Previous studies have demonstrated that orientation-specific deprivation in early life can lead to neural deficits of spatial vision in certain space, and can even result in meridional amblyopia. Individuals with astigmatism are the optimal and natural models for exploring this asymmetric development of spatial vision in the human visual system. This study aims to assess the contrast sensitivity function and EEG signals along two principal meridians in participants with regular astigmatism when being optimal optical corrected. Twelve participants with astigmatism and (...) thirteen participants with were recruited in the current study. CSFs and spatial sweep visual evoked potentials were measured with vertical and horizontal sinewave gratings along two principal meridians monocularly. Area under log CSF, spatial frequency threshold corresponding to 80% contrast gratings, and CSF acuity were calculated from CSF test. In addition, sVEP amplitudes and thresholds were calculated with the recursive least square method. Participants with astigmatism exhibited marked vertical-horizontal resolution disparities even after they were corrected with optimal optical corrections. CSF tests showed that AULCSF along weak meridian was lower than that along strong meridian in both groups. Significant meridional disparity of CSF acuity was also found in both groups. In addition, the MA group showed larger meridional disparity compared to the AST group. Spatial sVEP thresholds also supported the existence of marked meridional disparity. Our results suggest that meridian-specific partial deprivation in early life might lead to monocularly asymmetric development of spatial vision in the human visual system. In terms of application, we tested the feasibility and reliability of adopting psychophysical and EEG scalings to investigate the asymmetric development of spatial vision related to astigmatism. These paradigms are potentially applicable to reduce and even eliminate the meridional disparity in the primary visual cortex by adopting perceptual learning or other vision-related interventions. (shrink)

Meiotic defects cause abnormal chromosome segregation leading to aneuploidy in mammalian oocytes. Chromosome segregation is particularly error‐prone in human oocytes, but the mechanisms behind such errors remain unclear. To explain the frequent chromosome segregation errors, recent investigations have identified multiple meiotic defects and explained how these defects occur in female meiosis. In particular, we review the causes of cohesin exhaustion, leaky spindle assembly checkpoint (SAC), inherently unstable meiotic spindle, fragmented kinetochores or centromeres, abnormal aurora kinases (AURK), and clinical genetic variants (...) in human oocytes. We mainly focus on meiotic defects in human oocytes, but also refer to the potential defects of female meiosis in mouse models. (shrink)

BackgroundMental stress and imbalance of its two neural stress systems, the autonomic nervous system and the hypothalamic–pituitary–adrenal axis, are associated with chronic prostatitis/chronic pelvic pain syndrome and erectile dysfunction. However, the comprehensive analyses of psychological stress and stress systems are under-investigated, particularly in CP/CPPS patients complicated by lower urinary tract symptoms and ED.Materials and methodsParticipants were 95 patients in CP/CPPS+ED group, 290 patients in CP/CPPS group, 124 patients in ED group and 52 healthy men in control group. The National Institutes (...) of Health Chronic Prostatitis Symptom Index, the International Index of Erectile Function-5 and the International Prostate Symptom Score were used for assessing the disease severity of CP/CPPS, LUTS and ED. Psychometric self-report questionnaires including the Beck Anxiety Inventory, Perceived Stress Scale, Type A Personality Test and Symptom Checklist 90 were completed for distress from physical symptoms. Twenty-five subjects per group were randomly selected for further investigating the changes of the HPA axis and ANS. Saliva samples were taken on 3 consecutive days at 8 specific times with strict reference to time of morning awakening for evaluation of free cortisol. Heart rate variability as marker of the ANS was measured using 24 h electrocardiography, and time-and frequency-domain variables were analyzed.ResultsThe BAI and SCL-90 scores were significantly higher in the CP/CPPS+ED, CP/CPPS and ED groups compared with the control group. The PSS scores of both groups with ED were significantly higher than the control group. Compared with the CP/CPPS group, the differences of PSS, SCL-90 and TAPT scores were statistically significant in CP/CPPS+ED patients. The IPSS scores were shown to have significantly positive correlations with BAI, PSS and SCL-90 in the CP/CPPS patients. However, in all subjects, the IIEF-5 scores were shown to have significantly negative correlations with BAI, PSS, SCL-90 and quality of life score in NIH-CPSI. Cortisol awakening response parameters and diurnal cortisol levels did not significantly vary between the four groups. Time-dependent parameters of HRV also did not differ significantly across groups. In the frequency domain analysis, low frequency was significantly lower in ED patients when compared with CP/CPPS+ED patients and healthy controls, high frequency power was significantly higher in healthy controls compared to patients with ED, CP/CPPS and CP/CPPS+ED, and the CP/CPPS+ED group had significantly higher LF/HF ratio than the control group.ConclusionCP/CPPS and ED patients score exceedingly high on most psychosocial variables. The symptom scores of LUTS and ED positively correlate with the severity of psychological stress. Our findings also suggest that the ANS sympathovagal imbalance is associated with ED and LUTS in CP/CPPS, whereas HPA axis activity is not. (shrink)

