Progressive supranuclear palsy is a movement disorder with prominent tau neuropathology. Brain diseases with abnormal tau deposits are called tauopathies, the most common of which is Alzheimer's disease. Environmental causes of tauopathies include repetitive head trauma associated with some sports. To identify common genetic variation contributing to risk for tauopathies, we carried out a genome-wide association study of 1,114 individuals with PSP and 3,247 controls followed by a second stage in which we genotyped 1,051 cases and 3,560 controls for the (...) stage 1 SNPs that yielded P ≤ 10-3. We found significant previously unidentified signals associated with PSP risk at STX6, EIF2AK3 and MOBP. We confirmed two independent variants in MAPT affecting risk for PSP, one of which influences MAPT brain expression. The genes implicated encode proteins for vesicle-membrane fusion at the Golgi-endosomal interface, for the endoplasmic reticulum unfolded protein response and for a myelin structural component. © 2011 Nature America, Inc. All rights reserved. (shrink)

The aim of the Committee’s discussions is to contribute to giving the conceptual instruments to those in governments and to society, in a broad sense, so as to understand the complex, dynamic, changeable ethical issues and their importance and urgency, envisaging the possible scenarios and lines of action in social policies to be undertaken at public level. These lines of action should attempt, through the search for an ethical balance, to reconcile the needs of science and technology to progress with (...) the protection of human beings, health, environment, and future generations. In this way, ethics committees play a key role in developing and implementing institutional ethics. (shrink)

La instalación El archivo de los abuelos, 1995, es el resultado de un proyecto de investigación que el artista Christian Boltanski realizó junto con los estudiantes de la Universidad de Leuphana, Luneburgo (Alemania) en la misma institución. El archivo reúne efectos personales de los abuelos de los estudiantes de aquella generación. Se trata de una pieza significativa dentro de la obra del francés porque no se atiene a las características habituales de sus obras de archivo, a las que denomino «meta-archivos» (...) por su carácter posmoderno de desestabilización del concepto mismo de archivo, y consecuentemente, del de documento y del de historia. El proyecto hizo patente el silencio sobre el Tercer Reich imperante en la época dentro de las familias, e hizo que este pasado reprimido resurgiese. Asimismo, puso de manifiesto los orígenes nazis del campus universitario. Por estos motivos, pese a poder considerarse un «meta-archivo fallido», es una obra de arte relevante y pertinente a nivel socio-cultural, y dentro de la obra de Boltanski, al arrojar luz sobre sus tácitos modus operandi y objetivos habituales precisamente por no cumplirlos. (shrink)

Los desafíos en las lecturas de fuentes documentales aparecen de modo frecuente en los cruces entre antropología e historia. Tanto desde la antropología histórica como desde la etnohistoria —campos de interacción difusos y a veces superpuestos, en ambos casos la búsqueda de información cualitativa sobre grupos sociales del pasado proviene del estudio de fuentes documentales— han surgido metáforas útiles que se convirtieron en verdaderas metodologías: lectura a contrapelo, against the grain, along the grain, entre líneas, etc. Menos se ha discutido (...) sobre la composición del corpus y la periodización que las investigadoras hacemos o replicamos al abordar nuestros trabajos. Siguiendo a Walter Mignolo (1995) y otros, me interesa discutir la articulación de un corpus históricamente diverso a partir de la noción de “semiosis colonial”. De acuerdo con esta idea, los distintos tipos de fuentes se vinculan por el referente que comparten, la situación colonial, sean o no producidas durante el período colonial. A partir del caso de una serie de documentos escogidos para la primera mitad del siglo XX en Argentina, sugiero que el estudio de las continuidades y rupturas se beneficia de un corpus que no suele ser considerado por los estudios coloniales. Para el caso de los imaginarios sobre los grupos indígenas del Chaco, señalo algunos beneficios y desafíos en tomar dos tipos de fuentes distintas en su intención, producción y circulación (informes ministeriales e historiografía oficial) para dar cuenta de su relación con un período anterior. Considero que tal ejercicio, lejos de restar especificidad a nuestra tarea, contribuye con una comprensión más compleja del período colonial y con la posibilidad de una mejor comunicación des-disciplinaria. (shrink)

