Advances at the interface between the biological sciences and engineering are giving rise to emerging research fields such as synthetic biology. Harnessing the potential of synthetic biology requires timely and adequate translation into clinical practice. However, the translational research enterprise is currently facing fundamental obstacles that slow down the transition of scientific discoveries from the laboratory to the patient bedside. These obstacles including scarce financial resources and deficiency of organizational and logistic settings are widely discussed as primary impediments to translational (...) research. In addition, a number of socio-ethical considerations inherent in translational research need to be addressed. As the translational capacity of synthetic biology is tightly linked to its social acceptance and ethical approval, ethical limitations may—together with financial and organizational problems—be co-determinants of suboptimal translation. Therefore, an early assessment of such limitations will contribute to proactively favor successful translation and prevent the promising potential of synthetic biology from remaining under-expressed. Through the discussion of two case-specific inventions in synthetic biology and their associated ethical implications, we illustrate the socio-ethical challenges ahead in the process of implementing synthetic biology into clinical practice. Since reducing the translational lag is essential for delivering the benefits of basic biomedical research to society at large and promoting global health, we advocate a moral obligation to accelerating translational research: the “translational imperative.”. (shrink)

The author group of above-mentioned review paper was incorrectly published in the online article.

La théorie des optima de second rang est une contribution formelle au domaine de l’optimisation de l’utilité (ou du bien-être). Elle stipule que, dans certaines circonstances « imparfaites », l’approximation d’un idéal est sous-optimale. Dans cet article, nous tentons de déterminer si la théorie peut être utile aux conseillers œuvrant dans le secteur public. Nous présentons les conditions dans lesquelles la théorie pourrait s’avérer pertinente pour les conseillers du secteur public, et en particulier la condition d’inséparabilité entre différentes variables d’un (...) problème de politiques publiques. Nous tentons aussi de déterminer si ces conditions sont réunies dans différents documents produits par les conseillers en politiques publiques. Pour ce faire, nous analysons 40 publications récentes du secteur public québécois comprenant des recommandations. (shrink)

Peter Königs recently argued that, while autonomous robots generate responsibility gaps, such gaps need not be considered problematic. I argue that Königs’ compromise dissolves under analysis since, on a proper understanding of what “responsibility” is and what “gap” (metaphorically) means, their joint endorsement must repel an attitude of indifference. So, just as “calamities that happen but don’t bother anyone” makes no sense, the idea of “responsibility gaps that exist but leave citizens and ethicists unmoved” makes no sense.

Current debates in Clinical Legal Education (CLE) exclude essay writing as a legitimate form of ‘clinical’ pedagogy. This article argues that essay writing should be classified as a form of CLE due to its potential to mirror legal practice and enhance students' reflective capacities. By incorporating Hegelian dialectical reasoning, the paper proposes a structured approach to legal essay writing that includes thesis, antithesis, and synthesis. This method encourages students to engage deeply with legal arguments, reflecting on their merits and counterarguments. (...) The dialectical approach aligns with constructivist teaching methodologies, promoting critical thinking and practical skills relevant to legal practice and beyond. The article outlines the theoretical basis of this model and provides a practical framework for its implementation in legal education. It further connects this pedagogical strategy to the development of transferable skills that prepare students for professional legal environments. Through this dialectical method, the paper advocates for a more holistic and nuanced understanding of legal concepts, bridging the gap between academic theory and practical application, and, thus, making the case for the incorporation of Hegel-inspired essay writing into the definition of CLE. (shrink)

John Rawls's work (1971) has greatly contributed to rehabilitating equality as a basic social value, after decades of utilitarian hegemony,particularly in normative economics, but Rawls also emphasized that full equality of welfare is not an adequate goal either. This thesis was echoed in Dworkin's famous twin papers on equality (Dworkin 1981a,b), and it is now widely accepted that egalitarianism must be selective. The bulk of the debate on ‘Equality of What?’ thus deals with what variables ought to be submitted for (...) selection and how this selection ought to be carried out. (shrink)

In order to maximize human performance, defence forces continue to explore, develop, and apply human performance enhancement (HPE) methods, ranging from pharmaceuticals to (bio)technological enhancement. This raises ethical, legal, and societal concerns and requires organizing a careful reflection and deliberation process, with relevant stakeholders. We discuss a range of ethical, legal, and societal aspects (ELSA), which people involved in the development and deployment of HPE can use for such reflection and deliberation. A realistic military scenario with proposed HPE application can (...) serve as a starting point for such an iterative and participatory process. Stakeholders can discuss this application, modify its features, and design appropriate processes around it – for instance, procedures for informed consent. We propose that organizing aspects into these three categories – ethical, legal, and societal – can help involve appropriate interlocutors at different moments: legal aspects with people in strategy or management roles, from the start of a project; ethical aspects with people in operations and medical roles, during development; and societal aspects with people in communication and personnel roles, during deployment. Notably, we developed and discussed this framework and the three aspects in close collaboration with personnel from the military. (shrink)

