BackgroundClinical trials should be as inclusive as possible to facilitate equitable access to research and better reflect the population towards which any intervention is aimed. Informed by the UK’s National Institute for Health and Care Research (NIHR) Innovations in Clinical Trial Design and Delivery for the Under-served (INCLUDE) guidance, we audited oncology trials conducted by the Clinical Trials and Statistics Unit at The Institute of Cancer Research, London (ICR-CTSU) to identify whether essential documents were overtly excluding any groups and whether (...) sufficient data were collected to assess diversity of trial participants from groups suggested by INCLUDE as under-served by research in the UK.MethodsThirty cancer clinical trials managed by ICR-CTSU and approved between 2011–2021 were audited. The first ethics approved version of each trial’s protocol, patient information sheet, and patient completed questionnaire, together with the first case report forms (CRFs) version were reviewed. A range of items aligned with the INCLUDE under-served groups were assessed, including age, sex and gender, socio-economic and health factors. The scope did not cover trial processes in participating hospitals.ResultsData relating to participants’ age, ethnic group and health status were well collected and no upper age limit was specified in any trials’ eligibility criteria. 23/30 (77%) information sheets used at least one gendered term to address patients. Most CRFs did not specify whether they were collecting sex or gender and only included male or female categories. The median reading age for information sheets was 15–16 years (IQR: 14–15 – 16–17). Socio-economic factors were not routinely collected and not commonly mentioned in trial protocols.ConclusionsNo systemic issues were identified in protocols which would explicitly prevent any under-served group from participating. Areas for improvement include reducing use of gendered words and improving readability of patient information. The challenge of fully assessing adequate inclusion of under-served populations remains, as socio-economic factors are not routinely collected because they fall beyond the data generally required for protocol-specified trial endpoint assessments. This audit has highlighted the need to agree and standardise demographic data collection to permit adequate monitoring of the under-served groups identified by the NIHR. (shrink)

Judith Suissa and Alice Sullivan’s 2021 paper ‘The Gender Wars, Academic Freedom and Education’ holds that activism associated with the slogan ‘trans women are women’ harms progress towards the goals of shared learning and knowledge production. They hold that shared learning and knowledge production ground the value of the university. In response, we point out that academic freedom is not absolute, and that its contribution to learning and knowledge production is only part of a host of academic goods. Given (...) the hostile environment faced by trans people in the UK, absolute academic freedom in relation to questions about sex, gender, and gender identity should not be taken for granted. The focus of this article is on the following: (1) academic freedom is not absolute and should be responsibly curtailed when it causes harm, or hinders other educational goods; (2) public perceptions of ‘gender debates’ in the UK cause harm and hinder other educational goods; (3) academic debates about sex, gender, and gender identity could contribute to this harm and hindrance and should be undertaken only with care. (shrink)

This paper explains the metaphysical implications of the view that species are individuals (SAI). I first clarify SAI in light of the separate distinctions between individuals and classes, particulars and universals, and abstract and concrete things. I then show why the standard arguments given in defense of SAI are not compelling. Nonetheless, the ontological status of species is linked to the traditional "species problem," in that certain species concepts do entail that species are individuals. I develop the idea that species (...) names are rigid designators and show how this provides additional motivation for SAI. (shrink)

In this paper I use philosophical accounts on the relationship between trust and knowledge in science to apprehend this relationship on the Web. I argue that trust and knowledge are fundamentally entangled in our epistemic practices. Yet despite this fundamental entanglement, we do not trust blindly. Instead we make use of knowledge to rationally place or withdraw trust. We use knowledge about the sources of epistemic content as well as general background knowledge to assess epistemic claims. Hence, although we may (...) have a default to trust, we remain and should remain epistemically vigilant; we look out and need to look out for signs of insincerity and dishonesty in our attempts to know. A fundamental requirement for such vigilance is transparency: in order to critically assess epistemic agents, content and processes, we need to be able to access and address them. On the Web, this request for transparency becomes particularly pressing if (a) trust is placed in unknown human epistemic agents and (b) if it is placed in non-human agents, such as algorithms. I give examples of the entanglement between knowledge and trust on the Web and draw conclusions about the forms of transparency needed in such systems to support epistemically vigilant behaviour, which empowers users to become responsible and accountable knowers. (shrink)

Locke is often cited as a precursor to contemporary natural kind realism. However, careful attention to Locke’s arguments show that he was unequivocally a conventionalist about natural kinds. To the extent that contemporary natural kind realists see themselves as following Locke, they misunderstand what he was trying to do. Locke argues that natural kinds require either dubious metaphysical commitments (e.g., to substantial forms or universals), or a question-begging version of essentialism. Contemporary natural kind realists face a similar dilemma, and should (...) not appeal to Locke in their defense. (shrink)

