An abundance of data unequivocally shows that exercise can be an effective tool in the fight against obesity and its associated co-morbidities. Indeed, physical activity can be more effective than widely-used pharmaceutical interventions. Whilst metformin reduces the incidence of diabetes by 31% (as compared with a placebo) in both men and women across different racial and ethnic groups, lifestyle intervention (including exercise) reduces the incidence by 58%. In this context, it is notable that a group of prominent medics and exercise (...) scientists recently sent a well-publicised letter to the General Medical Council and Medical Schools Council calling for the introduction of evidence-based lifestyle education into all medical curricula. The letter warns that there is a lack of understanding of the impact that exercise and nutrition can have on physical health amongst doctors. In the absence of an educational overhaul, the signatories warn that the government is likely to fail to reach its goal of preventing tens of thousands of premature deaths from heart disease and cancer by 2020. Whilst we agree with the need to address this apparent lack of understanding, we argue that the ethical justification of doing so is not limited to this broadly beneficence-based justification. There is also a justification grounded in the duty of non-maleficence, that is, the duty to avoid unreasonably harming patients. This duty requires that doctors refrain from (i) preventing patients from undergoing beneficial treatment without good reason, (ii) exposing patients to unreasonable risks and (iii) reducing the therapeutic effect of an effective medical intervention. This requires an understanding of the physical impact of exercise. (shrink)

Some have recently argued that parents are morally obligated, under certain circumstances, to use pre-natal genetic intervention as a means of enhancement. Despite aiming to benefit the child, such intervention may produce serious and irreparable harm. In these cases, parents seem to have an obligation not to intervene, as such efforts make the child worse off. Julian Savulesu has argued that while harm raises doubts about the acceptability of genetic enhancement, genetic selection remains an obligation. This claim, however, (...) rests on an indefensible privileging of personal over impersonal harm. I propose instead that we reframe the debate as stemming from fundamentally different views about parental obligation. The objection from harm rests on an objectivist conception, according to which obligation is determined by all relevant facts, including unpredictable harm. Proponents of genetic enhancement, however, operate within subjectivist assumptions about obligation, according to which moral requirements are determined by reasons that are epistemically accessible to the relevant agents. I will argue here that because subjectivism offers a more reasonable conception of parental obligation, such unforeseeable harm does not remove a parent’s obligation to enhance. (shrink)

In this paper we make a proposal for reforming biomedical research that is aimed to align re-search more closely with the so-called fair-share principle according to which the proportions of global resources as-signed to different diseases should agree with the ratios of human suffering associated with those diseases.

I contend that mathematical domains are freestanding institutional entities that, at least typically, are introduced to serve representational functions. In this paper, I outline an account of institutional reality and a supporting metaontological perspective that clarify the content of this thesis. I also argue that a philosophy of mathematics that has this thesis as its central tenet can account for the objectivity, necessity, and atemporality of mathematics.

The requirements of rationality are fundamental in practical and theoretical philosophy. Nonetheless, there exists no correct account of what constitutes rational requirements. This paper attempts to provide a correct constitutive account of ‘rationality requires’. I argue that rational requirements are grounded in ‘necessary explanations of subjective incoherence’, as I shall put it. Rationality requires of you to X if and only if your rational capacities, in conjunction with the fact that you not-X, explain necessarily why you have a non-maximal degree (...) of subjective coherence. (shrink)

Sensory substitution devices are a type of sensory prosthesis that (typically) convert visual stimuli transduced by a camera into tactile or auditory stimulation. They are designed to be used by people with impaired vision so that they can recover some of the functions normally subserved by vision. In this chapter we will consider what philosophers might learn about the nature of the senses from the neuroscience of sensory substitution. We will show how sensory substitution devices work by exploiting the cross-modal (...) plasticity of sensory cortex: the ability of sensory cortex to pick up some types of information about the external environment irrespective of the nature of the sensory inputs it is processing. We explore the implications of cross-modal plasticity for theories of the senses that attempt to make distinctions between the senses on the basis of neurobiology. (shrink)