This article examines a genetic ancestry testing program called the Living History Project that was jointly organized by a nonprofit educational institute and a for-profit genealogy company in South Africa. It charts the precise mechanisms by which the LHP sought to shape a postapartheid genome through antiracist commitments aimed at contesting histories of colonial and apartheid rule in varied ways. In particular, it focuses on several tensions that emerged within three modes of material-discursive practice within the production of the LHP: (...) subject recruitment, informed consent, and participant reflections. In the end, it argues that several contradictory tensions were central to the making of the LHP’s postapartheid genome and that it should be understood as nonracial rather than antiracist. (shrink)

Resumo Entre 1988 e 1993, Iúri M. Lótman formulou algumas proposições sobre “a voz da massa anônima”: uma voz coletiva que, em certas situacões ligadas a crises de caráter cultural, é portadora de paixões violentas que podem produzir interferências profundas no curso da história. Em seus últimos trabalhos, o semioticista russo postulou, diante disso, a noção de uma semiótica das emoções como objeto de estudo para entender a dinâmica cultural, em especial de períodos tidos como revolucionários ou de transição, a (...) saber, quando a massa anônima é capaz de manipular os eventos ou quando, revendo o passado, confere aos eventos uma interpretação distorcida. Lótman focalizou, principalmente, a relação entre as grandes fraturas históricas, os mecanismos de autopropagação do medo e a criação cultural de bodes expiatórios. O presente estudo visa abordar a reflexão de Lótman sobre perseguição, com especial atenção à figura da mulher durante o fenômeno de caça às bruxas. ABSTRACT Between 1988 and 1993, Yuri Lotman composed a series of reflections on “the voice of the anonymous mass”: a collective voice that, in particular situations linked to a cultural crisis, is the bearer of striking passions, which can deeply influence history. In his late works, the Russian semiotician postulated, therefore, the idea of a semiotics of emotions as an object of study to understand the dynamics of culture, especially during periods perceived as revolutionary or transitional―namely, when the anonymous mass manipulates the events or, when looking back, gives them a distorted interpretation. Lotman focused in particular on the relationship between great historical fractures, the self-propagating mechanisms of fear, and the cultural creation of scapegoats. This paper is devoted to framing Lotman’s reflection on persecution, paying particular attention to women during the phenomenon of the witch hunt. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Reviewed by:Approaching the End: Eschatological Reflections on Church, Politics, and Life by Stanley Hauerwas, and: Without Apology: Sermons for Christ’s Church by Stanley HauerwasLaura M. HartmanApproaching the End: Eschatological Reflections on Church, Politics, and Life Stanley Hauerwas grand rapids, mi: eerdmans, 2013. 251 pp. $24.00Without Apology: Sermons for Christ’s Church Stanley Hauerwas new york: seabury books, 2013. 169 pp. $18.00Stanley Hauerwas is prolific. By my count, there are forty-six (...) books to his name, including these two from 2013. And yet in the preface to Without Apology, he writes, “I am often asked, ‘How many books have you written?’ My truthful answer must be, ‘I have no idea.’ … I could count them, but I have no interest in doing so” (ix). Hauerwas’s reluctance to number his career in books shows his preference for smaller units of measurement (“how some reader may find this sermon, or that sentence or chapter … helpful”), but it also reflects his view that he is not the sole author of his works. To his credit, he mentions two influential women—his wife, Paula Gilbert, an experienced clergywoman, and his assistant, Carole Baker, who gives the sermons a “work-over” after they are written (ix).Those who know Hauerwas know what to expect from these volumes: thoughtful arguments that unflinchingly assert the centrality of Christ and of the Church; a heavy dose of pacifism; major appearances from John Howard Yoder and Karl Barth (as well as multiple cameos from fascinating authors who are now on my to-read list); and accessible, open prose outlining clear, thought-provoking arguments. The two books reviewed here are quite different from one another: Without Apology is a book of sermons; Approaching the End is a book of essays loosely organized around a theme of eschatology. But both contain the hallmarks of “classic Hauerwas”—his signature mix of virtue ethics, communitarian interests, and narrative sensibilities.Without Apology contains recent sermons, primarily in Episcopal churches. Drawing on lectionary readings, Hauerwas brings his own theological interpretation and creates fairly short, satisfying sermons, which he readily describes (in Paula Gilbert’s words) as “tight” (87). This collection also includes four sermons on the topic of priesthood and some other writings of note: the already-classic “An Open Letter to Christians Beginning College” (good for use with Christian undergraduates) and “Sexing the Ministry” (food for thought for [End Page 215] seminarian and clergy alike). Without Apology manifests several major themes, but the biggest of these connects with the title: Hauerwas is “unapologetic” about his Christian faith and doesn’t engage in theology of the “apologetic” style. His emphasis, rather, is on being truthfully present with one another in the church community.Approaching the End promises eschatological reflections and delivers on the promise. Although he is writing about eschatology, Hauerwas strongly maintains that he is not reaching his own “end” and disavows any contention that Approaching the End is a kind of “swan song” (xiv). He addresses politics and war in several chapters. In “The End of Sacrifice: An Apocalyptic Politics,” he makes the case that if Christians believe Jesus’s sacrifice was “the end of all sacrifices,” then we should not “continue to participate in the sacrifice of war” (36). Similar themes emerge in “War and Peace,” later in the volume. In “Church Matters: On Faith and Politics,” Hauerwas writes, “One of the challenges Christians confront is how the politics we helped create has made it difficult to sustain the material practices constitutive of an ecclesial culture to produce Christians” (68). He welcomes the “end” of churches and denominations as we know them because “it means that the church is finally free to be a politics” (86).Hauerwas also discusses the future of churches and denominations. “The End of Protestantism” reiterates that “if the church is to be faithful … then we must recover what it means for the church to be an alternative politics” (92). This chapter’s emphasis on Methodism and his appraisal of Methodists as “free church Catholics” (94) is of note. In “Which Church? What Unity?” Hauerwas discusses the ecumenical movement, prompted by George Lindbeck’s challenge to do so (98). Hauerwas’s... (shrink)

