While N6‐methyladenosine (m6A) is a well‐known epigenetic modification in bacterial DNA, it remained largely unstudied in eukaryotes. Recent studies have brought to fore its potential epigenetic role across diverse eukaryotes with biological consequences, which are distinct and possibly even opposite to the well‐studied 5‐methylcytosine mark. Adenine methyltransferases appear to have been independently acquired by eukaryotes on at least 13 occasions from prokaryotic restriction‐modification and counter‐restriction systems. On at least four to five instances, these methyltransferases were recruited as RNA methylases. Thus, (...) m6A marks in eukaryotic DNA and RNA might be more widespread and diversified than previously believed. Several m6A‐binding protein domains from prokaryotes were also acquired by eukaryotes, facilitating prediction of potential readers for these marks. Further, multiple lineages of the AlkB family of dioxygenases have been recruited as m6A demethylases. Although members of the TET/JBP family of dioxygenases have also been suggested to be m6A demethylases, this proposal needs more careful evaluation. (shrink)

In a little over two hundred years, American legal thought moved from premodernism through modernism and into postmodernism. This book charts that intellectual voyage, stressing both the historical contexts in which ideas unfolded and the inherent force of the ideas themselves.Author Stephen M. Feldman first defines "premodernism," "modernism," and "postmodernism," then explains the development of American legal thought through these three intellectual periods. His narrative revolves around two broad, interrelated themes: jurisprudential foundations and the notion of progress. He points out (...) that much of American legal thought has grappled with the problem of identifying the foundations of the American judicial system and judicial decision making. The various ideas of jurisprudential foundations, moreover, are closely tied to shifting notions of progress-the definition of the term, assumptions about the possibility of progress, and hopes about how law might contribute to it.This book's broad historical sweep and its clear explanations of the competing theoretical positions of current legal scholarship make it indispensable to students and scholars of jurisprudence and American legal history. (shrink)

The title of my paper may look odd. If one is questioned “What is a dog?”, everyone could give a more or less valid answer. But to the question “What is not a dog?”, there can be innumerable answers which may be correct, but mostly quite unhelpful. Provisionally, what I intend to do under this title is to consider what we should not hold time to be. Through the history of ideas we meet various opinions and theories concerning what time (...) is. But it seems to me that most of them are not adequate enough, though each has its reason and often profound import as well. So I would like here to make a proposal for reconsidering how time appears in our life and thinking. (shrink)

A Select Bibliography Michael McMahon Sheehan Jacqueline Murray. 16 Ritual and Iconography 134 12-14c Studies in Medieval Domestic Architecture ed M.J. Swanton (London 1975). [English aristocratic housing] 135 11-12c WEDZKI,...

This paper explores the psychoanalytic conception of the unconscious and critiques it from a phenomenlogical perspective, especially Sartre and Heidegger, with a view to conceptualizing the unconscious from an ontological rather than psychological mindset.

Upshot: Michael Tomasello is Director of the Department of Developmental and Comparative Psychology and Co-Director of the Max Planck Institute for Evolutionary Anthropology in Leipzig. He completed his PhD with Ernst as his supervisor in 1980. In his reminiscence essay he describes the “total enculturation” he experienced on encountering Ernst von Glasersfeld.

Donald Davidson has made enormous contributions to the philosophy of action, epistemology, semantics and philosophy of mind and today is recognized as one of the most important analytical philosophers of the late twentieth century. Davidson's philosophy is characterised not only by its rigour and intellectual integrity but also by its continued interest in dialogue and re-evaluation of its paradigms. In the spirit of this openness, this volume brings together essays on the major themes of Davidson's thought by leading academics, along (...) with individually penned responses by the philosopher himself. (shrink)