Bone morphogenetic proteins (BMPs) are typically members of the transforming growth factor β (TGF-β) family with diverse roles in embryonic development. At least five genes with homology to BMPs are expressed during Xenopus development, along with their receptors and intracellular signalling pathways. The evidence suggests that BMPs have roles to play in both mesoderm induction and dorsoventral patterning. Studies in Xenopus have also identified a number of inhibitory binding proteins for the classical BMPs, encoded by genes such as chordin and (...) noggin. These proteins appear to be responsible for establishing a morphogen gradient of BMP4 activity, which specifies different dorsoventral fates in early gastrulae. An emerging theme is that inhibition of BMP signalling is an important mechanism regulating cell fate decisions in early development. BioEssays 21:751–760, 1999. © 1999 John Wiley & Sons, Inc. (shrink)

In this article, I articulate and explore a novel constructivist approach to metanormativity that is inspired by David Hume’s metaesthetics. This view, which I call perfectionist Humean constructivism, rejects the claim that practical reasons are constructed by each individual’s valuing attitudes, holding instead that they are constructed by humanity’s shared evaluative nature. I hold that this approach can plausibly respond to a persistent worry for extant versions of Humean constructivism without embracing the commitments of either a Kantian constructivism or a (...) metaphysically robust form of metanormative realism. (shrink)

A persistent paradox apparently infects disability civil rights claims. On the one hand, these rights claims are often understood to apply only to those who are sufficiently impaired in body or in mind to qualify for them because of the disadvantage they endure. On the other hand, asserting significant impairments threatens to undermine the plausibility of these claims as civil rights rather than as welfare for those who are dependent and in need of extra help. Behind this paradox lies a (...) type of categorical understanding of disability civil rights: that disability civil rights are only for those who fall into a category of disability and that this category should be defined in a particular way, in terms of disadvantaging disablement. In this article, I dispel this paradox by deploying a critical analysis of Elizabeth Barnes’s account of physical disability in her recent book, The Minority Body. In her book, Barnes makes the important critical point that disability is not “bad” difference. Instead, she argues that physical disability is a physical condition that the disability rights community is working to promote justice for. I argue that this account fails as a project of ameliorative social metaphysics because it fails to understand the role of impairment in the construction of disability antidiscrimination law. I also argue that her account risks privileging physical disability and is thus problematic as a starting place for examining disability justice. (shrink)

I begin by providing some background to conceptions of responsibility. I note the extent of disagreement in this area, the diverse and cross-cutting distinctions that are deployed, and the relative neglect of some important problems. These facts make it difficult to attribute responsibility for climate change, but so do some features of climate change itself which I go on to illuminate. Attributions of responsibility are often contested sites because such attributions are fundamentally pragmatic, mobilized in the service of a normative (...) outlook. We should be pluralists about responsibility and shape whatever conceptions can help to explain, guide, and motivate our responses to climate change. I sketch one such notion, ‘intervention-responsibility’, and argue that it should be ascribed to international regimes and organizations, states and other jurisdictions, individuals, and firms. Each has different capacities and thus different intervention-responsibilities responsibilities, but these differences are not always mirrored in public discussion. In particular, the moral responsibility of firms has been greatly neglected. (shrink)

A textbook for third year undergraduates and postgraduates. In a challenging philosophic investigation of the origin of consciousness and human culture, Dewart (religion, emeritus, U. of Toronto) proposes a theory to explain the origin of all specifically human traits. Complementing the theory of evolution through natural selection, it explains the emergence and those the continuing evolution of characterstics through the interaction of experience and speech. Annotation copyrighted by Book News, Inc., Portland, OR.

We explored the influence of negation on cognitive dynamics, measured using mouse‐movement trajectories, to test the classic notion that negation acts as an operator on linguistic processing. In three experiments, participants verified the truth or falsity of simple statements, and we tracked the computer‐mouse trajectories of their responses. Sentences expressing these facts sometimes contained a negation. Such negated statements could be true (e.g., “elephants are not small”) or false (e.g., “elephants are not large”). In the first experiment, as predicted by (...) the classic notion of negation, we found that negation caused more discreteness in the mouse trajectory of a response. The second experiment induced a simple context for these statements, yet negation still increased discreteness in trajectories. A third experiment enhanced the pragmatic context of sentences, and the discreteness was substantially diminished, with one primary measure no longer significantly showing increased discreteness at all. Traditional linguistic theories predict rapid shifts in cognitive dynamics occur due to the nature of negation: It is an operator that reverses the truth or falsity of an interpretation. We argue that these results support both propositional and contextual accounts of negation present in the literature, suggesting that contextual factors are crucial for determining the kind of cognitive dynamics displayed. We conclude by drawing broader lessons about theories of cognition from the case of negation. (shrink)

