Fundamental problems in developmental biology, such as the generation of asymmetry, differential transcription, and the execution of positional information, are all exhibited by a prokaryotic system, the Caulobacter cell cycle. Progeny cells resulting from each cell division have different developmental programs with respect to patterns of transcription and the initiation of DNA replication. The binary fission that yields dissimilar progeny results from asymmetry generated in the parent cell. An aspect of this fundamental developmental event is the temporally‐controlled biogenesis of a (...) polar flagellum. Several flagellar promoters require the histone‐like protein, integration host factor (IHF) for transcription activation. IHF introduces bends in DNA resulting in the reorganization of the higher‐order structure of the promoter region. These promoters appear to be transcribed from the chromosome in the swarmer pole of the predivisional cell. The newly replicated chromosomes in the predivisional cell differ in sedimentation coefficient and in the ability to initiate replication in the progeny cell. We hypothesize that the differential higher order structure of the two chromosomes contributes to both replication potential and transcription specificity. (shrink)

This volume is devoted entirely to exploring the role of animals in the thought of Immanuel Kant. Leading scholars address questions regarding the possibility of objective representation and intentionality in animals, the role of animals in Kant's scientific picture of nature, the status of our moral responsibilities to animals' welfare, and more.

Democracy and justice are often mutually antagonistic ideas, but in this innovative book Ian Shapiro shows how and why they should be pursued together. Justice must be sought democratically if it is to garner legitimacy in the modern world, he claims, and democracy must be justice-promoting if it is to sustain allegiance over time. _Democratic Justice_ meets these criteria, offering an attractive vision of a practical path to a better future. Wherever power is exercised in human affairs, Shapiro (...) argues, the lack of democracy will be experienced as injustice. The challenge is to democratize social relations so as to diminish injustice, but to do this in ways that are compatible with people’s values and goals. Shapiro shows how this can be done in different phases of the human life cycle, from childhood through the adult worlds of work and domestic life, retirement, old age, and approaching death. He spells out the implications for pressing debates about authority over children, the law of marriage and divorce, population control, governing the firm, basic income guarantees, health insurance, retirement policies, and decisions made by and for the infirm elderly. This refreshing encounter between political philosophy and practical politics will interest all those who aspire to bequeath a more just world to our children than the one we have inherited. (shrink)

Stewart Shapiro's aim in Vagueness in Context is to develop both a philosophical and a formal, model-theoretic account of the meaning, function, and logic of vague terms in an idealized version of a natural language like English. It is a commonplace that the extensions of vague terms vary with such contextual factors as the comparison class and paradigm cases. A person can be tall with respect to male accountants and not tall with respect to professional basketball players. The main (...) feature of Shapiro's account is that the extensions of vague terms also vary in the course of a conversation, even after the external contextual features, such as the comparison class, are fixed. A central thesis is that in some cases, a competent speaker of the language can go either way in the borderline area of a vague predicate without sinning against the meaning of the words and the non-linguistic facts. Shapiro calls this open texture, borrowing the term from Friedrich Waismann.The formal model theory has a similar structure to the supervaluationist approach, employing the notion of a sharpening of a base interpretation. In line with the philosophical account, however, the notion of super-truth does not play a central role in the development of validity. The ultimate goal of the technical aspects of the work is to delimit a plausible notion of logical consequence, and to explore what happens with the sorites paradox.Later chapters deal with what passes for higher-order vagueness - vagueness in the notions of 'determinacy' and 'borderline' - and with vague singular terms, or objects. In each case, the philosophical picture is developed by extending and modifying the original account. This is followed with modifications to the model theory and the central meta-theorems.As Shapiro sees it, vagueness is a linguistic phenomenon, due to the kinds of languages that humans speak. But vagueness is also due to the world we find ourselves in, as we try to communicate features of it to each other. Vagueness is also due to the kinds of beings we are. There is no need to blame the phenomenon on any one of those aspects. (shrink)

In the literature, predicativism is connected not only with the Vicious Circle Principle but also with the idea that certain totalities are inherently potential. To explain the connection between these two aspects of predicativism, we explore some approaches to predicativity within the modal framework for potentiality developed in Linnebo (2013) and Linnebo and Shapiro (2019). This puts predicativism into a more general framework and helps to sharpen some of its key theses.

