Despite claims from prominent scientists that SARS‐CoV‐2 indubitably emerged naturally, the etiology of this novel coronavirus remains a pressing and open question: Without knowing the true nature of a disease, it is impossible for clinicians to appropriately shape their care, for policy‐makers to correctly gauge the nature and extent of the threat, and for the public to appropriately modify their behavior. Unless the intermediate host necessary for completing a natural zoonotic jump is identified, the dual‐use gain‐of‐function research practice of viral (...) serial passage should be considered a viable route by which the novel coronavirus arose. The practice of serial passage mimics a natural zoonotic jump, and offers explanations for SARS‐CoV‐2's distinctive spike‐protein region and its unexpectedly high affinity for angiotensin converting enzyme (ACE2), as well as the notable polybasic furin cleavage site within it. Additional molecular clues raise further questions, all of which warrant full investigation into the novel coronavirus's origins and a re‐examination of the risks and rewards of dual‐use gain‐of‐function research. (shrink)

There is a steadily growing literature on the role of the immune system in psychiatric disorders. So far, these advances have largely taken the form of correlations between specific aspects of inflammation (e.g. blood plasma levels of inflammatory markers, genetic mutations in immune pathways, viral or bacterial infection) with the development of neuropsychiatric conditions such as autism, bipolar disorder, schizophrenia and depression. A fundamental question remains open: why are psychiatric disorders and immune responses intertwined? To address this would require a (...) step back from a historical mind–body dualism that has created such a dichotomy. We propose three contributions of active inference when addressing this question: translation, unification, and simulation. To illustrate these contributions, we consider the following questions. Is there an immunological analogue of sensory attenuation? Is there a common generative model that the brain and immune system jointly optimise? Can the immune response and psychiatric illness both be explained in terms of self-organising systems responding to threatening stimuli in their external environment, whether those stimuli happen to be pathogens, predators, or people? Does false inference at an immunological level alter the message passing at a psychological level (or vice versa) through a principled exchange between the two systems? (shrink)

This paper argues that a guaranteed income is not only consistent with the principle of reciprocity but is required for reciprocity. This conclusion follows from a three-part argument. First, if a guaranteed income is in place, all individuals have the same opportunity to live without working. Therefore, those who choose not to work do not take advantage of a privilege that is unavailable to everyone else. Second, in the absence of an unconditional income, society is, in effect, applying the principle, (...) “(S)he who does not work, will not eat.” If the application of this principle is to be consistent with reciprocity, it must be applied to everyone. Most modern industrial societies exempt many citizens from that choice. For example, the owners of external assets do not face the work-or-starve choice and do take advantage of a privilege that is not available to others. An unconditional guaranteed income is one way to eliminate that violation of reciprocity. Third, this paper addresses the criticism that the guaranteed income exploits middle-class workers by demonstrating that a basic income will have a positive effect on wages, which will at least partially counteract the effect of the taxes needed to pay for it. (shrink)

Reinhold's Letters on the Kantian Philosophy is arguably the most influential book ever written concerning Kant. It provides a helpful introduction to Kant's philosophy and a valuable explanation of how that philosophy can be understood as an appropriate Enlightenment solution to the 'pantheism dispute' which dominated thought in the era of German Idealism. The first edition of Kant's Critique of Pure Reason was slow in gaining a positive reception, but after Reinhold's Letters appeared Kant's Critical Philosophy suddenly attained the central (...) position which it has held to this day. The Letters also brought fame to Reinhold, who developed his own influential 'Elementary Philosophy' and was succeeded by the leading figures of German Idealism: Fichte, Schelling, and Hegel. This English edition of Reinhold's work includes the original 1786–7 version as well as all the major additions and changes from the 1790 edition. (shrink)

The intent of Jaspers' philosophizing then is simply to recall us to our authentic situation. This recall is not itself a doctrine; it is only the stimulus to an inward action each must perform for himself in communication with others. Jaspers' Existenz-philosophy is thus an attempt to consider and enact human honesty; it is philosophy, not as wisdom, but as the love of wisdom.

Accused of the murder of two men and the rape and murder of a Tombstone businessman's fiancâee, Matt Donohue must find the girl in the middle of Apache territory in order to clear his name.

This is one of Barth's most important works - far more important than may appear at first sight.... Here we have not merely one great theologian taking the measure of another. That in itself would be interesting enough. But in addition to that we are here shown one great theologian clarifying and crystallizing, in conversation with another, his own ideas as to the nature of theology and of the theologian's task. Scottish Journal of Theology.