There is substantial disagreement among philosophers of embodied cognitive science about the meaning of embodiment. In what follows, I describe three different views that can be found in the current literature. I show how this debate centers around the question of whether the science of embodied cognition can retain the computer theory of mind. One view, which I will label body functionalism, takes the body to play the functional role of linking external resources for problem solving with internal biological machinery. (...) Embodiment is thus understood in terms of the role the body plays in supporting the computational circuits that realize cognition. Body enactivism argues by contrast that no computational account of cognition can account for the role of commonsense knowledge in our everyday practical engagement with the world. I will attempt a reconciliation of these seemingly opposed views. (shrink)

This paper argues that practical reasoning is a mental process which leads a person from a set of existent mental states to an intention. In Section 1, I defend this view against two other proposals according to which practical reasoning either concludes in an action itself or in a normative belief. Section 2 discusses the correctness of practical reasoning and explains how the correctness of instrumental reasoning can be explained by the logical relations that hold between the contents of the (...) mental states. In Section 3, I explore the correctness of normative practical reasoning. I conclude with the sceptical view that correct practical reasoning cannot require us to intend to do what we believe we ought to do. (shrink)

Does a coherentist version of rationality issue requirements on states? Or does it issue requirements on processes? This paper evalu- ates the possibility of process-requirements. It argues that there are two possible definitions of state- and process-requirements: a satisfaction- based definition and a content-based definition. I demonstrate that the satisfaction-based definition is inappropriate. It does not allow us to uphold a clear-cut distinction between state- and process-requirements. We should therefore use a content-based definition of state- and pro- cess-requirements. However, a (...) content-based definition entails that ra- tionality does not issue process-requirements. Content-based process- requirements violate the principle that ‘rationality requires’ implies ‘can satisfy’. The conclusion of this paper therefore amounts to a radical re- jection of process-requirements of rationality. (shrink)

I argue that Brierley et al are wrong to claim that parents who request futile treatment are acting against the interests of their child. A better ethical ground for withholding or withdrawing life-prolonging treatment is not that it is in the interests of the patient to die, but rather on grounds of the limitation of resources and the requirements of distributive justice. Put simply, not all treatment that might be in a person's interests must ethically be provided.

According to the free energy principle all living systems aim to minimise free energy in their sensory exchanges with the environment. Processes of free energy minimisation are thus ubiquitous in the biological world. Indeed it has been argued that even plants engage in free energy minimisation. Not all living things however feel alive. How then did the feeling of being alive get started? In line with the arguments of the phenomenologists, I will claim that every feeling must be felt by (...) someone. It must have mineness built into it if it is to feel a particular way. The question I take up in this paper asks how mineness might have arisen out of processes of free energy minimisation, given that many systems that keep themselves alive lack mineness. The hypothesis I develop in this paper is that the life of an organism can be seen as an inferential process. Every living system embodies a probability distribution conditioned on a model of the sensory, physiological, and morphological states that are highly probably given the life it leads and the niche it inhabits. I argue for an ecological and enactive interpretation of free energy. I show how once the life of an organism reaches a certain level of complexity mineness emerges as an intrinsic part of the process of life itself. (shrink)

One popular line of argument put forward in support of the principle that the right is prior to the good is to show that teleological theories, which put the good prior to the right, lead to implausible normative results. There are situa- tions, it is argued, in which putting the good prior to the right entails that we ought to do things that cannot be right for us to do. Consequently, goodness cannot (always) explain an action's rightness. This indicates that (...) what is right must be determined independently of the good. In this paper, I argue that these purported counterexamples to teleology fail to establish that the right must be prior to the good. In fact, putting the right prior to the good can lead to sets of ought statements which potentially con- flict with the principle that ‘ought’ implies ‘can’. I argue that no plausible ethical theory can determine what is right independently of a notion of value or goodness. Every plausible ethical theory needs a mapping from goodness to rightness, which implies that right cannot be prior to the good. (shrink)

