Graphical AbstractGroup photo of the participants at the chromosome stability meeting in Jawaharlal Nehru Centre for Advanced Scientific Research (JNCASR), Bangalore, India. The meeting brought together the Indian scientific community and investigators from other countries working on various aspects of chromosome stability.

Meiotic recombination occurs preferentially at certain regions called hot spots and is important for generating genetic diversity and proper segregation of chromosomes during meiosis. Hot spots have been characterized most extensively in yeast, mice and humans. The development of methods based on sperm typing and population genetics has facilitated rapid and high‐resolution mapping of hot spots in mice and humans in recent years. With increasing information becoming available on meiotic recombination in different species, it is now possible to compare several (...) molecular features associated with hot‐spot loci. Further, there have been advances in our knowledge of the factors influencing hot‐spot activity and the role that they play in structuring the genome into haplotype blocks. We review the molecular features associated with hot spots in terms of their properties and mechanisms underlying their function and distribution. A large number of these features seem to be shared among hot spots from different species suggesting common mechanisms for their formation and function. BioEssays 28:45–56, 2006. © 2005 Wiley Periodicals, Inc. (shrink)

On April 3, 1995, the Fourth Circuit upheld the right of a Maryland hospital to terminate a surgeon who was HIV-positive ). A resident in the University of Maryland Neurosurgical Training Program was dismissed when hospital administrators learned of his infection with HIV. The resident, known as Dr. Doe, claimed that his termination violated federal laws protecting persons with disabilities. The court upheld the hospital's actions as lawful and affirmed the trial court's grant of summary judgment for the hospital.Dr. Doe (...) charged that his dismissal from the training program violated the Rehabilitation Act and the Americans with Disabilities Act. (shrink)

This monograph attempts to clarify one significant but much neglected aspect of Peirce's contribution to the philosophy of science. It was written in 1963 as my M. A. thesis at the Uni versity of Illinois. Since the topic is still neglected it is hoped that its pUblication will be of use to Peirce scholars. I should like to acknowledge my indebtedness to Dr. Max Fisch who broached this topic to me and who advised me con tinuously through its development, assisting (...) generously with his own insights and unpublished Peirce manuscripts. TABLE OF CONTENTS INTRODUCTION 1. A Current Issue in the Philosophy of Science 1 2. Peirce and His Theory of Abduction 5 3. The General Character of Abduction 7 PART I: THE EARLY THEORY 1. Peirce's Earliest Conception of Inference 11 2. Three Kinds of Inference and Three Figures of Syllogism 13 3. Ampliative Inference and Cognition 17 4. Induction and Hypothesis 20 5. The Method of Methods 23 PART II: THE LATER THEORY 1. The Transitional Period 28 2. Three Stages of Inquiry 31 3. Abduction and Guessing Instinct 35 4. Logic as a Normative Science 38 5. Hypothesis Construction and Selection 41 6. Abduction and Pragmatism 44 7. Economy of Research 47 8. Justification of Abduction 51 CONCLUSION 55 61 BIBLIOGRAPHY INTRODUCTION 1. (shrink)

The editor has arranged forty-nine essays on and by Santayana into eight chapters representing major areas of Santayana's thought such as "Materialism and Idealism," "Essence, Substance, and Existence," "Art and Beauty." The essays supposedly speak to their chapter titles and to each other to create "the sense of dialogue"; with a few exceptions they were not written as deliberate conversation. This "dialogue" treats the reader to a fine display of the variety of minds and interests at work in philosophy and (...) illustrates the fact that one man's philosophical arena is rarely another man's. From J. H. Randall, Jr. to John Crowe Ransom, a recurring point of contention is Santayana's conception of Essences and their relationship to Matter. The range of interpretation on this issue goes from plaintive objections that "Essences don't do anything!" to appreciative acknowledgment that "Essences don't do anything!". Arguments over "isms" abound; realism, idealism, epiphenominalism are examined from many angles besides Santayana's. Santayana is highlighted nicely, arranged in this way beside his critics. His ability to locate the vital force behind an idea and to indicate where specific thrusts of thought will lead evinces his title of philosopher and master critic. This collection is not limited in appeal to Santayana aficionados.--A. K. T. (shrink)

