While much attention has gone towards ethical, legal, and social implications of direct-to-consumer genetic testing over the past decades, the rise of new forms of consumer omics has largely escaped scrutiny. In this paper, we analyze the product descriptions, promotional messages, terms of service, and privacy policies of five epigenetic and seven microbiomic testing companies. The advent of such tests online represents a significant shift in consumer omics, from a focus on inherited molecules with genetic tests, to broader interest for (...) information about the lives of individuals, such as chronological and biological age, exposures, and lifestyle. Building on previous literature about direct-to-consumer genetic testing, and taking this shift into account, we identify limitations, gaps and inconsistencies in current practices and policies of the new companies. Best practice standards and regulations applicable across different omic sample and data types is a necessary first step in the promotion of responsible consumer omics. (shrink)

Peer reporting is a specific form of whistelblowing in which an individual discloses the wrongdoing of a peer. Previous studies have examined situational variables thought to influence a person's decision to report the wrongdoing of a peer. The present study looked at peer reporting from the individual level. Five hypotheses were developed concerning the relationships between (1) religiosity and ethical ideology, (2) ethical ideology and ethical judgments about peer reporting, and (3) ethical judgments and intentions to report peer wrongdoing.Subjects read (...) a vignette concerning academic cheating, and were asked to respond to a question-naire concerning the vignette. Data were analyzed using structural equation methodology. (shrink)

Various possibilities, that one is dreaming, that one is being deceived by a deceitful demon, that one is a brain in the vat being stimulated to think one has a body and is in a regular world, have been invoked to show that all one's experience-based beliefs might be false. Descartes in Meditation I advises that in order not to lapse into his careless everyday view of things he, or at least his meditator, should pretend that all his experience-based beliefs, (...) indeed all his …. (shrink)

Precursors of inferential capacities concerning self- and other- understanding may be found in the basic experience of social contingency and emotional sharing. The emergence of a sense of self- and other-agency receives special attention here, as a foundation for self-understanding. We propose that synchrony, an amodal parameter of contingent self-other relationships, should be especially involved in the development of a sense of agency. To explore this framework, we have manipulated synchrony in various ways, either by delaying mother’s response to infant’s (...) behaviour, disorganizing mother’s internal synchrony between face and voice, freezing the partner in a still attitude, or on the contrary maximizing synchrony through imitation. We report results obtained with healthy and clinical populations that are supposed to be at the beginning of basic experiences concerning the ownership of their actions: infants of 2 months and 6 months, low-functioning children with autism and MA matched young children with Down Syndrome. Our results support the idea of a two-step process linking understanding of self to understanding of other and leading on to form the concept of human beings as universally contingent entities. (shrink)

Decision making often requires making arbitrary choices (“picking”) between alternatives that make no difference to the agent, that are equally desirable, or when the potential reward is unknown. Using event-related potentials we tested the effect of age on this common type of decision making. We compared two age groups: ages 18–25, and ages 41–67 on a masked-priming paradigm while recording EEG and EMG. Participants pressed a right or left button following either an instructive arrow cue or a neutral free-choice picking (...) cue, both preceded by a masked arrow or neutral prime. The prime affected the behavior on the Instructed and the Free-choice picking conditions both in the younger and older groups. Moreover, electrophysiological “Change of Intention” (ChoI) was observed via lateralized readiness potential (LRP) in both age groups – the polarity of the LRP indicated first preparation to move the primed hand and then preparation to move the other hand. However, the older participants were more conservative in responding to the instructive cue, exhibiting a speed-accuracy trade-off, with slower response times, less errors in incongruent trials, and reduced probability of EMG activity in the non-responding hand. Additionally, “Change of Intention” was observed in both age groups in slow RT trials with a neutral prime as a result of an endogenous early intention to respond in a direction opposite the eventual instructing arrow cue. We conclude that the basic behavioral and electrophysiological signatures of implicit ChoI are common to a wide range of ages. However, older subjects, despite showing a similar dynamic decision trajectory as younger adults, are slower, more prudent and finalize the decision making process before letting the information affect the peripheral motor system. In contrast, the flow of information in younger subjects occurs in parallel to the decision process. (shrink)

This is the Second Edition of a well-received book that reflects a fresh, integrated coverage of the concepts and scientific measurement of stress and welfare of animals including humans. This book explains the basic biological principles of coping with many forms of adversity. The major part of this work is devoted to explaining scientifically usable concepts in stress and welfare. A wide range of welfare indicators are highlighted in detail with examples being drawn from man and other species. The necessity (...) for combining information from disciplines is emphasized with a one-health, one-welfare approach. This information forms the basis for a synthesis of new ideas. Among the issues covered are: - How brain and body systems regulate using feelings, physiological responses, behaviour and responses to pathology - Limits to adaptation - Assessing positive and negative welfare during both short-term and long-term situations - Ethical problems and suggested solutions A proper assessment of animal welfare is essential to take informed decisions about what is morally acceptable in terms of practice and in the development of a more effective legislation. This work encapsulates a very wide body of literature on scientific aspects of animal welfare and will thus prove a valuable asset for animal welfare scientists, psychologists, students and teachers of all forms of biology, behaviour, medicine, veterinary medicine and animal usage. (shrink)

