The discovery of the first intracellular substrate for insulin, IRS‐1, redirected the field of diabetes research and has led to many important advances in our understanding of insulin action. Detailed analysis of IRS‐1 demonstrates structure/function relationships for this modular docking molecule, including mechanisms of substrate recognition and signal propagation. Recent work has also identified other structurally similar molecules, including IRS‐2, the Drosophila protein, DOS, and the Grb2‐binding protein, Gab1, suggesting that this intracellular signalling strategy is conserved evolutionarily and is utilized (...) by an expanding number of receptor systems. In fact, IRS‐1 itself has been shown to be important in other growth factor and cytokine signalling systems, including growth hormone and several interleukins. Analysis of mice lacking IRS‐1 confirms an important physiological role for this protein in glucose metabolism and general cell growth in the intact animal. Disregulation of the signalling pathways integrated by the IRS proteins may contribute to the pathophysiology of non‐insulin‐dependent diabetes mellitus or other diseases. (shrink)

Applying a medical conception of toxicity to speech practices, this paper calls for an epidemiology of discursive toxicity. Toxicity highlights the mechanisms by which speech acts and discursive practices can inflict harm, making sense of claims about harms arising from speech devoid of slurs, epithets, or a narrower class I call ‘deeply derogatory terms.’ Further, it highlights the role of uptake and susceptibility, and so suggests a framework for thinking about damage variation. Toxic effects vary depending on one’s epistemic position, (...) access, and authority. An inferentialist account of discursive practice plus a dynamic view of the power of language games offers tools to analyze the toxic power of speech acts. A simple account of language games helps track changes in our discursive practices. Identifying patterns contributes to an epidemiology of toxic speech, which might include tracking increasing use of derogatory terms, us/them dichotomization, terms of isolation, new essentialisms, and more. Using this framework, I analyze some examples of speech already said to be toxic, working with a rough concept of toxicity as poison. Finally, exploring discursive toxicity pushes us to find ways that certain discursive practices might “inoculate” one to absorbing toxic messages, or less metaphorically, block one’s capacity to make toxic inferences, take deontic stances that foster toxicity, etc. (shrink)

The ideal introduction for students of semantics, Lexical Meaning fills the gap left by more general semantics textbooks, providing the teacher and the student with insights into word meaning beyond the traditional overviews of lexical relations. The book explores the relationship between word meanings and syntax and semantics more generally. It provides a balanced overview of the main theoretical approaches, along with a lucid explanation of their relative strengths and weaknesses. After covering the main topics in lexical meaning, such as (...) polysemy and sense relations, the textbook surveys the types of meanings represented by different word classes. It explains abstract concepts in clear language, using a wide range of examples, and includes linguistic puzzles in each chapter to encourage the student to practise using the concepts. 'Adopt-a-Word' exercises give students the chance to research a particular word, building a portfolio of specialist work on a single word. (shrink)

. The extended‐mind thesis is the claim that mentality need not be situated just in the brain, or even within the boundaries of the skin. Some versions take “extended selves” be to relatively transitory couplings of biological organisms and external resources. First, I show how EM can be seen as an extension of traditional views of mind. Then, after voicing a couple of qualms about EM, I reject EM in favor of a more modest hypothesis that recognizes enduring subjects of (...) experience and agents with integrated bodies. Nonetheless, my modest hypothesis allows subpersonal states to have nonbiological parts that play essential roles in cognitive processing. I present empirical warrant for this modest hypothesis and show how it leaves room for science and religion to coexist. (shrink)

Introduction to the Philosophy of Sport begins with the history of sport, delves into both the metaphysics and ethics of sport, and also addresses dimensions of the social and political elements of sport. This book is a comprehensive introduction to the philosophy of sport with a straightforward layout that professors can plan and build their courses around.