This paper contributes data from Paraguayan Guaraní (Tupí-Guaraní) to the discussion of how temporal reference is determined in tenseless languages. The empirical focus of this study is on finite clauses headed by verbs inflected only for person/number information, which are compatible only with non-future temporal reference in most matrix clause contexts. The paper first explores the possibility of accounting for the temporal reference of such clauses with a phonologically empty non-future tense morpheme, along the lines of Matthewson’s (Linguist Philos 29:673–713, (...) 2006 ) analysis of a similar phenomenon in St’át’imcets (Salish). This analysis is then contrasted with one according to which temporal reference is not constrained by tense in Paraguayan Guaraní, but only by context and temporal adverbials. A comparison of the two analyses, both of which are couched in a dynamic semantic framework, suggests empirical and theoretical advantages of the tenseless analysis over the tensed one. The paper concludes with a discussion of cross-linguistic variation of temporal reference in tensed and tenseless languages. (shrink)

Many jobs today are alienating: they damage the working person in psychological, mental, intellectual or psychosomatic ways; the psychosomatic damage may be permanent. This ill is due to a disregard for the basic psychological needs not gratified in a large number of workroles. It can be remedied without revolutionizing either the political or the economic-legal systems of pluralist democratic societies. Rather, we should revolutionize the image of the rank-and-file working person and attempt radical experiments in implementing new and democratic structures (...) in the workplace. The feasibility of all this is demonstrated by many successful and viable reforms. These are system-atically overlooked by backward-looking social scientists (Taylorist traditionalists, neo-Marxists and technological determinists). (shrink)

In Ethics 1p5, Spinoza asserts that “In Nature there cannot be two or more substances of the same nature or attribute”. This claim serves as a crucial premise in Spinoza’s argument for substance monism, yet Spinoza’s demonstration of the 1p5 claim is surprisingly brief and appears to have obvious difficulties. This paper answers the principle difficulties that have been raised in response to Spinoza’s argument for 1p5. The key to understanding the 1p5 argument lies in a proper understanding of the (...) substance-attribute relationship and the principles of metaphysical individuation that Spinoza accepts. (shrink)

The article focuses on the study on moral conflicts and ethical relativism. There are few theories in the history ethics that stated that a moral dilemma can not be adhered by to moral requirements. According to philosophy professor David Wong, occurrence of irresolvable moral disagreement is one of the normative problems. On the other hand, the author asserted that single-agent moral conflicts do not necessarily fall under the relativism theory.

I begin with a discussion of the value of privacy and what we lose without it. I then turn to the difficulties of preserving privacy for genetic information and other medical records in the face of advanced information technology. I suggest three alternative public policy approaches to the problem of protecting individual privacy and also preserving databases for genetic research:(1) governmental guidelines and centralized databases, (2) corporate self-regulation, and (3) my hybrid approach. None of these are unproblematic; I discuss strengths (...) and drawbacks of each, emphasizing the importance of protecting the privacy of sensitive medical and genetic information as well as letting information technology flourish to aid patient care, public health and scientific research. (shrink)

This paper begins with a discussion of the value of privacy,especially for medical records in an age of advancing technology.I then examine three alternative approaches to protection ofmedical records: reliance on governmental guidelines, the useof corporate self-regulation, and my own third hybrid view onhow to maintain a presumption in favor of privacy with respectto medical information, safeguarding privacy as vigorously andcomprehensively as possible, without sacrificing the benefitsof new information technology in medicine. None of the threemodels I examine are unproblematic, yet (...) it is crucial to weighthe strengths and weaknesses of these alternative approaches. (shrink)

Selon certains philosophes, le principe « devoir-implique-pouvoir » exprime une vérité analytique et permet d’inférer des énoncés normatifs sur la base de prémisses purement descriptives. Le principe DIP offrirait ainsi un contre-exemple à la fameuse loi de Hume. Le problème est que DIP permet uniquement de construire des raisonnements dont les conclusions sont des négations de normes. Or, selon certains auteurs, les négations de normes n’expriment pas de véritables jugements moraux. En ce sens, selon eux, DIP ne permet pas de (...) tirer des conclusions normatives sur la base de prémisses uniquement descriptives. Dans cet article, nous soutenons au contraire que les négations de normes sont de véritables normes et que DIP permet bien de déduire une conclusion normative à partir de prémisses purement descriptives. (shrink)

