The role of research ethics consultants in biomedical research has increased to the point that they have an advisory capacity at all research institutes. For such professionals, we have established an educational system, which includes teaching materials, training methods, and nationwide educational workshops. These workshops have served to examine the developed system’s usefulness and to provide realistic training for consultant candidates. In addition, we have used the current workshop to encourage clinical research investigators to participate. Subsequently, we examined its usefulness (...) as an opportunity to provide exposure to research ethics. In October 2019, we held a 1-day pilot workshop in Tokushima, Japan, which included a basic lecture in research ethics. During the lecture, two sets of materials were used for case discussion: case 1, covering issues related to a clinical trial, and case 2, covering issues related to human biological specimens. At the end of the workshop, a 30-item self-reporting anonymous questionnaire was provided. Of the 13 total participants, 9 were clinical research investigators and related personnel, while 6 had no direct intention to act as consultants. Respondents indicated that case 2 was more difficult than case 1. However, both cases were generally accepted as educational materials; thus, satisfaction was expressed in relation to both. As the evaluations of the cases were generally positive, we will further examine the usefulness of participation in the workshop in the cultivation of research ethics in the investigator community. (shrink)

Ariga Tetsutaro (1899–1977) war Professor für das Studium des Christentums an der Universität Kyoto und gehörte dort der zweiten Professoren-generation an. Er legte die Grundlagen der Patristik und der Erforschung des Christentums in Japan. In seinem Hauptwerk “Origenes” hatte er den Historismus in der Theologie erforscht, aber nachdem er seinen Dienst als Professor an der staatlichen Universität aufgenommen hatte, die die Trennung von Staat und Religion hochhielt, suchte er nach Wegen, ein ‘Studium des Christlichen’ zu etablieren, das sich von der (...) Theologie unterschied. Dabei dienten ihm Schleiermachers “Kurze Darstellung des theologischen Studiums” und die Tradition des deutschen liberalen Protestantismus als Anhaltspunkte. Anstatt der Theologie, die den Glauben als methodischen Ausgangspunkt hat, und der Religionswissenschaft, die nur die distanzierte Objektivität als Ausgangspunkt wählt, schlug er als neuen Versuch ein Christliches Studium mit akademischem Standpunkt vor, bei dem der Gelehrte eine Forschungshaltung einnimmt, die durch ein Mindestmaß an vernünftiger Kritik und ‘Ur-Sympathie’ gegenüber der Religion geprägt ist. (shrink)

1. Seikyō ronkō -- 2-3. Shibunrui -- 4-10. Rangai shorui -- 11-12. Genshi shiroku -- 13-14. Fukureki.

We can easily discriminate self-produced from externally generated sensory signals. Recent studies suggest that the prediction of the sensory consequences of one’s own actions made by forward model can be used to attenuate the sensory effects of self-produced movements, thereby enabling a differentiation of the self-produced sensation from the externally generated one. The present study showed that attenuation of sensation occurred both when participants themselves performed a goal-directed action and when they observed experimenter performing the same action, although they clearly (...) reported that the tones were produced by other during action observation and by themselves during their own action. These results suggest that sensory prediction of action modulates ongoing auditory processing irrespective of who produces the sounds and that the explicit judgment of agency does not necessarily rely on the same mechanisms on which implicit perceptual measures such as sensory attenuation rely. (shrink)

Dr. Sato's volume deals with the origin and formation of the political thought of pre-imperial Xun Zi, with close focus on this synthesizer's formative theory ...

Crew Pairing is one of the most important and difficult problems for airline companies. Nets to fuel costs, the crew costs constitute the largest cost of airlines, and the crew costs depend on the quality of the solution to the pairing problem. Conventional systems have been used to solve a daily model, which handles only regular flights with many simplifications, so a lot of corrections are needed to get a feasible solution and the quality of the solution is not so (...) high. A fully dated model, which handles regular flights and irregular flights simultaneously, is extremely hard and has not been solved directly hitherto. The number of irregular flights tend to increase in Europe and Japan, hence the resolution of the practical fully dated pairing system is desired. This paper presents a new approach which solves directly the fully dated crew pairing by Genetic Algorithms. GA is improved with stochastic processes to attack the fully dated model, and many heuristics are included in the decoding mecanism of the GA. For several hundred flights per day for fully dated 2 months scheduling period, the system found better or equivalent solutions to the human scheduler’s without any simplification from 5 to 20 times faster. (shrink)

人間は「生」を得た瞬間から「死」という「滅び」に向かって生きている。そうであるからこそ「生」を尊ぶという考え方が日本の美をつくってきた。日本の美意識の基層をなし、自然に美を見いだした「優美」。演技を七 分にとどめ、完全に演じ切らないことを説いた世阿弥の「幽玄」。慢心する秀吉を戒め、侘びることを説いた利休の「侘び」。旅の途中で寂びつくして命つきることを願った芭蕉の「さび」。西欧文化の影響が背景にある「 きれい」。そして、二一世紀に世界を席巻する「かわいい」とは―。日本の美の潮流を俯瞰し、心のふるさとに耳をすます。.