It is argued thatde dicto andde re beliefs are attitudes towards syntactically structured entities (sentences) in the head. In order to identify the content of ade dicto orde re belief, we must be able to match causal relations of belief states to natural language inferences. Such match-ups provide sufficient empirical justification for regarding those causal relations as syntactic transformations, that is, inferences. But only syntactically structured entities are capable of enjoying such inferential relations. Hence,de dicto andde re beliefs must be (...) syntactically structured. Given that beliefs are also brain states, it follows that they are sentences in the brain. The argument presented here is shown to be an improvement over similar arguments advanced by Harman and Fodor. (shrink)

PstS and DING proteins are members of a superfamily of secreted, high‐affinity phosphate‐binding proteins. Whereas microbial PstS have a well‐defined role in phosphate ABC transporters, the physiological function of DING proteins, named after their DINGGG N termini, still needs to be determined. PstS and DING proteins co‐exist in some Pseudomonas strains, to which they confer a highly adhesive and virulent phenotype. More than 30 DING proteins have now been purified, mostly from eukaryotes. They are often associated with infections or with (...) dysregulation of cell proliferation. Consequently, eukaryotic DING proteins could also be involved in cell–cell communication or adherence. The ubiquitous presence in eukaryotes of proteins structurally and functionally related to bacterial virulence factors is intriguing, as is the absence of eukaryotic genes encoding DING proteins in databases. DING proteins in eukaryotes could originate from unidentified commensal or symbiotic bacteria and could contribute to essential functions. Alternatively, DING proteins could be encoded by eukaryotic genes sharing special features that prevent their cloning. Both hypotheses are discussed. (shrink)

When judging what is fair, how do we decide how much weight to assign to the conflicting interests of different classes of people? This subject has received some attention in a utilitarian context, but has been largely neglected in the case of egalitarian societies of the kind studied by John Rawls. My Game Theory and the Social Contract considers the problem for a toy society with only two citizens. This paper examines the theoretical difficulties in extending the discussion to societies (...) with more than two citizens. (shrink)

Ken Elkins retired as chief photographer of the Anniston Star in 2000, and this selection of his work demonstrates his brilliant eye for finding and capturing images of rural southern lives and landscapes in all their difficulty, candor, and humor. These are unadorned images of a timeless landscape and proud resourceful people, who know well their neighbors, honor their past, and face the tests of daily life with wit and a stoic sense of endurance.

This essay is about how the notion of “structure” in ontic structuralism might be made precise. More specifically, my aim is to make precise the idea that the structure of the world is given by the relations inhering in the world, in such a way that the relations are ontologically prior to their relata. The central claim is the following: one can do so by giving due attention to the relationships that hold between those relations, by making use of certain (...) notions from algebraic logic. (shrink)

v. 1. The spectrum of consciousness ; No boundary ; Selected essays -- v. 2. The Atman Project ; Up from Eden -- v. 3. A sociable god ; Eye to eye -- v. 4. Integral psychology ; Transformations of consciousness ; Selected essays -- v. 5. Grace and grit : spirituality and healing in the life and death of Treya Killam Wilber. 2nd ed. -- v. 6. Sex, ecology, spirituality : the spirit of evolution. 2nd, rev. ed. -- v. (...) 7. A brief history of everything ; The eye of spirit -- v. 8. The marriage of sense and soul ; One taste. (shrink)

Philosophy Compass, Volume 17, Issue 4, April 2022.

In this paper, I consider the role of exact symmetries in theories of physics, working throughout with the example of gravitation set in Newtonian spacetime. First, I spend some time setting up a means of thinking about symmetries in this context; second, I consider arguments from the seeming undetectability of absolute velocities to an anti-realism about velocities; and finally, I claim that the structure of the theory licences us to interpret models which differ only with regards to the absolute velocities (...) of objects as depicting the same physical state of affairs. In defending this last claim, I consider how ideas and resources from the philosophy of language may usefully be brought to bear on this topic. (shrink)

