Combining human embryonic stem cells with SCNT has been a gold standard of stem cell research. Adding a particular individual's genes to pluripotent stem cells might lead to the development of personalized tissue repair or replacement. Enthusiasm for human embryonic stem cell research had flagged in recent years due to controversy over the moral status of in vitro embryos, scientific misconduct by researcher Woo Suk Hwang, and the discovery that induced pluripotent stem cells could be produced from somatic cells. Energy (...) shifted to research on somatic cells, but three successes in the United States during 2013 and 2014 may reinvigorate embryonic stem cell research. (shrink)

Metaphors used to describe new technologies mediate public understanding of the innovations. Analyzing the linguistic, rhetorical, and affective aspects of these metaphors opens the range of issues available for bioethical scrutiny and increases public accountability. This article shows how such a multidisciplinary approach can be useful by looking at a set of texts about one issue, the use of a newly developed technique for genetic modification, CRISPRcas9.

ABSTRACT:I reflect critically on the early modern philosophical canon in light of the entrenchment and homogeneity of the lineup of seven core figures: Descartes, Spinoza, Leibniz, Locke, Berkeley, Hume, and Kant. After distinguishing three elements of a philosophical canon—a causal story, a set of core philosophical questions, and a set of distinctively philosophical works—I argue that recent efforts contextualizing the history of philosophy within the history of science subtly shift the central philosophical questions and allow for a greater range of (...) figures to be philosophically central. However, the history of science is but one context in which to situate philosophical works. Looking at the historical context of seventeenth-century philosophy of mind, one that weaves together questions of consciousness, rationality, and education, does more than shift the central questions—it brings new ones to light. It also shows that a range of genres can be properly philosophical and seamlessly diversifies the central philosophers of the period. (shrink)

When anthropologists and other social scientists study health services in medical institutions, tensions sometimes arise as a result of the social scientists and health care professionals having different ideas about the ethics of research. In order to resolve this type of conflict and to facilitate mutual learning, we describe two general categories of research ethics framing: those of anthropology and those of medicine. The latter focuses on protection of the individual through the preservation of autonomy expressed through the requirement of (...) informed consent whereas the former focuses on broader political implications. After providing an example of a conflict, we outline four issues that characterize the occasional clashes between social scientists and medical staff: (1) a discrepancy in the way anthropologists perceive patients and medical staff; (2) ambiguity concerning the role of medical staff in anthropological research; (3) impediments to informed consent in qualitative research projects; and (4) property rights in data. Enhanced dialogue could serve to invigorate the ethical debate in both traditions. (shrink)

This paper explores Ronald Dworkin’s influential theory of constructive interpretation. It points out that this theory admits of two readings, which I call the “undemanding” and the “demanding” conceptions of constructive interpretation respectively. As I argue, Dworkin’s own presentation of the theory equivocates between these two conceptions, the former of which is utterly unproblematic, but the latter of which incorporates certain philosophical prejudices as to what it must mean for a practice to be purposive.

A consensus view appears to prevail among academics from diverse disciplines that biological races do not exist, at least in humans, and that race -concepts and race -objects are socially constructed. The consensus view has been challenged recently by Robin O. Andreasen's cladistic account of biological race. This paper argues that from a scientific viewpoint there are methodological, empirical, and conceptual problems with Andreasen's position, and that from a philosophical perspective Andreasen's adherence to rigid dichotomies between science and society, facts (...) and values, nature and culture, and the biological and the social needs to be relinquished. DNA forensics is just one field of research that reveals how race remains both idea and object for human population biologists, an indication that it is premature to accept the existence of a no- race consensus across the disciplines. DNA forensics research also demonstrates ways in which race is reified by scientists by the representation of what is cultural or social as natural or biological, and of what is dynamic, relative, and continuous as static, absolute, and discrete. The philosophical analysis of foundational concepts of human population biology such as population, race, and ethnic group is best served by foregoing traditional objectivist approaches for a critical stance that recognises the inextricability of the biological and the social. Introduction Consensus view: biological races do not exist Andreasen's defence of the biological reality of races as clades Biological permutations of race Conclusion. (shrink)

This paper questions the prevailing historical understanding that scientific racism "retreated" in the 1950s when anthropology adopted the concepts and methods of population genetics and race was recognized to be a social construct and replaced by the concept of population. More accurately, a "populational" concept of race was substituted for a "typological one"-this is demonstrated by looking at the work of Theodosius Dobzhansky circa 1950. The potential for contemporary research in human population genetics to contribute to racism needs to be (...) considered with respect to the ability of the typological-population distinction to arbitrate boundaries between racist society and nonracist, even anti-racist, science. I point out some ethical limits of "population thinking" in doing so. (shrink)