本书从神秘主义的视角,对于古代哲学的变迁提出了新的认识,对其中若干命题作了新的解释,对于古代哲学与礼法进行了初步的讨论.内容包括:早期儒家与神秘主义;《内业》与《大学》;《五行》与神秘主义等.

ObjectiveThe impact of the mindfulness-based stress reduction program on psychological outcomes and quality of life in lung cancer patients remains unclear. This meta-analysis aimed to evaluate the effectiveness of the MBSR program on psychological states and QoL in lung cancer patients.MethodsEligible studies published before November 2021 were systematically searched from PubMed, EMBASE, Cochrane Library, PsycINFO, China National Knowledge Infrastructure, and Wanfang databases. The risk of bias in eligible studies was assessed using the Cochrane tool. Psychological variables and QoL were evaluated (...) as outcomes. We used the Grading of Recommendations Assessment, Development and Evaluation system to grade the levels of evidence. Statistical analysis was conducted using RevMan 5.4 and STATA 14.0.ResultsA total of 17 studies involving 1,680 patients were included for meta-analysis eventually. MBSR program significantly relieved cancer-related fatigue and negative psychological states, enhanced positive psychological states, and improved quality of sleep. Evidence on MBSR programs' overall treatment effect for QoL revealed a trend toward statistical significance.ConclusionBased on our findings, the MBSR program shows positive effects on psychological states in lung cancer patients. This approach should be recommended as a part of the rehabilitation program for lung cancer patients.Systematic Review Registrationhttps://archive.org/details/osf-registrations-mwvbq-v1, identifier: 10.17605/OSF.IO/MWVBQ. (shrink)

Tian dao guan shi Zhongguo zhe xue de zhong yao gai nian, ye shi ru jiao de yi ge zhong yao wen ti, ji, shen me shi tian dao? Qi jin wei zhi, ji hu suo you de Zhongguo zhe xue zhu zuo, dou ren wei tian dao jiu shi zi ran gui lü. Ben shu jiang tong guo wen xian zi liao xiang dang dai de du zhe shuo ming, Zhongguo gu dai de tian dao, jiu shi tian zhi (...) dao, shang tian zhi dao. (shrink)

di 1 juan. Shi lun juan -- di 2 juan. Fan chou juan -- di 3 juan. Men lei juan.

Riben Jiuzhou da xue tu shu guan cang you gu xie Huizhou ben "Zhuzi yu lei" yi bai si shi juan. Huizhou ben shang cheng "Chi lu", xia qi li bian, zai yu lu dao yu lei de xing cheng guo cheng zhong chu yu guan jian de di wei, dui xue jie yan jiu zhu xi si xiang de xing cheng guo cheng, Zhu Xi men ren de qing kuang, jin ben "Zhuzi yu lei" de xing cheng guo cheng (...) yi ji zhong gu shi qi gu Han yu bai hua, ti gong le xin de cai liao he xin de shi ye. (shrink)