Evolution: The Basics is an engaging introduction to the history, development and science of the theory of evolution. Beginning pre-Darwin and concluding with the latest research and controversies, readers are introduced to the origins of the idea of evolution, the ways in which it has developed and been adapted over time and the science underpinning it all. Topics addressed include: • early theories of evolution • the impact of Darwin’s On the Origin of Species • the discovery of genetics and (...) Mendel’s experiments • molecular evolution and the discovery of DNA • the expansion of life and the persistence of disease • revisiting evolutionary ethics and the development of empathy. Evolution: The Basics examines the role of evolution in current debates and discusses the possible future developments in the field. This book is invaluable reading for all students and individuals seeking to understand the wide ranging sphere of evolutionary theory.  . (shrink)

All athletes experience victory and defeat, but how many truly learn from the experience of sport? For ancient Greek philosophers, sport was an integral part of education. Today, athletics programs remain in schools, but we face a growing gap between the modern sports experience and enduring educational values. This book seeks to bridge that gap by advocating a philosophical approach to the sports experience. Combining issues and ideas from traditional philosophy with contemporary analyses of sport and applied "thinking activities," this (...) book invites athletes to learn about life from their experience of sport. The text works its way from internal reflection to social interaction by addressing four important topics: self-discovery, responsibility, respect, and citizenship. This sequence is important because authentic self-knowledge is an essential foundation for effectively dealing with the personal and social challenges faced by philosophical athletes. Reid discusses specific issues such as violence, racism, and performance-enhancing drugs in their relevant contexts, although philosophical athletes focus on the big picture, approaching each issue from a complete vision of themselves, their moral commitments, and their social roles. Athletes as diverse as the teenage college recruit and the aging weekend-warrior will gain insight into their sports experience and into their lives. This philosophical approach maximizes what we can learn from sport and gives us the best chance for leading better lives because of it. (shrink)

Beginning with Aristotle, philosophers have taken artifacts to be ontologically deficient. This paper proposes a theory of artifacts, according to which artifacts are ontologically on a par with other material objects. I formulate a nonreductive theory that regards artifacts as constituted by - but not identical to - aggregates of particles. After setting out the theory, I rebut a number of arguments that disparage the ontological status of artifacts.

This book explores how some word meanings are paradigmatically related to each other, for example, as opposites or synonyms, and how they relate to the mental organization of our vocabularies. Traditional approaches claim that such relationships are part of our lexical knowledge (our "dictionary" of mentally stored words) but Lynne Murphy argues that lexical relationships actually constitute our "metalinguistic" knowledge. The book draws on a century of previous research, including word association experiments, child language, and the use of synonyms (...) and antonyms in text. (shrink)

Drawing on writers as diverse as Saul Kripke, Stanley Cavell, G. E. M. Anscombe, Jonathan Lear, and Bernard Williams, I offer an interpretation of Wittgenstein's key notion of a form of life that explains why Wittgenstein was so enigmatic about it. Then, I show how Hilary Putnam's criticism of Wittgenstein's philosophy of mathematics and Richard Rorty's support of (what he takes to be) Wittgenstein's legacy in the philosophy of mind both require mistaken assumptions about Wittgenstein's idea of a form of (...) life. Finally, I consider the extent to which the idea of a form of life is subject to Donald Davidson's critique of the idea of a conceptual scheme. (shrink)

The first-person perspective is a challenge to naturalism. Naturalistic theories are relentlessly third-personal. The first-person perspective is, well, first-personal; it is the perspective from which one thinks of oneself as oneself* without the aid of any third-person name, description, demonstrative or other referential device. The exercise of the capacity to think of oneself in this first-personal way is the necessary condition of all our self-knowledge, indeed of all our self-consciousness. As important as the first-person perspective is, many philosophers have not (...) appreciated the force of the data from the first-person perspective, and suppose that the first-person perspective presents no particular problems for the naturalizing philosopher. For example, Ned Block commented, “It is of course [phenomenal] consciousness rather than...self-consciousness that has seemed such a scientific mystery.” And David Chalmers says that self-consciousness is one of those psychological states that “pose no deep metaphysical enigmas.”. (shrink)

Children dependent on life-prolonging medical technology are often subject to a constant background risk of sudden death or catastrophic complications. Such children can be cared for in hospital, in an intensive care environment with highly trained nurses and doctors able to deliver specialised, life-saving care immediately. However, remaining in hospital, when life expectancy is limited, can considered to be a harm in of itself. Discharge home offers the possibility for an improved quality of life for the child and their family (...) but comes with significant medical risks.When making decisions for children, two ethical models predominate, the promotion of the child’s best interests or the avoidance of harm. However, in some circumstances, particularly for children with life-limiting and/or life-threatening illness, all options may be associated with risk. There are no good options, only potentially harmful choices.In this paper, we explore decisions made by one family in such circumstances. We describe a model adopted from risk management programmes beyond medicine, which offers a potential framework for identifying risks to the child that are morally permissible. Some risks and harms to a child, not ordinarily permitted, may be acceptable when undertaken in the pursuit of a specified desired good, so long as they are as low as reasonably practicable. (shrink)