This article aims to clarify the meaning of henology for Lacan and Žižek. Žižek apparently rejects Neoplatonic way of thinking, but by considering Lacanian Henology through its origin, Etienne Gilson, Lacanian henology and Žižek’s Hegelian reading of the One become converged. Both of them think the movement of the One from one principle and its two aspects. The principle is that the One gives something that it does not have, and it corresponds to Lacanian definition of love. Regarding its two (...) aspects, the first one is the logical necessity that generates necessarily the One, and the second is the logical contingency that generates contingently the surplus element. By this, we can clarify the theoretical development of each period of Lacan. In early Lacan, henology was a logic that ties his “the Symbolic” and Freudian Death drive. In middle Lacan, his main concern was the mathematical logic as the logic of the Id, and henology became the generative logic of the subject of enunciation or the subject of the jouissance. But at the same time, this movement produces as a co-product a inassimilable remainder, “object a” with the subject of signifiant. In late Lacan, by virtue of the “necessary” movement of the One and its “contingent” co-product, the universe of the discourse became indeterminate, undecidable, “not-all,” which means for Lacan “the contingent.” This characteristic became the logic of Lacanian “sexuation.”. (shrink)

Given the growing centrality of interdisciplinarity to scientific research, gaining a better understanding of successful interdisciplinary collaborations has become imperative. Drawing on extensive case studies of nine research networks in the social, natural, and computational sciences, we propose a construct that captures the multidimensional character of such collaborations, that of a shared cognitive–emotional–interactional platform. We demonstrate its value as an integrative lens to examine markers of and conditions for successful interdisciplinary collaborations as defined by researchers involved in these groups. We (...) show that markers and conditions embody three different dimensions: cognitive, emotional, and interactional; these dimensions are present in all networks, albeit to different degrees; the dimensions are intertwined and mutually constitutive; and they operate in conjunction with institutional conditions created by funders. We compare the SCEI platforms to available frameworks for successful interdisciplinary work. (shrink)

This article reports that some robustness of the notions of predicativity and of autonomous progression is broken down if as the given infinite total entity we choose some mathematical entities other than the traditionalω. Namely, the equivalence between normal transfinite recursion scheme and newdependent transfinite recursionscheme, which does hold in the context of subsystems of second order number theory, does not hold in the context of subsystems of second order set theory where the universeVof sets is treated as the given (...) totality. (shrink)

Interventions performed on a pregnant woman's body can affect the fetus in multiple ways. Such effects can be harmful to beneficial to the fetus. Unfortunately, the effects of new drugs and compoun...

Advanced new therapies, such as stem cell and gene therapies and xenotransplantation, represent challenges for regulatory and ethical review. Major drug agencies, such as in the U.S., India, and Europe, have asserted regulatory authority and require ethics review by local ethics review committees, using the same strict requirements as those for standard drug approvals. In spite of this, unapproved and undocumented stem cell clinics flourish in all of these places, suggesting that current approaches do not offer patients sufficient protection. Japan (...) has attempted another approach, requiring approvals at local levels for all regenerative medical procedures, and a faster approval of promising new interventions. The Japanese approach has, however, also been criticized as not striking a proper balance between early access and a proper assessment of safety and effectiveness. For smaller and less-resourced countries, such as Thailand, one major challenge is limited expertise to conduct the evaluation of these advanced new therapies. This article provides an overview of the issues facing regulators and proposes that countries should restrict the early adoption of advanced new therapies to specialized clinics with appropriate scientific and ethical expertise for review. Review in these institutions should focus on expert clinical benefit assessments for individual patients being offered such interventions, independently of whether they are offered as research or therapy. (shrink)

This short account summarizes our recent achievements in ultrafast coherent control of isolated molecules in the gas phase, and its ongoing applications to an ensemble of ultracold Rydberg atoms to explore quantum many-body dynamics.

The number of competing-brands changes by new product's entry. The new product introduction is endemic among consumer packaged goods firm and is an integral component of their marketing strategy. As a new product's entry affects markets, there is a pressing need to develop market response model that can adapt to such changes. In this paper, we develop a dynamic model that capture the underlying evolution of the buying behavior associated with the new product. This extends an application of a dynamic (...) linear model, which is used by a number of time series analyses, by allowing the observed dimension to change at some point in time. Our model copes with a problem that dynamic environments entail: changes in parameter over time and changes in the observed dimension. We formulate the model with framework of a state space model. We realize an estimation of the model using modified Kalman filter/fixed interval smoother. We find that new product's entry (1) decreases brand differentiation for existing brands, as indicated by decreasing difference between cross-price elasticities; (2) decreases commodity power for existing brands, as indicated by decreasing trend; and (3) decreases the effect of discount for existing brands, as indicated by a decrease in the magnitude of own-brand price elasticities. The proposed framework is directly applicable to other fields in which the observed dimension might be change, such as economic, bioinformatics, and so forth. (shrink)