BackgroundDespite its ubiquity in academic research, the phrase ‘ethical challenge(s)’ appears to lack an agreed definition. A lack of a definition risks introducing confusion or avoidable bias. Conceptual clarity is a key component of research, both theoretical and empirical. Using a rapid review methodology, we sought to review definitions of ‘ethical challenge(s)’ and closely related terms as used in current healthcare research literature.MethodsRapid review to identify peer-reviewed reports examining ‘ethical challenge(s)’ in any context, extracting data on definitions of ‘ethical challenge(s)’ (...) in use, and synonymous use of closely related terms in the general manuscript text. Data were analysed using content analysis. Four databases (MEDLINE, Philosopher’s Index, EMBASE, CINAHL) were searched from April 2016 to April 2021.Results393 records were screened, with 72 studies eligible and included: 53 empirical studies, 17 structured reviews and 2 review protocols. 12/72 (17%) contained an explicit definition of ‘ethical challenge(s), two of which were shared, resulting in 11 unique definitions. Within these 11 definitions, four approaches were identified: definition through concepts; reference to moral conflict, moral uncertainty or difficult choices; definition by participants; and challenges linked to emotional or moral distress. Each definition contained one or more of these approaches, but none contained all four. 68/72 (94%) included studies used terms closely related to synonymously refer to ‘ethical challenge(s)’ within their manuscript text, with 32 different terms identified and between one and eight different terms mentioned per study.ConclusionsOnly 12/72 studies contained an explicit definition of ‘ethical challenge(s)’, with significant variety in scope and complexity. This variation risks confusion and biasing data analysis and results, reducing confidence in research findings. Further work on establishing acceptable definitional content is needed to inform future bioethics research. (shrink)

We introduce two concepts—social certainty and social doubt—that help to articulate a variety of experiences of the social world, such as shyness, self-consciousness, culture shock, and anxiety. Following Carel's (2013) analysis of bodily doubt, which explores how a person's tacit confidence in the workings of their body can be disrupted and undermined in illness, we consider how an individual's faith in themselves as a social agent, too, can be compromised or lost, thus altering their experience of what is afforded by (...) the social environment. We highlight how a loss of bodily or social certainty can be shaped and sustained by the environments in which one finds oneself. As such, we show how certain individuals might be more vulnerable to experiences of bodily and social doubt than others. (shrink)

An outstanding reference source for the wide range of philosophical contributions made by women writing in Europe from about 1560 to 1780. It shows the range of genres and methods used by women writing in these centuries in Europe, thus encouraging an expanded understanding of our historical canon.

Previously published: London: Methuen, 1975.

Hellman and Shapiro explore the development of the idea of the continuous, from the Aristotelian view that a true continuum cannot be composed of points to the now standard, entirely punctiform frameworks for analysis and geometry. They then investigate the underlying metaphysical issues concerning the nature of space or space-time.

Diogenes’s exchange with Cicermos the Olympic pankratist is unusual in that it is both a dialectical exchange and is successful in changing Cicermos’s mind. Most Cynic rhetoric is physical or gestural and more often alienates than convinces. The puzzling difference is explained by the rhetorical choices Diogenes makes with his uniquely receptive audience.

The notion of potential infinity dominated in mathematical thinking about infinity from Aristotle until Cantor. The coherence and philosophical importance of the notion are defended. Particular attention is paid to the question of whether potential infinity is compatible with classical logic or requires a weaker logic, perhaps intuitionistic.

One of the first volumes in the new series of prestigious Oxford Handbooks, The Oxford Handbook of Jurisprudence and Philosophy of Law brings together specially commissioned essays by twenty-six of the foremost legal theorists currently writing, to provide a state of the art overview of jurisprudential scholarship.

In this book, Daniel Shapiro argues that the dominant positions in contemporary political philosophy - egalitarianism, positive rights theory, communitarianism, and many forms of liberalism - should converge in a rejection of central welfare state institutions. He examines how major welfare institutions, such as government-financed and -administered retirement pensions, national health insurance, and programs for the needy, actually work. Comparing them to compulsory private insurance and private charities, Shapiro argues that the dominant perspectives in political philosophy mistakenly think (...) that their principles support the welfare state. Instead, egalitarians, positive rights theorists, communitarians, and liberals have misunderstood the implications of their own principles, which in fact support more market-based or libertarian institutional conclusions than they may realize. Shapiro's book is unique in its combination of political philosophy with social science. Its focus is not limited to any particular country; rather it examines welfare states in affluent democracies and their market alternatives. (shrink)

Entry in International Encyclopedia of Ethics on Ethical considerations bearing on Argumentation.

