Advances at the interface between the biological sciences and engineering are giving rise to emerging research fields such as synthetic biology. Harnessing the potential of synthetic biology requires timely and adequate translation into clinical practice. However, the translational research enterprise is currently facing fundamental obstacles that slow down the transition of scientific discoveries from the laboratory to the patient bedside. These obstacles including scarce financial resources and deficiency of organizational and logistic settings are widely discussed as primary impediments to translational (...) research. In addition, a number of socio-ethical considerations inherent in translational research need to be addressed. As the translational capacity of synthetic biology is tightly linked to its social acceptance and ethical approval, ethical limitations may—together with financial and organizational problems—be co-determinants of suboptimal translation. Therefore, an early assessment of such limitations will contribute to proactively favor successful translation and prevent the promising potential of synthetic biology from remaining under-expressed. Through the discussion of two case-specific inventions in synthetic biology and their associated ethical implications, we illustrate the socio-ethical challenges ahead in the process of implementing synthetic biology into clinical practice. Since reducing the translational lag is essential for delivering the benefits of basic biomedical research to society at large and promoting global health, we advocate a moral obligation to accelerating translational research: the “translational imperative.”. (shrink)

The author group of above-mentioned review paper was incorrectly published in the online article.

John Rawls's work (1971) has greatly contributed to rehabilitating equality as a basic social value, after decades of utilitarian hegemony,particularly in normative economics, but Rawls also emphasized that full equality of welfare is not an adequate goal either. This thesis was echoed in Dworkin's famous twin papers on equality (Dworkin 1981a,b), and it is now widely accepted that egalitarianism must be selective. The bulk of the debate on ‘Equality of What?’ thus deals with what variables ought to be submitted for (...) selection and how this selection ought to be carried out. (shrink)

Whilst Bayesian epistemology is widely regarded nowadays as our best theory of knowledge, there are still a relatively large number of incompatible and competing approaches falling under that umbrella. Very recently, Wallmann and Williamson wrote an interesting article that aims at showing that a subjective Bayesian who accepts the principal principle and uses a known physical chance as her degree of belief for an event A could end up having incoherent or very implausible beliefs if she subjectively chooses the probability (...) of an event F for which she has much poorer evidence. They also argued that their own version of objective Bayesianism is completely immune to that challenge. In this article, after having presented the strongest version of Wallmann’s and Williamson’s argument, I will show that if successful, it has far-reaching consequences and would not only invalidate moderate subjective Bayesianism and imprecise probalism but also a form of objective Bayesianism that relies on conditionalisation, the principal principle, reference classes, and the principle of indifference applied to the most basic partitions. I then argue that their argument can be defeated by adding the rule that it is always irrational to choose a probability that can be computed from the known probabilities associated to one’s other beliefs. I finally argue that the authors’ main intuition that probabilities have different degrees of reliability favours imprecise Bayesianism over precise Bayesianism. (shrink)

Artificial language learning experiments have become an important tool in exploring principles of language and language learning. A persistent question in all of this work, however, is whether ALL engages the linguistic system and whether ALL studies are ecologically valid assessments of natural language ability. In the present study, we considered these questions by examining the relationship between performance in an ALL task and second language learning ability. Participants enrolled in a Spanish language class were evaluated using a number of (...) different measures of Spanish ability and classroom performance, which was compared to IQ and a number of different measures of ALL performance. The results show that success in ALL experiments, particularly more complex artificial languages, correlates positively with indices of L2 learning even after controlling for IQ. These findings provide a key link between studies involving ALL and our understanding of second language learning in the classroom. (shrink)

This thought-provoking collection sheds light on the plight of our nonhuman primate cousins--and what we can do to help.

Many writers claim that human kinds are significantly different from biological and natural kinds. Some suggest that humans kinds are unique because social structures are essential for the etiology of human kinds. Others argue that human cultural evolution is decidedly different from other forms of evolution. In this paper I suggest that the gulf between humans and our biological relatives is not as wide as some argue. There is a taxonomic difference between human and nonhuman organisms, but such factors as (...) social structure and cultural evolution do not distinguish us from many other organisms. (shrink)

Der Mensch als „homo viator“ ist ein Topos, der sich in der Literatur und Philosophie, aber auch in diversen religiösen Traditionen unterschiedlicher Epochen finden lässt. Der vorliegende Sammelband konzentriert sich auf die Thematisierung dieses Bildes vom Menschen, der auf dem Wege ist, durch das moderne Existenzdenken.

I applaud Fenton and Wiers' attempt to find a demarcation point between cases of addiction that fall within the range of normal function and those that may count as disease. However, I argue that continua don't offer demarcation points, the mechanisms involved are not demonstrably different, and trying to pin down subjectivity doesn't help.

Ainslie’s contribution offers a useful refinement of his powerful model of intertemporal bargaining. However, he focuses mostly on the cognitive mechanisms of choice. I suggest that these interact with emotional, personality, and developmental dynamics that cannot be ignored, either psychologically or neurally.

