Synthetic genomics is a new field of research in which small DNA pieces are assembled in a series of steps into whole genomes. The highly reduced genomes of host‐associated bacteria are now being used as models for de novo synthesis of small genomes in the laboratory. Bacteria with the smallest genomes identified in nature provide nutrients to their hosts, such as amino acids, co‐factors and vitamins. Comparative genomics of these bacteria enables predictions to be made about the gene sets required (...) for core cellular functions and the associated metabolic network for the biosynthesis of host‐selected compounds. Synthetic biology may ultimately enable researchers to make customized cell‐specific organelles for the production and delivery of drugs to humans and domestic animals. Synthetic genomics may also become the method of choice for functional analyses of genes and genomes from bacteria that cannot be cultivated in the laboratory. (shrink)

Over the last decade, AI models of language and word meaning have been dominated by what we might call a statistics-of-occurrence, strategy: these models are deep neural net structures that have been trained on a large amount of unlabeled text with the aim of producing a model that exploits statistical information about word and phrase co-occurrence in order to generate behavior that is similar to what a human might produce, or representations that can be probed to exhibit behavior similar to (...) what a human might produce (meaningsemblant behavior). Examples of what we can call Statistics-of-Occurrence Models (SOMs) include: Word2Vec (CBOW and Skip-Gram), BERT, GPT-3, and, most recently, ChatGPT. Increasingly, there have been suggestions that such systems have semantic understanding, or at least a proto-version of it. This paper argues against such claims. I argue that a necessary condition for a system to possess semantic understanding is that it function in ways that are causally explainable by appeal to its semantic properties. I then argue that SOMs do not plausibly satisfy this Functioning Criterion. Rather, the best explanation of their meaning-semblant behavior is what I call the Statistical Hypothesis: SOMs do not themselves function to represent or produce meaningful text; they just reflect the semantic information that exists in the aggregate given strong correlations between word placement and meaningful use. I consider and rebut three main responses to the claim that SOMs fail to meet the Functioning Criterion. The result, I hope, is increased clarity about why and how one should make claims about AI systems having semantic understanding. (shrink)

What is it to base a belief on reasons? Existing attempts to give an account of the basing relation encounter a dilemma: either one appeals to some kind of neutral process that does not adequately reflect the way basing is a content‐sensitive first‐personal activity, or one appeals to linking or bridge principles that over‐intellectualize and threaten regress. We explain why this dilemma arises, and diagnose the commitments that are key obstacles to providing a satisfactory account. We explain why they should (...) be rejected anyway, and then offer a new, knowledge‐first virtue epistemological theory of the basing relation that shows how we can substantially theorize about mental processes without these commitments. The resulting view plausibly captures the way in which basing is an inherently mental and content‐sensitive process. (shrink)

The world of wage labour seems to have become a soulless machine, an engine of social and environmental destruction. Employees seem to be nothing but 'cogs' in this system - but is this true? Located at the intersection of political theory, moral philosophy, and business ethics, this book questions the picture of the world of work as a 'system'. Hierarchical organizations, both in the public and in the private sphere, have specific features of their own. This does not mean, however, (...) that they cannot leave room for moral responsibility, and maybe even human flourishing. Drawing on detailed empirical case studies, Lisa Herzog analyses the nature of organizations from a normative perspective: their rule-bound character, the ways in which they deal with divided knowledge, and organizational cultures and their relation to morality. The volume examines how individual agency and organizational structures would have to mesh to avoid common moral pitfalls and develops the notion of 'transformational agency', which refers to a critical, creative way of engaging with one's organizational role while remaining committed to basic moral norms. The volume goes on to explore the political and institutional changes that would be required to re-embed organizations into a just society. Whether we submit to 'the system' or try to reclaim it, Herzog argues, is a question of eminent political importance in our globalized world. (shrink)

Experiences of emotion are content-rich events that emerge at the level of psychological description, but must be causally constituted by neurobiological processes. This chapter outlines an emerging scientific agenda for understanding what these experiences feel like and how they arise. We review the available answers to what is felt (i.e., the content that makes up an experience of emotion) and how neurobiological processes instantiate these properties of experience. These answers are then integrated into a broad framework that describes, in psychological (...) terms, how the experience of emotion emerges from more basic processes. We then discuss the role of such experiences in the economy of the mind and behavior. (shrink)

