Bone morphogenetic proteins (BMPs) are typically members of the transforming growth factor β (TGF-β) family with diverse roles in embryonic development. At least five genes with homology to BMPs are expressed during Xenopus development, along with their receptors and intracellular signalling pathways. The evidence suggests that BMPs have roles to play in both mesoderm induction and dorsoventral patterning. Studies in Xenopus have also identified a number of inhibitory binding proteins for the classical BMPs, encoded by genes such as chordin and (...) noggin. These proteins appear to be responsible for establishing a morphogen gradient of BMP4 activity, which specifies different dorsoventral fates in early gastrulae. An emerging theme is that inhibition of BMP signalling is an important mechanism regulating cell fate decisions in early development. BioEssays 21:751–760, 1999. © 1999 John Wiley & Sons, Inc. (shrink)

Answering important public health questions often requires collection of sensitive information about individuals. For example, our understanding of how HIV is transmitted and how to prevent it only came about with people's willingness to share information about their sexual and drug-using behaviors. Given the scientific need for sensitive, personal information, researchers have a corresponding ethical and legal obligation to maintain the confidentiality of data they collect and typically promise in consent forms to restrict access to it and not to publish (...) identifying data.The interests of others, however, can threaten researchers' promises of confidentiality when legal demands are made to access research data. In some cases, the subject of the litigation is tightly connected to the research questions, and litigants' interest in the data is not surprising. Researchers conducting studies on tobacco or occupational or other chemical exposures, for example, are relatively frequent targets of subpoenas. (shrink)

In “Meeting the Moment: Bioethics in the Time of Black Lives Matter,” Camisha Russell calls for transforming “bioethics-as-usual” with help from “outsiders”. Prior scholars agree...

This article provides an ecological theory of face perception that elucidates the basis of the various perceptions. It then reviews research on first impressions elicited by facial qualities that are associated with fitness, emotion, race, age, and sex, in each case making links to ecological theory. It aims to identify facial qualities that inform social perceptions and reflect the zeitgeist at the time in social psychology. The emphasis is on understanding the cognitive mechanisms engaged in social perception, and this is (...) typically accomplished by providing information about social qualities in lists of trait words. The article demonstrates face perception research pertinent to the detection of socially relevant qualities in faces—attractiveness, emotions, race, age, and sex—as well as associated behavioral affordances, which have typically been assessed by trait ratings. (shrink)

Administraation of antiretroviral therapy to women during pregnancy, labor and delivery, and to infants postnatally can dramatidy reduce mother-to- child HIV transmission. However, pregnant women need to know that they are HIV-infected to take advantage of antiretroviral therapy, and many women do not know their HIV status. One-half of HIV-infected infants in the United States were bornto women who had not been tested for HIV or for whom the time of testing was not known. Although fewer than 400infants are infected (...) perinatally in the United States each year, that number could be reduced even further through policies aimed at HIV testing during pregnancy.The reasons toadopt such a policy are strong: the pathophysiology of perinatal transmission is clear, prophylaxis is effective and safe, and the intended beneficiaries of the intervention - babies - cannot protect themselves. (shrink)

This volume is a collection of essays in appreciation, analysis and honor of Paul Ziff, one of the leading American philosophers of the post-World War II period. The essays address questions that loomed large in Ziff's own work. Essays by Zeno Vendler, Jay Rosenberg, and Tom Patton address topics in philosophy of language: understanding, misunderstanding, rules, regularities, and proper names. Michael Resnik examines the nature of numbers, Rita Nolan addresses `mutant predicates', and Peter Alexander discusses microscopes and corpuscles. Douglas C. (...) Long ruminates on Ziff's claim that machines can neither think nor feel. The essays of Dale Jamieson, Bill E. Lawson, Douglas Dempster, and Joseph Ullian address various questions in aesthetics: aesthetic appreciation and morality, expression, the scope of appreciation, and the aesthetics of sport. In the spirit of Ziff, Douglas Stalker criticizes some of the `mush' that looms large in our intellectual lives. The volume begins with a reminiscence by Paul Benacerraf, and ends with selections from an unpublished volume of plays by Paul Ziff. The volume should appeal to anyone whose work has been influenced by Ziff, or is interested in central philosophical problems concerning language, mind, and art. (shrink)

In theory, flawed arguments are not individually sufficient to justify a conclusion, but several may converge to do so. This is an empirical study of how arguers respond to a series of imperfect causal arguments during a serious conversation. People became less critical of the flawed arguments as more of the arguments appeared. The study gives empirical evidence that ordinary arguers permit sufficiency to accumulate during an extended discussion.