Ben shu fen shang xia liang ge bu fen,Shang bian shi zhu zi yu lei wen xian yan jiu,Xia bian shi zhu zi yu lei ci hui yan jiu.Quan shu yi gong fen wei 9 zhang.Di yi zhang xu lun,Shou xian jie shao le zhu xi yu zhu zi yu lei,Qi ci jin xing le xue shu hui gu,Zong jie le jin 20 nian lai(jie zhi 2009 nian)Guo nei wai zhu zi yu lei yan jiu de sheng kuang he qu (...) de de zhu yao cheng jiu,Zui hou ti chu ben shu de yan jiu fang fa he yi yi.Di er zhang yan jiu tong xing ben zhu zi yu lei ji cheng shu zhi qian de ji ge zhong yao ban ben.Di san zhang wei zhong hua ben zhu zi yu lei yu song ke ben hui an xian sheng zhu wen gong yu lu de yi wen bi jiao.Di si zhang wei zhong hua ben zhu zi yu lei yu chao xian gu xie ben zhu zi yu lei yi wen bi jiao.Di wu zhang yan jiu zhu zi yu lei de wen xian xue jia zhi.Di liu zhang he di qi zhang ji zhong yan jiu zhu zi yu lei de fu yin ci.Di ba zhang tao lun zhu zi yu lei zhong de duo yin jie ci yu.Di jiu zhang zong jie chan shu zhu zi yu lei de yu ti te zheng,Yu yan te dian he yan jiu jia zhi. (shrink)

Ben shu nei rong bao kuo: ren lei wei he ru ci duo shi; dong fang gu dian de Afanda Wutuobang; sheng ren jiu jing wei shui xiao lao; zhi li de xian du yu xu wei you guo lun; deng gao si wang, man mu zhu ji hai shi man mu la ji; nan yi yong yu yan wen zi biao da yu chuan shou de da dao deng.

Social semiotics is now widely regarded as one of the leading research areas. This study is the first attempt to present a holistic overview of social semiotics based on the data in the Web of Science core collection database from 2001 to 2020. The study investigates, among other issues, social semiotics’ publishing tendency, the most productive authors, countries, institutions, and hotspots. The results exhibit a steady rise in its publications and citations. The current analysis verifies the growing quantitative and qualitative (...) research contributions and influences of this field. Furthermore, what the journals focus on are the innovative and contemporary themes, manifested predominantly in sign, multimodality, gender, experimental semiotics, advertising, culture, and social media, which involve a wide range of methodologies to make the research more acceptable and constructive. These results are expected to offer refreshing insights that inspire scholars in formulating scientific agendas and advising their research strategies, thereby facilitating substantial contributions to the domain. (shrink)

This study explores the dark side of leadership, treats creative self-efficacy as a mediator, and frames supervisor bullying and employee creativity in the context of social cognition and social comparison. We theorize that with a high social comparison orientation, the combination of high supervisory abuse toward themselves (own abusive supervision) and low supervisory abuse toward other team members (peer abusive supervision) leads to a double whammy effect: When employees are “singled out” for abuse, these victims suffer from not only low (...) creative self-efficacy due to supervisory abuse but also low supervisory creativity ratings. Results based on our two-wave data collected from multiple sources—253 employees and their 77 immediate supervisors—support our theory. The significant three-way interaction effect reveals that when social comparison orientation is high and peer abusive supervision is low (Time 1), own abusive supervision (Time 1) creates the strongest negative impact on creative self-efficacy (Time 2), which is significantly related to supervisory low creativity rating (Time 2). Our discoveries of egregious bullying offer provocative theoretical, empirical, and practical implications to the fields of leadership, abusive supervision, creativity, and business ethics. (shrink)

Seit der Antike wird der Musik eine große emotionale Wirkung zugeschrieben. Bis heute sind unterschiedliche Erklärungsmodelle diskutiert worden. Das betrifft zunächst das Phänomen der Gefühle im Allgemeinen, aber auch die Frage nach der Ursache der ästhetischen Empfindungen im Besonderen. Die Gefühlslehre von Carl Stumpf versucht u. a. in seiner Auseinandersetzung mit William James (James-Lange-Theorie, die vornehmlich auf die somatische Genese der Emotionen insistiert) Erklärungsansätze zu entwickeln, die sowohl kognitive als auch emotional-wertende psychische Funktionen berücksichtigen. Dennoch ist in Bezug auf das (...) nur scheinbar triviale Verhältnis von Hören und Fühlen, Musik und Emotionalität unter stringent wissenschaftlichen Kriterien erst ein Anfang gemacht worden, weil die Thematik - wie der Band zeigt - von einer bislang unterschätzten Komplexität zeugt, die zukünftig wohl nur mit vereinten interdisziplinären Kräften einem besseren Verständnis näherzubringen sein wird. (shrink)

