We respond to a Letter to the Editor regarding "Principlism and contemporary ethical considerations for providers of transgender health care." We address criticisms by Castle & Klein (2024) of blatant fatphobia related to the ethical elements concerning BMI restrictions for gender-affirming surgery. Our response corrects several mischaracterizations of the article and clarifies our position. My co-authors and I remain focused on advocating for patient-centered, ethically sound, evidence-based, and equitable healthcare policies.

Background: Transgender health care is a subject of much debate among clinicians, political commentators, and policy-makers. While the World Professional Association of Transgender Health (WPATH) Standards of Care (SOC) establish clinical standards, these standards contain implied ethics but lack explicit focused discussion of ethical considerations in providing care. An ethics chapter in the SOC would enhance clinical guidelines. Aims: We aim to provide a valuable guide for healthcare professionals, and anyone interested in the ethical aspects of clinical support for gender (...) diverse and transgender people of all ages. Recognizing that the WPATH is a global association, we address broad challenges. We offer a reflection on general ethical principles, providing conceptual tools for healthcare providers, patients, and families to navigate the specific challenges they might encounter in transgender health care, in line with WPATH’s worldwide mission and scope. Method: This article employs a descriptive analysis, and our framework of reference is the four principles of biomedical ethics: respect for autonomy, beneficence, nonmaleficence, and justice. Results: The article presents a discussion on the four ethical principles as applied to transgender health care. We address issues such as respect for patient autonomy in decision-making, the role of beneficence and nonmaleficence in clinical interventions, and the importance of justice in equitable treatment and access to care. Some of the ethical concerns we address in this article pertain to the current sociopolitical climate, where there has been increasing legal interference, internationally, for transgender and nonbinary people, particularly youth, seeking medical care. Discussion: We highlight the interplay between ethical principles and clinical practice, underscoring the need for ethical guidance in addressing the diverse challenges faced by healthcare providers and patients in transgender health care. We advocate for continuous refinement of ethical thinking to ensure that transgender health care is not only medically effective but also ethically sound. (shrink)

This article establishes a dialogue between the philosopher Axel Honneth and the feminist scholars Silvia Federici and Nancy Fraser. The aim is to emphasize the limits of Honneth’s philosophical reflections on the normative dimension of the family developed in Freedom’s Right. First, I present his ideas on how a normative expectation of social freedom permeates familial relations. According to him, after women entered the labour market, a normative notion of symmetrical participation in the family was produced. I aim to (...) defend here that, whether normative or not, this idea of family is not only limited but also false, since it does not consider the dilemmas of social reproduction whose consequences contradict social freedom. Next, I develop Federici’s and Fraser’s analyses of how families have always faced conflicts concerning the requirements of social reproduction and have produced diverse forms of subjugation that go against the very idea of the family as an unquestioned sphere of freedom. It is necessary to analyse how families produce new forms of subjugation to transform familial relations into truly possible ways of being socially free – and this requires making visible some figures who structure the family, such as nannies, friends and grandparents. (shrink)

Humility, in a variety of forms, has been examined in educational contexts in recent years. However, its association with a particular pedagogical method remains an unexplored area of inquiry. Likewise, social justice and student voice are a concern in international education arenas, including in higher education, but are not usually connected to virtue acquisition or demonstration. The student voice for social justice (SVSJ) pedagogical method, based on the framework of Nancy Fraser, seeks to aid practitioners in higher education to (...) ensure that social justice and student voice, mediated by notions of humility, are at the forefront of higher education practices across disciplines. This is accomplished by creating spaces for students’ active participation and voice in course content development and classroom learning. In this paper, we expand philosophical explorations of intellectual humility (IH) and cultural humility (CH) as virtues that mediate teaching and learning practices and interactions in classrooms during SVSJ implementation. This ensures that each student is recognised as an important knowledge holder and that diverse ways of knowing, knowledge systems and cultural traditions are valued in higher education teaching and learning spaces. (shrink)