This paper discusses the neo-logicist approach to the foundations of mathematics by highlighting an issue that arises from looking at the Bad Company objection from an epistemological perspective. For the most part, our issue is independent of the details of any resolution of the Bad Company objection and, as we will show, it concerns other foundational approaches in the philosophy of mathematics. In the first two sections, we give a brief overview of the "Scottish" neo-logicist school, present a generic form (...) of the Bad Company objection and introduce an epistemic issue connected to this general problem that will be the focus of the rest of the paper. In the third section, we present an alternative approach within philosophy of mathematics, a view that emerges from Hilbert's Grundlagen der Geometrie (1899, Leipzig: Teubner; Foundations of geometry (trans.: Townsend, E.). La Salle, Illinois: Open Court, 1959.). We will argue that Bad Company-style worries, and our concomitant epistemic issue, also affects this conception and other foundationalist approaches. In the following sections, we then offer various ways to address our epistemic concern, arguing, in the end, that none resolves the issue. The final section offers our own resolution which, however, runs against the foundationalist spirit of the Scottish neo-logicist program. (shrink)

Modal logic has been used to analyze potential infinity and potentialism more generally. However, the standard analysis breaks down in cases of divergent possibilities, where there are two or more possibilities that can be individually realized but which are jointly incompatible. This paper has three aims. First, using the intuitionistic theory of choice sequences, we motivate the need for a modal analysis of divergent potentialism and explain the challenges this involves. Then, using Beth–Kripke semantics for intuitionistic logic, we overcome those (...) challenges. Finally, we apply our modal analysis of divergent potentialism to make choice sequences comprehensible in classical terms. (shrink)

We develop a point-free construction of the classical one- dimensional continuum, with an interval structure based on mereology and either a weak set theory or logic of plural quantification. In some respects this realizes ideas going back to Aristotle,although, unlike Aristotle, we make free use of classical "actual infinity". Also, in contrast to intuitionistic, Bishop, and smooth infinitesimal analysis, we follow classical analysis in allowing partitioning of our "gunky line" into mutually exclusive and exhaustive disjoint parts, thereby demonstrating the independence (...) of "indecomposability" from a non-punctiform conception. It is surprising that such simple axioms as ours already imply the Archimedean property and that they determine an isomorphism with the Dedekind-Cantor structure of R as a complete, separable, ordered field. We also present some simple topological models of our system, establishing consistency relative to classical analysis. Finally, after describing how to nominalize our theory, we close with comparisons with earlier efforts related to our own. (shrink)

This paper argues that Gareth Evans' treatment of first person reference based on the myriad ways we have of receiving information about our bodies and location, cannot secure the guaranteed reference exhibited by first person reference. It faces a problem both when a subject fails to receive such information about herself, and when she receives misinformation.

Some philosophers have offered structural representations as an alternative to indicator-based representations. Motivating these philosophers is the belief that an indication-based analysis of representation exhibits two fatal inadequacies from which structural representations are spared: such an analysis cannot account for the causal role of representational content and cannot explain how representational content can be made determinate. In fact, we argue, indicator and structural representations are on a par with respect to these two problems. This should not be surprising, we contend, (...) given that the distinction between indicator and structural representations is better conceived as one involving degree rather than kind. (shrink)

In previous work, Hellman and Shapiro present a regions-based account of a one-dimensional continuum. This paper produces a more Aristotelian theory, eschewing the existence of points and the use of infinite sets or pluralities. We first show how to modify the original theory. There are a number of theorems that have to be added as axioms. Building on some work by Linnebo, we then show how to take the ‘potential’ nature of the usual operations seriously, by using a modal (...) language, and we show that the two approaches are equivalent. (shrink)

We invite systematic consideration of the metaphors of cycles and circulation as a long-term theme in the history of the life and environmental sciences and medicine. Ubiquitous in ancient religious and philosophical traditions, especially in representing the seasons and the motions of celestial bodies, circles once symbolized perfection. Over the centuries cyclic images in western medicine, natural philosophy, natural history and eventually biology gained independence from cosmology and theology and came to depend less on strictly circular forms. As potent ‘canonical (...) icons’, cycles also interacted with representations of linear and irreversible change, including arrows, arcs, scales, series and trees, as in theories of the Earth and of evolution. In modern times life cycles and reproductive cycles have often been held to characterize life, in some cases especially female life, while human efforts selectively to foster and disrupt these cycles have harnessed their productivity in medicine and agriculture. But strong cyclic metaphors have continued to link physiology and climatology, medicine and economics, and biology and manufacturing, notably through the relations between land, food and population. From the grand nineteenth-century transformations of matter to systems ecology, the circulation of molecules through organic and inorganic compartments has posed the problem of maintaining identity in the face of flux and highlights the seductive ability of cyclic schemes to imply closure where no original state was in fact restored. More concerted attention to cycles and circulation will enrich analyses of the power of metaphors to naturalize understandings of life and their shaping by practical interests and political imaginations. (shrink)