I here address Descartes' account of human nature as a union of mind and body by appealing to The Passions of the Soul. I first show that Descartes takes us to be able to reform the naturally instituted associations between bodily and mental states. I go on to argue that Descartes offers a teleological explanation of body-mind associations (those instituted both by nature and by artifice). This explanation sheds light on the ontological status of the union. I suggest that it (...) affords a way of understanding how mind and body form a true unit without compromising Descartes' dualism. (shrink)

This article contributes to carework scholarship by examining the nexus of gender, class, and race in long-term care facilities. We draw out a family ideology at work that promotes good care of residents and thus benefits nursing homes. We also found that careworkers value fictive kin relationships with residents, yet we uncover how the family model may be used to exploit these low-income careworkers. Reflecting a subordinate and racialized version of being “part of the family,” we call for an ethic (...) of reciprocity and for concrete change toward valuing equally the humanity of those who need and those who give care. (shrink)

Impaired hand proprioception can lead to difficulties in performing fine motor tasks, thereby affecting activities of daily living. The majority of children with unilateral cerebral palsy experience proprioceptive deficits, but accurately quantifying these deficits is challenging due to the lack of sensitive measurement methods. Robot-assisted assessments provide a promising alternative, however, there is a need for solutions that specifically target children and their needs. We propose two novel robotics-based assessments to sensitively evaluate active and passive position sense of the index (...) finger metacarpophalangeal joint in children. We then investigate test-retest reliability and discriminant validity of these assessments in uCP and typically developing children, and further use the robotic platform to gain first insights into fundamentals of hand proprioception. Both robotic assessments were performed in two sessions with 1-h break in between. In the passive position sense assessment, participant's finger is passively moved by the robot to a randomly selected position, and she/he needs to indicate the perceived finger position on a tablet screen located directly above the hand, so that the vision of the hand is blocked. Active position sense is assessed by asking participants to accurately move their finger to a target position shown on the tablet screen, without visual feedback of the finger position. Ten children with uCP and 10 age-matched TDC were recruited in this study. Test-retest reliability in both populations was good >0.79). Proprioceptive error was larger for children with uCP than TDC, indicating discriminant validity. The active position sense was more accurate than passive, and the scores were not correlated, underlining the need for targeted assessments to comprehensively evaluate proprioception. There was a significant effect of age on passive position sense in TDC but not uCP, possibly linked to disturbed development of proprioceptive acuity in uCP. Overall, the proposed robot-assisted assessments are reliable, valid and a promising alternative to commonly used clinical methods, which could help gain a better understanding of proprioceptive impairments in uCP, facilitating the design of novel therapies. (shrink)

The most important parent of the idea of property in the person (self-ownership) is undoubtedly John Locke. In this article, we argue that the origins of this idea can be traced back as far as the third century BCE, to classical Stoicism. Stoic cosmopolitanism, with its insistence on impartiality and the moral equality of all persons, lays the foundation for the idea of self-ownership, which is then given support in the doctrine of oikeiosis and the corresponding belief that nature had (...) made all human beings equal, self-preserving, and self-regarding. On the Stoic account, self-ownership (or our preferred term self-guardianship) is a natural correlate and consequence of oikeiosis, the natural urge to self-preservation, proprioception, and the individuation that came with it. In recognising that people are separate and individual, and entrusting each individual’s welfare to herself, Zeus appears to make everyone a ‘self-guardian’. We uniquely argue that Locke was directly inspired by these Stoic ideas, which he then develops and incorporates into his own theory. (shrink)

John Marshall aims, in Descartes’s Moral Theory, to “introduce Descartes’s moral thought to an anglophone audience”. He provides such an introduction not only in that he surveys Descartes’s writings on ethics from the Discourse, through his correspondence, to The Passions of the Soul, but also in that he presents a sustained argument for a reading of how these writings all fit together.

back in about 1984 or 1985, when I'd been in graduate school for a couple of years at Northwestern University in Evanston, Illinois, I started hanging around with three chemists who shared a house. They were colleagues of my roommate, a chemistry grad student. One of them, no kidding, was named Lloyd A. Bumm, who would always introduce himself by saying, "My name is the best joke I know." Lloyd was a quirky, curious guy who often explored unusual places around (...) the City, unlike the typical chemistry grad student. For instance, he frequently would head into Chicago on Sunday mornings to go to this crazy street market he knew about. He invited me to go with him one weekend; he was looking for a power supply, whatever... (shrink)

In this paper, I investigate an important aspect of Kant’s theory of pure sensible intuition. I argue that, according to Kant, a pure concept of space warrants and constrains intuitions of finite regions of space. That is, an a priori conceptual representation of space provides a governing principle for all spatial construction, which is necessary for mathematical demonstration as Kant understood it.Author Keywords: Kant; Space; Pure sensible intuition; Philosophy of mathematics.