The exhibition Space/Sight/Self was designed to study the role of portraiture in contemporary art as a nexus of three issues identity, vision, and place. The goal was to produce a portrait, as it were, of contemporary portraiture. This catalog documents the exhibition and helps to facilitate viewers' reflections and responses about the spaces, sights, and selves that enable us to construct and question our identity.".

The housing sector is currently under pressure: demographic shifts, urbanisation as well as the availability and costs of housing have led to increasing prices. Concerns are being raised that these rising housing costs could lead to intergenerational conflicts. While older generations often live in their privatelyowned dwellings, younger cohorts struggle to become homeowners, moving the field of housing into the spotlight of national debates. We analyse the importance of housing for Europeans using data from Eurobarometer. Results show that the relevance (...) of housing increased between 2008 and 2018. However, generational differences were found: while older and younger people see housing as an important topic at the country level, only the younger generation seems to be affected personally. Online Appendix. (shrink)

Resumo: A pesquisa aqui apresentada resulta de uma reflexão sobre as epistemologias subalternas, sobretudo de matrizes africanas, tomando como exemplo a etnomatemática. O discurso filosófico sobre o “epistemicídio” dos saberes locais e tradicionais, por parte do paradigma científico dominante, pode ser aplicado a vários âmbitos disciplinares, entre os quais a matemática, nas suas duas vertentes principais, a aritmética e a geometria, que representa um caso paradigmático e significativo. Teorizada pela primeira vez pelo brasileiro D’Ambrosio e o holandês-moçambicano Paulus Gerdes, a (...) etnomatemática vive hoje uma contradição: ela foi aceite em termos epistemológicos, mas, especialmente em África, teve muitos problemas em se afirmar, entrando com dificuldades nos curricula oficiais. A pesquisa mostra como se deu tal processo, em Moçambique, um país símbolo do caminho da etnomatemática africana, em consideração da contribuição de Gerdes e da educação progressiva na primeira fase da sua independência.: This work aims at carrying out a reflection on the subaltern epistemologies, considering as an example the Ethnomathematics. The philosophical discourse on the “epistemicide of local and traditional knowledge by the dominant scientific paradigm can be aplied to various disciplinary fields. Among them it is possible to find Mathematics, in its two main branches, arithmetic and geometry. Mathematics represents a paradigmatic and meaningful case. It has been theorized for the first time by the Brazilian D’Ambrosio and the Dutch-Mozambican Paulus Gerdes, ethnomathematics is living today a contradiction: it was accepted in epistemological terms, but, especially in Africa, it registered many problems in assert itself, showing difficulties in being accepted in official curricula. The research shows how this process occurred in Mozambique, a symbolic country for African ethnomathematics, both in consideration of Gerdes’ contribution and of the progressive education during the first phase of its independence. (shrink)