It is widely held that Bayesian decision theory is the final word on how a rational person should make decisions. However, Leonard Savage--the inventor of Bayesian decision theory--argued that it would be ridiculous to use his theory outside the kind of small world in which it is always possible to "look before you leap." If taken seriously, this view makes Bayesian decision theory inappropriate for the large worlds of scientific discovery and macroeconomic enterprise. When is it correct to use Bayesian (...) decision theory--and when does it need to be modified? Using a minimum of mathematics, Rational Decisions clearly explains the foundations of Bayesian decision theory and shows why Savage restricted the theory's application to small worlds. The book is a wide-ranging exploration of standard theories of choice and belief under risk and uncertainty. Ken Binmore discusses the various philosophical attitudes related to the nature of probability and offers resolutions to paradoxes believed to hinder further progress. In arguing that the Bayesian approach to knowledge is inadequate in a large world, Binmore proposes an extension to Bayesian decision theory--allowing the idea of a mixed strategy in game theory to be expanded to a larger set of what Binmore refers to as "muddled" strategies. Written by one of the world's leading game theorists, Rational Decisions is the touchstone for anyone needing a concise, accessible, and expert view on Bayesian decision making. (shrink)

The Royal Liverpool Children’s Inquiry investigated the circumstances leading to the removal, retention, and disposal of human tissue, including children’s organs, at the Royal Liverpool Children’s NHS Trust . It recommended changes to procedures for obtaining consent for postmortems and retaining organs and tissues for research or education. However, the report contains five areas of confusion. Firstly, it allowed the cultural and historical traditions of horror over the use and misuse of body parts to suffuse the logical analysis of past (...) wrongs and future rights. Secondly, it makes an inappropriate conflation between seeking redress for past wrongs and shaping future policy. Thirdly, the report takes a muddled stance over the value of bodily integrity at burial. Fourthly, the report is inconsistent over the justification for future organ and tissue collections. Fifthly, the notion of “respect” is used with troublesome looseness. The extent to which subsequent policy work has furthered the search for greater ethical clarity over these difficult issues is discussed, together with reflection on three particular improvements that could be made to the process of such an inquiry. (shrink)

Ken Binmore's previous game theory textbook, Fun and Games, carved out a significant niche in the advanced undergraduate market; it was intellectually serious and more up-to-date than its competitors, but also accessibly written. Its central thesis was that game theory allows us to understand many kinds of interactions between people, a point that Binmore amply demonstrated through a rich range of examples and applications. This replacement for the now out-of-date 1991 textbook retains the entertaining examples, but changes the organization to (...) match how game theory courses are actually taught, making Playing for Real a more versatile text that almost all possible course designs will find easier to use, with less jumping about than before. In addition, the problem sections, already used as a reference by many teachers, have become even more clever and varied, without becoming too technical. Playing for Real will sell into advanced undergraduate courses in game theory, primarily those in economics, but also courses in the social sciences, and serve as a reference for economists. (shrink)

In the literature over the Ramsey-sentence approach to structural realism, there is often debate over whether structural realists can legitimately restrict the range of the second-order quantifiers, in order to avoid the Newman problem. In this paper, I argue that even if they are allowed to, it won’t help: even if the Ramsey sentence is interpreted using such restricted quantifiers, it is still an implausible candidate to capture a theory’s structural content. To do so, I use the following observation: if (...) a Ramsey sentence did encode a theory’s structural content, then two theories would be structurally equivalent just in case they have logically equivalent Ramsey sentences. I then argue that this criterion for structural equivalence is implausible, even where frame or Henkin semantics are used. (shrink)

How may we characterize the intrinsic structure of physical quantities such as mass, length, or electric charge? This article shows that group-theoretic methods—specifically, the notion of a free and transitive group action—provide an elegant way of characterizing the structure of scalar quantities, and uses this to give an intrinsic treatment of vector quantities. It also gives a general account of how different scalar or vector quantities may be algebraically combined with one another. Finally, it uses this apparatus to give a (...) simple intrinsic treatment of Newtonian gravitation. (shrink)

Suppose that one thinks that certain symmetries of a theory reveal “surplus structure”. What would a formalism without that surplus structure look like? The conventional answer is that it would be a reduced theory: a theory which traffics only in structures invariant under the relevant symmetry. In this paper, I argue that there is a neglected alternative: one can work with a sophisticated version of the theory, in which the symmetries act as isomorphisms.

