The author group of above-mentioned review paper was incorrectly published in the online article.

Advances at the interface between the biological sciences and engineering are giving rise to emerging research fields such as synthetic biology. Harnessing the potential of synthetic biology requires timely and adequate translation into clinical practice. However, the translational research enterprise is currently facing fundamental obstacles that slow down the transition of scientific discoveries from the laboratory to the patient bedside. These obstacles including scarce financial resources and deficiency of organizational and logistic settings are widely discussed as primary impediments to translational (...) research. In addition, a number of socio-ethical considerations inherent in translational research need to be addressed. As the translational capacity of synthetic biology is tightly linked to its social acceptance and ethical approval, ethical limitations may—together with financial and organizational problems—be co-determinants of suboptimal translation. Therefore, an early assessment of such limitations will contribute to proactively favor successful translation and prevent the promising potential of synthetic biology from remaining under-expressed. Through the discussion of two case-specific inventions in synthetic biology and their associated ethical implications, we illustrate the socio-ethical challenges ahead in the process of implementing synthetic biology into clinical practice. Since reducing the translational lag is essential for delivering the benefits of basic biomedical research to society at large and promoting global health, we advocate a moral obligation to accelerating translational research: the “translational imperative.”. (shrink)

Historians of science have long believed that Abraham Trembley’s celebrity and impact were attributable chiefly to the incredible regenerative phenomena demonstrated by the polyp, which he discovered in 1744, and to the new experimental method he devised to investigate them. This essay shows that experimental method alone cannot account for Trembley’s success and influence; nor are the marvels of the polyp sufficient to explain its scientific and cultural impact. Experimental method was but one element in a new conception of the (...) laboratory that called for both experimental and para‐experimental skills whose public availability depended on a new style of communication. The strategy of generosity that led Trembley to dispatch polyps everywhere enabled experimental naturalist laboratories to spread throughout Europe, and the free circulation of living objects for scientific research led practitioners to establish an experimental field distinct from mechanical physics. Scholars reacted to the marvels of the polyp by strengthening the boundaries between the public and academic spheres and, in consequence, opened a space for new standards in both scientific work and the production of celebrity.… comme l’Auteur de l’Histoire des Polypes, il a passé de plein vol à l’immortalité.—Julien Offrey de La Mettrie … comme l’Auteur de l’Histoire des Polypes, il a passé de plein vol à l’immortalité.—Julien Offrey de La Mettrie. (shrink)

In the course of legal reasoning—whether for purposes of deciding an issue, justifying a decision, predicting how an issue will be decided, or arguing for how it should be decided—one often is required to reach conclusions based on a balance of reasons that is not straightforwardly reducible to the application of rules. Recent AI and Law work has modeled reason-balancing, both within and across cases, with set-theoretic and rule- or value-ordering approaches. This article explores a way to model balancing in (...) quantitative terms that may yield new questions, insights, and tools. (shrink)

Introduction L’analyse des temporalités de l’action constitue une entrée pertinente pour aborder les rapports sociaux de domination. À sa manière, la revue Temporalités a perpétué cette tradition des sciences sociales qui observent les inégalités et les différenciations sociales, analysent leurs logiques, en insistant sur les relations étroites entre temporalités et pouvoir. Mais les articles de Temporalités, à l’exception d’un dossier sur les temps sexués de l’activité (Bess..

Although the topic has been extensively studied, many issues about understanding of indirect requests in children are still unsolved. Our contribution is to distinguish genuine and ironic hints, focusing on the latter. We examined the understanding of ironic hints and ironic imperatives in 5- to 9-year-old children and in adults, in various situational contexts. The main result of this study was that ironic hints were more difficult to understand than ironic imperatives only when the context was neutral. When the context (...) was ironic, there was no significant difference. Discussion highlights how context enables young children to understand very indirect requests like ironic hints. (shrink)