Recent years have witnessed a growth in the literature in Western languages devoted to Mou Zongsan 牟宗三.1 Among the New Confucians, Mou's writings are regarded as the most argumentative and the most systematic. He is also one who has engaged with Western philosophers such as Kant, Wittgenstein, Russell, Whitehead, Hegel, and Heidegger. This essay addresses a more primordial theme: how does Mou Zongsan compare with Heidegger when they come to the central issue of the self-transformation of traditions and the question (...) of cultural communication and integration? In relation to these concerns, they respectively formulate the notion of the self-reversal of moral reason (or of liangzhi 良知... (shrink)

The prediction of the secondary structure of a protein from its amino acid sequence is an important step towards the prediction of its three-dimensional structure. However, the accuracy of ab initio secondary structure prediction from sequence is about 80 % currently, which is still far from satisfactory. In this study, we proposed a novel method that uses binomial distribution to optimize tetrapeptide structural words and increment of diversity with quadratic discriminant to perform prediction for protein three-state secondary structure. A benchmark (...) dataset including 2,640 proteins with sequence identity of less than 25 % was used to train and test the proposed method. The results indicate that overall accuracy of 87.8 % was achieved in secondary structure prediction by using ten-fold cross-validation. Moreover, the accuracy of predicted secondary structures ranges from 84 to 89 % at the level of residue. These results suggest that the feature selection technique can detect the optimized tetrapeptide structural words which affect the accuracy of predicted secondary structures. (shrink)

The Mòzǐ is among the founding texts of the Chinese philosophical tradition, presenting China's earliest ethical, political, and logical theories. The collected works introduce concepts, assumptions, and issues that had a profound, lasting influence throughout the classical and early imperial eras. Mòzǐ and his followers developed the world's first ethical theory, and presented China's first account of the origin of political authority from a state of nature. They were prominent social activists whose moral and political reform movement sought to improve (...) the welfare of the common people and eliminate elite extravagance and misuse of power. -/- In this new translation, Chris Fraser focuses on the philosophical aspects of the writing and allows readers to truly enter the Mohists' world of thought. This abridged edition includes the essential political and social topics of concern to this vital movement. Informed by traditional and recent scholarship, the translation presents the Mohists' ideas and arguments clearly, precisely, and coherently, while accurately reflecting the meaning, terminology, and style of the original. (shrink)

This article addresses the relations between ‘nature’ and ‘culture’ (and those characteristics associated with ‘the natural’ and ‘the cultural’) in the context of the debates about Prozac. Following Marilyn Strathern, I focus specifically on the contested issue of enablement - that is, on what Prozac does or does not enable, and on the relation between enablement and enhancement, normality and pathology. I argue that the implications of the model of the brain that accompanies explanations of Prozac are such that commentators (...) are obliged to address not only the nature of normality but also the nature of nature itself. Through a close analysis of these debates, I suggest that critiques of Prozac should be understood not as objections to reductionism - to a biology that closes things down - but rather to one that opens things up: that opens up the relations between nature, culture, biology and the individual, relations that are now cross-cut and thrown about by artificiality. Objections to Prozac, then, might be characterized as an attempt to put these concepts back into their ‘proper’ positions, to re-establish the relationality between them. In conclusion, I argue that the biology put forward by proponents of psychopharmacology, regardless of the desirability of the latter, challenges not only the frequent assumptions that are made about the claims of materialist science, but also some of the terms and concepts that are commonly deployed in the social sciences. (shrink)

Looks at the history of the idea of time, the origins of the universe, relativity, life, the brain's perception of time, aging, death, memory, and time keeping ...

Misrecognition, taken seriously as unjust social subordination, cannot be remedied by eliminating prejudice alone. In this rejoinder to Richard Rorty, it is argued that a politics of recognition and a politics of redistribution can and should be combined. However, an identity politics that displaces redistribution and reifies group differences is deeply flawed. Here, instead, an alternative 'status' model of recognition politics is offered that encourages struggles to overcome status subordination and fosters parity of participation. Integrating this politics of recognition with (...) redistribution enables a coherent Left vision that could redress injustices of culture and of political economy simultaneously. (shrink)

Résumé Le mouvement israélien pour la justice sociale (J14) a surpris par son intensité et sa durée. Cet entretien revient sur les origines du mouvement, la critique de la souveraineté israélienne mais décrit les voies singulières qui traversent l’Assemblée du peuple, représentante du vaste courant d’indignation dans tout le pays. L’hétérogénéité sociale et culturelle du mouvement, la participation de minorités nationales prenant leur part dans la refondation de la politique, le dépassement de la gauche classique et du Bloc pour la (...) paix font que ce mouvement peut être considéré comme durable. (shrink)

Using the knowledge and experience of education practitioners and theorists, these volumes look at the connection between education and society.

