Anticipating the ethical impact of emerging technologies is an essential part of responsible innovation. One such emergent technology is the digital twin which we define here as a living replica of a physical system (human or non-human). A digital twin combines various emerging technologies such as AI, Internet of Things, big data and robotics, each component bringing its own socio-ethical issues to the resulting artefacts. The question thus arises which of these socio-ethical themes surface in the process and how they (...) are perceived by stakeholders in the field. In this report we present the results of a qualitative study into the socio-ethical benefits and socio-ethical risks of using digital twins in healthcare. Employing insights from ethics of technology and the Quadruple Helix theory of innovation, we conducted desk research of white literature and 23 interviews with representatives from the four helixes: industry, research, policy and civil society. The ethical scan revealed several important areas where the digital twin can produce socio-ethical value (e.g., prevention and treatment of disease, cost reduction, patient autonomy and freedom, equal treatment) but also several important areas of socio-ethical risks (e.g., privacy and property of data, disruption of existing societal structures, inequality and injustice). We conclude with a reflection on the employed analytical tool and suggestions for further research. (shrink)

Some mathematical proofs explain why the theorems they prove hold. This paper identifies several challenges for any counterfactual account of explanation in mathematics (that is, any account according to which an explanatory proof reveals how the explanandum would have been different, had facts in the explanans been different). The paper presumes that countermathematicals can be nontrivial. It argues that nevertheless, a counterfactual account portrays explanatory power as too easy to achieve, does not capture explanatory asymmetry, and fails to specify why (...) certain proofs are explanatory and others are not. Greater informativeness about counterfactual dependence can even yield less explanatory power. (shrink)

Dans la pensée philosophique d'Emmanuel Levinas, le mot « Dieu » n'est pas inaudible. Il peut venir à l'idée. Il peut tomber sous le sens – en deçà de tout sens thématisé, à revers des prétentions souveraines de la conscience. À la condition toutefois que parvienne à être décrite l'intrigue anarchique que ce mot noue dans l'idée de l'Infini, dans le Visage, dans la Kénose du sujet, dans le Dire du verset ou l'Emphase de la métaphore.Les articles recueillis dans cet (...) ouvrage tentent, sous ces divers aspects, de décrire l'inouïe Transcendance de ce mot « Dieu » désormais arraché à toute archê – à tout fondement onto-théo-logique. Ils se hasardent aussi à suggérer les résonnances théologiques et bibliques de cet « autrement dire Dieu » préservant l'anarchie du Transcendant. C'est par le Haut que se noue tout vrai dialogue entre le philosophique et le théologique. (shrink)

The Food and Drug Administration authorizes the marketing of a drug only for uses that the manufacturer has demonstrated to be safe and effective, based on evidence from at least two clinical trials. However, the FDA does not regulate the practice of medicine, so physicians may prescribe drugs in any manner they choose. Prescribing drugs in ways that deviate from the uses specified in the FDA-approved drug label, package insert, and marketing authorization is referred to as off-label prescribing. This occurs (...) when physicians prescribe a drug for a therapeutic purpose other than the one approved by the FDA; treat patients in a different age cohort or gender than the population on which it was tested; or prescribe a different dose, for a different duration of use, or a different mode of administration than indicated on the label. (shrink)

This article argues that the misalignment of private profit-maximizing objectives with public health needs causes institutional corruption in the pharmaceutical sector and systematically leads firms to act contrary to public heath. The article analyzes how financial incentives generate a business model promoting harmful practices and explores several means of realigning financial incentives in order to foster therapeutic innovation and promote the rational use of medicines.

texte aujourd’hui fameux, repose sur un document connu également de la Vie latine d’Adam et Ève et que l’auteur qoumrânien a remanié. nowadays a famous text, depends on a document which is also known from the Latin Life of Adam and Eve, and which has been reworked by the author from Qumran.

Models of cognitive vulnerability claim that depressive symptoms arise as a result of an interaction between negative affect and cognitive reactions, in the form of dysfunctional attitudes and negative inferential style. We present a model that complements this approach by focusing on the appraisal processes that elicit and differentiate everyday episodes of emotional experience, arguing that individual differences in appraisal patterns can foster negative emotional experiences related to depression (e.g., sadness and despair). In particular, dispositional appraisal biases facilitating the elicitation (...) of these emotions more frequently and more intensely. This, in turn, is likely to have a negative influence on cognitive processing and emotion regulation in general. (shrink)

Television series explicitly pursue an entertainment goal rather than a learning one; nevertheless, they convey information about care. French and American series depicting doctors and care workers have reached record-breaking audiences. Spectators try to understand care as an activity through dramatic situations. They are all the more curious and liable to consider the activity of the nurses as a vicariant model that they wish to become a doctor or a care worker. Which behaviors get the spectators’ attention? Which reasoning do (...) they deduce from them? Does the paramedical training then modify the representations they form about care and the nursing profession while watching television series? (shrink)