I offer an argument regarding chances that appears to yield a dilemma: either the chances at time t must be determined by the natural laws and the history through t of instantiations of categorical properties, or the function ch(•) assigning chances need not satisfy the axioms of probability. The dilemma's first horn might seem like a remnant of determinism. On the other hand, this horn might be inspired by our best scientific theories. In addition, it is entailed by the familiar (...) view that facts about chances at t are ontologically reducible to facts about the laws and the categorical history through t. However, that laws are ontologically prior to chances stands in some tension with the view that chances are governed by laws just as categorical-property instantiations are. The dilemma's second horn entails that if chances are in fact probabilities, then this is a matter of natural law rather than logical or conceptual necessity. I conclude with a suggestion for going between the horns of the dilemma. This suggestion involves a generalization of the notion that chances evolve by conditionalization. Introduction "Chances evolve by conditionalization" How might the lawful magnitude principle be defended? A historical interlude What if chances failed to be determined by the laws and categorical facts? (shrink)

Contemporary financial markets have recently witnessed a sea change with the ‘algorithmic revolution’, as trading automats are used to ease the execution sequences and reduce market impact. Being constantly monitored, they take an active part in the shaping of markets, and sometimes generate crises when ‘they mess up’ or when they entail situations where traders cannot go backwards. Algorithms are software codes coding practices in an IT significant ‘textual’ device, designed to replicate trading patterns. To be accepted, however, they need (...) to comply with regulatory texts, which are nothing else but codes of conduct coding accepted practices in the markets. In this article, I draw on ethnographic fieldwork in order to open these black boxes, while trying to describe their existence as devices encapsulating several points of views. I address the question of a possible misalignment between those visions, and more specifically try to draw the consequences raised by such discrepancies as regards the future of financial regulation. (shrink)

Der Mensch als „homo viator“ ist ein Topos, der sich in der Literatur und Philosophie, aber auch in diversen religiösen Traditionen unterschiedlicher Epochen finden lässt. Der vorliegende Sammelband konzentriert sich auf die Thematisierung dieses Bildes vom Menschen, der auf dem Wege ist, durch das moderne Existenzdenken.

For centuries, religion and philosophy have been the primary basis for efforts to guide humans to be more ethical. However, training in ethics and religion and imparting positive values and morality tests such as those emanating from the categorical imperative and the Golden Rule have not been enough to protect humankind from its bad behaviors. To improve ethics education educators must better understand aspects of human nature such as those that lead to “self-deception” and “personal bias.” Through rationalizations, faulty reasoning (...) and hidden bias, individuals trick themselves into believing there is little wrong with their own unethical behavior. The application of science to human nature offers the possibility of improving ethics education through better self-knowledge. The author recommends a new paradigm for ethics education in contemporary modern society. This includes the creation of a new field called “applied evolutionary neuro-ethics” which integrates science and social sciences to improve ethics education. The paradigm can merge traditional thinking about ethics from religious and philosophical perspectives with new ideas from applied evolutionary neuro-ethics. (shrink)

Glymour, Scheines, Spirtes, and Kelly argue for ‘Spearman's Principle’: one should (ceteris paribus) favour the theory whose ‘free parameters’ need assume no particular values for the theory to save the ‘constraints’ holding of the phenomena. I argue that the rationale they give for Spearman's Principle fails, but that (contra Cartwright) Spearman's Principle cannot be made to favour either of two theories depending on how they are expressed. I examine how one must motivate the demand for a scientific explanation of a (...) parameter's value and how one justifies believing that a constraint should be explained independent of any parameter's particular value. (shrink)

Selectional preferences have a long history in both generative and computational linguistics. However, since the publication of Resnik's dissertation in 1993, a new approach has surfaced in the computational linguistics community. This new line of research combines knowledge represented in a pre‐defined semantic class hierarchy with statistical tools including information theory, statistical modeling, and Bayesian inference. These tools are used to learn selectional preferences from examples in a corpus. Instead of simple sets of semantic classes, selectional preferences are viewed as (...) probability distributions over various entities. We survey research that extends Resnik's initial work, discuss the strengths and weaknesses of each approach, and show how they together form a cohesive line of research. (shrink)

This article explores a training need common to every stage of a teacher’s career : the need to be accompanied. It takes an integrative perspective on the process of the situated learning of teaching, throughout the career, from the pre-service practicums to the period of entrance in the profession then to the in-service training. Providing a reflexive accompaniment of the teachers’ practical experiences is here presented as a central factor for linking the training and the work environments. The first part (...) of the article exposes our conception of a reflexive accompaniment and justifies its importance for the evolution of the teaching practices. Then, we describe how we were convinced of that importance through our role as directors of two teacher training devices, one in Switzerland, one in Quebec. Finally, the third part of the article is devoted to the training of the persons that practice such an accompaniment. (shrink)

I applaud Fenton and Wiers' attempt to find a demarcation point between cases of addiction that fall within the range of normal function and those that may count as disease. However, I argue that continua don't offer demarcation points, the mechanisms involved are not demonstrably different, and trying to pin down subjectivity doesn't help.