Although I reject neuronormativity -- an idea central to the Brain Disease Model of Addiction -- Henden and Gjelsvik argue that the disease definition might refer to normativity in nonneural domains. They profess that a cognitive dysfunction, or a mismatch of evolutionary intentions, could also qualify as norm violations, thus legitimizing the disease label. The need for dividing lines is questioned as well. I rebut these criticisms in turn, but I must admit they are thought provoking.

The utilitarian economist and Nobel Laureate John Harsanyi and the liberal egalitarian philosopher John Rawls were two of the most eminent scholars writing on problems of social justice in the last century. This volume pays tribute to Harsanyi and Rawls by investigating themes that figure prominently in their work. In some cases, the contributors explore issues considered by Harsanyi and Rawls in more depth and from novel perspectives. In others, the contributors use the work of Harsanyi and Rawls as points (...) of departure for pursuing the construction of theories for the evaluation of social justice. The introductory essay by the editors provides background information on the relevant economics, game theory, philosophy, and social choice theory, as well as readers' guides to the individual contributions, to make this volume widely accessible to scholars in a wide range of disciplines. (shrink)

This paper distinguishes an index ordering and a social ordering function as a simple way to formalize the indexing problem in the social choice framework. Two main conclusions are derived. First, the alleged dilemma between welfarism and perfectionism is shown to involve a third possibility, exemplified by the fairness approach to social choice. Second, the idea that an individual is better off than another whenever he has more (goods, functionings, etc.) in all dimensions, which is known to enter in conflict (...) with the Pareto principle, can be partly salvaged by adopting the fairness approach. (shrink)

The French philosopher, Gilles Deleuze, is emerging as one of the most important and influential philosophers of the 20th century, having published widely on philosophy, literature, language, psychoanalysis, art, politics, and cinema. However, because of the ‘experimental’ nature of certain works, combined with the manner in which he draws upon a variety of sources from various disciplines, his work can seem difficult, obscure, and even ‘willfully obstructive’. In an attempt to resist such impressions, this paper will seek to provide an (...) accessible introduction to Deleuze's work, and to begin to discuss how it can be employed to provide a significant critique and reconceptualization of the theoretical foundations and therapeutic practices of psychiatry, psychotherapy, and mental health nursing. In order to do this, the paper will focus upon Deleuze's masterwork, and the cornerstone to his philosophy as a whole, Difference and Repetition; in particular, it will discuss how his innovative and challenging account of time can be employed to provide a conception of human life as a ‘continuity’, rather than as a series of distinct ‘moments’ or ‘events’. As well as discussing the manner in which his work can provide us with an understanding of how life is different and significant for each human being, this paper will also highlight the potential importance of Deleuze's work for logotherapy, for the recent ‘turn’ to ‘narrative’ as a psychotherapeutic approach and for contemporary mental health care's growing interest in ‘social constructionism’. As such, this paper also seeks to stimulate further discussion and research into the importance and the relevance of Deleuze's work for the theory and practice of psychiatry, psychotherapy, and mental health nursing. (shrink)

The common view of the “Arab street” fails to capture essential dimensions of the role of public opinion and public discourse in the politics of Arab states. The rising importance of transnational Arab television and print media has created a public arena outside the control of states. Arguments about issues of shared concern in this Arabist public sphere have had important implications for political identity, beliefs, expectations, and behavior. Arab responses to the ongoing crisis in Iraq demonstrate the political significance (...) of these debates. (shrink)

In a model of private good allocation, we construct social orderings which depend only on ordinal non-comparable information about individual preferences. In order to avoid Arrovian-type impossibilities, we let those social preferences take account of the shape of individual indifference curves. This allows us to introduce equity and cross-economy robustness properties, inspired by the theory of fair allocation. Combining such properties, we characterize two families of fair social orderings.

Berridge's nuanced approach to the conceptualization of addiction as a disease is easier for me to accept than most others. In fact, Berridge and I agree on many core features of addiction, but still not on how to label it. When competing definitions reach a standoff on intellectual grounds, we should look at the clinical utility of each. And here I think that Berridge misses a critical insight. Yet, we end by agreeing to keep listening to each other.

The diversity of contemporary "capitalisms" underscores the need to supplant the amorphous concept of structure with more precise concepts, particularly institutions and networks. All institutions entail both embodied and relational aspects. Institutions are relational insofar as they map obligatory patterns of "getting by and getting along"—institutional orders—that steer stable social fields over time. Institutions are simultaneously embodied as institutional paradigms, part of a larger bodily agency Pierre Bourdieu called habitus. Institutions are in turn tightly coupled to networks between various people (...) based on, but not reducible to, strategic interests. Yet social interaction sometimes exceeds institutional boundaries, giving rise to disjunctive fields and underscoring the prominence of institutional failures in the unfolding of antagonistic relations such as warfare. Such disjunctive fields can be tracked in relation to some transnational networks at the global level without assuming developmental convergence. This last point underscores the meaning of neoclassical sociology, which eschews assumptions of developmental convergence at the global level. (shrink)

This article shows how Plato’sParmenidesexplores the relationship between place and the geometric forms that are inscribed in it, independently of sensation, becoming and causality. The analysis concurs with essential points of what is said in theTimaeusaboutkhôra, this receptacle deprived of any intrinsic qualities, on which every sensitive reality is drawn.

