Previous studies have demonstrated that orientation-specific deprivation in early life can lead to neural deficits of spatial vision in certain space, and can even result in meridional amblyopia. Individuals with astigmatism are the optimal and natural models for exploring this asymmetric development of spatial vision in the human visual system. This study aims to assess the contrast sensitivity function and EEG signals along two principal meridians in participants with regular astigmatism when being optimal optical corrected. Twelve participants with astigmatism and (...) thirteen participants with were recruited in the current study. CSFs and spatial sweep visual evoked potentials were measured with vertical and horizontal sinewave gratings along two principal meridians monocularly. Area under log CSF, spatial frequency threshold corresponding to 80% contrast gratings, and CSF acuity were calculated from CSF test. In addition, sVEP amplitudes and thresholds were calculated with the recursive least square method. Participants with astigmatism exhibited marked vertical-horizontal resolution disparities even after they were corrected with optimal optical corrections. CSF tests showed that AULCSF along weak meridian was lower than that along strong meridian in both groups. Significant meridional disparity of CSF acuity was also found in both groups. In addition, the MA group showed larger meridional disparity compared to the AST group. Spatial sVEP thresholds also supported the existence of marked meridional disparity. Our results suggest that meridian-specific partial deprivation in early life might lead to monocularly asymmetric development of spatial vision in the human visual system. In terms of application, we tested the feasibility and reliability of adopting psychophysical and EEG scalings to investigate the asymmetric development of spatial vision related to astigmatism. These paradigms are potentially applicable to reduce and even eliminate the meridional disparity in the primary visual cortex by adopting perceptual learning or other vision-related interventions. (shrink)

BackgroundMental stress and imbalance of its two neural stress systems, the autonomic nervous system and the hypothalamic–pituitary–adrenal axis, are associated with chronic prostatitis/chronic pelvic pain syndrome and erectile dysfunction. However, the comprehensive analyses of psychological stress and stress systems are under-investigated, particularly in CP/CPPS patients complicated by lower urinary tract symptoms and ED.Materials and methodsParticipants were 95 patients in CP/CPPS+ED group, 290 patients in CP/CPPS group, 124 patients in ED group and 52 healthy men in control group. The National Institutes (...) of Health Chronic Prostatitis Symptom Index, the International Index of Erectile Function-5 and the International Prostate Symptom Score were used for assessing the disease severity of CP/CPPS, LUTS and ED. Psychometric self-report questionnaires including the Beck Anxiety Inventory, Perceived Stress Scale, Type A Personality Test and Symptom Checklist 90 were completed for distress from physical symptoms. Twenty-five subjects per group were randomly selected for further investigating the changes of the HPA axis and ANS. Saliva samples were taken on 3 consecutive days at 8 specific times with strict reference to time of morning awakening for evaluation of free cortisol. Heart rate variability as marker of the ANS was measured using 24 h electrocardiography, and time-and frequency-domain variables were analyzed.ResultsThe BAI and SCL-90 scores were significantly higher in the CP/CPPS+ED, CP/CPPS and ED groups compared with the control group. The PSS scores of both groups with ED were significantly higher than the control group. Compared with the CP/CPPS group, the differences of PSS, SCL-90 and TAPT scores were statistically significant in CP/CPPS+ED patients. The IPSS scores were shown to have significantly positive correlations with BAI, PSS and SCL-90 in the CP/CPPS patients. However, in all subjects, the IIEF-5 scores were shown to have significantly negative correlations with BAI, PSS, SCL-90 and quality of life score in NIH-CPSI. Cortisol awakening response parameters and diurnal cortisol levels did not significantly vary between the four groups. Time-dependent parameters of HRV also did not differ significantly across groups. In the frequency domain analysis, low frequency was significantly lower in ED patients when compared with CP/CPPS+ED patients and healthy controls, high frequency power was significantly higher in healthy controls compared to patients with ED, CP/CPPS and CP/CPPS+ED, and the CP/CPPS+ED group had significantly higher LF/HF ratio than the control group.ConclusionCP/CPPS and ED patients score exceedingly high on most psychosocial variables. The symptom scores of LUTS and ED positively correlate with the severity of psychological stress. Our findings also suggest that the ANS sympathovagal imbalance is associated with ED and LUTS in CP/CPPS, whereas HPA axis activity is not. (shrink)