In order to maximize human performance, defence forces continue to explore, develop, and apply human performance enhancement (HPE) methods, ranging from pharmaceuticals to (bio)technological enhancement. This raises ethical, legal, and societal concerns and requires organizing a careful reflection and deliberation process, with relevant stakeholders. We discuss a range of ethical, legal, and societal aspects (ELSA), which people involved in the development and deployment of HPE can use for such reflection and deliberation. A realistic military scenario with proposed HPE application can (...) serve as a starting point for such an iterative and participatory process. Stakeholders can discuss this application, modify its features, and design appropriate processes around it – for instance, procedures for informed consent. We propose that organizing aspects into these three categories – ethical, legal, and societal – can help involve appropriate interlocutors at different moments: legal aspects with people in strategy or management roles, from the start of a project; ethical aspects with people in operations and medical roles, during development; and societal aspects with people in communication and personnel roles, during deployment. Notably, we developed and discussed this framework and the three aspects in close collaboration with personnel from the military. (shrink)

Ethics education in the professions has become close to compulsory with continuing education following suit. What is the de facto as opposed to the de jure function of an ethics education program? Have they increased compliance with laws and codes of conduct? Is that the goal? What would an ethics education program look like that was not primarily concerned with compliance with relevant laws or professional codes and not merely an exercise in good public relations? I argue that, ultimately, ethics (...) education is about happiness… not happiness as we generally think of it today, but in the Aristotelian sense of “fulfillment” and the collateral good that is generated for clients and the profession. As a result of this point of view I argue that ethics is not a subject in the normal sense of the term but a meta-subject which implies that teaching ethics as a class or stand alone module in a law, policy or practice management course is usually ineffective. Another implication is that the richest source for moral reflection within a profession are case studies generated by students in clinical assignments, despite the inherent risks associated with making these cases prominent. (shrink)

Whilst Bayesian epistemology is widely regarded nowadays as our best theory of knowledge, there are still a relatively large number of incompatible and competing approaches falling under that umbrella. Very recently, Wallmann and Williamson wrote an interesting article that aims at showing that a subjective Bayesian who accepts the principal principle and uses a known physical chance as her degree of belief for an event A could end up having incoherent or very implausible beliefs if she subjectively chooses the probability (...) of an event F for which she has much poorer evidence. They also argued that their own version of objective Bayesianism is completely immune to that challenge. In this article, after having presented the strongest version of Wallmann’s and Williamson’s argument, I will show that if successful, it has far-reaching consequences and would not only invalidate moderate subjective Bayesianism and imprecise probalism but also a form of objective Bayesianism that relies on conditionalisation, the principal principle, reference classes, and the principle of indifference applied to the most basic partitions. I then argue that their argument can be defeated by adding the rule that it is always irrational to choose a probability that can be computed from the known probabilities associated to one’s other beliefs. I finally argue that the authors’ main intuition that probabilities have different degrees of reliability favours imprecise Bayesianism over precise Bayesianism. (shrink)

Der Mensch als „homo viator“ ist ein Topos, der sich in der Literatur und Philosophie, aber auch in diversen religiösen Traditionen unterschiedlicher Epochen finden lässt. Der vorliegende Sammelband konzentriert sich auf die Thematisierung dieses Bildes vom Menschen, der auf dem Wege ist, durch das moderne Existenzdenken.

I applaud Fenton and Wiers' attempt to find a demarcation point between cases of addiction that fall within the range of normal function and those that may count as disease. However, I argue that continua don't offer demarcation points, the mechanisms involved are not demonstrably different, and trying to pin down subjectivity doesn't help.

Ainslie’s contribution offers a useful refinement of his powerful model of intertemporal bargaining. However, he focuses mostly on the cognitive mechanisms of choice. I suggest that these interact with emotional, personality, and developmental dynamics that cannot be ignored, either psychologically or neurally.

Although I reject neuronormativity -- an idea central to the Brain Disease Model of Addiction -- Henden and Gjelsvik argue that the disease definition might refer to normativity in nonneural domains. They profess that a cognitive dysfunction, or a mismatch of evolutionary intentions, could also qualify as norm violations, thus legitimizing the disease label. The need for dividing lines is questioned as well. I rebut these criticisms in turn, but I must admit they are thought provoking.

