The life sciences are increasingly being called on to produce “socially robust” knowledge that honors the social contract between science and society. This has resulted in the emergence of a number of “broad social issues” that reflect the ethical tensions in these social contracts. These issues are framed in a variety of ways around the world, evidenced by differences in regulations addressing them. It is important to question whether these variations are simply regulatory variations or in fact reflect (...) a contextual approach to ethics that brings into question the existence of a system of “global scientific ethics”. Nonetheless, within ethics education for scientists these broad social issues are often presented using this scheme of global ethics due to legacies of science ethics pedagogy. This paper suggests this may present barriers to fostering international discourse between communities of scientists, and may cause difficulties in harmonizing (and transporting) national regulations for the governance of these issues. Reinterpreting these variations according to how the content of ethical principles is attributed by communities is proposed as crucial for developing a robust international discourse. To illustrate this, the paper offers some empirical fieldwork data that considers how the concept of dual-use (as a broad social issue) was discussed within African and UK laboratories. Demonstrating that African scientists reshaped the concept of dual-use according to their own research environmental pressures and ascribed alternative content to the principles that underpin it, suggests that the limitations of a “global scientific ethics” system for these issues cannot be ignored. (shrink)

This article critically engages with the influential theory of ‘‘molecularized biopower’’ and ‘‘politics of life’’ developed by Paul Rabinow and Nikolas Rose. Molecularization is assumed to signal the end of population-centred biopolitics and the disciplining of subjects as described by Foucault, and the rise of new forms of biosociality and biological citizenship. Drawing on empirical work in Science and Technology Studies, we argue that this account is limited by a focus on novelty and assumptions about the transformative power of (...) the genetic life sciences. We suggest that biopower consists of a more complex cluster of relationships between the molecular and the population. The biological existence of different human beings is politicized through different complementary and competing discourses around medical therapies, choices at the beginning and end of life, public health, environment, migration and border controls, implying a multiple rather than a singular politics of life. (shrink)

Available for the first time in English, Roger's masterwork of intellectual history situates the life sciences within the larger context of French Enlightenment thought and the history of institutions.

This volume explores the intersection between early modern philosophy and the life sciences by presenting the contributions of important but often neglected figures such as Cudworth, Grew, Glisson, Hieronymus Fabricius, Stahl, Gallego, Hartsoeker, and More, as well as familiar figures such as Descartes, Spinoza, Leibniz, Malebranche, and Kant.

Following recent debate on the relations between philosophy of science and the sciences, we wish to draw attention to some actual ways of training both young philosophers of science and young life scientists and clinicians. First, we recall a successful case of training philosophers of the life sciences in a strictly scientific environment. Second, after a brief review of the reasons why life scientists and clinicians are currently asking for more ethics, more methodology of science, (...) and more philosophy of science in the training of life scientists and clinicians, we present two training models that could spur the discussion on how to meet the requests coming from the scientific community. We argue that in order to reflect on mutual relations between philosophy of science and the sciences and to foster proper interactions, issues regarding the topics considered, the features of educational curricula, and the institutional organizations should be addressed jointly. (shrink)

Although in the last decades increasingly more philosophers have paid attention to the life sciences, traditionally physics has dominated general philosophy of science. Does a focus on the life sciences and medicine produce a different philosophy of science and indeed a different conception of knowledge? Here Cristina Chimisso does not attempt to give a comprehensive answer to this question; rather, she presents a case study focussed on Georges Canguilhem. Canguilhem continued the philosophical tradition that we now (...) call historical epistemology, and always referred very closely to the philosophy of Gaston Bachelard. However, whereas Bachelard primarily studied the history of chemistry and physics, Canguilhem turned to the life sciences, medicine and psychiatry. Chimisso investigates their respective conceptions and uses of norms. Chimisso argues that some crucial differences in how they regarded norms, seldom emphasised by Canguilhem himself and indeed by critics, stem from the sciences on which they concentrated. (shrink)

Field Life examines the practice of science in the field in the Great Plains and Rocky Mountains of the American West between the 1860s and the 1910s, when the railroad was the dominant form of long-distance transportation. Grounded in approaches from environmental history and the history of technology, it emphasizes the material basis of scientific fieldwork, joining together the human labor that produced knowledge with the natural world in which those practices were embedded. Four distinct modes of field practice, (...) which were shared by different field science disciplines, proliferated during this period—surveys, lay networks, quarries, and stations—and this book explores the dynamics that underpinned each of them. Using two diverse case studies to animate each mode of practice, as well as the making of the field as a place for science, Field Life combines textured analysis of specific examples of field science on the ground with wider discussion of the commonalities in the practices of a diverse array of field sciences, including the earth and physical sciences, the life and agricultural sciences, and the human sciences. By situating science in its regional environmental context, Field Life analyzes the intersection between the cosmopolitan knowledge of science and the experiential knowledge of people living in the field. Examples of field science in the Plains and Rockies range widely: geological surveys and weather observing networks, quarries to uncover dinosaur fossils and archaeological remains, and branch agricultural experiment stations and mountain biological field stations. (shrink)