With the publication of Reason and Existenz, originally delivered as a series of five lectures at the University of Groningen in 1935, one of the most important of Jaspers's philosophic works is made available to the English-speaking world. It concerns itself with a general statement of the principal philosophic categories which have given uniqueness to Jaspers's thinking: existence, freedom, and history, and the limit-situations of death, suffering, and sin. Written shortly after Jaspers's major systematic work and before his analysis of (...) the problem of truth, Reason and Existenz occupies a primary position in the development of his thought. (shrink)

THE PAPER IS A FOOTNOTE TO C B MARTIN AND KARL PFEIFER, "INTENTIONALITY AND THE NON-PSYCHOLOGICAL," "PHIL PHENOMENOL RES" 46 (1986) 531-554. A CHARACTERIZATION OF INTENTIONALITY NOT CONSIDERED THEREIN IS SHOWN, NONETHELESS, ALSO TO FAIL TO DISTINGUISH BETWEEN INTENTIONAL STATES AND MERELY PHYSICAL CAUSAL CAPACITIES.

Keine ausführliche Beschreibung für "Die Transzendentalienlehre im Corpus Aristotelicum" verfügbar.

A group of theologians collaborated to publish a commentary on the Encyclical letter Haurietis Aquas. Among these were brothers Hugo and Karl Rahner. Their contribution is a theological reflection on the veneration of the Sacred Heart of Jesus, an example of a rich connection between spiritual reality and theological thought before the Second Vatican Council. In this case we see a remote theological preparation of the Council and an important theological work which was later developed by the Council itself. (...) All this was happening around the time when the Institute of Spirituality at the Gregorian University was founded. (shrink)

This work has been selected by scholars as being culturally important, and is part of the knowledge base of civilization as we know it. This work was reproduced from the original artifact, and remains as true to the original work as possible. Therefore, you will see the original copyright references, library stamps (as most of these works have been housed in our most important libraries around the world), and other notations in the work. This work is in the public domain (...) in the United States of America, and possibly other nations. Within the United States, you may freely copy and distribute this work, as no entity (individual or corporate) has a copyright on the body of the work. As a reproduction of a historical artifact, this work may contain missing or blurred pages, poor pictures, errant marks, etc. Scholars believe, and we concur, that this work is important enough to be preserved, reproduced, and made generally available to the public. We appreciate your support of the preservation process, and thank you for being an important part of keeping this knowledge alive and relevant. (shrink)

The areas of interest of the scholar of religious studies, Karl E. Grozinger, are diverse. His research is concentrated on the religious and cultural history of Judaism throughout the ages: Israel in antiquity, the era of rabbinical traditional literature, philosophy of religion during the Middle Ages, the kabbalistic tradition, as well as Jewish thinkers and devout movements in contemporary times. On the occasion of Professor Grozinger's seventieth birthday, numerous scholars present the first fruits of their current research as a (...) first look into the tendencies of future research in Jewish studies. In accordance with this scholar's broad interests, the volume Jewish Lifeworlds and Jewish Thought, edited by Nathanael Riemer, is comprised of contributions to a wide variety of topics of Jewish cultural history.With contributions by Hermann Lichtenberger, Hanna Liss, Ronit Meroz, Yoav Elstein, Susanne Talabardon, Nathanael Riemer, Giuseppe Veltri, Dirk Westerkamp, Thomas Meyer, Daniel Jutte, Frederek Musall, Robert Jutte, J. Friedrich Battenberg, Admiel Kosman, Rella Kushelevsky, Elvira Grozinger, Simon Bronner, Avidov Lipsker, Jascha Nemtsov, Rebekka Denz, Micha Brumlik, Micha? Galas, Manja Herrmann, Hans-Michael Haussig, Anat Feinberg, Adam Lipszyc, Vivian Liska, Julius H. Schoeps, Edward D'browa, Ewa Geller, Manfred Voigts, Mordechai Lewy and Stanislaw Krajewski. (shrink)

Karl Schuhmann’s essay focuses on a central problem which Hobbes set out to remedy, namely, the politically disruptive potential of those making claims of immediate supernatural experience, based, for example, on dreams, the embassies of angels and visions. Confident of victory despite his variance not only with common but also learned opinion, Hobbes offers his natural philosophy as the way both to lay the ghosts of superstition and to prevent political aggrandizement through popular credulity. Tracing the philosopher’s use of (...) the Greek concept of phantasia, as first employed by Aristotle and then in scholastic terminology, Schuhmann uncovers the political point contained in Hobbes’s insistence on motion and matter in his natural science. (shrink)

A primer of the often overlooked yet significant writings of Marx on religion.