This paper is an attempt to examine issues and problemsraised by agricultural biotechnology by drawing on the richnessof contemporary ideas in ethical theory and thereby contribute tothe project of establishing new approaches to these problems. Thefundamental argument is that many of the negative aspects ofagricultural biotechnology are generated at the level of theunderlying conceptual frameworks that shape the technology''sinternal modes of organization, rather than the unintendedeffects of the application of an inherently benevolent set oftechniques. If ``food ethics'''' is to address (...) the adverse impacts ofagricultural biotechnology, it must ultimately challenge theseconceptual frames, which, I argue, emerge from Enlightenment,liberal, political, and economic theory.The translation of traditional bioethics (focusing on principlessuch as autonomy and rights, justice, and well being) into foodethics does not produce the critical tools that are ableadequately to challenge the harmful legacy of Enlightenmentthinking. What is needed are reorientations of ethics that arecapable of formulating concepts and approaches that to someextent break with the presuppositions that underpin biotechnologyat its foundation. This paper suggests that narrative andfeminist critiques of medical bioethics are a good place to startin this project. (shrink)

Essentially we show recent data to shed new light on the thorny controversy of how teeth arose in evolution. Essentially we show (a) how teeth can form equally from any epithelium, be it endoderm, ectoderm or a combination of the two and (b) that the gene expression programs of oral versus pharyngeal teeth are remarkably similar. Classic theories suggest that (i) skin denticles evolved first and odontode‐inductive surface ectoderm merged inside the oral cavity to form teeth (the ‘outside‐in’ hypothesis) or (...) that (ii) patterned odontodes evolved first from endoderm deep inside the pharyngeal cavity (the ‘inside‐out’ hypothesis). We propose a new perspective that views odontodes as structures sharing a deep molecular homology, united by sets of co‐expressed genes defining a competent thickened epithelium and a collaborative neural crest‐derived ectomesenchyme. Simply put, odontodes develop ‘inside and out’, wherever and whenever these co‐expressed gene sets signal to one another. Our perspective complements the classic theories and highlights an agenda for specific experimental manipulations in model and non‐model organisms. (shrink)

The latest elaborate work on the Saturnian goes back definitely to the view that the metre is quantitative in character, not accentual, or halfaccentual. This theory then, which is at the same time the oldest, may at present be considered to hold the field, and the burden of proof will presumably lie on those who advocate a counter-theory. In putting forward such a theory I shall make two, as I think, justifiable assumptions: that that theory should be accounted the best (...) which throws most light on the origin of the Saturnian, and that the Saturnian is an exceedingly primitive metre, and that an explanation of a primitive metre need not be very complicated to be intelligible. (shrink)

The concept of right or fit is an important element entailed, but not fully articulated, in the concept of action or practice in Aristotle's theory of virtue; which, however, turns to be of the utmost importance in later Western ethics. Right is concerned with both feelings and actions, and is not the same for all individuals. It lies in between the two extremes of the spectrum of practical affairs, yet by no means equidistant from them. This account of the concept (...) of fitness or right is derived from the categories of quantity, relationship, and quality rather than from that of substance. Thus, it seems that virtue is relative to vice or error within a continuous existence. If, however, the right of passion and action is environmental and concrete, is it multiple and not singular? To this question, Aristotle gives his reply on two levels: On the level of concrete practitioners, what is right and fit to one man might not be so to another man, and hence the right of practice is not singular but multiple; whereas on the level concerned with the only right choice compared with the two extremes or errors, the right of practice will always be singular. /// "正确"是隐含于亚里士多德的德性学说中的一个重要而未充分展开的，在 后来的西方伦理学中却变成极为重要的关于行为或实践的概念。"正确"与感情和 行为都相关。"正确"并不是对所有人同样的。它是两端间的那个中间，但井不始 终与两端距离相等。对适度或正确的这种说明基本上是从数量、关系与性质范畴引 出，而不是从实体范畴引出的述说。所以，德性似乎始终是在一种有连续性的存在 中相对于恶或错误而言的。感情与行为的正确如果是环境的、具体的，它是否是多 而不是一?亚里士多德在两个层面上回答这个问题。在相对于具体实践者的层面， 对我而言的适度或正确很可能不同于对你而言的，实践的正确不是一而是多:在相 对于两端或错误唯有一个正确的选择而言，实践的正确始终只是一。. (shrink)

This chapter contains sections titled: The Military and Technology A Nano‐Enabled Military A Nano‐Enabled Defense System Ethical Concerns.