A unique introduction to the philosophy of science with special emphasis on the life sciences. Part I presents elementary but fundamental concepts and problems in epistemology and their relation to questions of scientific methodology. Part II deals with case studies from the history of biology which illustrate particular philosophical points while Part III progresses to more complex ideas as on the nature and methodology of science. Part IV discusses the limitations of scientific enquiry and its relations to other (...) systems of knowledge and interpretation. (shrink)

The successful decoding of human genome and subsequent advances in new life sciences innovation create technological presuppositions of a new possibility of justice i.e. the just distribution of both social and natural goods. Although Rawlsians attempt to expand their theory to include this new possibility, they fail to provide plausible metrics of social justice in the genomics and post-genomics era. By contrast, Senians seem to succeed to do so through their index of basic capabilities. This paper explores what (...) might be regarded as a Senian perspective of distributive justice in new life sciences innovation. The argument is that, by comparing freedoms instead of primary goods, the capability theory allows not only for the identification of injustices linked to natural lottery but also for their elimination through the use of new genomic technologies, including gene-based diagnostics, gene therapy, somatic cell engineering and germ-line engineering. These innovative technologies seem to have the potential to reduce variability in natural goods and therefore enable individuals to convert social goods into well-being or welfare. (shrink)

In this interview, Anne Fagot-Largeault discusses with Thierry Bardini her recollections of the life and work of French philosopher Gilbert Simondon (1924–1989). The discussion covers Simondon’s theory of individuation and considers its influences on contemporary thinkers such as Gilles Deleuze and François Laruelle. Fagot-Largeault situates Simondon’s thinking within the broader context of 20th-century biological research and the development of life sciences. Informed by her personal association and experiences working with Simondon, her reminiscences shed light on the unique (...) character of Simondon as a person and as a thinker. (shrink)

"All art should become science and all science art; poetry and philosophy should be made one." Friedrich Schlegel's words perfectly capture the project of the German Romantics, who believed that the aesthetic approaches of art and literature could reveal patterns and meaning in nature that couldn't be uncovered through rationalistic philosophy and science alone. In this wide-ranging work, Robert J. Richards shows how the Romantic conception of the world influenced (and was influenced by) both the lives of the people who (...) held it and the development of nineteenth-century science. Integrating Romantic literature, science, and philosophy with an intimate knowledge of the individuals involved—from Goethe and the brothers Schlegel to Humboldt and Friedrich and Caroline Schelling—Richards demonstrates how their tempestuous lives shaped their ideas as profoundly as their intellectual and cultural heritage. He focuses especially on how Romantic concepts of the self, as well as aesthetic and moral considerations—all tempered by personal relationships—altered scientific representations of nature. Although historians have long considered Romanticism at best a minor tributary to scientific thought, Richards moves it to the center of the main currents of nineteenth-century biology, culminating in the conception of nature that underlies Darwin's evolutionary theory. Uniting the personal and poetic aspects of philosophy and science in a way that the German Romantics themselves would have honored, The Romantic Conception of Life alters how we look at Romanticism and nineteenth-century biology. (shrink)

Comparative to the commonplace focus onto developments in mathematics and physics, the life sciences appear to have received relatively sparse attention within the early history of analytic philosophy. This paper addresses two related aspects of this phenomenon. On the one hand, it asks: to the extent that the significance of the life sciences was indeed downplayed by early analytic philosophers, why was this the case? An answer to this question may be found in Bertrand Russell’s 1914 (...) discussions of the relation between biology and philosophy. Contrary to received views of the history of analytic philosophy, Russell presented his own ‘logical atomism’ in opposition not only to British Idealism, but also to ‘evolutionism’. On the other hand, I will question whether this purported neglect of the life sciences does indeed accurately characterise the history of analytic philosophy. In answering this, I turn first to Susan Stebbing’s criticisms of Russell’s overlooking of biology, her influence on J.H. Woodger, and her critical discussion of T.H. Huxley’s and C.H. Waddington’s application of evolutionary views to philosophical questions. I then discuss the case of Moritz Schlick, whose evolutionist philosophy has been overlooked within recent debates concerning Logical Empiricism’s relation to the philosophy of biology. (shrink)

Empirical studies of life science research and biotechnologies in Asia show how assemblages of life articulate bioethics governance with global moralities and reveal why the global harmonization of bioethical standards is contrived.