The utilitarian economist and Nobel Laureate John Harsanyi and the liberal egalitarian philosopher John Rawls were two of the most eminent scholars writing on problems of social justice in the last century. This volume pays tribute to Harsanyi and Rawls by investigating themes that figure prominently in their work. In some cases, the contributors explore issues considered by Harsanyi and Rawls in more depth and from novel perspectives. In others, the contributors use the work of Harsanyi and Rawls as points (...) of departure for pursuing the construction of theories for the evaluation of social justice. The introductory essay by the editors provides background information on the relevant economics, game theory, philosophy, and social choice theory, as well as readers' guides to the individual contributions, to make this volume widely accessible to scholars in a wide range of disciplines. (shrink)

This paper distinguishes an index ordering and a social ordering function as a simple way to formalize the indexing problem in the social choice framework. Two main conclusions are derived. First, the alleged dilemma between welfarism and perfectionism is shown to involve a third possibility, exemplified by the fairness approach to social choice. Second, the idea that an individual is better off than another whenever he has more (goods, functionings, etc.) in all dimensions, which is known to enter in conflict (...) with the Pareto principle, can be partly salvaged by adopting the fairness approach. (shrink)

The French philosopher, Gilles Deleuze, is emerging as one of the most important and influential philosophers of the 20th century, having published widely on philosophy, literature, language, psychoanalysis, art, politics, and cinema. However, because of the ‘experimental’ nature of certain works, combined with the manner in which he draws upon a variety of sources from various disciplines, his work can seem difficult, obscure, and even ‘willfully obstructive’. In an attempt to resist such impressions, this paper will seek to provide an (...) accessible introduction to Deleuze's work, and to begin to discuss how it can be employed to provide a significant critique and reconceptualization of the theoretical foundations and therapeutic practices of psychiatry, psychotherapy, and mental health nursing. In order to do this, the paper will focus upon Deleuze's masterwork, and the cornerstone to his philosophy as a whole, Difference and Repetition; in particular, it will discuss how his innovative and challenging account of time can be employed to provide a conception of human life as a ‘continuity’, rather than as a series of distinct ‘moments’ or ‘events’. As well as discussing the manner in which his work can provide us with an understanding of how life is different and significant for each human being, this paper will also highlight the potential importance of Deleuze's work for logotherapy, for the recent ‘turn’ to ‘narrative’ as a psychotherapeutic approach and for contemporary mental health care's growing interest in ‘social constructionism’. As such, this paper also seeks to stimulate further discussion and research into the importance and the relevance of Deleuze's work for the theory and practice of psychiatry, psychotherapy, and mental health nursing. (shrink)

The common view of the “Arab street” fails to capture essential dimensions of the role of public opinion and public discourse in the politics of Arab states. The rising importance of transnational Arab television and print media has created a public arena outside the control of states. Arguments about issues of shared concern in this Arabist public sphere have had important implications for political identity, beliefs, expectations, and behavior. Arab responses to the ongoing crisis in Iraq demonstrate the political significance (...) of these debates. (shrink)

Berridge's nuanced approach to the conceptualization of addiction as a disease is easier for me to accept than most others. In fact, Berridge and I agree on many core features of addiction, but still not on how to label it. When competing definitions reach a standoff on intellectual grounds, we should look at the clinical utility of each. And here I think that Berridge misses a critical insight. Yet, we end by agreeing to keep listening to each other.

Mark C. Taylor _Hiding_ Chicago, Illinois: University of Chicago Press, 1997 ISBN: 0-226-79159-9 354 pp.

Dans Les Nuées, Aristophane adresse des critiques à Socrate auxquelles Platon répond philosophiquement dans l’Apologie. Or le Socrate des Nuées porte des traits de Protagoras, et certains reproches attribués à l’un valent pour l’autre. Comme pour Socrate, Platon a composé pour Protagoras une apologie, dans le Théétète. Si nous comparons les accusations de la pièce à ce que Platon prête à Protagoras, nous constatons qu’il se fait son défenseur. Mais pour quelle raison et à quel point de vue? Par une (...) analyse des concepts de geloion et de mimèsis comique, on montre comment Platon déploie une stratégie de réappropriation de la pensée de Protagoras – pour lui donner un tour philosophique qui constitue en même temps une réflexion critique sur le statut de l’objet comique.In the Apology, Plato gives a philosophical answer to critics contained in Aristophanes’ Clouds. However, through Socrates, The Clouds target Protagoras too. As a matter of fact, Plato composed an apology for him, as well in the Theaetetus, that answers the charges in the comedy against Protagoras, becoming in a certain way his « lawyer ». But why and what for? Analysing the concepts of geloion and comic mimesis, we show how Plato undertakes to give a philosophical reading of Protagoras’ thought, which, in the same time, constitutes a critical thinking about the object of comedy. (shrink)

La critique platonicienne de la démocratie est résolument philosophique, contestant le modèle anthropologique et épistémologique sous-jacent au nom des aberrations historiques auxquelles il est condamné. Cet article examine les deux principaux moteurs de l’analyse platonicienne : 1) l’absence d’unité, qui se traduit par une oligarchie de fait et par une dispersion des citoyens, plus soucieux de leur liberté individuelle que de l’intérêt de la cité ; 2) une théorie de la connaissance qui, aussi implicite soit-elle, dissocie savoir et pouvoir. Il (...) en résulte une prise de distance à l’égard d’un modèle où l’homme démocratique serait jugé compétent par nature à exercer des responsabilités. (shrink)