It is often thought that the numerous contradictory perspectives in Margaret Cavendish's writings demonstrate her inability to reconcile her feminism with her conservative, royalist politics. In this book Lisa Walters challenges this view and demonstrates that Cavendish's ideas more closely resemble republican thought, and that her methodology is the foundation for subversive political, scientific and gender theories. With an interdisciplinary focus Walters closely examines Cavendish's work and its context, providing the reader with an enriched understanding of women's contribution to (...) early modern scientific theory, political philosophy, culture and folklore. Considering also Cavendish's ideas in relation to Hobbes and Paracelsus, this volume is of great interest to scholars and students of literature, philosophy, history of ideas, political theory, gender studies and history of science. (shrink)

In this paper we address Bernard Williams' argument for the undesirability of immortality. Williams argues that unavoidable and pervasive boredom would characterise the immortal life of an individual with unchanging categorical desires. We resist this conclusion on the basis of the distinction between habitual and situational boredom and a psychologically realistic account of significant factors in the formation of boredom. We conclude that Williams has offered no persuasive argument for the necessity of boredom in the immortal life. 1.

The present study provides evidence that valence focus and arousal focus are important processes in determining whether a dimensional or a discrete emotion model best captures how people label their affective states. Individuals high in valence focus and low in arousal focus fit a dimensional model better in that they reported more co-occurrences among like-valenced affective states, whereas those lower in valence focus and higher in arousal focus fit a discrete model better in that they reported fewer co-occurrences between like-valenced (...) affective states. Taken together, these findings suggest that one static, nomothetic theory may not accurately describe the subjective affective experience of all individuals. (shrink)

One of the deepest tensions in Locke’s Essay, a work full of profound and productive conflicts, is one between Locke’s metaphysical tendencies—his inclination to presuppose or even to argue for substantive metaphysical positions—and his devout epistemic modesty, which seems to urge agnosticism about major metaphysical issues. Both tendencies are deeply rooted in the Essay. Locke is a theorist of substance, essence, quality. Yet, his favorite conclusions are epistemically pessimistic, even skeptical; when it comes to questions about how the world is (...) constituted, our understandings cannot penetrate very far. Locke seems torn between metaphysics and modesty, between dogmatism and skepticism. This chapter will consider two specific examples of this sort of tension. The first involves the ontology of body, and the second, the ontology of mind. The conflict concerning bodily natures looks like this: As is well-known, Locke typically describes bodies in the terms of the corpuscularian science of his day, as exemplified especially by the natural philosopher Robert Boyle. Locke’s characterizations of the real essences of bodies are mechanist. He envisions them as corpuscularian textures-- spatial arrangements of particles possessing size. (shrink)

(1999). Princess Elizabeth and Descartes: The union of soul and body and the practice of philosophy. British Journal for the History of Philosophy: Vol. 7, No. 3, pp. 503-520. doi: 10.1080/09608789908571042.

Knowing Words will be welcomed by sinologists, classicists, and scholars of comparative philosophy and literature.

Such an absence seems ultimately fatal. Yet as this volume amply demonstrates, the richness of his social theory can be opened up by contemporary feminism.

I. Introduction Siris, Berkeley's last major work, is undeniably a rather odd book. It could hardly be otherwise, given Berkeley's aims in writing it, which are three-fold: 'to communicate to the public the salutary virtues of tar-water,'1 to provide scientific background supporting the efficacy of tar-water as a medicine, and to lead the mind of the reader, via gradual steps, toward contemplation of God.2 The latter two aims shape Berkeley's extensive use of contemporary natural science in Siris. In particular, Berkeley's (...) focus on what he calls fire (or aether or light) as a quasiuniversal 'cause' of natural change3 serves these purposes, for the 'activity' of the aether, in his view, can both explain the miraculous virtues of a certain medicine, i.e. tar-water, and reveal God's action and his divine order.4 Berkeley's corpuscular speculations, including his use of fire-theory, are not especially idiosyncratic as natural philosophy. In his theorizing, as Jessop and other have noted, he is heavily indebted to the work of Hermann Boerhaave, the Dutch chemist, botanist, and physician whose teachings were highly influential in mid-eighteenth century Britain.5 Boerhaave, along with other Dutch natural philosophers cited by Berkeley, assigned a central role in accounting for physio-chemical activity to fire, a subtle, insensible particulate substance, sometimes identified with light. (shrink)

ABSTRACT The following are purported to be common-sense features of the world: time’s passage, the unreality of the future, the existence of ‘genuine’ change. All of these common-sense features are accommodated by accepting the phenomenon of absolute becoming, a view of temporal passage in which the unreal future comes into existence in the present. Indeed, most philosophers who lay claim to common-sense views of time accept absolute becoming. I argue that absolute becoming has deeply unintuitive consequences. Specifically, proponents of absolute (...) becoming face what I call the coordination problem: in the absence of a connection between the existing present and the unreal future, one must, but cannot, explain how whatever comes into existence preserves the continuing regularity of the world. The standard options to explain the continuing regularity of the world take the form of appealing to enforcers—causation, laws of nature, and dispositions—to guarantee that what comes into existence preserves these regularities. I show that the very nature of a world in which there is no future means that enforcers cannot guarantee this regular nature of the world. Absolute becoming should therefore be rejected: the future does not come into existence; it already exists. (shrink)