This research project substantially extends the reach of serial argument theory from its nearly exclusive application to close relationships, into the workplace. Data were gathered on general motivation to engage in a serial argument, specific goals, several tactics, and three outcome measures. Results indicated causal relations from goals and motivations to tactics, and from tactics to outcomes. A structural equation model was successful in fitting the whole system of variables. Results were generally compatible with those found in relational and classroom (...) settings, and help build the case that serial arguing has certain base characteristics that may not change much when settings are quite substantially different. (shrink)

The new field of quantitative health risk assessment owes its emergence much more to the 'market pull' of demand from societal decision-making processes than to dramatic advances in our ability to make the desired predictions. This paper discusses problems and opportunities in the current practice of quantitative risk estimation under three broad headings: Basic (Technical) Assessment Methodology, and Methods for Assessing Uncertainty; Conception of the Problem for Analysis, and Ways of Expressing Results; and Defining Appropriate Roles for Expert Analysts in (...) Social Decision Processes. Finally, borrowing from work of McMullin, the paper offers some criteria for judging risk assessment theories other than the generally unavailable 'goodness-of-fit' procedures. (shrink)

Leslie Stephen (1832–1904) was a writer, philosopher and literary critic whose work was published widely in the nineteenth century. As a young man Stephen was ordained deacon, but he later became agnostic and much of his work reflects his interest in challenging popular religion. This two-volume work, first published in 1876, is no exception: it focuses on the eighteenth-century deist controversy and its effects, as well as the reactions to what Stephen saw as a revolution in thought. Comprehensive and (...) full of detailed analysis, this is an important work in the history of ideas. Volume 2 focuses on eighteenth-century moral philosophy, political philosophy and literature, and on the literary and religious reactions to the revolution in thought. Utilitarianism is discussed at length, as well as the work of thinkers such as Shaftesbury, Mandeville, Burke and Adam Smith. (shrink)

This brief essay summarizes the content of the current issue of Tradition and Discovery which is devoted to a symposium on similarities between and relevance to each other of the work of Blythe Clinchy, one ofthe authors of Women’s Ways of Knowing, and the work of Michael Polanyi. The background of Women’s Ways of Knowing is sketched for readers without independent familiarity with it.

In a diverse and complex world, the notion of ‘cultural competence’ is offered by some as an ethical solution to health care work which is culturally naïve or inappropriate. Notions of cultural competence, however, may obscure the fact that many clinicians, regardless of background, may feel ill equipped to deal with difference in their daily work. Drawing largely on South African examples, I suggest that issues of cultural incompetence, linked both to personal anxieties and to the ways in which health (...) care systems are structured, may be important to explore — personally, professionally, and politically. Through examining the difficulties of our own work and recognizing these, we may learn more only by learning a set of skills about the ‘other’. (shrink)

It is argued that there can only be a small-finite number of mathematical objects; that these objects range from the very concrete to the very abstract; and that mathematics is essentially not concerned with objects but with concepts. This viewpoint is described as mentalist and is upheld over Platonism, intuitionism, and formalism.

ABSTRACT Bernard Yack’s Longing for Total Revolution asserts that a prominent tradition of modern moral and political theory is founded on the binary opposition between nature and culture. Yack rejects this dichotomy in favor of an Aristotelean outlook, and in so doing embraces the opposition between the ancients and the moderns. Neither binary is as oppositional as Yack suggests. There is, however, a more viable distinction to be made between the ancients and the moderns—concerning the role played by teleology—and it (...) better serves the purpose of mapping the historical trajectory of moral and political theorizing. Teleology does not survive modernity, and it is this development that was truly revolutionary. (shrink)

Mill's discussion of ‘the internal sanction’ in chapter III of Utilitarianism does not do justice to his understanding of internal sanctions; it omits some important points and obscures others. I offer an account of this portion of his moral psychology of motivation which brings out its subtleties and complexities. I show that he recognizes the importance of internal sanctions as sources of motives to develop and perfect our characters, as well as of motives to do our duty, and I examine (...) in some detail the various ways in which these sanctions give rise to motivating desires and aversions. (shrink)

Leslie Stephen, author, literary critic, social commentator and the first editor of the Dictionary of National Biography, published his two-volume History of English Thought in the Eighteenth Century in 1876. This led him to further investigation and study of utilitarianism, whose proponents believed that human action should be guided by the principle of ensuring the happiness of the greatest number of people. While working on many other projects, especially the Dictionary, and haunted by domestic tragedy in the sudden death (...) of his second wife in 1895, Stephen struggled for two decades with this undertaking, calling it the 'utilitarian bog': the long-awaited three-volume work was finally published in 1900. Volume 1 gives the social and political context of the rise of utilitarianism and examines its leading theorist, Jeremy Bentham. (shrink)