Discourses between Ayōttitācar, 1845-1914 and Ma. Ciṅkāravēlu,1860-1946 on Buddhism. These were published in Tamilan̲, Tamil magazine, published between 1907-1914.

The recent struggle over the confirmation of Clarence Thomas and the credibility of Anita Hill raises in a dramatic and pointed way many of the issues at stake in theorizing the public sphere in contemporary society. At one level, the Senate Judiciary Committee hearings on Hill’s claim that Thomas sexually harassed her constituted an exercise in democratic publicity as it has been understood in the classical liberal theory of the public sphere. The hearings opened to public scrutiny a function of (...) government, namely, the nomination and confirmation of a Supreme Court justice. They thus subjected a decision of state officials to the force of public opinion. Through the hearings, in fact, public opinion was constituted and brought to bear directly on the decision itself, affecting the process by which the decision was made as well as its substantive outcome. As a result, state officials were held accountable to the public by means of a discursive process of opinion and will formation.Yet that classical liberal view of the public sphere does not tell the whole story of these events.1 If were examine the Thomas confirmation struggle more closely, we see that the very meaning and boundaries of the concept of publicity was at stake. The way the struggle unfolded, moreover, depended at every point on who had the power to successfully and authoritatively define where the line between the public and the private would be drawn. It depended as well on who had the power to police and defend that boundary. 1. See Jürgen Habermas, The Structural Transformation of the Public Sphere: An Inquiry into a Category of Bourgeois Society, trans. Thomas Burger. Nancy Fraser is associate professor of philosophy and faculty fellow of the Center for Urban Affairs and Policy Research at Northwestern University, where she also teaches in the women’s studies program. She is the author of Unruly Practices: Power, Discourse, and Gender in Contemporary Social Theory. She is currently working on Keywords of the Welfare State, a jointly authored book with Linda Gordon. (shrink)

Dance creation involves complex psychological activities. Although previous studies have conducted extensive investigations on the psychological aspects of choreographers’ creations, little is known regarding the psychological barrier of choreographers in terms of creativity. The study aims to explore the psychological barrier of innovation in dance choreography, which is a kind of situation between mental illness and mental problems. The research shows that improvisational dance is a free dance with the human body as a material carrier, and it is a dance (...) form that the dancer’s thinking is transformed into dance action to express their inner thoughts. The improvement of the potential creative thinking of dance creators through the improvisational dance movement and structure are explored. Meanwhile, the theoretical ideas of psychologists have been applied to the cultivation and improvement of improvisational dance creativity, which has made full certification and supplement. Moreover, through psychological experiments, it is proved that improvisational dance is an important way to release and develop creativity. Based on the theory of psychology, feasible suggestions are given to improve students’ creative ability in the process of improvisational dance teaching. (shrink)

In multimodal multiobjective optimization problems, multiple Pareto optimal sets, even some good local Pareto optimal sets, should be reserved, which can provide more choices for decision-makers. To solve MMOPs, this paper proposes an evolutionary algorithm with clustering-based assisted selection strategy for multimodal multiobjective optimization, in which the addition operator and deletion operator are proposed to comprehensively consider the diversity in both decision and objective spaces. Specifically, in decision space, the union population is partitioned into multiple clusters by using a density-based (...) clustering method, aiming to assist the addition operator to strengthen the population diversity. Then, a number of weight vectors are adopted to divide population into N subregions in objective space. Moreover, in the deletion operator, the solutions in the most crowded subregion are first collected into previous clusters, and then the worst solution in the most crowded cluster is deleted until there are N solutions left. Our algorithm is compared with other multimodal multiobjective evolutionary algorithms on the well-known benchmark MMOPs. Numerical experiments report the effectiveness and advantages of our proposed algorithm. (shrink)