Purpose: The purpose of this paper is to provide a description of an innovative web-based ethics module that was designed to integrate ethics education across four accounting courses over two years (second and third year courses) in a large Australian tertiary institution. Approach: The approach taken in designing the ethics web-based module was to base the foundations of the module on Rest’s (1976) ethical behavior model with the adoption of a longitudinal approach to thecoverage of financial reporting ethical issues. Practical (...) Implications: The key objectives of the module are to improve students’ awareness and sensitivity to accounting ethics, and to foster student learning in an interesting and stimulating manner, leading to in-depth understanding of accounting ethics. Originality/value of paper: This paper provides a description of an original web-based approach to delivering ethics education to accounting students across four university courses. Its value lies in not only the innovative and interactive ethics education approach but also in providing feedback from students and the profession. (shrink)

Sex offenders are sometimes offered or required to undergo pharmacological interventions intended to diminish their sex drive (anti-libidinal interventions or ALIs). In this paper, we argue that much of the debate regarding the moral permissibility of ALIs has been founded on an inaccurate assumption regarding their intended purpose—namely, that ALIs are intended solely to realise medical purposes, not correctional goals. This assumption has made it plausible to assert that ALIs may only permissibly be administered to offenders with their valid consent, (...) in line with the approach taken to most other interventions with a medical aim. However, we argue that, contrary to this assumption, the state's intention in relation to at least some ALIs is, at least in part, to achieve correctional objectives. We evaluate two legal regimes for ALI provision—section 645 of the California Penal Code and the mental health regime in England and Wales. In each case, we identify the state's implicit purpose in imposing ALIs and argue that the Californian and English regimes both serve as counterexamples to the view that ALIs are intended solely for medical purposes. While the moral implications of our argument are not straightforward, it raises the question whether consent is required for permissible imposition of ALIs, and more generally, whether the moral permissibility of crime-preventing interventions using medical means should be assessed against the standards of medical ethics or against those of criminal justice ethics. (shrink)

Journal of Social Philosophy, EarlyView.

As a modern academic Ulysses, the historical scientist is enticed by numerous plausible scientific theories that can explain the historical data in search of the truth. However, the predicament of her work is to inevitably crash onto the rocks and cliffs of uncertainty. The problem discussed in this paper is that several scientific models can be suitable to account for the same empirical observations. The risk of falling into speculation is looming, and exceedingly dangerous in science. This is also the (...) case in archaeological sciences, such as bioarchaeology. A bioarchaeologist frequently encounters traces of disease in ancient skeletons, and pertinent patterns may often result from equally probable different causes. This is a methodological issue commonly encountered in the interpretation of pathological patterns in human remains, and constitutes part of the problem known in bioarchaeology as the osteological paradox. During an informal trilogue, three characters discuss the osteological paradox, and attempt to define it in philosophical terms. The aim of this work is to present the problems of scientists with the philosophical approach to the debate between scientific realism and antirealism, focusing in particular on the so-called problem of underdetermination. Our original approach is to apply the distinction between ‘how-possibly’ models and ‘how-actually’ models by Alisa Bokulich to archaeological issues, integrating various fields of science with a multidisciplinary and omnivorous approach. The trilogue ends providing the historical scientist with reasons and means to believe in her ability to conceive of true and reliable scientific models to interpret the historical past. (shrink)

Free and informed choice is an oft-acknowledged ethical basis for living kidney donation, including parental living kidney donation. The extent to which choice is present in parental living kidney donation has, however, been questioned. Since parents can be expected to have strong emotional bonds to their children, it has been asked whether these bonds make parents unable to say no to this donation. This article combines a narrative analysis of parents’ stories of living kidney donation with a philosophical discussion of (...) conditions for parental decision-making. Previous research has shown that parents often conclude that it is “natural” to donate. Our study shows that this naturalness needs to be understood as part of a story where parental living kidney donation is regarded as natural and as a matter of non-choice. Our study also highlights the presence of a parenthood moral imperative of always putting one’s child’s needs before one’s own. On the basis of these results, we discuss conditions for decision-making in the context of parental LKD. We argue that the presence of a parenthood moral imperative can matter with regard to the decision-making process when parents consider whether to volunteer as living kidney donors, but that it need not hamper choice. We emphasise the need for exploring relational and situational factors in order to understand parental decision-making in the context of parental LKD. (shrink)