This paper criticizes the role of intuition-based ascriptions of cognition that are closely related to the ascription of mind. This practice hinders the explication of a clear and stable target domain for the cognitive sciences. To move forward, the proposal is to cut the notion of cognition free from such ascriptions and the intuition-based judgments that drive them. Instead, cognition is reinterpreted and developed as a scientific concept that is tied to a material domain of research. In this reading, (...) cognition becomes a changeable theoretical concept that can and must be adapted to the findings within this target domain. Taking humans as the best-established existing example of the relevant material target domain, this central case is extended to include all living systems. To clarify what it is about living systems that warrants their role as cognitive target domain, the new concept of cobolism is introduced as a complement to metabolism. Cobolism refers to the systematic ways in which each living system encompasses structures, processes and external events that maintain the fundamental metabolic processes that constitute the core of each living system. Cobolism is perfectly general, applies to bacterial and human cases alike, and provides a general format to describe wildly different cognitive organizations. It provides a clear target for the cognitive sciences to work on, turning them into what we can call the cognitive life sciences. (shrink)

There is a crisis of valuation practices in the current academic life sciences, triggered by unsustainable growth and “hyper-competition.” Quantitative metrics in evaluating researchers are seen as replacing deeper considerations of the quality and novelty of work, as well as substantive care for the societal implications of research. Junior researchers are frequently mentioned as those most strongly affected by these dynamics. However, their own perceptions of these issues are much less frequently considered. This paper aims at contributing to (...) a better understanding of the interplay between how research is valued and how young researchers learn to live, work and produce knowledge within academia. We thus analyze how PhD students and postdocs in the Austrian life sciences ascribe worth to people, objects and practices as they talk about their own present and future lives in research. We draw on literature from the field of valuation studies and its interest in how actors refer to different forms of valuation to account for their actions. We explore how young researchers are socialized into different valuation practices in different stages of their growing into science. Introducing the concept of “regimes of valuation” we show that PhD students relate to a wider evaluative repertoire while postdocs base their decisions on one dominant regime of valuing research. In conclusion, we discuss the implications of these findings for the epistemic and social development of the life sciences, and for other scientific fields. (shrink)

Offers a practical philosophy of the life sciences, showing how scientific reasoning can, in limited contexts, be translated into the language of philosophy, and how science can correct the philosophy of science.

Against the background of the current discussion about self-organization theories and complexity theories and their application within biology and ecology, the question of teleology gains a new significance. Some scholars insist on the total elimination of any reference to teleology from the realm of the natural sciences. However, it seems especially hard to eradicate teleological expressions from scientific language when the issue of understanding living beings is at stake. For this reason, other scholars opt for a middle path that (...) allows for some teleological language. Yet, it is an open question whether teleological expressions are to be considered as playing a merely metaphorical or a necessary heuristic role in the sciences. Moreover, the ontological presuppositions, which underpin different positions in the debate, need to be depicted and analyzed. This paper aims at addressing the question of teleology within the life sciences by taking into account both Kant’s critical philosophy and Whitehead’s ontology. My analysis starts with Georg Toepfer’s distinction among different concepts of teleology and then focuses on the role of “internal purposiveness” (innere Zweckmäßigkeit) for biology today. I show how purposiveness (Zweckmäßigkeit; hereafter: ZM) corresponds to a very complex form of reciprocal causation (Wechselwirkung) rather than to any model of final causation. Drawing on Kant’s analysis of “natural purposes” in the Critique of Judgment as well as selforganization theory, I claim that reciprocal causation – however complex it might well be – is not sufficient to describe living beings adequately. However, since the natural sciences are still caught up in the presuppositions of modern scientistic and materialistic ontology, a step beyond mere efficient causation seems to be impossible within their methodological framework. And yet, as I will show, a genuine teleology of nature implies the idea of anticipation of totality. This kind of teleological consideration is presented at first in its role as a regulative concept in Kantian terms. Finally, I follow the path of Whitehead’s ‘philosophy of organism’ and claim for natural teleology the state of a necessary ontological presupposition. Whitehead’s ontology offers an ontological underpinning for teleological issues that, by avoiding any recourse to supernatural forces, invites life and natural sciences to a fruitful dialogue at the limit of their methodological boundaries, pressing them beyond their unreflected presuppositions. (shrink)