Lisa Tessman’s Moral Failure: On the Impossible Demands of Morality raises important questions about ideal theory, oppression, and the role of action guidance in normative philosophy. After a brief overview of feminist and anti-racist philosophers’ critiques of ideal theory, I examine Tessman’s claim that nonideal oppression theorists focus too narrowly on action guidance and thereby obscure other important normative issues, such as the problem of moral failure. Although I agree with Tessman’s advocacy of a wider focus—and with her suggestion (...) that situations of inevitable moral failure are particularly important to examine in contexts of oppression—I question whether nonideal oppression theorists actually emphasize action guidance to the exclusion of other concerns. I conclude with a brief examination of the way that ideal and nonideal theory have been defined and understood in debates about normative methodology, and I suggest that a move away from Rawls’s account of the ideal/nonideal distinction would benefit feminists and other oppression theorists. (shrink)

This book offers a balanced and comprehensive account of philosophical thought from the middle of the fourteenth century to the emergence of modern philosophy at the turn of the seventeenth century.

This is the first book to explore the ethical thought of Pierre Gassendi, the seventeenth-century French priest who rehabilitated Epicurean philosophy in the ...

Although George Berkeley himself made no major scientific discoveries, nor formulated any novel theories, he was nonetheless actively concerned with the rapidly evolving science of the early eighteenth century. Berkeley's works display his keen interest in natural philosophy and mathematics from his earliest writings (Arithmetica, 1707) to his latest (Siris, 1744). Moreover, much of his philosophy is fundamentally shaped by his engagement with the science of his time. In Berkeley's best-known philosophical works, the Principles and Dialogues, he sets up his (...) idealistic system in opposition to the materialist mechanism he finds in Descartes and Locke. In De Motu, Berkeley refines and extends his philosophy of science in the context of a critique of the dynamic accounts of motion offered by Newton and Leibniz. And in Siris, Berkeley's flirtation with neo-Platonism draws inspiration from the fire theory of Boerhaave as well as Newton's aetherial speculations in the Queries of the Optics. In examining Berkeley's critical engagement with the natural philosophy of his time, we will thus improve our understanding of not just his philosophy of science, but of his philosophical corpus as a whole. (shrink)

In this article the increasing significance of Bourdieu’s social theory is mapped in recent sociological accounts of gender in late-modern societies. What is highlighted in particular is the influence of Bourdieu’s social theory, and especially his arguments regarding critical reflexivity and social transformation, on a specific thesis which is common to a number of contemporary feminist accounts of gender transformations in late modernity. Here it is suggested that in late modernity there is a lack of fit between habitus and field (...) in certain public spheres of action via an increasing transposition or movement of the feminine habitus from private to public spheres, which is linked to a heightened critical reflexivity vis-à-vis gender and to detraditionalization. In this article, however, a number of limits regarding this line of argument are highlighted, especially those flowing from the unproblematic coupling of reflexivity with detraditionalization. This exploration in turn leads to a critical discussion of Bourdieu’s ideas regarding social transformation. In particular it is asked why, when thinking about social transformation, does Bourdieu abandon his own principles regarding practice? (shrink)

Thomas Pogge and Andrew Kuper suggest that we should promote an ‘institutional’ solution to global poverty. They advocate the institutional solution because they think that non-governmental organizations (NGOs) can never be the primary agents of justice in the long run. They provide several standard criticisms of NGO aid in support of this claim. However, there is a more serious problem for institutional solutions: how to generate enough goodwill among rich nation-states that they would be willing to commit themselves to supranational (...) institutional reforms. In the current international political climate, the implementation of such institutional reforms introduces several intractable problems, including difficulties of global coordination and enforcement. I defend the solution of NGO aid from the criticisms presented by Pogge and Kuper, and propose how it might be reformed. My main suggestion is that all practising NGOs should be required to be ‘accountable for reasonableness’ in the sense that Norman Daniels and James Sabin have outlined. (shrink)

In this chapter I defend the doxastic account of delusions and offer some reasons to believe that the double-bookkeeping argument against doxasticism (delusions are not beliefs because they do not drive action) should be resisted.