This study aims to characterise Human Research Ethics Committee (HREC) members’ perceptions on five main themes associated with ethics reviews, namely, the nature of research, ethical/moral issues, assent, participants’ risk and HREC prerogatives issues. Three hundred and sixteen HREC members from over 200 HRECs throughout Australia responded to an online questionnaire survey. The results show that in general, HREC members’ beliefs are reasoned and align with sound principles of ethical reviews. There seems to be a disposition for living up to (...) ethical/moral values, avoiding the issue of consent waivers and respecting participants’ welfare, as well as a sense of ambiguity about HREC prerogatives. Problematic areas were a tendency towards over-valuing quantitative research methods for their perceived validity and a neutral view on issuing consent waivers to participants with intellectual disability and, finally, the belief that research that limits disclosure, plans deception or actively conceals is morally unjustifiable. Implications for professional development and policy-making are discussed. (shrink)

Nous appelons «thèse des descriptions multiples» l'opinion qui veut qu'une seule et même action peut etre decrite de plusieurs façons différentes selon que Ton prend en considération ou non les différentes conséquences, plus ou moins lointaines, de cette action. Cette thèse joue chez certains penseurs un rôle essentiel dans la solution du problème de l'individuation des actions. Chez D. Davidson notamment, elle intervient de façon décisive dans la démonstration de sa fameuse thèse que toute action se réduit à des mouvements (...) corporels. Nous entendons montrer, premièrement, que la thèse des descriptions multiples, à supposer même qu'elle soit vraie, ne saurait remplir le rôle que lui assigne Davidson dans le contexte de l'individuation des actions; deuxièmement, que cette thèse est fondée en fait sur l'ignorance de certaines distinctions importantes concernant l'action et le langage de l'action. (shrink)

What defence does the Narrative Practice Hypothesis have against the charge that it is a covert form of externalist theory theory ? I discuss and reject Dan Hutto's own strategies and argue that the NPH remains vulnerable to a threat of collapse into externalist TT as long as narrative folk-psychological explanation is differentiated from simple belief-desire explanation merely by a degree of complexity, subtlety and/or context-sensitivity. It is entirely plausible, however, that there is a more principled distinction between these two (...) types of explanation of human behaviour. I defend such a distinction and show how it eliminates the threat of collapse into TT entirely. (shrink)

AUTOUR DE LA RELIGION REFLEXIVE. Le concept de réflexivité chez Jean-Marc Ferry. Réflexions sur le point de vue moral. Dépasser l'ex-communication politique du religieux. AUTOUR DE LA REPUBLIQUE CREPUSCULAIRE. Prendre l'Europe au sérieux. Une éthique de la reconnaissance internationale. Pour une république européenne placée sous le signe de l'aurore.

¿En qué consiste el sentimiento de lo sublime? ¿Cual es su naturaleza, su estatuto? ¿Qué tipo de relaciones teje con la imaginación y la intuición intelectual del “elemento de lo inteligible”? ¿Cómo están presentes allí afectividad y Gemüt? ¿Cómo entender su relación con los afectos, lo afectivo, el sentir y el sentimiento? Las respuestas a estas cuestiones son empren didas por Richir en este corto texto en el que comenta y analiza detalladamente algunos de los parágrafos más notables de la (...) Crítica del discernimiento de Kant; se detiene magistralmente en la “Observación general sobre la exposición de los juicios estéticos reflexionantes”, con la que Kant cierra la “Analítica de lo sublime”, para concluir con tres observaciones que no sólo constituyen una visión general del texto sino, también, los trazos generales de su propia pro puesta: i) los afectos como sensaciones, temporalizados en presente y situados en relación al espacio y al Leib, son siempre acogidos por el Gemüt, no como una “señal” física, sino como algo ya incorpóreo y capaz de constituir, en los actos intencionales, la hylé fenomenológica (por lo demás inmaterial); ii) las afecciones son, en el Gemüt, aquello en lo que éste experimenta sus movimientos, de suyo ajenos al presente y al espacio, y que se despliegan sin trayectoria en un “elemento” que no es el elemento de lo inteligible, aunque no es ajeno a él. iii) finalmente, el Gemüt, que tiene relación con la afectividad, con el alma e incluso con el espíritu, es algo así como la raíz, “la fuente de todo”, una de cuyas dimensiones es la afectividad, primordial o ar caica, el corazón (thymos) o la intimidad que puede resonar con el elemento de lo inteligible por ser lo radicalmente externo (aunque de una exterioridad no espacial), y esto, por la mediación del esquematismo y de su interrupción. Estas tres posiciones llevarán a Richir muy cerca de la definición Kantiana del Gemüt: “el ánimo es por sí solo; es todo vida, el mismo principio de la vida”. (shrink)