My aim in this paper is to contribute to the substantial body of feminist scholarship on the place of women in Aristotle’s psychic and political hierarchy. Whereas the traditional point of departure for such analyses is more typically Aristotle’s Politics, mine is his hylomorphic or organizational/ecological account of what defines a living thing and its powers in de Anima. My primary claim is that although his de Anima account does offer a more promising view of what defines particular kinds of (...) living things, including human beings qua the power of intellection, it does not ultimately save him from the ambiguity endemic to his account of women’s capacity to deliberate in his Politics. Such a result is significant for feminists who, in seeking nondualistic accounts of embodied human existence, have sometimes turned to Aristotle’s hylomorphism for support, but, I suggest, might be better off to seek such support elsewhere. (shrink)

Environmental Dilemmas focuses on the ethical problems and dilemmas that emerge in place-based professional practices—architecture, landscape architecture, planning, engineering, and construction management. Mugerauer and Manzo connect decision-making to major ethical theories, principles, and rules, and professional codes of ethics.

The aim of this article is to show that human persons belong, ontologically, in social ontology. After setting out my views on ontology, I turn to persons and argue that they have first-person perspectives in two stages (rudimentary and robust) essentially. Then I argue that the robust stage of the first-person persective is social, in that it requires a language, and languages require linguistic communities. Then I extend the argument to cover the rudimentary stage of the first-person perspective as well. (...) I conclude by enumerating ways in which human persons differ from nonhuman animals. (shrink)

According to the Constitution View of persons, a human person is wholly constituted by (but not identical to) a human organism. This view does justice both to our similarities to other animals and to our uniqueness. As a proponent of the Constitution View, I defend the thesis that the coming-into-existence of a human person is not simply a matter of the coming-into-existence of an organism, even if that organism ultimately comes to constitute a person. Marshalling some support from developmental psychology, (...) I give a broadly materialistic account of the coming-into-existence of a human person. I argue for the metaphysical superiority of the Constitution View to Biological Animalism, Thomistic Animalism, and other forms of Substance Dualism. I conclude by discussing the single implication of the Constitution View for thinking about abortion. Footnotesa Thanks to Gareth Matthews and Catherine E. Rudder for comments. I am also grateful to other contributors to this volume, especially Robert A. Wilson, Marya Schechtman, David Oderberg, Stephen Braude, and John Finnis. (shrink)

Although language has long been regarded as a primarily arbitrary system, sound symbolism, or non-arbitrary correspondences between the sound of a word and its meaning, also exists in natural language. Previous research suggests that listeners are sensitive to sound symbolism. However, little is known about the specificity of these mappings. This study investigated whether sound symbolic properties correspond to specific meanings, or whether these properties generalize across semantic dimensions. In three experiments, native English-speaking adults heard sound symbolic foreign words for (...) dimensional adjective pairs and for each foreign word, selected a translation among English antonyms that either matched or mismatched with the correct meaning dimension. Listeners agreed more reliably on the English translation for matched relative to mismatched dimensions, though reliable cross-dimensional mappings did occur. These findings suggest that although sound symbolic properties generalize to meanings that may share overlapping semantic features, sound symbolic mappings offer semantic specificity. (shrink)

I am grateful to Dean Zimmerman, Michael Rea, and Derk Pereboom for their close criticism and helpful suggestions for Persons and Bodies. My ideas—especially about the definition of ‘constitution’—have been significantly improved by their comments.