Human‐animal chimeras—creatures composed of a mix of animal and human cells—have come to play an important role in biomedical research, and they raise ethical questions. This article focuses on one particularly difficult set of questions—those related to the moral status of human‐animal chimeras with brains that are partly or wholly composed of human cells. Given the uncertain effects of human‐animal chimera research on chimeric animals’ cognition, it would be prudent to ensure we do not overlook or underestimate their moral status. (...) However, to assess moral status, we first need to determine what kinds of capacities are morally relevant. The standard view holds that it matters, morally, if chimeric animals develop uniquely human cognitive capacities. I argue that this view is mistaken, highlighting three problems with it: that we can think of examples of uniquely human cognitive capacities that are not morally significant, that we can think of examples of morally significant cognitive capacities that are not uniquely human, and that evidence that some cognitive capacity is shared with nonhuman animals does not undermine claims that this capacity is morally significant. We need a better framework for thinking about the moral status of part‐human beings. (shrink)

Ethical business creates social value. That’s the theme of this bold new volume, heralding and defending this rapidly-growing new conception of capitalism making its way into the mainstream. It provides clear and succinct guidelines for how to evaluate what counts as an ethical business as well as how and why ethical businesses tend to succeed better over the long term. The book is jargon-free and targeted primarily at thought leaders and academics in business and philosophy who will want to use (...) it in their business ethics classes. Each chapter has been selected for its ability to engage a wide audience without oversimplifying the content. -/- All twelve chapters are original and authored by leading business ethicists including William Shaw, Tony Simons, Duane Windsor, and Mark Schwartz. Each piece makes use of recent empirical evidence or ethical theory (or both) in order to present a detailed yet overarching picture of what ethical business looks like—and how to achieve it—in today’s global environment. (shrink)

The Hegel-Deleuze relation has usually been considered as one of opposition, because of Deleuze’s explicit anti-Hegelian statements. This article refutes the main conceptual grounds to this opposition: the critique of the negative and of the circle of return. It aims to present the possibilities offered by considering the Hegel-Deleuze relation as a problematic, productive one. “Hegel-Deleuze” would be a relation prior to the supposed terms. To achieve this, we bind them through the concept of Idea. This traditional concept of philosophy, (...) which crowns the Hegelian system (also known as absolute idealism), appears in a key position in Deleuze’s Difference and Repetition. It allows Deleuze to consider thought not as an image of the external reality or the condition of possible experience, but as the genetic principle of real experience. Even if Deleuze accuses Hegel of positing his Idea as the ground for the eternal repetition of the same, this article proposes to interpret it as the source of creation of a reality always different from itself. (shrink)

We do not always benefit from the expansion of our choice sets. This is because some options change the context in which we must make decisions in ways that render us worse off than we would have been otherwise. One promising argument against paid living kidney donation holds that having the option of selling a ‘spare’ kidney would impact people facing financial pressures in precisely this way. I defend this argument from two related criticisms: first, that having the option to (...) sell one’s kidney would only be harmful if one is pressured or coerced to take this specific course of action; and second, that such forms of pressure are unlikely to feature in a legal market. (shrink)

In Markets Without Limits and a series of related papers, Jason Brennan and Peter Jaworski argue that it is morally permissible to buy and sell anything that it is morally permissible to possess and exchange outside of the market. Accordingly, we should open markets in “contested commodities” including blood, gametes, surrogacy services, and transplantable organs. This paper clarifies some important aspects of the case for market boundaries and in so doing shows why there are in fact moral limits to the (...) market. I argue that the case for restricting the scope of the market does not turn on the idea that some things are constitutively non-market goods; it turns instead on the idea that treating some things according to market norms would threaten the realization of particular kinds of human interests. (shrink)

A theoretical assumption of this chapter on time in mind is that people ought to take phenomenological descriptions of temporal experience at face value. The chapter begins with a brief review of Rick Grush's trajectory estimation model of temporal representation – the predictive inference model. It introduces the issues of whether temporal properties as they appear should be thought of as primary or secondary qualities. A constraint runs from the best science of the mind back to phenomenology that the best (...) phenomenological descriptions of experience cohere with the best science of the human mind. Grush's model bears a close resemblance to computational theories in neuroscience that take perception to consist in predictive inference. A section explains the relationship between the Orwellian interpretation of postdiction and the Husserlian view of temporal experience. The chapter also presents a discussion on “the time as its own representation view” (TOR) and supervenience thesis (SUP). (shrink)

Greely’s target article outlines six categories of ethical issues associated with human brain surrogate research. Some of these issues are familiar from other research contexts; others, less...

