the first approved gene therapy procedure was rocky and fraught with controversy. The biology of human gene therapy is very complex, and there are still many techniques that need to be developed and diseases that need to be understood more fully before gene therapy is well established. The public policy debate surrounding the possible use of genetically engineered material in human subjects is equally complex. Major participants in the debate come from the fields of biology, government, law, medicine, philosophy, politics, and religion, each bringing different views to the discussion.In studying the ethics of gene therapy, one should draw a distinction between [End Page 63] therapy on somatic (non-reproductive) cells and germ (reproductive) cells. Only the germ cells carry the genes that will be passed on to the next generation. Reactions to gene therapy have varied widely. Some commentators on gene therapy object to any form of genetic manipulation, no matter how well-intentioned (VI, Rifkin 1983). Another reaction is to allow the use of somatic-cell therapy, but not to approve the use of germ-line therapy, which could have unforeseeable effects on future generations. A different stance is that, with proper regulation and safeguards, germ-line gene therapy is a logical extension of the progress made to date and that it is an ethically acceptable procedure.TechniquesTo date, 43 research protocols have been approved for somatic-cell gene therapy in the United States. The techniques employed in each protocol vary, but in general a virus is used as a "vector" to insert the desired gene into the DNA of the patient's cells, in order to compensate for a defective gene. For Ashanti's gene therapy, this technique involved obtaining white blood cells and introducing properly functioning genes into as many of the cells as possible. The normal genes were delivered through the use of a specially-engineered virus.Although similar techniques are used in germ-line gene therapy, the procedure is more difficult. There are two basic ways to perform germ-line gene therapy: (1) to treat a preimplantation embryo that carries a serious genetic defect before its implantation in the mother, which necessitates the use of in vitro fertilization techniques; or (2) to treat the germ cells (sperm or egg cells) of afflicted adults so that the genetic defects would not be passed on to their offspring, which requires the technical expertise to delete the defective gene and insert a properly functioning replacement. Because of the complexity of the procedures involved and the attendant ethical controversy, germ-line therapy is not currently performed.Candidate Diseases for Gene TherapyAt present, gene therapy is likely to be most successful in treating diseases that are caused by single-gene defects and has been approved for treating diseases such... (shrink)

Photographer Keithan captures on film the rural landscape's aging and historic barns. But rather than a sad chronicle of America's rural decline, she presents a visual story of endurance and perseverance, of a way of life that continues to thrive. The b&w photographs from each of Michigan's 80 counties are enriched by her narrative, often including histories from the barn owners themselves.