The article addresses the role and being of the voice, and its relation with the echo in two contexts. We start with Plato’s cave myth and the dynamic between the interior and the exterior of the cave. Then we look at the relationship between the voice-echo and the exterior. The exterior is analyzed from a series of literary, musical, and cinematographic works. The constant and guiding line, how independent the voice is; its articulation with the speaking subject; its autonomous possibilities (...) and its plural richness. (shrink)

En este artículo recorro algunas de las páginas de la obra kantiana que introducen la problemática de los otros seres racionales, me centro para ello en Historia universal de la naturaleza y Teoría del cielo, la Fundamentación de la metafísica de las costumbres y la Antropología en sentido pragmático. Mi propuesta es que la hipótesis de la existencia de otras formas de racionalidad, que en algunos textos Kant sitúa en otros planetas, nos proporciona una perspectiva necesaria para poder dar alguna (...) respuesta a la cuestión ¿qué es el ser humano? Si bien Kant aborda en textos muy relevantes la forma de tener por verdad la existencia de tales seres, lo realmente importante es el ser capaces de asumir esa perspectiva para reflexionar en torno a nuestra racionalidad. (shrink)

El duelo literario se concibe desde la ficción como un recurso empleado por los escritores contemporáneos que, ante la imposibilidad de un duelo individual, buscan mediante la narración sanar las muertes ultrajadas por la 163ltima dictadura militar argentina; en tiempos donde la memoria de las generaciones recientes se encuentra vulnerable al olvido que el Estado ha tratado, en vano, imponer. Por ello escribir, sobre todo a partir del periodo de redemocratización, se convierte en una encrucijada entre la versión de los (...) vencedores y los vencidos, donde el pasado se conecta con el futuro para NO OLVIDAR. (shrink)

This article seek to highlight the aspects — explicit or implicit — that indicate the close attention paid by much American musicology of this century to the phenomenological level of musical events or, more generally, of the sound event. Starting from general considerations on American music and some of its protagonists, the article focuses on Elliott Carter, on his poetics, and on his theories expressed in his writings.Carter's compositional choices and his consciousness of the intrinsic complexity they assume theoretically provide (...) a starting point for a phenomenological study of many aspects of compositional experience: from consideration of instrumental language with its structural phenomenological (and historical) implications, to more global evaluation of the centrality of temporal and rhythmic subjects. (shrink)