One common objection to establishing regulated live donor organ markets is that such markets would be exploitative. Perhaps surprisingly, exploitation arguments against organ markets have been widely rejected in the philosophical literature on the subject. It is often argued that concerns about exploitation should be addressed by increasing the price paid to organ sellers, not by banning the trade outright. I argue that this analysis rests on a particular conception of exploitation, and outline two additional ways that the charge of (...) exploitation can be understood. I argue that while increasing payments to organ sellers may mitigate or eliminate fair benefits exploitation, such measures will not necessarily address fair process exploitation or complicity in injustice. I further argue that each of these three forms of wrongdoing is relevant to the ethics of paid living organ donation, as well as the design of public policy more generally. (shrink)

My commentary takes up the two issues Heras-Escribano focusses on in the precis of his book: the ontology and normativity of affordances. The dispositional account of affordances Heras-Escribano ….

Luke Semrau argues that the documented harms of existing organ markets do not undermine the case for establishing regulated systems of paid kidney donation. He offers two arguments in support of this conclusion. First, Semrau argues that the harms of kidney selling are straightforwardly amenable to regulatory solution. Second, Semrau argues that even in existing black markets, sellers would likely have experienced greater harm if the option of selling a kidney were not available. This commentary challenges both of Semrau’s claims. (...) I argue that there is no reason to believe that kidney sellers benefit from the current black market trade in organs, and highlight a number of potential issues regarding the effectiveness and feasibility of Semrau’s proposed market regulations. (shrink)

Neuronal signalling involves multiple neuropeptides that are diverse in structure and function. Complex patterns of tissue‐specific expression arise from alternate RNA splicing of neuropeptide‐encoding gene transcripts. The pattern of expression and its role in cell signalling is diffecult to study at the level of single neurons in the complex vertebrate brain. However, in the model molluscan system, Lymnaea, it is possible to show that alternate mRNA expression of the FMRFamide gene is specific to single identified neurons. Two different transcripts are (...) expressed in a mutually exclusive manner in different neurons. Post‐translational processing of the two precursor proteins leads to completely distinct sets of neuropeptide transmitters. The function of these transmitter cocktails, resulting from alternate mRNA splicing, was studied physiologically in identified neurons forming part of a behaviourally important network regulating heartbeat. (shrink)

Duas formulações oferecidas por Leibniz de seu princípio de causalidade são examinadas, e a incompatibilidade, segundo Leibniz, do princípio com a possibilidade de causas indiferentes com respeito a seus efeitos é considerada. Acompanhamos o desenvolvimento de sua teoria da escolha a partir de suas teses sobre causalidade e indiferença. Por fim, procuramos explicar por que Leibniz sustentava que sua teoria de escolha não exclui a liberdade. Some remarks about causality, choice and freedom in LeibnizTwo statements of Leibniz’ principle of causality (...) are discussed, and their alleged incompatibility with there being causes which are indifferent with respect to their effects is considered. We follow the development of his theory of choice on the basis of his views on causality and indifference. Finally, we attempt to explain why Leibniz maintained that his theory of choice does not rule out freedom. (shrink)

Two aspects of the chromatin repeat length (r t) are discussed: (i) Why is r t, longer for slowly dividing cells than in rapidly dividing cells?, and (ii) Why is the temporal evolution of r ta decreasing function of time (t) in mammalian cortical neurons, whereas it is an increasing function of t for granule cells around the time of birth? These questions are discussed in terms of a hypothesis which assumes a correlation between deoxyribonucleic acid (DNA) packaging, transcription, and (...) replication. (shrink)