Drug resistant epilepsy is one of the most complex, multifactorial and polygenic neurological syndrome. Besides its dynamicity and variability, it still provides us with a model to study brain-behavior relationship, giving cues on the anatomy and functional representation of brain function. Given that onset zone of focal epileptic seizures often affects different anatomical areas, cortical but limited to one hemisphere, this condition also let us study the functional differences of the left and right cerebral hemispheres. One lateralized function in the (...) human brain is emotional prosody, and it can be a useful ictal sign offering hints on the location of the epileptogenic zone. Besides its importance for effective communication, prosody is not considered an eloquent domain, making resective surgery on its neural correlates feasible. We performed an Electronic databases search (Medline and PsychINFO) from inception to July 2017 for studies about prosody in epilepsy. The search terms included “epilepsy,” “seizure,” “emotional prosody,” and “vocal affect.” This review focus on emotional prosody processing in epilepsy as it can give hints regarding plastic functional changes following seizures (preoperatively), resection (post operatively), and also as an ictal sign enabling the assessment of dynamic brain networks. Moreover, it is argued that such reorganization can help to preserve the expression and reception of emotional prosody as a central skill to develop appropriate social interactions. (shrink)

This edited collection covers Friedrich Waismann's most influential contributions to twentieth-century philosophy of language: his concepts of open texture and language strata, his early criticism of verificationism and the analytic-synthetic distinction, as well as their significance for experimental and legal philosophy. -/- In addition, Waismann's original papers in ethics, metaphysics, epistemology and the philosophy of mathematics are here evaluated. They introduce Waismann's theory of action along with his groundbreaking work on fiction, proper names and Kafka's Trial. -/- Waismann is known (...) as the voice of Ludwig Wittgenstein in the Vienna Circle. At the same time we find in his works a determined critic of logical positivism and ordinary language philosophy, who anticipated much later developments in the analytic tradition and devised his very own vision for its future. (shrink)

In light of the close connection between the ontological hierarchy of set theory and the ideological hierarchy of type theory, Øystein Linnebo and Agustín Rayo have recently offered an argument in favour of the view that the set-theoretic universe is open-ended. In this paper, we argue that, since the connection between the two hierarchies is indeed tight, any philosophical conclusions cut both ways. One should either hold that both the ontological hierarchy and the ideological hierarchy are open-ended, or that neither (...) is. If there is reason to accept the view that the set-theoretic universe is open-ended, that will be because such a view is the most compelling one to adopt on the purely ontological front. (shrink)

Since the 1960s a resurgence of interest in the moral foundations of politics has fueled debates about the appropriate sources of our political judgments. Ian Shapiro analyzes and advances these debates, discussing them in an accessibly style. He defends a view of politics called _critical naturalism_ as a third way between the neo-Kantian theory of John Rawl's and the contextual arguments of Richard Rorty, Michael Walzer, Alasdair MacIntyre and others. He formulates a new justification for democratic politics and an (...) innovative account of the nature of political argument. (shrink)

The present work is a systematic study of five frameworks or perspectives articulating mathematical structuralism, whose core idea is that mathematics is concerned primarily with interrelations in abstraction from the nature of objects. The first two, set-theoretic and category-theoretic, arose within mathematics itself. After exposing a number of problems, the book considers three further perspectives formulated by logicians and philosophers of mathematics: sui generis, treating structures as abstract universals, modal, eliminating structures as objects in favor of freely entertained logical possibilities, (...) and finally, modal-set-theoretic, a sort of synthesis of the set-theoretic and modal perspectives. (shrink)

Recent research, especially with functional brain imaging, demonstrated cases where the administration of a placebo produces objective effects in tissues that are indistinguishable from those of the real therapeutic agents. This phenomenon has been shown in treatments of pain, depression, Parkinsonism, and more. The main ethical complaint against placebo treatment is that it is a kind of deception, where supposedly we substitute what works just psychologically for a real drug that actually works on the tissue level. We claim that the (...) scientific findings bring to a new level the seeming deconstruction of the distinction between “placebo” and “real” drugs, and that instances of placebo treatment which fulfill this criterion should be recognized as a unique category—we call it “comparable placebo treatment” (CPT). The paper uses an analysis of the notion of deception to argue that CPT does not amount to deception; that it can preserve patient autonomy; and that it is therefore morally legitimate. (shrink)