Our world suffers. Some people suffer more than others. Since the first part of 2020, ours is justly described as a time of uncertainty, threat, and upheaval. In this article, we offer reflections threaded narratively, told from the specificity of our societal contexts in Iran, Canada, and Australia. What might we learn in the present and anticipated future from people living chronically within conditions of uncertainty and immobility and also those experiencing uncertainty and immobility for the first time? We argue (...) that reflexive comparative analysis bridging social and visual analysis, anchored in embodied conditions of such people, offers a way to learn from responses to COVID-19 while also being an exercise in ethical research practice. This reflection builds on and extends from our scholarly collaborations that have been ongoing since 2015. Our title recognizes this specific virus as stealthy. Importantly, our choice of words identifies resident Iranians—whose experiences were the original impetuses for this paper, and whose lives provide its empirical basis —as equally steely. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Religious Perspectives on Bioethics, Part 2Laura Jane Bishop (bio) and Mary Carrington Coutts (bio)This is Part Two of a two part Scope Note on Religious Perspectives on Bioethics. Part One was published in the June 1994 issue of this Journal. This Scope Note has been arranged in alphabetical order by the name of the religious tradition.Contents for Parts 1 and 2Part 1I.GeneralVI.HinduismII.African Religious TraditionsVII.IslamIII.Bahá'í FaithVIII.JainismIV.Buddhism and ConfucianismIX.JudaismV.Eastern OrthodoxyPart 2I.Native (...) American ReligiousChristian Scientist TraditionsEpiscopal/AnglicanII.ProtestantismEvangelicalGeneralJehovah's WitnessAnabaptist (Church of theLutheranBrethren, Friends SocietyMethodist/Wesleyan(Quaker), and Mennonite/NazareneAmish/Hutterite)Presbyterian/ReformedAssemblies of GodSeventh-day AdventistBaptistUnitarian UniversalistChurch of Jesus Christ of theUnited Church of Christ Latter-day SaintsIII.Roman CatholicismChristian Church (Disciples of Christ)[End Page 357]IntroductionThe many religions of the world bring diverse, and occasionally divergent attitudes to bioethical issues. These beliefs may guide patients and health care professionals as they seek or provide health care. In an attempt to facilitate understanding of and access to information about these beliefs in our pluralistic and global society, this Scope Note identifies literature by the world's major religious groups on topics relating to bioethics.Topics covered by this Scope Note include general attitudes to health and health care, the physician-patient relationship, treatment refusal, abortion, contraception, sterilization, reproductive technologies, genetics, mental health, human experimentation, organ transplantation and donation, death, euthanasia, suicide, and prolongation of life. Material was not available on all of these topics for each religion.The literature gathered here represents only a small portion of the available writing on religion and medicine for these faith traditions in the United States, and is limited to that which comments explicitly on bioethical issues. Some faiths have a rich tradition of writing on bioethics, for others the literature is more limited. Variation in coverage is not intended to indicate the relative importance of a faith but reflects accessibility and space constraints. Individuals interested in obtaining additional information are encouraged to contact the National Reference Center for Bioethics Literature.It is important to remember that doctrinal and theological differences exist even within the same denomination and that views of individual patients, family members, and health care providers should be sought.Native North American ShamanismAvery, Charlene. Native American Medicine: Traditional Healing. Journal of the American Medical Association 265 (17): 2271, 2273, 1 May 1991. A brief description of the general principles of Southwestern Native American religions is provided. Most tribes believe that health and religious well-being are interconnected.Day, Thomas W. Cross-Cultural Medicine at Home. Minnesota Medicine 75 (3): 15-17, March 1992. The Ojibwe tribe's view of health incorporates spiritual health and emphasizes a holistic approach to health care that encompasses a harmonious balance between the individual, community, and nature, as well as between body, mind, and spirit.Hirschfelder, Arlene B., and Molin, Paulette. The Encyclopedia of Native American Religions. New York: Facts on File, 1992. 367 p. A survey of Native American religions is provided, including tribal histories, descriptions of religious ceremonies, and biographical sketches.Hultkrantz, Åke. Health, Religion, and Medicine in Native North American Traditions. In Healing [End Page 358] and Restoring: Health and Medicine in the World's Religious Traditions, ed. Lawrence Sullivan, pp. 327-58. New York: Macmillan, 1989. Hultkrantz summarizes the Native American attitude toward medicine and health care, explaining that belief in the supernatural and its powers is one of the most important tenets of life. Ailing persons are aided by those who have been trained to act as mediators between the sick individual and the supernatural powers. Attitudes toward health and disease, and the role of the medicine man are demonstrated through the use of examples taken from many tribes.Hultkrantz, Åke. Shamanic Healing and Ritual Drama: Health and Medicine in Native North American Religious Traditions. New York: Crossroad, 1992. 197 p. Hultkrantz surveys the varied traditions of Native North Americans and their outlook on medical care, health, and religion, and emphasizes that Native American medical beliefs... (shrink)

En esta nota crítica (i) se hace una breve descripción de cada uno de los artículos que componen Orayen: de la forma lógica al significado, (ii) se señalan algunas cuestiones que no están claras en ellos o en las réplicas de Orayen y, (iii) en la medida de lo posible, se indica si los autores desarrollan ulteriormente los problemas abordados en sus artículos. The aim of this critical note is threefold: (i) it briefly describes and comments on each of the (...) articles of Orayen: de la forma lógica al significado; (ii) identifies some issues that may not be clear enough or not fully developed whether in the articles or even in Orayen's replies; (iii) as far as possible, it refers to further studies made by the authors themselves on the same, or quite related, subjects addressed by them in their papers. (shrink)