Theories of the human person differ greatly in their ability to underwrite a metaphysics of resurrection. This paper compares and contrasts a number of such views in light of the Christian doctrine of resurrection. In a Christian framework, resurrection requires that the same person who exists on earth also exists in an afterlife, that a postmortem person be embodied, and that the existence of a postmortem person is brought about by a miracle. According to my view of persons (the Constitution (...) View), a human person is constituted by—but not identical to—a human organism. A person has a first-person perspective essentially, and an organism has interrelated biological functions essentially. I shall argue for the superiority the Constitution View as a metaphysical basis for resurrection. (shrink)

Some philosophers take personal identity to be a matter of self-narrative. I argue, to the contrary, that self-narrative views cannot stand alone as views of personal identity. First, I consider Dennett’s self-narrative view, according to which selves are fictional characters—abstractions, like centers of gravity—generated by brains. Neural activity is to be interpreted from the intentional stance as producing a story. I argue that this is implausible. The inadequacy is masked by Dennett’s ambiguous use of ‘us’: sometimes ‘us’ refers to real (...) human beings, and sometimes ‘us’ refers to selves or fictional characters. Second, I consider Schechtmann’s view that self-narratives create persons in order for there to be a self-narrative. Finally, I offer my own account of persons. (shrink)

The prevailing view of Christian philosophers today seems to be that Christianity requires a libertarian conception of free will. Focusing on Augustine’s mature anti-Pelagian works, I try to show that the prevailing view is in error. Specifically, I want to show that---on Augustine’s view of grace-a libertarian account of free will is irrelevant to salvation. On Augustine’s view, the grace of God through Christ is sufficient as weIl as necessary for salvation. Salvation is entirely in the hands of God, totally (...) independent of anything that any human being might do. And faith, the human response to salvation, is best understood in terms of a compatibilist account of freedom. (shrink)

This essay asks about the return to nature and “life itself” in contemporary feminist philosophy and theory, from the new materialisms to feminist science studies to environmental ethics and critical animal studies. Unlike traditional naturalisms, the contemporary turn to nature is explicitly posthumanist. Shifting their focus away from anti-essentialist critiques of woman-as-nature, these new feminist philosophies of nature have turned toward nonhuman animals, the cosmos, the climate, and life itself as objects of ethical concern. Drawing on Foucault, the essay probes (...) the ethical meanings of the term “life itself” invoked in many of these renaturalizing projects. Focusing especially on the archival matter that guides Foucault’s thinking, I suggest that we rethink “life itself” not as a transhistorical substance but as the unstable materiality of history. I then reframe Foucault’s archival, genealogical perspective through the lens of the Anthropocene and geological time. Reconceiving our archive as a fossil record, I suggest that Foucault has much to contribute to environmental challenges to human exceptionalism and the anthropogenic destruction of other species and ourselves. (shrink)

Although prominent Christian theologians and philosophers have assumed the truth of mind/body dualism, I want to raise the question of whether the Christian ought to be a mind/body dualist. First, I sketch a picture of mind, and of human persons, that is not a form of mind/body dualism. Then, I argue that the nondualistic picture is compatible with a major traditional Christian doctrine, the doctrine of the resurrection of the dead. Finally, I suggest that if a Christian need not be (...) a mind/body dualist, then she should not be a mind/body dualist. (shrink)

Arguments about temporal becoming often get nowhere. One reason for the impasse lies in the fact that the issue has been formulated as a choice between science on the one hand and common sense (or ordinary language) on the other as the primary source of ontological commitment.' Often' proponents of attributing temporal becoming to the physical universe look to everyday temporal concepts, find them infested with notions involving temporal becoming and conclude that becoming is a basic feature of the physical (...) world. Their opponents may look to physical science, find no reference to temporal becoming and conclude that becoming is not part of the extramental universe.2 Thus construed, the issue of temporal becoming is not directly amenable to argument. This stalemate will be broken, however, if I accomplish my aim: to (re)formulate the question of temporal becoming so that it is subject to adjudication; to show how objections to the thesis of the mind-dependence of becoming can fruitfully be seen (and in a sense unified) as attacks on a single argument for the thesis, an argument from physics; and to defend the con'elusion of the argument from physics from heretofore unanswered objections. The question of the status of temporal becoming is the question of the status of past, present and future.' Events which are at one time in the future, are said to become present and subsequently to recede into the past. Since past and future can be defined as 'earlier than now' and 'later than.. (shrink)

The expression ‘nonreductive materialism’ refers to a variety of positions whose roots lie in attempts to solve the mind-body problem. Proponents of nonreductive materialism hold that the mental is ontologically part of the material world; yet, mental properties are causally efficacious without being reducible to physical properties.s After setting out a minimal schema for nonreductive materialism (NRM) as an ontological position, I’ll canvass some classical arguments in favor of (NRM).1 Then, I’ll discuss the major challenge facing any construal of (NRM): (...) the problem of mental causation, pressed by Jaegwon Kim. Finally, I’ll offer a new solution to the problem of mental causation. (shrink)