We are logical pluralists who hold that the right logic is dependent on the domain of investigation; different logics for different mathematical theories. The purpose of this article is to explore the ramifications for our pluralism concerning normativity. Is there any normative role for logic, once we give up its universality? We discuss Florian Steingerger’s “Frege and Carnap on the Normativity of Logic” as a source for possible types of normativity, and then turn to our own proposal, which postulates that (...) various logics are constitutive for thought within particular practices, but none are constitutive for thought as such. (shrink)

One of the first volumes in the new series of prestigious Oxford Handbooks, The Oxford Handbook of Jurisprudence and Philosophy of Law brings together specially commissioned essays by twenty-six of the foremost legal theorists currently writing, to provide a state of the art overview of jurisprudential scholarship.

The ‘new normality’ of food crises requires nuanced understandings of emergent responses. Through an exploratory analysis of public-facing reports from major food governance actors, this study empirically outlines mainstream solution frames for addressing the contemporary food crisis and the ways in which these differ from the 2008 food crisis. Using food regime theory as the theoretical underpinning, four con­sistently used solution frames are identified that provide insight into the organizing principles of the third food regime: promoting trade liberalization, emphasizing agricultural (...) productivism, mobilizing private finance, and leveraging data. The latter two involve recent shifts in governance responses that shape global food governance and impact global food insecurity in novel ways. (shrink)

Στα πλαίσια του προγράμματος « Ποταμιά-Άγιος Σωζόμενος, η ανασύνθεση των τοπίων στη μεσαιωνική Ανατολή », η κεραμική που συλλέχτηκε στη διάρκεια της πρόσφατης επιφανειακής έρευνας, παρά τον αποσπασματικό χαρακτήρα της, έδωσε νέα στοιχεία για τη Φραγκική και την Οθωμανική περίοδο τόσο στη συγκεκριμένη θέση όσο και σε ολόκληρο το νησί. Η μελέτη της δίνει πληροφορίες όχι μόνο για την επιτόπια παραγωγή και εκείνη της ευρύτερης περιοχής αλλά και για τη διακίνηση αγγείων από τη δυτική και την ανατολική λεκάνη της Μεσογείου. (...) Η αποσπασματικότητα του υλικού αντισταθμίζεται από τον όγκο του και από τον επαναλαμβανόμενο χαρακτήρα των διαφόρων κεραμικών κατηγοριών, οι οποίες ταξινομήθηκαν κατά τύπους και χρονολογικές περιόδους. Στο άρθρο προτείνεται μια νέα ταξινόμηση της κυπριακής κεραμικής με βάση τις παλαιότερες έρευνες αλλά και τα πρόσφατα ευρήματα. (shrink)

It is sometimes said that there are two, competing versions of W. V. O. Quine’s unrelenting empiricism, perhaps divided according to temporal periods of his career. According to one, logic is exempt from, or lies outside the scope of, the attack on the analytic-synthetic distinction. This logic-friendly Quine holds that logical truths and, presumably, logical inferences are analytic in the traditional sense. Logical truths are knowable a priori, and, importantly, they are incorrigible, and so immune from revision. The other, radical (...) reading of Quine does not exempt logic from the attack on analyticity and a priority. Logical truths and inferences are themselves part of the web of belief, and the same global methodology applies to logic as to any other part of the web, such as theoretical chemistry or ordinary beliefs about ordinary objects. Everything, including logic, is up for grabs in our struggle for holistic confirmation. The purpose of this paper is to examine the law of non-contradiction, and the concomitant principle of ex falso quodlibet, from the perspective of the principles advocated by the radical Quine. I show that he has no compelling reason to accept either of these. To put it bluntly, neither the law of non-contradiction nor the rule of ex falso quodlibet is empirically confirmed, and these principles fare poorly on the various criteria for theory acceptance on the methodology of the radical Quine. So the radical Quine is led rather quickly and rather directly into something in the neighborhood of Graham Priest’s dialetheism. (shrink)

Lucy F. O'Brien; XII*—The Problem of Self-Identification, Proceedings of the Aristotelian Society, Volume 95, Issue 1, 1 June 1995, Pages 235–252, https://doi.o.

Typically, a logic consists of a formal or informal language together with a deductive system and/or a model-theoretic semantics. The language is, or corresponds to, a part of a natural language like English or Greek. The deductive system is to capture, codify, or simply record which inferences are correct for the given language, and the semantics is to capture, codify, or record the meanings, or truth-conditions, or possible truth conditions, for at least part of the language.