This study examines the association between mystical experience, as captured by the Francis-Louden Mystical Orientation Scale, and psychological health, as captured by the Eysenckian three dimensional model of personality, among 329 students attending a state university in Turkey. The data reported no significant association between mystical orientation and psychoticism scores, and a small but significant positive association between mystical orientation and neuroticism scores, after controlling for sex differences. This finding suggests that there may be a small inverse association between mystical (...) experience and psychological health among students in Turkey. (shrink)

The modern critical tradition’s strategy for defeating the demon of self doubt and securing certainty, as Hannah Arendt has written, restricts serious candidates for belief to those whose conditions of truth can be rendered wholly immanent to focal consciousness within a point of view that is simply taken for granted. Thereby it forecloses the possibility of recognizing the partiality of its own perspective vis-a-vis that of others, taking into account the relevant perspectives of other persons, and reaching any kind of (...) sense in common between perspectives. The institutionalization of this strategy in 20th century academic life is amply and insightfully documented in Bruce Wilshire’s Moral Collapse of the University. Michael Polanyi, in his writings, adumbrates a post-critical intellectual ethos in whichthe making of sense in common between persons of differing perspective is central to the enterprise of teaching, learning, and research. Key elements of such an intellectual ethos are articulated and explored. (shrink)

Largely in response to Epicurus’ famous challenge, philosophers have been quite imaginative in coming up with ways in which death is bad. Most often, death is described as an instrumental bad. Given that I would have obtained additional welfare benefits had I not died when I did, my death causes me to miss out on intrinsic goods I might otherwise have obtained. In this article, however, I argue that the standard account (and its corollaries) misses an important feature of the (...) dis/value of death. I argue that some deaths can be good – intrinsically good – for the person who dies. (shrink)

In her book Uneasy Virtue, Julia Driver presents an account of motive or trait utilitarianism, one that has been taken as “the most detailed and thoroughly defended recent formulation” of consequential virtue ethics. On Driver's account character traits are morally virtuous if and only if they generally lead to good consequences for society. Various commentators have taken Driver to task over this account of virtue, which she terms “pure evaluational externalism.” They object that, on Driver's account of virtue, it could (...) turn out that traits traditionally understood as pernicious are actually virtuous. While many writers have speculated about the forms new 'virtues' might take in a hypothetical world, I will argue that at least one trait that is seemingly pernicious but would have to be counted as virtuous by Driver already exists. (shrink)

Blanchot’s Thomas the Obscure and Death Sentence are marked by the imperative to hear the call of night, of darkness, and death. In each work, the ear is enlisted to undermine the prominence accorded to the eye. If sight is essential to measure and confirm the space separating subjects from objects or subjects from other subjects, Blanchot introduces hearing as a way to collapse this protective distance. The border between inside and outside becomes porous, and the subject is no longer (...) protected by vision’s capacity to establish a neutral and demonstrable distance between itself and the object of sight. As vision becomes catastrophic, hearing assumes an ascendant role. Thomas and Anne each hear the call of death, as well as cries, laments and sudden sounds that burst through silence. The characters of Death Sentence also hear and respond to a variety of calls, including the call to yield to death and the open grave. In both works, Blanchot provides a literary space in which sounds... (shrink)

Who doesn't wish they hopped out of bed each feeling energized and ready to tackle whatever challenges lie ahead? In Morning Rituals, author Leslie Koren is here to help, with practices that will have readers kicking their day off right! This tidy volume offers dozens of invigorating, empowering exercises for the body and spirit: Set an intention for the day. Drink a glass of lemon water. Write morning pages. Do a set of push-ups, or a series of energizing yoga (...) poses. Pull a tarot card. Take a moment to be still, over a cup of tea or a book of poetry. Whatever rituals speak to you, do them with intention and do them regularly, and you'll find that your morning sets the tone for a brighter, calmer, more productive day. Each prompt includes straightforward instructions as well as ways to personalize and improvise the idea. This beautifully photographed book will make for a thoughtful, loving gift-perfect for Mom, a recent graduate, or someone in need of a pick-me-up, or as a way to treat yourself. (shrink)

Derrida's Glas found one of its most attentive readers in Maurice Blanchot, whose fragmentary volume L'Ecriture du désastre responds in a number of ways to Derrida's book, in particular to its reading of Hegel. This article retraces the silent dialogue between Derrida and Blanchot as it unfolds in the two texts mentioned as well as in several others, including some of Blanchot's earlier essays and fiction, notably La Folie du jour and L'Arrêt de mort.

Chapter INTRODUCTION WHY STUDY INDIAN PHILOSOPHY TODAY ? Indian philosophy in the past has been ingenious and original, a worthy contender with Greek and ...