The risks associated with the techniques of medically assisted procreation (MAP) rapidly became well-known, and in such a short space of time that no biomedical domain remained untouched by the great deal of thinking and the expression of a multitude of opinions it provoked. MAP is evolving between two poles: quality/misuse (even violation) and evidence/fantasy. The ethics will be evoked in the clinical reality from which they spring and where their justification lies. The three objects common to these ethics, the (...) oocyte, the embryo and the child, are illustrated in this context. MAP has as its corollary access to the oocyte, the fertilization of which will take place in vitro. Access to the embryo, on the other hand, enables the clinician, for the purposes of diagnosis [preimplantation genetic diagnosis (PGD), predictive medicine], or even soon for therapeutic purposes (gene therapy) to draw close to a boundary, to trespass beyond which may be seen by humanity to threaten its very origins and integrity: the alienation of the human genome. For the infertile couple, the missing child may take on a dimension of which they would have been unaware, had they not been forced to express their desire. The burden of the imaginary child may, in this way, become a heavier load to bear when, after such desire, he comes into being. MAP puts the goal of normalisation within reach and, in doing so, accentuates the risk of the burden of the attributed representation of the child. On the one hand, MAP offers a tremendous diagnostic and therapeutic potential, while on the other it opens the door to excess and delirium. In this melting pot, ethics, catalysed by this new source of problematics, has discovered a favourite area in which to define and redefine itself. We propose the intervention of ethics on three different levels. Before the elaboration of the law: on first reflection, ethics may influence the responsibilities of the legislator, by taking care that the law does not obscure the biomedical and socioeconomic contexts of MAP and, thereby, also include other related and complementary aspects dealing with the same subject. The secondary discussion of ethics should influence the application of legal protection, by taking into account the rapid technological and social development of MAP, there too, by discussing the whole, rather than the details which will obscure the object. The ethical reflection of the clinician, who is aware of these difficulties, is guided by elements that are specific to his position as a doctor. The cohesion of the team around the clinician and the ethics specialist enables us to develop consensual clinical ethics that are transmissible and therefore teachable. This complex role can, in our view, only be acted out directly in the clinical situation, where the constant, direct relationship with the object of the reflection and the treatment allows ethics to take into account the contingencies of medical practice: we invite the ethics specialist to take part in our clinical activity on a daily basis. (shrink)

Dans Les Nuées, Aristophane adresse des critiques à Socrate auxquelles Platon répond philosophiquement dans l’Apologie. Or le Socrate des Nuées porte des traits de Protagoras, et certains reproches attribués à l’un valent pour l’autre. Comme pour Socrate, Platon a composé pour Protagoras une apologie, dans le Théétète. Si nous comparons les accusations de la pièce à ce que Platon prête à Protagoras, nous constatons qu’il se fait son défenseur. Mais pour quelle raison et à quel point de vue? Par une (...) analyse des concepts de geloion et de mimèsis comique, on montre comment Platon déploie une stratégie de réappropriation de la pensée de Protagoras – pour lui donner un tour philosophique qui constitue en même temps une réflexion critique sur le statut de l’objet comique.In the Apology, Plato gives a philosophical answer to critics contained in Aristophanes’ Clouds. However, through Socrates, The Clouds target Protagoras too. As a matter of fact, Plato composed an apology for him, as well in the Theaetetus, that answers the charges in the comedy against Protagoras, becoming in a certain way his « lawyer ». But why and what for? Analysing the concepts of geloion and comic mimesis, we show how Plato undertakes to give a philosophical reading of Protagoras’ thought, which, in the same time, constitutes a critical thinking about the object of comedy. (shrink)

La critique platonicienne de la démocratie est résolument philosophique, contestant le modèle anthropologique et épistémologique sous-jacent au nom des aberrations historiques auxquelles il est condamné. Cet article examine les deux principaux moteurs de l’analyse platonicienne : 1) l’absence d’unité, qui se traduit par une oligarchie de fait et par une dispersion des citoyens, plus soucieux de leur liberté individuelle que de l’intérêt de la cité ; 2) une théorie de la connaissance qui, aussi implicite soit-elle, dissocie savoir et pouvoir. Il (...) en résulte une prise de distance à l’égard d’un modèle où l’homme démocratique serait jugé compétent par nature à exercer des responsabilités. (shrink)