Ferroptosis, a form of regulated cell death triggered by lipid hydroperoxide accumulation, has an important role in a variety of diseases and pathological conditions, such as cancer. Targeting ferroptosis is emerging as a promising means of therapeutic intervention in cancer treatment. Polyunsaturated fatty acids, reactive oxygen species, and labile iron constitute the major underlying triggers for ferroptosis. Other regulators of ferroptosis have also been discovered recently, among them the mechanistic target of rapamycin complex 1 (mTORC1), a central controller of cell (...) growth and metabolism. Inhibitors of mTORC1 have been used in treating diverse diseases, including cancer. In this review, we discuss recent findings linking mTORC1 to ferroptosis, dissect mechanisms underlying the establishment of mTORC1 as a key ferroptosis modulator, and highlight the potential of co‐targeting mTORC1 and ferroptosis in cancer treatment. This review will provide valuable insights for future investigations of ferroptosis and mTORC1 in fundamental biology and cancer therapy. (shrink)

The article explores Chinese rural migrants’ perspective on work and their relations with each other and with the Chinese state by drawing upon the ethnographical study of a group of rural home renovators in Beijing in the 1990s. The rural renovators were dubbed “guerrilla” workers because of their physical mobility, irregular employment, and unregistered status. After considering the novelty of guerrilla workfare in China, the article demonstrates the bifurcation of migrants’ social networks along the lines of work and everyday association, (...) locates the politics of worker-state interaction at the place of their everyday living, and explores their understanding of work that is remarkably devoid of nostalgia for state socialism. (shrink)

Post-stroke depression is a serious complication of stroke that significantly restricts rehabilitation. The use of immersive virtual reality for stroke survivors is promising. Herein, we investigated the effects of a novel immersive virtual reality training system on PSD and explored induced effective connectivity alterations in emotional networks using multivariate Granger causality analysis. Forty-four patients with PSD were equally allocated into an immersive-virtual reality group and a control group. In addition to their usual rehabilitation treatments, the participants in the immersive-virtual reality (...) group participated in an immersive-virtual reality rehabilitation program, while the patients in the control group received 2D virtual reality rehabilitation training. The Hamilton Depression Rating Scale, modified Barthel Index, and resting-state functional magnetic resonance imaging data were collected before and after a 4-week intervention. rsfMRI data were analyzed using multivariate GCA. We found that the immersive virtual reality training was more effective in improving depression in patients with PSD but had no statistically significant improvement in MBI scores compared to the control group. The GCA showed that the following causal connectivities were strengthened after immersive virtual reality training: from the amygdala, insula, middle temporal gyrus, and caudate nucleus to the dorsolateral prefrontal cortex; from the insula to the medial prefrontal cortex; and from the thalamus to the posterior superior temporal sulcus. These causal connectivities were weakened after treatment in the control group. Our results indicated the neurotherapeutic use of immersive virtual reality rehabilitation as an effective non-pharmacological intervention for PSD; the alteration of causal connectivity in emotional networks might constitute the neural mechanisms underlying immersive-virtual reality rehabilitation in PSD. (shrink)

近年來關於賽伯格與後人類主義的論述在西方世界方興未艾，論者紛紛從科學、醫學、宗教、哲學、倫理學、社會學、文學與文化研究等各個不同面向思考人們正在經歷的後人類世界。但對一般中文讀者而言，這兩個新詞彙所指 涉的意義仍相當模糊。本書收錄了國內外關於賽伯格與後人類主義的重要論文，嘗試探討人與科技、身體與環境、精神與物質兩者界線逐漸消弭的後人類社會裡的危機與轉機。本書討論之內容相當廣泛，除了探討大眾文化所透露 出的哲學內涵，也從生態文學談到科幻小說，本身即為一部賽伯格文本，不但充斥著許多有意思的矛盾或裂縫，也跨越了各個不同的學門界線，多元豐富的內容相信能夠給予中文讀者提供一個從文學、文化研究角度思索賽伯格與 後人類的獨特視野。.