This article deals with physico-mathematical approaches to anatomy in post-Harveyan physiology. But rather than looking at questions of iatromechanics and animal locomotion, which often attracted this approach, I look at the problem of how blood returned to the heart – a part of the circulation today known as venous return but poorly researched in the early modern period. I follow the venous return mechanisms proposed by lesser-known authors in the mechanization of anatomy, such as Jean Pecquet (1622–1674) and Nicolaus Steno (...) (1638–1686), alongside the more famous Giovanni Alfonso Borelli (1608–1679). Their mechanisms differed only in small details. Yet, these minor differences highlight significant aspects of the mechanization of the life sciences in the seventeenth century. First, they relied more on observations than hitherto acknowledged, even if only indirectly. Second, their mechanisms drew more from the physico-mathematical disciplines than from the trending corpuscularian philosophies of their time. Finally, these mechanisms led to a more accurate understanding of the circulation that remains valid today, thus revealing their cognitive benefits. In short, through the single problem of how blood returned to the heart, this article portrays the increasing complexity of anatomy in the early modern period. (shrink)

The free-energy principle states that all systems that minimize their free energy resist a tendency to physical disintegration. Originally proposed to account for perception, learning, and action, the free-energy principle has been applied to the evolution, development, morphology, anatomy and function of the brain, and has been called a postulate, an unfalsifiable principle, a natural law, and an imperative. While it might afford a theoretical foundation for understanding the relationship between environment, life, and mind, its epistemic status is unclear. (...) Also unclear is how the free-energy principle relates to prominent theoretical approaches to life science phenomena, such as organicism and mechanism. This paper clarifies both issues, and identifies limits and prospects for the free-energy principle as a first principle in the life sciences. (shrink)

The aim of the book is to explore common concerns regarding methodological individualism in different fields of the life sciences broadly construed. It will address conceptual problems regarding individuals and their relation and dependence on the collectivities they are part of and consider innovative new viewpoints, grounded in specific scientific projects that question the present descriptions and understanding and raise challenges. A wide variety of recent, influential contributions in the life sciences utilize notions of collectivity, sociality, (...) rich interactions and emergent phenomena, as essential explanatory tools to handle numerous persistent scientific questions in the life sciences. -/- Examples range from gene expression and regulation, the dynamics of bacterial populations, the ecological developmental biology of symbiosis, levels of selection, to communication, motion and patterns of behavior in diverse life forms, the role of social institutions and cultural dynamics in human evolution, and the psychological basis for social norms. The book is being structured so that fruitful and rewarding disciplinary interactions take place among researchers and scholars who have been concerned with overcoming methodological individualism. -/- The books includes a section of four papers on holobionts and the hologenome theory and a special memorial article on the work of the late Prof. Eshel Ben-Jacob authored by Herbert Levine. (shrink)

Towards biodeconstruction -- Between life and death: différance -- The absolute programme -- The text and the living -- Between life and death: the bond -- Beyond life death: autoimmunity -- Living on: the arche-performative.

Best known as a moralist and one of the founders of the Scottish Common Sense school of philosophy, Thomas Reid was also an influential scientific thinker. Here his work on the life sciences is studied in detail, bringing together unpublished transcripts of his most important papers on natural history, physiology, and materialist metaphysics. Part I provides the first published account of Reid's reflections on the highly controversial theories surrounding muscular motion and the reproduction of plants and animals and (...) relates them to the broader Enlightenment debates on these issues. It also contains the first systematic reconstruction of Reid's opposition to materialism and views his polemics against the noted Dissenter Joseph Priestley in terms of their differing interpretations of the Newtonian legacy, their conflicting philosophical assumptions, and the cultural politics of Common Sense philosophy in the 1770s. Part II reproduces a selection of Reid's most significant papers on the life sciences, including his Glasgow Literary Society discourses on muscular motion and on Priestley's materialism, as well as other manuscripts that document the development of his scientific ideas. (shrink)

Both science and theology involve philosophy. They both involve reasoned argument, evaluation of possible explanations, clarification of concepts, ways of interpreting experience, understanding the present significance of what has gone before us, and other such eminently philosophical tasks. They both involve philosophy, especially when they enter into dialogue with each other. In fact, they involve philosophical thinking even when they may not be aware of it. In this paper I will explore a specific area of philosophy that is particularly important (...) as a bridge between theology and science. I am referring to the area of meaning. Questions regarding meaning are fundamental because whatever is said about the nature of life, by scientists, by theologians, or by anyone else, must be expressed in meaningful words. Meaning is like the ground we walk on. It constitutes what we need to proceed with our activity. Without solid ground under our feet, we cannot go anywhere. (shrink)

In this thesis we have examined the complex interaction between intellectual property rights, life sciences and global justice. Science and the innovations developed in its wake have an enormous effect on our daily lives, providing countless opportunities but also raising numerous problems of justice. The complexity of a problem however does not liberate society as a whole from moral responsibilities. Our intellectual property regimes clash at various points with human rights law and commonly held notions of justice.