Meiotic defects cause abnormal chromosome segregation leading to aneuploidy in mammalian oocytes. Chromosome segregation is particularly error‐prone in human oocytes, but the mechanisms behind such errors remain unclear. To explain the frequent chromosome segregation errors, recent investigations have identified multiple meiotic defects and explained how these defects occur in female meiosis. In particular, we review the causes of cohesin exhaustion, leaky spindle assembly checkpoint (SAC), inherently unstable meiotic spindle, fragmented kinetochores or centromeres, abnormal aurora kinases (AURK), and clinical genetic variants (...) in human oocytes. We mainly focus on meiotic defects in human oocytes, but also refer to the potential defects of female meiosis in mouse models. (shrink)

Tian dao guan shi Zhongguo zhe xue de zhong yao gai nian, ye shi ru jiao de yi ge zhong yao wen ti, ji, shen me shi tian dao? Qi jin wei zhi, ji hu suo you de Zhongguo zhe xue zhu zuo, dou ren wei tian dao jiu shi zi ran gui lü. Ben shu jiang tong guo wen xian zi liao xiang dang dai de du zhe shuo ming, Zhongguo gu dai de tian dao, jiu shi tian zhi (...) dao, shang tian zhi dao. (shrink)

ObjectiveThe impact of the mindfulness-based stress reduction program on psychological outcomes and quality of life in lung cancer patients remains unclear. This meta-analysis aimed to evaluate the effectiveness of the MBSR program on psychological states and QoL in lung cancer patients.MethodsEligible studies published before November 2021 were systematically searched from PubMed, EMBASE, Cochrane Library, PsycINFO, China National Knowledge Infrastructure, and Wanfang databases. The risk of bias in eligible studies was assessed using the Cochrane tool. Psychological variables and QoL were evaluated (...) as outcomes. We used the Grading of Recommendations Assessment, Development and Evaluation system to grade the levels of evidence. Statistical analysis was conducted using RevMan 5.4 and STATA 14.0.ResultsA total of 17 studies involving 1,680 patients were included for meta-analysis eventually. MBSR program significantly relieved cancer-related fatigue and negative psychological states, enhanced positive psychological states, and improved quality of sleep. Evidence on MBSR programs' overall treatment effect for QoL revealed a trend toward statistical significance.ConclusionBased on our findings, the MBSR program shows positive effects on psychological states in lung cancer patients. This approach should be recommended as a part of the rehabilitation program for lung cancer patients.Systematic Review Registrationhttps://archive.org/details/osf-registrations-mwvbq-v1, identifier: 10.17605/OSF.IO/MWVBQ. (shrink)

本书从神秘主义的视角,对于古代哲学的变迁提出了新的认识,对其中若干命题作了新的解释,对于古代哲学与礼法进行了初步的讨论.内容包括:早期儒家与神秘主义;《内业》与《大学》;《五行》与神秘主义等.

Riben Jiuzhou da xue tu shu guan cang you gu xie Huizhou ben "Zhuzi yu lei" yi bai si shi juan. Huizhou ben shang cheng "Chi lu", xia qi li bian, zai yu lu dao yu lei de xing cheng guo cheng zhong chu yu guan jian de di wei, dui xue jie yan jiu zhu xi si xiang de xing cheng guo cheng, Zhu Xi men ren de qing kuang, jin ben "Zhuzi yu lei" de xing cheng guo cheng (...) yi ji zhong gu shi qi gu Han yu bai hua, ti gong le xin de cai liao he xin de shi ye. (shrink)