Unlike his contemporaries Virginia Woolf and Henry James, Kipling always denied he was a critic. But his letters, speeches, and stories are full of comments on writing and writers. This collection, including many formerly unpublished private letters and papers, details Kipling's response to the commercialisation of literature and the emerging role of the writer as celebrity in the turbulent literary world of the 1890s and beyond. They reveal a mind intensely concerned with questions of literary value, with language and imagination, (...) with truth, realism, and romanticism. Kipling's fame made him a significant spokesperson for important segments of the reading public - the soldiers, engineers, and functionaries central to Britain's imperial expansion. He profoundly influenced English literary language and our perception of English national character. This book offers access to the private and public history of a writer whose continuing influence is still a matter of fierce controversy. (shrink)

This article analyses the two main rhetorical techniques of “argumentation” and “persuasion” employed in politico-philosophical debates recorded in early Chinese argumentative texts of the Warring States period. Through the analysis of pertinent case studies drawn from the received literature, the contribution explores the formal, structural, and grammatical features of these techniques, with attention paid to the wide selection of rhetorical and literary devices they make use of. It also further provides an overview of the historical and socio-cultural background against which (...) such techniques developed among so called “wandering persuaders”, who were travelling from court to court to offer their services as political advisors and diplomats to the local rulers of the time. (shrink)

In the 17th and 18th centuries, mathematics was understood to be the science that systematized our knowledge of magnitude, or quantity. But the mathematical notion of magnitude and the methods used to investigate it underwent a period of radical transformation during the modern period, which forced philosophers of mathematics to confront a changing mathematical landscape. In this context, the modern philosopher of mathematics had to provide an account of the apriority and applicability of mathematical reasoning, as such reasoning was then (...) understood. Early modern mathematical reasoning and the accounts of such reasoning offered by Newton, Descartes, Leibniz, and Kant are explained and discussed. (shrink)

About one-third of Australians use the services of complementary and alternative medicine (CAM); but debate about the role of CAM in public healthcare is vociferous. Despite this, the mechanisms driving CAM healthcare choices are not well understood, especially in rural Australia. From 2016 to 2018, 2,679 persons from the Goulburn Valley, northern Victoria, were surveyed, 28% (755) of whom reporting visiting CAM practitioners. A Generalized Linear Mixed Model was used to assess associations between various socio-demographic variables and the use of (...) CAM services. The strongest significant inverse (p < 0.05) association with CAM use overall was being unemployed, with markedly lower odds of using CAM than those employed full-time (OR 0.22 [0.12, 0.41]). The next strongest inverse relationship was being retired (OR 0.44 [0.30, 0.65]). The strongest positive associations were with English spoken at home (OR 2.38 [1.34, 4.24]), private health insurance (hospital cover) (1.57 [1.28, 1.91]), being Australian born (OR 1.61 [1.14, 2.28]), and female sex (1.25 [1.02, 1.52])). Females had significantly higher odds of using osteopathy than males (OR 1.98 [1.33, 2.96]) but there were no significant sex differences for chiropractic or massage. This is the first such study conducted solely for a rural Australian population. The drivers of CAM use differed from previous nation-wide studies and they varied across modalities. The factors identified here as being associated with CAM use could be used by CAM practitioners in developing person-centred services. Similarly, the findings are relevant to primary-care services in understanding what sectors of society might eschew conventional health care for CAM in rural regions, where health services are often limited. (shrink)

Motivated by a conviction that mass incarceration and state execution are among the most important ethical and political problems of our time, the contributors to this volume come together from a diverse range of backgrounds to analyze, critique, and envision alternatives to the injustices of the U.S. prison system, with recourse to deconstruction, phenomenology, critical race theory, feminism, queer theory, and disability studies. They engage with the hyper-incarceration of people of color, the incomplete abolition of slavery, the exploitation of prisoners (...) as workers and as “raw material” for the prison industrial complex, the intensive confinement of prisoners in supermax units, and the complexities of capital punishment in an age of abolition. (shrink)

In this paper, I combine sources from environmental psychology with insights from the everyday aesthetics literature to explore the concept of ‘everyday heritage’, formerly introduced by Saruhan Mosler. Highlighting the potential of heritage in its everyday context shows that symbolic, aesthetic, and broadly conceived affective factors may be as important as architectural, historical, and artistic issues when it comes to conceiving of heritage value. Indeed, there seems to be more to a heritage site than its official inscription on the UNESCO (...) register. A place is included as part of our heritage primarily because it matters to us. People live in, form relationships with, and derive existential and affective meanings from it. Above and beyond its official significance, a heritage site is thus a living dimension that plays a vital role in the everyday life and social practices of people, who transform it into a place of human significance. (shrink)