An earlier version of this paper was presented at the 2011 IEEE International Symposium on Technology and Society at Saint Xavier University in Chicago, Illinois. Perhaps the most remarkable characteristic of digital social games such as Zynga's FarmVille is that they are designed in such a way that any user, regardless of their skills and experience, can familiarise themselves in a matter of moments with the object of the game, the interface, and the tools and options involved in playing them. (...) In contrast, developers of collaborative platforms for teaching and research have been struggling for the last 15 to 20 years to gain a wide acceptance among users, and with very limited success. Although simple and intuitive usability has long been recognised as a key design goal, no-one has, apparently, yet succeeded in integrating all the tools and functions required for academic work into a platform with an intuitive interface that target groups make enthusiastic use of. This paper investigates which principles and features may be adopted to make the use of these platforms easier and more intuitive. This electronic document is a "live" template. The various components of your paper [title, text, heads, etc.] are already defined on the style sheet, as illustrated by the portions given in this document. (shrink)

Resumen: El objetivo de este ensayo es presentar el procedimiento, hallazgos y lecciones de una revisión de literatura soportada en elementos estructurados y sistemáticos en una investigación cuyo objetivo es encontrar condiciones de satisfacción para una teoría integrada de la acción colectiva desde la economía política. El resultado de este ejercicio es la exposición de cómo la revisión sistemática de literatura interioriza en el aspecto metodológico de las investigaciones cualitativas la intuición de los autores, sin dejar de lado la asepsia (...) de las revisiones estructuradas. El aporte radica entonces en discutir la importancia de la adopción de reglas para la búsqueda y revisión bibliográfica, al tiempo de advertir la necesidad de incorporar algunos criterios subjetivos para complementar dichas reglas rígidas que supone un protocolo estructurado.: This essay presents the procedure, findings and lessons of a review of literature supported by structured and systematic elements in a research whose objective is to find satisfaction conditions for an integrated theory of collective action from political economy. The result of this exercise is the exposition of how the systematic review of literature internalizes in the methodological aspect of qualitative research the intuition of the authors, without neglecting the asepsis of structured reviews. The contribution then lies in discussing the importance of adopting rules for searching and reviewing the literature, while noting the need to incorporate some subjective criteria to complement these rigid rules that are a structured protocol. (shrink)

Tras constatar la existencia de un corpus de más de doscientos cómics publicados a lo largo de casi un siglo que incorporan representaciones gráficas de Alejandro Magno, en el presente trabajo se analizan aquellas obras que muestran al personaje desde una perspectiva histórico-biográfica y con una finalidad didáctica, publicadas por vez primera en los Estados Unidos de la década de 1920 bajo la forma de tiras de prensa y dos décadas más tarde en Europa en tanto que contenidos de las (...) revistas destinadas a un público infantil, así como su posterior evolución en ambos escenarios geográficos a lo largo del siglo XX. (shrink)

In their recent paper in this journal, Zümrüt Alpinar-Şencan and colleagues review existing dignity-based objections to organ markets and outline a new form of dignity-based objection they believe has more merit: one grounded in a social account of dignity. This commentary clarifies some aspects of the social account of dignity and then shows how this revised account can be applied to other perennial issues in bioethics, including the ethics of human embryo research and the ethics of creating part-human chimeras.

Social relationships are essential for humans; neglecting our social needs can reduce wellbeing or even lead to the development of more severe issues such as depression or substance dependency. Although essential, some individuals face major challenges in forming and maintaining social relationships due to the experience of social anxiety. The burden of social anxiety can be reduced through accessible assessment that leads to treatment. However, socially anxious individuals who seek help face many barriers stemming from geography, fear, or disparities in (...) access to systems of care. But recent research suggested digital behavioral markers as a way to deliver cheap and easily accessible digital assessment for social anxiety: As earlier work shows, players with social anxiety show similar behaviors in virtual worlds as in the physical world, including tending to walk farther around other avatars and standing farther away from other avatars. The characteristics of the movement behavior in-game can be harnessed for the development of digital behavioral markers for the assessment of social anxiety. In this paper, we investigate whether implicit as well as explicit digital behavioral markers, proposed by prior work, for social anxiety can be used for predicting the level of social anxiety. We show that both, explicit and implicit digital behavioral markers can be harnessed for the assessment. Our findings provide further insights about how game-based digital behavioral markers can be used for the assessment of social anxiety. (shrink)