The twenty-two essays collected for this book range widely in theme, style, and quality. The essays, a majority of which were previously unpublished, are arranged in three sections: 1) Early Essays, containing one particularly fine essay, "The Soul at Play," originally intended as part of Santayana's Soliloquies in England; 2) Later Essays, in which the title essay and "Friendship" are outstanding; and 3) Philosophical Essays, offering commentaries on Russell, Dewey, and James, on his own philosophy, and "On the False Steps (...) of Philosophy." The book's last article, "What is the Ego?", is an elaboration of his criticism of those "German Prophets" who return from self-contemplation "as greedy as children and as stubborn as Inquisitors." Santayana's manner of exposition often involves the elaboration of a single image or metaphor. When an image or metaphor is employed which can bear the weight of subtle distinctions, he is brilliant; but when the metaphor is too weak to encompass his thinking, then his writing becomes flowery and decadent. The essays, unfinished and fragmentary for the most part, are frequently little more than a single extended metaphor--sometimes over-extended. The fragmentary, possibly only experimental, ideas in these essays invite comparison with their use in his completed works. The book will be of special interest to someone already familiar with Santayana.--A. K. T. (shrink)

Prior apparently left a substantially completed manuscript dealing with the objects of thought when he died in 1969. Geach and Kenny have edited this material, supplementing it with both published and unpublished other writings, including an appendix on names in lieu of Prior's intended final chapter. The result is an interesting, often non-standard, discussion of many issues central to philosophical logic. There are two major concerns treated--what is it that we think?, and what is it that we think about?. These (...) are the two principle ways in which 'thinking of' can occur as a relation for Prior. An examination of the first sense results in a defense of the view that propositions, as language-independent logical constructions, are the objects of thought. In doing so, a large number of related issues are discussed to include criticisms of extentionalist [[sic]] theses, a sympathetic version of the assertive redundancy theory of truth, and an account of non-assertoric logic. Prior also devotes chapters to paradoxes such as that of the liar, and to Tarskian and alternative semantics. Perhaps the most interesting section of the book is that devoted to discussing what sentences are about, especially when their ostensible subjects are non-existent, e.g., "The King of France is bald." It is not clear just what his positive views are, but Prior has a number of criticisms directed against current intentionalistic views of names as well as against Russellian names. His chief worry seems to concern oratio obliqua constructions in which a reporter does not believe in the existence of that of which/whom a reportee speaks. Although critical of writers influenced by either the early Brentano or the later Russell, Prior appears to be sympathetic to both schools in that he seems to view non-demonstrative sentences as never being directly about their subjects. Thus, neither "Gustavus is bald" nor "The King of Sweden is bald" would be about the King of Sweden, i.e., Gustavus. However, since Gustavus is the King of Sweden, the sentences are indirectly about him. Presumably, such a move precludes a reporter's being committed to the reportee's ontology, thereby avoiding the difficulty. An interesting but undeveloped aspect of his view is the role of background stories in our use of names. While some use is made of formal logic in the Polish notation, unfamiliarity with either is not a bar to following the text as English translations and keys are provided. It is unfortunate that we cannot look forward to further elucidation of Prior's views.--K. T. (shrink)

This article questions social constructionists' claims to introduce Wittgenstein's philosophy to psychology. The philosophical fiction of a neonate Crusoe is introduced to cast doubt on the interpretations and use of the private language argument to support a new psychology developed by the constructionists. It is argued that a neonate Crusoe's viability in philosophy and apparent absence in psychology offends against the integrity of the philosophical contribution Wittgenstein might make to psychology. The consequences of accepting Crusoe's viability are explored as they (...) appear in both philosophy and psychology. (shrink)

JL Austin exercised in Post-war Oxford an intellectual authority similar to that of Wittgenstein in Cambridge. Although he completed no books of his own and published only seven papers, Austin became through lectures and talks one of the acknowledged leaders in what is called ‘Oxford philosophy’ or ‘ordinary language philosophy’. Few would dispute that among analytic philosophers Austin stands out as a great and original philosophical genius. Three volumes of his writing, published after his death, have become classics in analytical (...) philosophy: _Philosophical Papers_; _Sense and Sensibilia_; and _How to Do Things with Words_. First published in 1979, this book is a collection of critical essays on Austin’s philosophy written by well-known philosophers, many of whom knew Austin personally. A number of essays included were especially written for this volume, but the majority have appeared previously in various journals or books, not all easy to obtain. (shrink)

The recent revival of Confucianism in the PRC raises questions regarding the legitimacy of cultivating Confucian virtues such as ren, li and xiao in an educational context. This article is based on the assumptions that education is an ideologically laden practice and that moral virtues have the potential of functioning to sustain hegemony and other forms of social control. By focusing on the Xiao Jing, a lesser known Confucian classic, it offers the Confucian account of filial piety a charitable reading (...) which then proceeds to examine the ideological dimension of filial piety. By employing concepts such as naturalisation and the public–private distinction in my analysis, I argue that filial piety should be understood through a critical lens. While the question ‘Is filial piety a virtue?’ cannot be answered in a simple, straightforward manner, the discussion on filial piety presented in this article has the potential to shed light on the relationship between politics and moral education. (shrink)