Although the category “race” fails as a postulated natural kind, racial, ethnic, national, linguistic, religious, and other group designations might nonetheless be considered projectible insofar as they support inductive inferences in biomedicine. This article investigates what it might mean for group concepts in population genetics and genomics to be projectible and whether the projectibility of such predicates licenses the representation of their corresponding classes as natural kinds according to currently prevailing projectibility-based accounts of natural kinds. The article draws on a (...) case study from cancer genetics, specifically, breast cancer risk in Ashkenazi Jewish women. (shrink)

The ability to recognize failures presupposes the ability to recognize achievements. By the same logic, ethical failures are identifiable only to the extent to which ethical achievements are identifiable. This article examines the possibility of cultural criticism in Whitehead’s metaphysics. The first part of this article challenges Isabelle Stenger’s nonnormative reading of Whitehead, while the second part employs my alternative reading in order to critique two different accounts of the nature of ideals. The main focus of this critique is Derrida’s (...) account of the autoimmunity of democracy and the aporetic structure of justice. (shrink)

The Human Genome Project (HGP) has been criticised from an evolutionary perspective for three reasons: completely ignoring genetic variation; improperly treating either all or some genetic variation as deviation from a norm; and mistakenly seeking to define species in terms of essential properties possessed by all and only member organisms. The first claim is unfounded; the second and third claims are more on target. Nevertheless, it is a mistake to use the typological-population distinction to oppose molecular genetics and evolutionary genetics (...) in order to characterise HGP mapping and sequencing aims, especially the production of a DNA reference sequence, as 'anti-evolutionary' and 'pre-Darwinian.' These aims are consistent with certain strands in twentieth-century evolutionary thought: Muller's classical theory, Kimura's neutral and 'effectively neutral' theories, and, to a lesser extent, Dobzhansky's balance theory of the genetic structure of natural populations. In practice, population-based approaches to human genetic variation are similarly vulnerable to charges of 'typological' and 'essentialist' thinking in their treatment of genetic variation as deviation. This means that the Human Genome Diversity Initiative will not provide a population-based panacea for an overly typological HGP, as its proponents contend. Substituting related, and less rhetorically-charged, conceptual, empirical, and metaphysical distinctions for the typological-population distinction furnishes a better way to assess the concept of the normal genome from an evolutionary perspective. (shrink)

"In her essay "Choosing the Margin," bell hooks draws attention to the way uncritical celebrations of difference and otherness often act as an alibi for progressive politics. The recent proliferation of discourses on alterity, particularly with the growth of Levinas studies, makes hooks's critique all the more relevant for ethical and political theory today. To what extent has this emphasis on alterity affected the dynamics of philosophical and political life? Does it fall into the trap that hooks identifies here as (...) a mask with which privileged subjects present themselves as critical thinkers, while failing to listen to the diverse voices of concrete others gathered under the rubric of "the Other"? It is one thing to affirm one's infinite responsibility for the Other, and quite another thing to make good on that responsibility in specific contexts, especially in a political landscape where some faces are more visible than others, and some voices more likely to be heard. Unless we can flesh out Levinas's ethical project with a political project of resisting oppression, his ethics risks a level of abstraction that covers over its own blind spots. And unless we can distinguish rigorously between otherness as a sign of political exclusion and otherness as a source of ethical command, we risk repeating the conflation of certain others with a position of weakness and victimhood, where "we" can feel responsible for "them" without having to listen to anyone but ourselves.". (shrink)

This article explores how theoretical arguments in relation to the concepts of embodiment and identity can allow one to analyse and explore the cultural and psychological significance of a contemporary set of practices of the `hallucinatory self', exemplified by members of the Hearing Voices Network. The article considers work in `critical psychology', which has largely been ignored by media and cultural theory. Through specific analysis of the ways in which a group of voice-hearers are enacting their identities outside of the (...) frameworks of the `psy' disciplines, the limits of current theories of identity will be exemplified. The article suggests that cultural and social theory must move beyond `consumption' as one of the key sites of subjectification, and begin to explore the significance of sites organized through divisions made between the normal and the abnormal. This will involve developing theories of subject formation which can adequately theorize the relations between truth, power and desire, and can pay attention to those situated practices which produce the various possibilities of experience in relation to contemporary forms of selfhood. (shrink)

Intellectual property can be an important asset for academic institutions. Good data management practices are important for capture, development and protection of intellectual property assets. Selected issues focused on the relationship between data management and intellectual property are reviewed and a thesis that academic institutions and scientists should honor their obligations to responsibly manage data.