Research on language processing has shown that the disruption of conceptual integration gives rise to specific patterns of event-related brain potentials —N400 and P600 effects. Here, we report similar ERP effects when adults performed cross-domain conceptual integration of analogous semantic and mathematical relations. In a problem-solving task, when participants generated labeled answers to semantically aligned and misaligned arithmetic problems, the second object label in misaligned problems yielded an N400 effect for addition problems. In a verification task, when participants judged arithmetically (...) correct but semantically misaligned problem sentences to be “unacceptable,” the second object label in misaligned sentences elicited a P600 effect. Thus, depending on task constraints, misaligned problems can show either of two ERP signatures of conceptual disruption. These results show that well-educated adults can integrate mathematical and semantic relations on the rapid timescale of within-domain ERP effects by a process akin to analogical mapping. (shrink)

Cyclin‐dependent kinases are Ser/Thr protein kinases best known for their cell cycle roles, where CDK1 triggers mitotic onset in all eukaryotes. CDKs are also involved in various other cellular processes, some of which, such as transcription and centrosome duplication, are coupled to cell cycle progression. A new study suggests that the mitotic CDK network is active at low levels in non‐dividing, differentiating precursors of multiciliated cells, and that it drives ciliogenesis. Manipulating the activity of CDK1 or PLK1 altered transitions between (...) the amplification, growth, and disengagement phases, in a manner analogous to the control of passage through different phases of mitosis. How the dynamics of the mitotic kinase network are controlled in these post‐mitotic cells, and whether other cell cycle regulators are also involved, remains unknown. In the present mini‐review we suggest that the redeployment of cell cycle regulators to control steps of differentiation in non‐dividing cells might be a more general, hitherto under‐recognized, feature of cell regulation. (shrink)

Clinical trials on healthy volunteers generate unique ethical challenges both because participants accept potential physical risks without the possibility of direct medical benefit and because participants’ financial motivations to enroll in trials could lead to their exploitation. Despite the large volume of published empirical studies and ethical analyses of healthy volunteer research, there has been little concerted effort to change how healthy‐volunteer research is overseen or regulated. A new collaborative effort to do so is the VolREthics (Volunteers in Research and (...) Ethics) Initiative. Launched in 2022, this initiative brings together an international community to engage questions about how healthy volunteers could best be protected from the risks of harm and exploitation while the validity of clinical trials is optimized. (shrink)

text as original form and reprinted in 2020.

The author critiques the progressive approach of two contemporary educational philosophers on the topic of fear and learning. Using a postmodern integral approach, this article examines the tendency of reductionism, individualism, and psychologism as part of a hegemonoic liberalism and modernism in discourses on fear and learning commonly adopted by educators....

First Edition 1995, Second Edition 2012.

This chapter offers an analysis of the speech conditions constitutive for the staging of political disagreement. Rather than seeking to offer an explanation for various situations of protest, however, it aims to identify what, if anything, is unique or peculiar to such modes of address. Drawing on the resources of speech act theory, the chapter suggests a reading of ‘dissensual speech’ as a form of ‘unauthorised’ speech through which the ‘people’ appear, however, evanescently. It analyses the peculiarities of dissensual speech (...) in the following ways: first, in terms of specifying its modes of utterance, which are identified with phatic and agonic modes of address and, second, in terms of its performative attitudes. In analysing the latter, I turn to Foucault’s notion of parrēsiastic speech in order to confront a paradox that arises with my reading of dissensual speech viewed in terms of ‘performatives’, since parrēsia—‘speaking truth to power’—is radically opposed to two fundamental rules that govern performatives and illocutionary forces: that they are conventional and that their enunciator must be authorised to use them. The chapter proposes a resolution to this contradiction by showing that an affinity exists between parrēsiastic speech and dissensual speech insofar as both entail ‘risk’ to the speaker in uttering a truth. The question then is whether it is possible to collectivise that risk, or whether parrēsia necessarily remains the speech of the individual martyr. (shrink)