German Description: Wo bleibt die Aufklarung in Zeiten postmoderner Weite und fundamentalistischer Willkur? Die Autorinnen und Autoren widmen sich dem Thema aus drei Perspektiven: Zum einen untersuchen sie, was Aufklarung wissenschaftstheoretisch bedeuten kann. Zweitens ermitteln sie die Potenziale, die in der Beschaftigung mit der Epoche Aufklarung stecken. Schliesslich analysieren die Beitrage aufklarerische Diskurse. So setzen sich die Texte in der Festschrift fur Thomas Stamm-Kuhlmann mit dem aufklarerischen Impetus mittelalterlicher Karten, Hayden Whites oder Michel Foucaults auseinander; sie bieten einen Einblick in (...) die Paradoxien der danischen oder amerikanischen Aufklarung; und sie verweisen auf die aufklarerischen Wurzeln der europaischen Idee, von Volkssouveranitat, Rechtsstaat und Gewaltenteilung, der hygienischen Volkserziehung in der DDR oder der Auseinandersetzung mit Geschichtsrevisionismus und Postmoderne. English Description: Where does the Enlightenment remain in times of postmodern emptiness and fundamentalist caprice? The authors consider this theme from three perspectives: first, they examine what the Enlightenment can mean epistemologically. Second, they look into the potential which arises from an engagement with the Age of Enlightenment. Finally, they analyze the scholarly contributions to the Enlightenment discourse. Thus the texts in the Festschrift for Thomas Stamm-Kuhlmann deal with the Enlightenment impulse of medieval maps between Hayden White and Michel Foucau. (shrink)

Wie kommt es, dass sich Menschen an normative Ordnungen halten, und aus welchen Normen bestehen diese? Die Frage nach deren bindender Kraft beleuchten die philosophischen Beiträge dieses Bandes. Ergänzend wird aus historischer Sicht untersucht, wie sich unterschiedliche Rechtfertigungsweisen von Ordnungen entwickelt haben. Der Konstruktion neuer internationaler Rechtsordnungen gehen die rechtswissenschaftlichen Beiträge nach. Aus politikwissenschaftlicher Perspektive wird schließlich gezeigt, auf welchen Prinzipien die institutionelle Gestaltung unserer politischen Welt beruht beziehungsweise beruhen sollte.

This study investigated the neuropsychological profile of college students who engage in binge drinking using comprehensive neuropsychological tests evaluating verbal/non-verbal memory, executive functions, and attention. Groups were determined based on scores on the Korean version of the Alcohol Use Disorder Identification Test and Alcohol Use Questionnaire. There were 79 and 81 participants in the BD and non-BD groups, respectively. We administered the Korean version of the California Verbal Learning Test and Rey-Osterrieth Complex Figure Test to evaluate verbal and non-verbal memory, (...) respectively, and measured executive functions using the Wisconsin Card Sorting Test, Trail-Making Test, Controlled Oral Word Association Test and Stroop Color-Word Test. We administered the d2 test to evaluate attention. Neuropsychological performance was analyzed by multivariate analysis of variance. The BD group showed significantly poorer performance in the long-term free recall condition of the K-CVLT and delayed recall condition of the RCFT and completed significantly fewer categories on the WCST than the non-BD group. In addition, there were significant negative associations among the AUDIT-K total score, AUQ binge score, and long-term free recall score of the K-CVLT. There were significant negative associations between the total AUDIT-K score and delayed recall RCFT score, and between the total AUDIT-K total score and numbers of completed categories on the WCST. These results indicate that college students who participate in BD have difficulties with verbal/non-verbal memory and executive functions, and further suggest that excessive alcohol use could have detrimental effects on the hippocampal-prefrontal circuit even with a relatively short period of alcohol use. (shrink)

Fingerprint recognition is the most widely used identification method at present. However, it still falls short in terms of cross-platform and algorithmic complexity, which exerts a certain effect on the migration of fingerprint data and the development of the system. The conventional image recognition methods require offline standard databases constructed in advance for image access efficiency. The database can provide a pre-processed image via a specific method that probably is compatible merely with the specific recognition algorithm. Then, the specific recognition (...) algorithm starts the process of retrieving these specific pre-proessing images for recognition and inevitably will be blocked from other datasets. The proposed method in this research designed an embedded image processing algorithm based on a Siamese neural network in the recognition method that allows the proposed method to recognize images from any source without constructing a database for image storage in advance. In this research, the proposed method was applied to fingerprint recognition and evaluation of the proposed method was evaluated. The results showed that the accuracy of the proposed algorithm was up to 92%, and its F1 score was up to 0.87. Compared with the conventional fingerprint matching methods, its significant advantage in the FRR, FAR, and CR jointly indicated the remarkable correct recognition rate of the proposed method. (shrink)