There are well-known problems associated with the idea of gravitational energy in general relativity. We offer a new perspective on those problems by comparison with Newtonian gravitation, and particularly geometrized Newtonian gravitation. We show that there is a natural candidate for the energy density of a Newtonian gravitational field. But we observe that this quantity is gauge dependent, and that it cannot be defined in the geometrized theory without introducing further structure. We then address a potential response by showing that (...) there is an analogue to the Weyl tensor in geometrized Newtonian gravitation. (shrink)

This article considers the following question: What is the relationship between supervenience and reduction? I investigate this formally: first, by introducing a recent argument by Christian List to the effect that one can have supervenience without reduction; then, by considering how the notion of Nagelian reduction can be related to the formal apparatus of definability and translation theory; then, by showing how, in the context of propositional theories, topological constraints on supervenience serve to enforce reducibility; and, finally, by showing how (...) constraints derived from the theory of ultraproducts can enforce reducibility in the context of first-order theories. (shrink)

Natural Justice is a bold attempt to lay the foundations for a genuine science of morals using the theory of games. Since human morality is no less a product of evolution than any other human characteristic, the book takes the view that we need to explore its origins in the food-sharing social contracts of our prehuman ancestors. It is argued that the deep structure of our current fairness norms continues to reflect the logic of these primeval social contracts, but the (...) particular fairness norm a society operates is largely a product of cultural evolution. In pursuing this point, the book proposes a naturalistic reinterpretation of John Rawls' original position that reconciles his egalitarian theory of justice with John Harsanyi's utilitarian theory by identifying the environment appropriate to each. (shrink)

A central issue in the philosophical debates over general relativity concerns the status of the metric field: should it be regarded as part of the background arena in which physical fields evolve, or as a physical field itself? In this paper, we approach this debate through its relationship to the so-called "Problem of Space": the problem of determining which abstract, mathematical geometries are candidate descriptions of physical space. In particular, we explore the way that Hermann Weyl tackled the Problem of (...) Space in the wake of general relativity, and argue that Weyl’s proposed solution reveals a “middle way” between bare-manifold and manifold-plus-metric accounts of spacetime. (shrink)

If categorical equivalence is a good criterion of theoretical equivalence, then it would seem that if some class of mathematical structures is represented as a category, then any other class of structures categorically equivalent to it will have the same representational capacities. Hudetz (2019a) has presented an apparent counterexample to this claim; in this note, I argue that the counterexample fails.

Ever since the publication of his first book, The Spectrum of Consciousness, written when he was twenty-three, Ken Wilber has been identified as the most comprehensive philosophical thinker of our times. This introductory sampler, designed to acquaint newcomers with his work, contains brief passages from his most popular books, ranging over a variety of topics, including levels of consciousness, mystical experience, meditation practice, death, the perennial philosophy, and Wilber's integral approach to reality, integrating matter, body, mind, soul, and spirit. Here (...) is Wilber's writing at its most reader-friendly, discussing essential ideas of the world's great psychological, philosophical, and spiritual traditions in language that is lucid, engaging, and inspirational. (shrink)

This paper argues that much of the literature on interpreting scientific theories presupposes a certain picture of what interpretation involves: a picture according to which interpreting a theory is like translating from one language to another. In place of this “external” approach to interpretation, this paper proposes an “internal” approach, according to which interpretation is more concerned with delineating a theory’s internal semantic architecture.

This Element explores what it means for two theories in physics to be equivalent, and what lessons can be drawn about their structure as a result. It does so through a twofold approach. On the one hand, it provides a synoptic overview of the logical tools that have been employed in recent philosophy of physics to explore these topics: definition, translation, Ramsey sentences, and category theory. On the other, it provides a detailed case study of how these ideas may be (...) applied to understand the dynamical and spatiotemporal structure of Newtonian mechanics - in particular, in light of the symmetries of Newtonian theory. In so doing, it brings together a great deal of exciting recent work in the literature, and is sure to be a valuable companion for all those interested in these topics. (shrink)

[Ken Gemes] In some texts Nietzsche vehemently denies the possibility of free will; in others he seems to positively countenance its existence. This paper distinguishes two different notions of free will. Agency free will is intrinsically tied to the question of agency, what constitutes an action as opposed to a mere doing. Deserts free will is intrinsically tied to the question of desert, of who does and does not merit punishment and reward. It is shown that we can render Nietzsche's (...) prima facie conflicting assertions regarding free will compatible by interpreting him as rejecting deserts free will while accepting the possibility of agency free will. It is argued that Nietzsche's advances an original form of compatibilism which takes agency free will to be a rare achievement rather than a natural endowment. /// [Christopher Janaway] This paper aims to distinguish a conception of 'free will' that Nietzsche opposes (that of the pure agent unaffected by contingencies of character and circumstance) and one that he supports. In Human, All Too Human Nietzsche propounds the 'total unfreedom' of the will. But by the time of Beyond Good and Evil and the Genealogy he is more concerned (a) to trace the affective psychological states underlying beliefs in both free will and 'unfree will', (b) to suggest that the will might become free in certain individuals, a matter of having a consistent strong character, self-knowledge, and ability to create values. The paper explores the kind of autonomy required in agents who would 'revalue' existing values. (shrink)