Ainslie’s contribution offers a useful refinement of his powerful model of intertemporal bargaining. However, he focuses mostly on the cognitive mechanisms of choice. I suggest that these interact with emotional, personality, and developmental dynamics that cannot be ignored, either psychologically or neurally.

Although I reject neuronormativity -- an idea central to the Brain Disease Model of Addiction -- Henden and Gjelsvik argue that the disease definition might refer to normativity in nonneural domains. They profess that a cognitive dysfunction, or a mismatch of evolutionary intentions, could also qualify as norm violations, thus legitimizing the disease label. The need for dividing lines is questioned as well. I rebut these criticisms in turn, but I must admit they are thought provoking.

Philosophy and Phenomenological Research, Volume 99, Issue 3, Page 739-748, November 2019.

The physics of color and the psychology of color naming are not isomorphic. Physically, the spectrum is continuous with regard to wavelength colors change qualitatively from one wavelength region to another. The psychological characterization of hue that characterizes color vision has been revealed in a series of modern psychophysical studies with human adults and infants and with various infrahuman species, including vertebrates and invertebrates. These biopsychological data supplant an older psycholinguistic and anthropological literature that posited that language and culture alone (...) influence perceptual processes; language and culture may modify color naming beyond basic categorizations. (shrink)

The French philosopher, Gilles Deleuze, is emerging as one of the most important and influential philosophers of the 20th century, having published widely on philosophy, literature, language, psychoanalysis, art, politics, and cinema. However, because of the ‘experimental’ nature of certain works, combined with the manner in which he draws upon a variety of sources from various disciplines, his work can seem difficult, obscure, and even ‘willfully obstructive’. In an attempt to resist such impressions, this paper will seek to provide an (...) accessible introduction to Deleuze's work, and to begin to discuss how it can be employed to provide a significant critique and reconceptualization of the theoretical foundations and therapeutic practices of psychiatry, psychotherapy, and mental health nursing. In order to do this, the paper will focus upon Deleuze's masterwork, and the cornerstone to his philosophy as a whole, Difference and Repetition; in particular, it will discuss how his innovative and challenging account of time can be employed to provide a conception of human life as a ‘continuity’, rather than as a series of distinct ‘moments’ or ‘events’. As well as discussing the manner in which his work can provide us with an understanding of how life is different and significant for each human being, this paper will also highlight the potential importance of Deleuze's work for logotherapy, for the recent ‘turn’ to ‘narrative’ as a psychotherapeutic approach and for contemporary mental health care's growing interest in ‘social constructionism’. As such, this paper also seeks to stimulate further discussion and research into the importance and the relevance of Deleuze's work for the theory and practice of psychiatry, psychotherapy, and mental health nursing. (shrink)

The diversity of contemporary "capitalisms" underscores the need to supplant the amorphous concept of structure with more precise concepts, particularly institutions and networks. All institutions entail both embodied and relational aspects. Institutions are relational insofar as they map obligatory patterns of "getting by and getting along"—institutional orders—that steer stable social fields over time. Institutions are simultaneously embodied as institutional paradigms, part of a larger bodily agency Pierre Bourdieu called habitus. Institutions are in turn tightly coupled to networks between various people (...) based on, but not reducible to, strategic interests. Yet social interaction sometimes exceeds institutional boundaries, giving rise to disjunctive fields and underscoring the prominence of institutional failures in the unfolding of antagonistic relations such as warfare. Such disjunctive fields can be tracked in relation to some transnational networks at the global level without assuming developmental convergence. This last point underscores the meaning of neoclassical sociology, which eschews assumptions of developmental convergence at the global level. (shrink)

This article shows how Plato’sParmenidesexplores the relationship between place and the geometric forms that are inscribed in it, independently of sensation, becoming and causality. The analysis concurs with essential points of what is said in theTimaeusaboutkhôra, this receptacle deprived of any intrinsic qualities, on which every sensitive reality is drawn.