Ben shu yi dong zhong shu zi ran guan wei shi jiao,Chan shu le dong zhong shu de"tian ren gan ying"lun,"wu lei lei bi"he"xun ming de li"de fang fa lun,Yi tian wei yuan ben de yu zhou lun,"bian er you chang"de bian zheng tian dao guan,Yi ji dong zhong shu you guan yuan qi,Yin yang,Wu xing de zi ran ke xue si xiang,Zai zong ti shang ken ding le dong zhong shu zai jie shi he ren shi zi ran gui (...) lü shang de jin bu xing,Ken ding le dong zhong shu dui zhong guo gu dai zi ran ke xue de gong xian,Bing pi ping le yi wang dui dong zhong shu bu gong zheng di ping pan.Ben shu tong shi ye zhi chu le dong zhong shu de mou xie si xiang dui hou shi de fu mian ying xiang. (shrink)

The moral theology of Hans G. Ulrich is presented here in English for the first time. These collected essays represent the culmination of a lifetime of reflection on Christian living from this German theologian in conversation with Luther, Bonhoeffer, and contemporary philosophers and theologians. Ulrich's ethics affirms the lively presence of the living work of God in orienting the daily life of Christians. This presence enables members of the Church to live as creatures trusting in God's promises, bearing witness in (...) political and economic spheres, and trusting in life as a gift in response to bioethical issues. Ulrich's fresh take on living out of the promise of God yields further guidance on issues in international relations, economics, parenting, disability, and more. (shrink)

Machiavellianism is a double-edged sword in leadership. While Machiavellian leaders can be successful, they also can be amoral, influencing their followers to exhibit unethical, counterproductive, and corrupt behaviors. The extant research surrounding Machiavellian leadership has focused narrowly on how followers tacitly endorse such leader behaviors rather than standing up to the leader through whistleblowing. Drawing upon affective events theory (AET), this research examines the relationship between a leader’s Machiavellian traits, followers’ moral anger and empathic concern, and the likelihood of whistleblowing. (...) We conducted three complementary studies that examine our model. First, in a time-lagged, leader–follower field study, we examined the indirect relationship between Machiavellian leadership and whistleblowing through follower moral anger. Then, we adopted the causal chain design and conducted two independent recall experiments using the critical incident technique to establish the moderating role of follower empathetic concern on the causal relationship between Machiavellian leadership and moral anger, and the causal relationship between moral anger and whistleblowing. This research contributes to the literature by highlighting the emotional dynamics that explain a constructive follower response to leader Machiavellianism. (shrink)

Der Alltag der Medizin sowie gesundheitspolitische Losungsstrategien legen nahe, dass unser Gesundheitssystem massgeblich vom biomedizinisch-technischen Fortschritt und der Finanzierbarkeit gepragt ist. In diesem Band kommen Mediziner, Juristen und Gesundheitswissenschaftler zu Wort, die der Uberzeugung sind, dass die entscheidenden Fragen zur Zukunft unseres Gesundheitssystems ethischer Natur sind. Sei es auf der Systemebene der Gesundheitspolitik, der Ebene der Versorgung, sei es in Interaktionszusammenhangen oder seien es rechtliche Gratwanderungen beim Umgang mit Fehlern oder der Patientenverfugung - es geht um die Fragen: Was kann, (...) darf, soll die Medizin, welche Menschenbilder und Visionen des Zusammenlebens liegen ihr zugrunde? Wie viel Zeit bleibt, daruber nachzudenken, Optionen zu entwerfen? - Neben fuhrenden Fachvertretern kommen Patienten und Angehorige zu Wort. Ihre Erfahrungen fliessen ein in ein mosaikartiges Gesamtbild, das uns hilft, die Medizin der Zukunft im Sinne einer Kontextsteuerung mitzugestalten. (shrink)