Artifacts are objects intentionally made to serve a given purpose; natural objects come into being without human intervention. I shall argue that this difference does not signal any ontological deficiency in artifacts qua artifacts. After sketching my view of artifacts as ordinary objects, I’ll argue that ways of demarcating genuine substances do not draw a line with artifacts on one side and natural objects on the other. Finally, I’ll suggest that philosophers have downgraded artifacts because they think of metaphysics as (...) resting on a distinction between what is “mind­independent” and what is “mind­ dependent.” I’ll challenge the use of any such distinction as a foundation for metaphysics. (shrink)

Eco-Nihilism: The Philosophical Geopolitics of the Climate Change Apocalypse argues that there are no versions of conquest capital compatible with the fact of a finite planet, and that the pursuit of growth is destined to not only exhaust our planetary resources, but generate profound social injustice and geopolitical violence in its pursuit.

This report analyzes the role Japanese women play in the traditional art of the tea ceremony and its meaning for their lives. It is based on data collected for a larger study which explored the ways in which a cultural art transmits its practice and values to Japanese and foreign learners, conducted in Tokyo, Kyoto, and Yokohama, Japan, from 1983 to 1985. Using the Urasenke school, which accounts for approximately 70 percent of all practitioners as a case study, this report (...) explores the impact of women's participation as professionals and students on the organizational structure and activities of the school. Interviews with 31 teachers and 55 students, professionals, and amateurs provided the data to explore the ways in which the art has accommodated women's interests. (shrink)

In the large recent literature on the nature of human persons, persons are usually studied in isolation from the world in which they live. What persons are most fundamentally, philosophers say, are human animals, or brains, or perhaps souls -- without any consideration of the social and physical environments without which persons would not exist. In this article, I want to compensate for such overly narrow focus. Instead of beginning with the nature of persons cut off from any environment, I (...) shall begin with metaphysical consideration of the world of which persons are a part. I shall then briefly describe my view of persons, according to which persons are material objects like other concrete things in the world, but are unique in their first-person perspectives. Finally, I shall consider some of the special relations that persons, and only persons, have to other things in the world. (shrink)

Cheri Lynne Carr explores the very real potential of Deleuze's clandestine use of Kantian critique for developing a new ethical practice. This new practice is built on an idea implicit in much of Deleuzian thought: the idea of critique as a way of life.

Many Christians who argue against Christian materialism direct their arguments against what I call ‘Type-I materialism’, the thesis that I cannot exist without my organic body. I distinguish Type-I materialism from Type-II materialism, which entails only that I cannot exist without some body that supports certain mental functions. I set out a version of Type-II materialism, and argue for its superiority to Type-I materialism in an age of science. Moreover, I show that Type-II materialism can accommodate Christian doctrines like the (...) Resurrection of the Body, the Incarnation, and the intermediate state (if there is one). (shrink)

Metaphysics has enjoyed a vigorous revival in the last few decades. Even so, there has been little ontological interest in the things that we interact with everyday—trees, tables, other people.1 It is not that metaphysicians ignore ordinary things altogether. Indeed, they are happy to say that sentences like ‘The daffodils are out early this year’ or ‘My computer crashed again’ are true. But they take the truth of such sentences not to require that a full description of reality mention daffodils (...) or computers. Many metaphysicians now interpret the apparent variety of things in the world as variety only of concepts applied to things that are basically of the same sort—for example, sums of particles or of temporal parts of particles. (shrink)

Social Externalism is the thesis that many of our thoughts are individuated in part by the linguistic and social practices of the thinker’s community. After defending Social Externalism and arguing for its broad application, I turn to the kind of defeasible first-person authority that we have over our own thoughts. Then, I present and refute an argument that uses first-person authority to disprove Social Externalism. Finally, I argue briefly that Social Externalism—far from being incompatible with first-person authority—provides a check on (...) first-personal pronouncements and thus saves first-person authority from being simply a matter of social convention and from collapsing into the subjectivity of “what seems right is right.”. (shrink)

Cognitive Science, Volume 46, Issue 1, January 2022.