Ben shu fen shang xia liang ge bu fen,Shang bian shi zhu zi yu lei wen xian yan jiu,Xia bian shi zhu zi yu lei ci hui yan jiu.Quan shu yi gong fen wei 9 zhang.Di yi zhang xu lun,Shou xian jie shao le zhu xi yu zhu zi yu lei,Qi ci jin xing le xue shu hui gu,Zong jie le jin 20 nian lai(jie zhi 2009 nian)Guo nei wai zhu zi yu lei yan jiu de sheng kuang he qu (...) de de zhu yao cheng jiu,Zui hou ti chu ben shu de yan jiu fang fa he yi yi.Di er zhang yan jiu tong xing ben zhu zi yu lei ji cheng shu zhi qian de ji ge zhong yao ban ben.Di san zhang wei zhong hua ben zhu zi yu lei yu song ke ben hui an xian sheng zhu wen gong yu lu de yi wen bi jiao.Di si zhang wei zhong hua ben zhu zi yu lei yu chao xian gu xie ben zhu zi yu lei yi wen bi jiao.Di wu zhang yan jiu zhu zi yu lei de wen xian xue jia zhi.Di liu zhang he di qi zhang ji zhong yan jiu zhu zi yu lei de fu yin ci.Di ba zhang tao lun zhu zi yu lei zhong de duo yin jie ci yu.Di jiu zhang zong jie chan shu zhu zi yu lei de yu ti te zheng,Yu yan te dian he yan jiu jia zhi. (shrink)

di 1 juan. Shi lun juan -- di 2 juan. Fan chou juan -- di 3 juan. Men lei juan.

Ben shu nei rong bao kuo: ren lei wei he ru ci duo shi; dong fang gu dian de Afanda Wutuobang; sheng ren jiu jing wei shui xiao lao; zhi li de xian du yu xu wei you guo lun; deng gao si wang, man mu zhu ji hai shi man mu la ji; nan yi yong yu yan wen zi biao da yu chuan shou de da dao deng.

Seit der Antike wird der Musik eine große emotionale Wirkung zugeschrieben. Bis heute sind unterschiedliche Erklärungsmodelle diskutiert worden. Das betrifft zunächst das Phänomen der Gefühle im Allgemeinen, aber auch die Frage nach der Ursache der ästhetischen Empfindungen im Besonderen. Die Gefühlslehre von Carl Stumpf versucht u. a. in seiner Auseinandersetzung mit William James (James-Lange-Theorie, die vornehmlich auf die somatische Genese der Emotionen insistiert) Erklärungsansätze zu entwickeln, die sowohl kognitive als auch emotional-wertende psychische Funktionen berücksichtigen. Dennoch ist in Bezug auf das (...) nur scheinbar triviale Verhältnis von Hören und Fühlen, Musik und Emotionalität unter stringent wissenschaftlichen Kriterien erst ein Anfang gemacht worden, weil die Thematik - wie der Band zeigt - von einer bislang unterschätzten Komplexität zeugt, die zukünftig wohl nur mit vereinten interdisziplinären Kräften einem besseren Verständnis näherzubringen sein wird. (shrink)

With the development of artificial intelligence, it is imperative to combine design methods with new technologies. From the perspective of the personalized design of derived images of art paintings, this study analyzes the new user demand generated by the current situation and background of personalized design, puts forward a new method of derivative design based on AI emotion analysis, verifies the feasibility of the new method by constructing a personalized design system of derived images of art paintings driven by facial (...) emotion features, and explores the method of combining AI emotion recognition, emotion analysis, and personalized design. This study provides new ideas for the design of art derivatives for the future with massive personalized demand. Thinking and practicing from the perspective of the development of new technology will promote the change of design paradigms in the digital age. (shrink)