We give a general proof showing that if the evolution from one state to another is not reversible, then the projective measurements on the superposition of these two states are impossible. Applying this no-go result to the Schrödinger’s cat paradox implies that if something is claimed to be a real Schrödinger’s cat, there will be no measurable difference between it and a trivial classical mixture of ordinary cats in any physically implementable process, unless raising the dead becomes reality. Other similar (...) macroscopic quantum superpositions cannot be observed either, due to the lack of non-commuting measurement bases. Our proof does not involve any quantum interpretation theory and hypothesis. (shrink)

Recently, Frauchiger and Renner proposed a Gedankenexperiment, which was claimed to be able to prove that quantum theory cannot consistently describe the use of itself. Here we show that the conclusions of Frauchiger and Renner actually came from their incorrect description of some quantum states. With the correct description there will be no inconsistent results, no matter which quantum interpretation theory is used. Especially, the Copenhagen interpretation can satisfy all the three assumptions,, and of Frauchiger and Renner simultaneously, thus it (...) has no problem consistently describing the use of itself. (shrink)

Solid-state processing of metal material is a very complex physical and chemical process, which is coupled by a series of variations including heat transfer, momentum transfer, mass transfer, and phase change. Applying three-dimensional finite element numerical method to the simulation of solid-state processing can perform analysis of metal material’s forging processes before production trial production, can obtain their relevant information such as material flow law, temperature field, and strain field under the minimum physical test conditions, thereby predicting metal material’s forming (...) defects and improving their forging quality. On the basis of summarizing and analyzing previous research works, this paper expounded the current status and significance of solid-state processing of metal materials, elaborated the development background, current status, and future challenges of 3D finite element numerical simulation, introduced the discrimination method and free surface solution method of numerical simulation calculation, conducted finite element model’s geometric assumptions, material selection, element division, model establishment, parameter selection, and initial and boundary condition determination, and simulated and analyzed rheological casting, remelting heating, thixoforming, and rotary piercing processes of metal materials. The results show that the 3D finite element numerical method can not only simulate various processes of flow field, temperature field, stress field, and microstructure in solid-state processing but also can provide a reliable basis for effectively obtaining a reasonable description and finding a more optimized design plan for metal material processing in a short time, which plays an important role in understanding and analyzing solid metal forming process, controlling and optimizing process parameters, guiding and mastering rheological casting, and secondary heating and rotary piercing of metal materials. (shrink)

本书从生态文艺的基本观念到历史扫描,进而比较宏观地把握中国美学中的生态思想及中国古代艺术中生态性体验的特点,并由此通过对中国古代美学与艺术的生态特点的认识,通过对其理论及审美转换性的把握而引申至现代, 着力挖掘其现代意义及价值。.

The vital role of reward in guiding visual attention has been supported by previous literatures. Here, we examined the motivational impact of monetary reward feedback stimuli on visual attention selection using an event-related potential component called stimulus-preceding negativity and a standard contextual cueing paradigm. It has been proposed that SPN reflects affective and motivational processing. We focused on whether incidentally learned context knowledge could be affected by reward. Both behavior and brain data demonstrated that contexts followed by reward feedback not (...) only gave rise to faster implicit learning but also obtained a larger CC effect. (shrink)

Point-of-interest recommendations are a popular form of personalized service in which users share their POI location and related content with their contacts in location-based social networks. The similarity and relatedness between users of the same POI type are frequently used for trajectory retrieval, but most of the existing works rely on the explicit characteristics from all users’ check-in records without considering individual activities. We propose a POI recommendation method that attempts to optimally recommend POI types to serve multiple users. The (...) proposed method aims to predict destination POIs of a user and search for similar users of the same regions of interest, thus optimizing the user acceptance rate for each recommendation. The proposed method also employs the variable-order Markov model to determine the distribution of a user’s POIs based on his or her travel histories in LBSNs. To further enhance the user’s experience, we also apply linear discriminant analysis to cluster the topics related to “Travel” and connect to users with social links or similar interests. The probability of POIs based on users’ historical trip data and interests in the same topics can be calculated. The system then provides a list of the recommended destination POIs ranked by their probabilities. We demonstrate that our work outperforms collaborative-filtering-based and other methods using two real-world datasets from New York City. Experimental results show that the proposed method is better than other models in terms of both accuracy and recall. The proposed POI recommendation algorithms can be deployed in certain online transportation systems and can serve over 100,000 users. (shrink)