A vital process in maintaining a low genetic error rate is the removal of mismatched bases in DNA. The importance of this process in E. coli is demonstrated by the 100–1000 fold increase in mutation frequency observed in cells deficient in this repair system(1). Mismatches can arise as a consequence of recombination, errors in replication and as a result of spontaneous chemical deamination, the latter process resulting in an estimated twelve T:G mismatches per genome per day in mammalian cells(2). Recent (...) studies, discussed here, provide evidence for the existence of specific mismatch repair systems in mammalian and human cells. (shrink)

Sowohl die wissenschaftliche als auch die lebensweltliche Praxis sind ohne den Austausch von Gründen nicht denkbar, und dennoch ist notorisch unklar, was man unter Gründen eigentlich verstehen sollte: Was ist ihr ontologischer und erkenntnistheoretischer Status? Sind sie objektiv oder subjektiv? In welchem Verhältnis stehen praktische und theoretische Gründe zueinander? Was können Gründe überhaupt leisten? Die in diesem Band versammelten Kongressbeiträge untersuchen das Thema »Gründe« aus den unterschiedlichen Perspektiven der verschiedenen Strömungen der zeitgenössischen Philosophie. Dieser Pluralismus spiegelt sich auch in den (...) Hauptvorträgen wider, für die Seyla Benhabib, Lorraine Daston, Peter Gärdenfors, Jürgen Habermas, Franz von Kutschera, Susan Neiman und Robert Pippin gewonnen werden konnten. (shrink)

L’article cherche à savoir si une explication neuroscientifique de la conscience est possible et à quoi elle pourrait ressembler. Plus particulièrement, je me pencherai sur l’affirmation qu’à chaque expérience donnée correspond un système de représentation neural qui constitue la base de survenance minimale de cette expérience. J’appellerai cette hypothèse « la thèse de survenance minimale ». Je soutiens que cette thèse peut se lire de deux façons que je nommerai lectures localiste et holiste. Les théories localistes cherchent à définir quelle (...) est la base de survenance minimale des expériences particulières. Elles laissent de côté les questions sur la nature de la conscience des êtres et considèrent la base neurale de leur conscience comme une condition causale circonstancielle nécessaire à l’expérience d’une conscience particulière. Les holistes, d’autre part, donnent la priorité à la conscience des êtres et affirment que nous pouvons rendre compte des états de conscience particuliers seulement dans un contexte d’explication de la conscience des êtres. J’affirme que toute explication scientifique de la conscience doit rendre compte de ce que j’appellerai « une sensation minimale de soi », intrinsèque à tout état conscient. Les théories holistes sont les plus aptes à tenir compte de cet aspect. Enfin, j’affirme que l’explication sensori-motrice dynamique de la conscience peut se combiner avec une approche holiste de la base neurale de la conscience. Une telle combinaison d’approches compense l’opposition à la thèse de survenance minimale de certains défenseurs de l’explication sensori motrice dynamique distingués . Elle offre également un cadre de développement pour une explication neuroscientifique de la sensation minimale de soi. (shrink)

InHow the Mind Uses the BrainRalph Ellis and Natika Newton develop a novel embodied, enactive theory of consciousness, according to which consciousness has its basis in neural systems that prepare the system to perform actions of emotional significance to the organism. Consciousness emerges out of self-organising processes which function in such a way as to contribute to, and maintain, the organism’s overall wellbeing. I’ll begin this review by reconstructing Ellis and Newton’s view of consciousness as a self-organising process, and then (...) go on to compare and contrast the enactive theory with the model of consciousness Chris Frith has outlined in his lectures. (shrink)

Veissière and colleagues make a valiant attempt at reconciling an internalist account of implicit cultural learning with an externalist account that understands social behaviour in terms of its environment-involving dynamics. However, unfortunately the author's attempt to forge a middle way between internalism and externalism fails. We argue their failure stems from the overly individualistic understanding of the perception of cultural affordances they propose.