Recent advances in neuroscience indicate that analysis of bio-signals such as rest state electroencephalogram and eye-tracking data can provide more reliable evaluation of children autism spectrum disorder than traditional methods of behavior measurement relying on scales do. However, the effectiveness of the new approaches still lags behind the increasing requirement in clinical or educational practices as the “bio-marker” information carried by the bio-signal of a single-modality is likely insufficient or distorted. This study proposes an approach to joint analysis of EEG (...) and eye-tracking for children ASD evaluation. The approach focuses on deep fusion of the features in two modalities as no explicit correlations between the original bio-signals are available, which also limits the performance of existing methods along this direction. First, the synchronization measures, information entropy, and time-frequency features of the multi-channel EEG are derived. Then a random forest applies to the eye-tracking recordings of the same subjects to single out the most significant features. A graph convolutional network model then naturally fuses the two group of features to differentiate the children with ASD from the typically developed subjects. Experiments have been carried out on the two types of the bio-signals collected from 42 children. The results indicate that the proposed approach can achieve an accuracy of 95% in ASD detection, and strong correlations exist between the two bio-signals collected even asynchronously, in particular the EEG synchronization against the face related/joint attentions in terms of covariance. (shrink)

Leading Chinese and Western philosophers work alongside one another to explore the writings of one of the twentieth century’s most perplexing and original ethical and metaphysical thinkers. Comparative discussion of Lévinas on phenomenology, ethics, metaphysics and political philosophy within European philosophy and with Chinese philosophy Innovative accounts of Lévinasian themes of surpassing phenomenology, post-Heideggerian philosophy, the philosophy of saintliness, transcendence and immanence, time and sensibility, desire, death, political philosophy, the subject, and the space of communicativity.

Ben shu yi dong zhong shu zi ran guan wei shi jiao,Chan shu le dong zhong shu de"tian ren gan ying"lun,"wu lei lei bi"he"xun ming de li"de fang fa lun,Yi tian wei yuan ben de yu zhou lun,"bian er you chang"de bian zheng tian dao guan,Yi ji dong zhong shu you guan yuan qi,Yin yang,Wu xing de zi ran ke xue si xiang,Zai zong ti shang ken ding le dong zhong shu zai jie shi he ren shi zi ran gui (...) lü shang de jin bu xing,Ken ding le dong zhong shu dui zhong guo gu dai zi ran ke xue de gong xian,Bing pi ping le yi wang dui dong zhong shu bu gong zheng di ping pan.Ben shu tong shi ye zhi chu le dong zhong shu de mou xie si xiang dui hou shi de fu mian ying xiang. (shrink)

From the perspectives of manager cognition and behavior selection, this paper analyzes the cognitive basis of manufacturer’s green innovation and discovers that the embodied cognition of the manager has an important influence on the selection of green innovation behavior. Next, the behavior activation in the four stages of manufacturer’s green innovation, namely, initiation, termination, change, and solidification, was analyzed, and two behavior selections were proposed: the adaptive legitimacy with institutional logic as the cognitive starting point and the strategic legitimacy with (...) efficiency logic as the cognitive starting point. On this basis, the authors examined four types of manufacturer decisions of green innovation driven by manager cognition and behavior selection. The examination reveals how should the manager, facing the growing environmental pressure, form a correct cognition, select the right behavior, and make the proper green innovation decision, which promotes the green, sustainable development of manufacturers. (shrink)

Proof-theoretic semantics (P-tS) is an innovative approach to grounding logical meaning in terms of proofs rather than traditional truth-conditional semantics. The point is not that one provides a proof system, but rather that one articulates meaning in terms of proofs and provability. To elucidate this paradigm shift, we commence with an introduction that contrasts the fundamental tenets of P-tS with the more prevalent model-theoretic approach to semantics. The contribution of this paper is a P-tS for a substructural logic, intuitionistic multiplicative (...) linear logic (IMLL). Specifically, we meticulously examine and refine the established P-tS for intuitionistic propositional logic. Subsequently, we present two novel and comprehensive forms of P-tS for IMLL. Notably, the semantics for IMLL in this paper embodies its resource interpretation through its number-of-uses reading (restricted to atoms). This stands in contrast to the conventional model-theoretic semantics of the logic, underscoring the value that P-tS brings to substructural logics. (shrink)