The risks associated with the techniques of medically assisted procreation (MAP) rapidly became well-known, and in such a short space of time that no biomedical domain remained untouched by the great deal of thinking and the expression of a multitude of opinions it provoked. MAP is evolving between two poles: quality/misuse (even violation) and evidence/fantasy. The ethics will be evoked in the clinical reality from which they spring and where their justification lies. The three objects common to these ethics, the (...) oocyte, the embryo and the child, are illustrated in this context. MAP has as its corollary access to the oocyte, the fertilization of which will take place in vitro. Access to the embryo, on the other hand, enables the clinician, for the purposes of diagnosis [preimplantation genetic diagnosis (PGD), predictive medicine], or even soon for therapeutic purposes (gene therapy) to draw close to a boundary, to trespass beyond which may be seen by humanity to threaten its very origins and integrity: the alienation of the human genome. For the infertile couple, the missing child may take on a dimension of which they would have been unaware, had they not been forced to express their desire. The burden of the imaginary child may, in this way, become a heavier load to bear when, after such desire, he comes into being. MAP puts the goal of normalisation within reach and, in doing so, accentuates the risk of the burden of the attributed representation of the child. On the one hand, MAP offers a tremendous diagnostic and therapeutic potential, while on the other it opens the door to excess and delirium. In this melting pot, ethics, catalysed by this new source of problematics, has discovered a favourite area in which to define and redefine itself. We propose the intervention of ethics on three different levels. Before the elaboration of the law: on first reflection, ethics may influence the responsibilities of the legislator, by taking care that the law does not obscure the biomedical and socioeconomic contexts of MAP and, thereby, also include other related and complementary aspects dealing with the same subject. The secondary discussion of ethics should influence the application of legal protection, by taking into account the rapid technological and social development of MAP, there too, by discussing the whole, rather than the details which will obscure the object. The ethical reflection of the clinician, who is aware of these difficulties, is guided by elements that are specific to his position as a doctor. The cohesion of the team around the clinician and the ethics specialist enables us to develop consensual clinical ethics that are transmissible and therefore teachable. This complex role can, in our view, only be acted out directly in the clinical situation, where the constant, direct relationship with the object of the reflection and the treatment allows ethics to take into account the contingencies of medical practice: we invite the ethics specialist to take part in our clinical activity on a daily basis. (shrink)

Berridge's nuanced approach to the conceptualization of addiction as a disease is easier for me to accept than most others. In fact, Berridge and I agree on many core features of addiction, but still not on how to label it. When competing definitions reach a standoff on intellectual grounds, we should look at the clinical utility of each. And here I think that Berridge misses a critical insight. Yet, we end by agreeing to keep listening to each other.

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Recent scholarship on the idea of communism leads to questions of organization and what Michael Hardt refers to as “the problem of leadership.” Beyond the critical assessment of the crises of contemporary capitalism, and beyond the existing social democratic solutions, a psychoanalytically-informed Žižekian notion of the party offers solutions to ultra-left theories of networked horizontalism as well as versions of the party that repeat the problems of communist modernism. If the context of climate change, economic inequality and political authoritarianism require (...) that we reconsider “what is to be done” about global neoliberal capitalism, then the idea of the political party, understood in terms of Jacques Lacan’s Discourse of the Analyst, can provisionally occupy the place of a neutral knowledge of the objective demands of history that is premised on the experiences of the emancipatory left. Like the Analyst, the party does not stand in for or represent the people. However, through the fetishistic aspect of representation, as opposed to materially or ontologically-grounded guarantees for political power, the party registers a minimal difference from a technocratic University Discourse and an ultra-left Discourse of the Hysteric. (shrink)

Jean-Marc Ferry est titulaire de la Chaire de Philosophie de l'Europe de l'Université de Nantes, professeur honoraire en Science politique et Philosophie morale à l'Université libre de Bruxelles, auteur notamment des Puissances de l'expérience (1991), l'une des oeuvres les plus importantes récemment publiées dans le champ de la philosophie sociale et politique, de la philosophie tout court (Paul Ricoeur), La Question de l'État européen (2001), Les Grammaires de l'intelligence (2004), La Raison et la Foi (2016).