Life sciences and emerging technologies raise a plethora of issues. Besides practical, bioethical and policy issues, they have broader, cultural implications as well, affecting and reflecting our zeitgeist and world-view, challenging our understanding of life, nature and ourselves as human beings, and reframing the human condition on a planetary scale. In accordance with the aims and scope of the journal, LSSP aims to foster engaged scholarship into the societal dimensions of emerging life sciences (Chadwick and (...) Zwart 2013) and via this thematic series, the journal provides a podium for authors who intend to address concrete issues from a ‘continental philosophical’ perspective, which may in- clude (post)phenomenology, hermeneutics, dialectics, (post)structuralism, psychoanalysis, critical theory and similar approaches. The series aims to contribute to a diagnostics of the present and a prognostics of the future, focusing on critical normative challenges (such as embodiment, intimate technologies, social justice, biopower, nanomedicine, human enhancement and the anthropocene) and building on the work of key authors such as Hegel (1830), Heidegger (1953, 1953/1954), Bachelard (1938), Canguilhem (1975), Lacan (1966, 1969-1970/1991), Habermas (1968), Serres (1972), Foucault (1969), Žižek (2006/2009), Stiegler (2010), Sloterdijk (2001, 2009) and others, but targeting con- crete up-to-date events and case studies against the backdrop of broader developments within the techno-scientific culture. (shrink)

With In Search of Mechanisms, Carl F. Craver and Lindley Darden offer both a descriptive and an instructional account of how biologists discover mechanisms. Drawing on examples from across the life sciences and through the centuries, Craver and Darden compile an impressive toolbox of strategies that biologists have used and will use again to reveal the mechanisms that produce, underlie, or maintain the phenomena characteristic of living things. They discuss the questions that figure in the search for mechanisms, (...) characterizing the experimental, observational, and conceptual considerations used to answer them, all the while providing examples from the history of biology to highlight the kinds of evidence and reasoning strategies employed to assess mechanisms. At a deeper level, Craver and Darden pose a systematic view of what biology is, of how biology makes progress, of how biological discoveries are and might be made, and of why knowledge of biological mechanisms is important for the future of the human species. (shrink)

What do you do when you're not asleep and not eating? You're most likely waiting - to finish work, to get home, to finish your duties. This book aims to describe how many people experience waiting and how important this is, in popular and highbrow culture and in real life and how we cope with it.

Over the course of the last three decades, computer simulations have become a major tool of doing science and engaging with the world, not least in an effort to predict and intervene in a future to come. Born in the context of the Second World War and the discipline of physics, simulations have long spread into most diverse fields of enquiry and technological application. This paper introduces a topical collection focussing on simulations in the life sciences. Echoing the (...) current state of tinkering, fast developments, segmentation of knowledge and interdisciplinary collaboration, and in an effort to bridge the science-humanities divide, the contributors to this collection come from multiple disciplinary backgrounds, including information studies, cognitive sciences, philosophy and biology. The ambiguous character of simulations, their cutting across scientific disciplines, analysis and prediction, understanding and doing, gave rise to their success in contemporary life sciences and has been the object of much scientific debate. One of the main aims of this topical collection, by contrast, is to call into question the assumption of an obvious use and easy transfer of methods between fields of knowledge as diverse as, e.g. physics and biology. The collection presents historical case studies from various biological sub-fields. The articles study how simulations are used and the ways they contribute specifically to our understanding of life. Taking up Sergio Sismondo’s description of simulations as “compromises” and “glue”, they also critically engage with the question of what exactly the life sciences have been gluing together over the last two decades. (shrink)

Metaphors used to describe new technologies mediate public understanding of the innovations. Analyzing the linguistic, rhetorical, and affective aspects of these metaphors opens the range of issues available for bioethical scrutiny and increases public accountability. This article shows how such a multidisciplinary approach can be useful by looking at a set of texts about one issue, the use of a newly developed technique for genetic modification, CRISPRcas9.