This chapter offers an analysis of the speech conditions constitutive for the staging of political disagreement. Rather than seeking to offer an explanation for various situations of protest, however, it aims to identify what, if anything, is unique or peculiar to such modes of address. Drawing on the resources of speech act theory, the chapter suggests a reading of ‘dissensual speech’ as a form of ‘unauthorised’ speech through which the ‘people’ appear, however, evanescently. It analyses the peculiarities of dissensual speech (...) in the following ways: first, in terms of specifying its modes of utterance, which are identified with phatic and agonic modes of address and, second, in terms of its performative attitudes. In analysing the latter, I turn to Foucault’s notion of parrēsiastic speech in order to confront a paradox that arises with my reading of dissensual speech viewed in terms of ‘performatives’, since parrēsia—‘speaking truth to power’—is radically opposed to two fundamental rules that govern performatives and illocutionary forces: that they are conventional and that their enunciator must be authorised to use them. The chapter proposes a resolution to this contradiction by showing that an affinity exists between parrēsiastic speech and dissensual speech insofar as both entail ‘risk’ to the speaker in uttering a truth. The question then is whether it is possible to collectivise that risk, or whether parrēsia necessarily remains the speech of the individual martyr. (shrink)

Introduction In September of 1973, I defended my doctoral thesis in the field of European cultural history. I was two months shy of my twenty-seventh ...

This paper questions the introduction of national teaching strategy for all ages from five to eleven. It is proposed that the lack of developmentally appropriate practice in the early teaching of literacy is inappropriate and may be counter-productive to the long term goals of high literacy standards.

The first in a new series with Australian Catholic University, this collection of essays deals with two important themes. 'Faith' and 'reason' are heavily weighted words. They point to elemental aspects of human existence. The papers and discussions presented strive to clarify and corelate these basic activities or dimensions of human beings. In all the complexities of the possible relationships and interweaving of faith and reason, two kinds of questions keep recurring. One the one hand, what is the value of (...) human intelligence, and how is it endorsed and supported by faith' On the other hand, what is the distinctive intelligence or rationality of faith, and how does it relate to the perennial search for wisdom represented in it various philosophical forms' Contributors include: Marilyn McCord Adams, Raimond Gaita, John Haldane, John McDermott SJ, Kevin Hart, and Anthony Kelly CSsR. (shrink)

The advancement of the methodology and praxis called fearanalysis by the author for the past 20 years, is a process of application, theorizing, and then refining the craft. It is becoming evident that in many ways the work of fearanalysis is in large part forensic--among its many forms of interrogation....

The author, having studied fear as a subject for 25 years, has adopted several new conceptualizations for that study. Fearology is the discipline, fearanalysis is one of the major practices, and 'Fear' Studies is the overarching domain of valuing and containing the critical discourses and methodologies, findings and applications of a new scholarship on the topic of fear in the 21st century....

LEGO tells about not just LEGO architecture but architecture generally: its objects, its aesthetic properties, and how people judge them. To illustrate how thinking about LEGO can help people with such matters, this chapter considers some scenarios. These scenarios illustrate two very different ways of thinking about architecture. On the one hand, people might think architectural objects (more commonly, "works of architecture"), like buildings, bridges, and aqueducts, have forms that stand on their own, and which thereby do not depend on (...) historical, environmental, or any other contexts. On the other hand, they might think that architectural objects are best understood (maybe only understood) if they have one or more kinds of contextual information. From a different angle, some might see formalism as a better fit with original LEGO world design than with real‐world architectural design. Proponents of formalism take note of what makes architectural objects distinctive. (shrink)

This case details the new product development and approval of Posilac®, an animal drug product pioneered by the Monsanto Company. The product is a genetically engineered hormone known as bovine somatotropin and was targeted for sale to dairy farmers to enhance the milk production of their herds. At the time of its development and subsequent introduction to the market, Posilac® represented one the first applications of genetic engineering in food production and as such, it became a lightning rod for controversy. (...) As Monsanto sought approval for this product from the U.S. Food and Drug Administration, it encountered vigorous opposition from a variety of consumer and trade interests. The case recounts the arduous approval process and explains how industry and public policy debates largely focused on issues of product labeling. (shrink)