Suppose that you are soon to be a parent and you learn that there are some simple measures that you can take to make sure that your child will be healthy. In particular, suppose that by following the doctor’s advice, you can prevent your child from having a disability, you can make your child immune from a number of dangerous diseases and you can even enhance its future intelligence. All that is required for this to happen is that you (or (...) your partner) comply with lifestyle and dietary requirements. Do you and your partner have any moral reasons (or moral obligations) to follow the doctor’s advice? Would it make a difference if, instead of following some simple dietary requirements, you consented to genetic engineering to make sure that your child was free from disabilities, healthy and with above average intelligence? In this paper we develop a framework for dealing with these questions and we suggest some directions the answers might take. (shrink)

Traditional disciplinary guidelines are inadequate to address some of the ethical dilemmas that emerge when conducting research on violence against women and girls. This article is organized according to the ethical principles of respect for persons, privacy and confidentiality, justice, beneficence, and nonmaleficence. In the article, I describe dilemmas involved in cross-cultural research, research on children, informed consent, voluntariness, coercion, deception, safety, mandated reporting, and dissemination. In the article, I include examples from qualitative and quantitative studies in many nations. I (...) also offer suggestions for researchers and institutional review boards. (shrink)

ArgumentThis essay considers the work of projection and the hand of the projectionist as important components of the social space of the cinema as it comes into being in the nineteenth century and the early decades of the twentieth. I bring the concept of Maurice Merleau-Ponty on the place of the body as an entity that applies itself to the world “like a hand to an instrument” into a discussion of the pre-cinematic projector as an instrument that we can interpret (...) as evidence of the experience of the work of the projectionist in the spirit of film theory and media archaeology, moving work on instrumentation in a different direction from the analysis of the work of the black box in laboratory studies. Projection is described as a psychological as well as a mechanical process. It is suggested that we interpret the projector not simply in its activity as it projects films, but in its movement from site to site and in the workings of the hand of its operator behind the scenes. This account suggests a different perspective on the cinematic turn of the nineteenth century, a concept typically approached through the study of the image, the look, the camera, and the screen. (shrink)

This article focuses on the new economy. While a number of recent analyses have considered how new economic arrangements rework a range of material relations, this article suggests that such considerations have tended to stop short of considering how material relations may be reconstituting vis-à-vis the people who are working in the new economy. This is so, it will be argued, because there is a pervasive assumption of what is termed a social contract model of personhood, where people are assumed (...) to own or at least to strive to accumulate skills, capacities and abilities (that is, labour power) as forms of property in the person. However, what this article underscores is that the relations between people and their labour in the new economy are being reworked. In particular, it highlights how qualities previously associated with people are being disentangled and are becoming the object of processes of qualification and re-qualification. However, such qualities do not take the form of property in the person as claims towards the ‘ownership’ of this labour lie in the domain of audience effects - that is, in relations external to the person. This shift, it is argued further, locates labour in the new economy firmly in the domain of the production and circulation of cultural value. Indeed, more broadly this article suggests that the now commonplace idea that economy and culture are de-differentiating involves a previously unrecognized restructuring of the relations between people and property and even the end of the modern notion of personhood. (shrink)

Rational Intuition explores the concept of intuition as it relates to rationality through mediums of history, philosophy, cognitive science, and psychology.

Rebecca Skloot, The Immortal Life of Henrietta Lacks, New York: Crown Publishers, 2010, reviewed by Lisa S. Parker.

In the 17th and 18th centuries, mathematics was understood to be the science that systematized our knowledge of magnitude, or quantity. But the mathematical notion of magnitude and the methods used to investigate it underwent a period of radical transformation during the modern period, which forced philosophers of mathematics to confront a changing mathematical landscape. In this context, the modern philosopher of mathematics had to provide an account of the apriority and applicability of mathematical reasoning, as such reasoning was then (...) understood. Early modern mathematical reasoning and the accounts of such reasoning offered by Newton, Descartes, Leibniz, and Kant are explained and discussed. (shrink)

A route to Homer -- Homeric or sung speech -- Reconsidering Xenophanes -- Rreconsidering speech -- Parmenides' poem -- The way it seems.

The essays in this Focus section expand the notion of writing insect histories of science by attending to matters of space and scale, ecological relationships, and institutional silences. They magnify diverse understandings about how the worlds of insects are noticed and understood by humans, what has historically counted as “insect,” and who narrates histories (of science). In doing so, the collection offers methodological suggestions for studying tiny animals in history that broaden the scope of often overlapping material, cultural, linguistic, political, (...) ethical, economic, and biological domains. It is precisely this magnified attention that foregrounds the domains’ interdependence and is necessary to make sense of additional bearers or forms of agency. (shrink)