Objectives: This study aimed to provide a comprehensive understanding of all intervention for learning burnout by meta-analyzing their effects.Methods: Relevant studies that had been published up to September 18, 2020, were identified through a systematic search of the PubMed, Web of Science, the China National Knowledge Infrastructure, and Wan Fang databases. Eligible studies included randomized control trials of any learning burnout intervention conducted among students. The Jadad scale was used to evaluate the quality of the study. Random-effect meta-analyses, subgroup analyses, (...) meta-regression analysis, and sensitivity analysis were conducted. Funnel plots and Egger's tests were used to evaluate publication bias. Duval and Tweedie's non-parametric trim-and-fill method was used to adjust the effect of publication bias.Results: Of the 5,245 articles found, 39 met the inclusion criteria for the systematic review. There were 3,400 students, including 1,847 students in the intervention group and 1,553 in the control group. A meta-analysis of 44 studies showed that the interventions were effective. Subgroup analyses were conducted according to education, scales, intervention measures, and intervention time. The results showed that, compared with the control group, the learning burnout scores of undergraduates, secondary vocational students, and middle school students were significantly lower. Based on different scales, all interventions were also effective. The funnel plot was asymmetric and consistent with the results of Egger's test. The trim-and-fill method was used, and seven missing studies were merged to obtain a symmetric funnel plot.Conclusions: This meta-analysis indicated that learning burnout interventions are effective. The subgroup analyses showed that group counseling is the most widely used, exercise intervention is probably the most effective, and 8 weeks or more is the appropriate intervention time. An integrated intervention study based on the factors of learning burnout adds value. More studies are needed to supplement the results in the future. (shrink)

本书包括:系统自然观、演进自然观、生态自然观、科学技术观、历史科学技术观、社会科学技术观等.

The aim of this study is to develop an integrative model linking the effect of authoritarian leadership and differential leadership on employee turnover intention, and further explore the moderating role of the in-group/out-group on the above-mentioned relationships. We collected a sample of 624 supervisor–subordinate dyads from 87 teams in Mainland China and Taiwan. We find that, at the individual level, authoritarian leadership is positively related with employee turnover intention, and the relationship will be enhanced especially when the subordinate is an (...) in-group member. Through hierarchical linear modeling analysis, we find a negative relationship between differential leadership and employee turnover intention, significantly moderated by the within-team mean degree and the within-team variance degree of in-group/out-group. Contributions, limitations, and future research directions are discussed. (shrink)

The Chinese traditional culture includes three systems of thought: Confucianism, Daoism and Buddhism. The first two are Chinese culture, and Buddhism is a foreign religion introduced from India. Although there had been conflicts among the three systems of thoughts, but integration is the mainstream in the development of Chinese cultural thought. Thus, Chinese culture has developed into a system by uniting the three religions into one with Confucianism at the centre supported by Daoism and Buddhism. For over 2,000 years, Buddhism (...) has interacted with all levels of Chinese culture such as literature, philosophy, morality, arts, architecture and religions. As a result, Buddhism has successfully integrated into the traditional Chinese culture and has become one of the three pillars. In this paper, I will discuss the Buddhist impact on Chinese culture from the following four points: (1) philosophy and moral teaching; (2) religions and popular beliefs; (3) language and literature; and (4) art and architecture. (shrink)

As an important branch of applied anthropology, business anthropology has developed well in China in the recent past. This has attracted the attention of not only the academic society but also of industrial and commercial circles. This article illustrates the emergence and the development of business anthropology in China, and affirms the work of Chinese pioneers in this branch of cultural anthropology. It elaborates on what contemporary management and anthropological scholars have contributed to promote business anthropology in that country. Moreover, (...) it expounds, from various perspectives, on the role that business anthropology can play for/in China. China is a large country developing at an astonishing speed. Chinese society is transforming from a traditional agricultural and pre-industrial phase into a post-industrial and commercial phase. Therefore, the development of business anthropology in China is promising. (shrink)

本书共分为黄宗羲的生平与著作、黄宗羲的思想与学术、黄宗羲与清代浙东经史学派3篇,主要内容包括从复社名士到抗清御史、以讲学著述为经世之务、振聋发聩的民主启蒙政治思想等.

Volume 46, Issue 6, November 2020, Page 708-726.