Objective: To audit doctors’ knowledge of informed consent.Design: 10 consent scenarios with “true”, “false”, or “don’t know” answers were completed by doctors who care for children at a large district general hospital. These questions tested clinicians’ knowledge of who could give consent in different clinical situations.Setting: Royal United Hospital, Bath, UK.Results: 51 doctors participated . Paediatricians scored higher than other clinicians . Only 36% of paediatricians and 8% of other clinicians realised that the biological father of a child born before (...) 1 December 2003 needed a court order or a parental responsibility agreement to acquire parental responsibility, and thus be able to consent on behalf of his child, if he was not married to the child’s mother. Non-paediatric clinicians were unsure or incorrect when tested on situations where people with parental responsibility do not agree, or where young people , who are Fraser competent do not want to consult their parents. Most clinicians did not know that the parents of a 20-year-old man with severe learning difficulties are unable to consent to surgery on his behalf, and many non-paediatricians were unclear on who could give consent when a child lived with foster parents.Conclusion: Clinicians who obtain consent for the treatment of children need to increase their knowledge on who is able to give informed consent to ensure best practice. (shrink)

Revised to reflect the current status of scientific and professional theory, practices, and debate across all facets of ethical decision making, this latest edition of Celia B. Fisher's acclaimed book demystifies the American Psychological Association's (APA) Ethical Principles of Psychologists and Code of Conduct. The Fifth Edition explains and puts into practical perspective the format, choice of wording, aspirational principles, and enforceability of the code. Providing in-depth discussions of the foundation and application of each ethical standard to the broad (...) spectrum of scientific, teaching, and professional roles of psychologists, this unique guide helps practitioners effectively use ethical principles and standards to morally conduct their work activities, avoid ethical violations, and, most importantly, preserve and protect the fundamental rights and welfare of those whom they serve. This edition retains and expands upon the critical content of the previous editions to help readers apply the Ethics Code to contemporary social issues in the conduct of responsible psychological science and practice. (shrink)

Background: Recent research demonstrates that people sometimes make different medical decisions for others than they would make for themselves. This finding is particularly relevant to end-of-life decisions, which are often made by surrogates and require a trade-off between prolonging life and maintaining quality of life. We examine the impact of decision role, patient age, decision maker age and multiple individual differences on these treatment decisions. Methods: Participants read a scenario about a terminally ill cancer patient faced with a choice between (...) an aggressive chemotherapy regimen that will extend life by two years and palliative treatments to control discomfort for one remaining month. Participants were randomly assigned to one of three decision roles (patient, physician, or an abstract other) and the scenario randomly varied whether the patient was described as 25 or 65-years old. Results: When deciding for a 65-year old patient, approximately 60% of participants selected aggressive chemotherapy regardless of decision role. When deciding for a 25-year old patient, however, participants were more likely to select chemotherapy for a patient (physician role) or another person (abstract other) than for themselves (70%, 67%, and 59%, respectively). In addition, confidence that powerful others (eg, physicians) control one’s health, as well as respondents’ age and race, consistently predicted treatment choices. Conclusions: Patient age appears to influence medical decisions made for others but not those that we make for ourselves. These findings may help to explain the discord that often occurs when younger cancer patients refuse life-extending treatments. (shrink)

Instalada na Universidade Federal do Rio Grande do Sul (UFRGS) logo após o golpe civil-militar 1964, a Comissão Especial de Investigação Sumária (Ceis) teve como objetivo investigar ações consideradas subversivas, envolvendo professores, funcionários e estudantes. A presente pesquisa buscou saber como tal acontecimento é hoje relembrado por alguns estudantes da época, diretamente envolvidos naquele contexto. Para a busca de dados, optou-se pela História Oral, coletando narrativas de cinco sujeitos, além de pesquisa documental: atas, fichas de informações, ofícios e matérias no (...) jornal Correio do Povo. Para fundamentar a análise, foram utilizados referenciais advindos de Alistair Thompson, entre outros. Além de abordar situações da repressão instalada na universidade, o texto também apresenta alguns desdobramentos acerca do processo de pesquisa que adota a memória como fonte a ser considerada no processo analítico. (shrink)