The debate on the status and legality of cannabis continues to gain momentum. Here, personal anecdotes combined with academic and scientific reports combine to sharpen some of the fascinating philosophical issues associated with cannabis use. A frank, professionally informed and playful discussion of cannabis usage in relation to philosophical inquiry Considers the meaning of a ‘high’, the morality of smoking marijuana for pleasure, the slippery slope to more dangerous drugs, and the human drive to alter our consciousness Not only incorporates (...) contributions from philosophers, psychologists, sociologists or legal, pharmacological, and medical experts, but also non-academics associated with the cultivation, distribution, and sale of cannabis Brings together an international team of writers from the United States, Canada, UK, Finland, Switzerland, South Africa, and New Zealand. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Ethics & the Environment 12.2 (2007) 125-127MuseSearchJournalsThis JournalContents[Access article in PDF]Whither Environmental Philosophy?Dale JamiesonBy most reasonable standards, environmental philosophy has been an enormous success since its beginnings in the 1970s. Courses in the subject are now taught around the world, there are many opportunities for publishing, there are two dedicated graduate programs, and there are even some jobs in the field.Yet these marks of success mask some problems. (...) Environmental philosophy is fragmented along many dimensions and there are no widely shared standards of competence. The available jobs often go to surprising candidates whose skills and interests are extremely diverse. Too much publication appears in "specialist" journals, unnoticed by anyone but other contributors. Unconstructive debates, often reminiscent in tone, substance, and rancor of the old and new left, linger. In light of all this, I am no longer surprised when I meet people active in environmental studies and causes who claim to be environmental ethicists but who are almost entirely ignorant of the academic field that bears the name.It is well known that the environment suffers because it is not a well-bounded domain (like the economy, for example), but is rather multi-dimensional and implicated in almost every area of human choice and action. This problem is reproduced in environmental philosophy, [End Page 125] which impinges on many fields, disciplines, and areas of inquiry, but is still struggling to find its own boundaries and identity.One of the core challenges for environmental philosophy is to understand its audience and to whom it is responsible. Historically, the field grew out of the discipline of philosophy, but many who consider themselves environmental philosophers are hostile to the discipline as it is currently practiced. They don't read the journals, go to the conferences, or try very hard to integrate their concerns into the discipline as a whole. Another possible home for environmental philosophy is environmental studies which is a self-consciously interdisciplinary field. Trouble is, environmental studies has many of the same problems as environmental philosophy without even a home discipline to secede from or rebel against. It also carries the added burden of delivering a respectable major to large numbers of eager, but often intellectually impatient, undergraduates. Perhaps one day environmental philosophy will be absorbed into an expanded field of bioethics, which increasingly sees itself as concerned not only with medicine, but with health, a concept that many believe applies broadly across the biosphere.Some put their faith in "public philosophy" or the "policy turn." I can hardly object. When pluralism, pragmatism and inherent value were all the rage in environmental philosophy, I was writing about climate change, zoos, and preserving urban landmarks. Yet it must be acknowledged that with the exception of Peter Singer (whom many would not consider an environmental philosopher), those who have touched the public most deeply in recent years have largely been writing about traditional philosophical concerns rather than about applied, practical, or interdisciplinary problems. Some examples: Paul Boghossian's critique of relativism was favorably reviewed in much of the popular press, including The Wall Street Journal. Anthony Appiah's Cosmopolitanism won the Arthur Ross Book Award from the highly influential Council on Foreign Relations. Books on free will and the philosophy of religion are everywhere; Daniel Dennett has almost become a household name. Most strikingly of all is Harry Frankfurt's On Bullshit, originally a critique of deconstruction delivered to a Yale seminar in the 1980s, which beginning in 2005 spent 26 weeks on the New York Times best seller list. It's enough to make you wonder what relevance is and whether it's really relevant.What is to be done? For fear of sounding like a third-rate marriage [End Page 126] counselor, the field needs communication and good will. These are the necessary building blocks for constructing a common sense of identity. The signs are encouraging but equivocal. The June conference in Colorado, now entering its fifth year, has been an important forum for communication, as has the International Society for Environmental Ethics meetings held in conjunction with the divisional meetings of... (shrink)

This rich and varied collection of essays addresses some of the most fundamental human questions through the lenses of philosophy, literature, religion, politics, and theology. Peter Augustine Lawler and Dale McConkey have fashioned an interdisciplinary consideration of such perennial and enduring issues as the relationship between nature and history, nature and grace, reason and revelation, classical philosophy and Christianity, modernity and postmodernity, repentance and self-limitation, and philosophy and politics.

Colorado has consistently had one of the highest rates of suicide in the United States, and El Paso County has the highest number of suicide and firearm-related suicide deaths within the state. Community-based solutions like those of the Suicide Prevention Collaborative of El Paso County may be more effective in preventing suicide as they are specific to local issues, sensitive to local culture, and informed by local data, community members, and stakeholders.