Bioethicists appearing in the media have been accused of "shooting from the hip" (Rachels, 1991). The criticism is sometimes justified. We identify some reasons our interactions with the press can have bad results and suggest remedies. In particular we describe a target (fostering better public dialogue), obstacles to hitting the target (such as intrinsic and accidental defects in our knowledge) and suggest some practical ways to surmont those obstacles (including seeking out ways to write or speak at length, rather than (...) in sound bites). We make use of our own research into the way journalists quote bioethicists. We end by suggesting that the profession as a whole look into this question more fully. (shrink)

Surrender-and-catch is a protest against [... our time] and an attempt at remembrance of what a human being can be. The sociology of knowledge is a protest against its hypocrisy and against unexamined social influences. Like surrender, the sociology of knowledge does not fear but passionately seeks what is true and thus, like surrender, is a remembrance, proclamation, and celebration of the spirit. Both ideas, that of the sociology of knowledge and that of surrender, are critical, polemical, radical [...]; so (...) is the sociology of knowledge also in its practice, while in its practice surrender is cognitive live. Using a [...] distinction developed by Mannheim, we may also say that the sociology of knowledge is an extrinsic interpretation of its time, our time; surrender, an intrinsic one: the former is, advocates, and practices such an extrinsic (sociological) interpretation but needs the latter to overcome the relativism it encounters in its practice by its remembrance, rediscovery, reinvention, the catch, of what is common to all human beings, what is universally human (Wolff, 1982., pp. 265–266). (shrink)

Business Ethics and medical ethics are in principle compatible: In particular, the tools of business ethics can be useful to those doing healthcare ethics. Health care could be conducted as a business and maintain its moral core.

HOWARD POOLE ARGUES THAT "THERE IS A RATIONAL NECESSITY LINKING NEGATIVE ATTITUDES TO PORNOGRAPHY WITH A READINESS TO IMPOSE CENSORSHIP." HIS ARGUMENT HAS THREE PREMISES: FIRST, THAT TO CALL SOMETHING OBSCENE IS TO EXPRESS STRONG BUT OFTEN NONMORAL DISAPPROVAL; SECOND, THAT THIS STRONG DISAPPROVAL COMMITS ONE TO SEEK LEGISLATION KEEPING THE MATERIAL FROM CHILDREN; THIRD, THAT SUCH LEGISLATION IS A FORM OF CENSORSHIP. I QUESTION EACH PREMISE.

Reading, a micro-level and subjective activity, is a mechanism through which gender is constructed and reinforced. Drawing on insights from cultural studies and feminist literary critics, and applying sociological perspectives and methodologies, we explored how 53 women and men read and interpreted two short stories, William Faulkner's “A Rose for Emily” and Jayne Anne Phillip's “Home.” We found that the gender of the readers had relatively few effects on their interpretations, but that indicators of life experience were influential. In general, (...) more substantial life experience as reflected in greater age, being married, and having children was associated with more sympathetic, empathic reactions to the major characters. Ideological positions also influenced readers' interpretations, when those positions were relevant to the themes of the text; these individual values and attitudes were associated with more particularistic patterns of empathy. Rather than dismissing gender as an influence on reading, however, we suggest that gender influences reading and interpretation partially through the pervasive gender-markings of social context. (shrink)

One of the most difficult contemporary issues facing the bioethics of clinical research is balancing the maintaining of a universality of ethics standards with a sensitivity to cultural issues and differences. The concept of “vulnerability” for research subjects is especially apt for investigating the ethical and cultural issues surrounding the conduct of genetic research among new immigrants to the United States, using the Sudanese Nuer and Dinka tribes, recently settled in the Midwest, as an example. Issues of cultural vulnerability arise (...) for some immigrants, related to relationship to the earth and to kinship issues, that threaten the narrative richness of a subject's life as well as the way she situates herself in the world. (shrink)

End user participation in design is widely believed to benefit system development. In 1992, when the U.S. National Research Council advocated broadening research in computer science, it strongly recommended collaborative projects in which the user/ application discipline was an equal partner with computer science. This article exam ines the incentives and costs in user-designer relationships and argues that the costs to users are unexpected and often not assumable and that there are asymmetries inherent in the user-designer relationship that destabilize the (...) collaboration. The article draws on a case study of Sequoia 2000, a multimillion dollar collaboration between computerscien tists and global change researchers. (shrink)

Aristotle wrote that "the ultimate purpose in studying ethics is not as it is in other inquiries, the attainment of theoretical knowledge; we are not conducting this inquiry in order to know what virtue is, but in order to become good, else there would be no advantage in studying it." Ethics for Life is a multicultural and interdisciplinary introductory ethics textbook that provides students with an ethics curriculum that has been shown to significantly improve students' ability to make real-life moral (...) decisions. (shrink)

The growing assumption thattransnational corporations (TNCs) will apply``best practice'''' and ``international standards''''in their operations in developing countries hasseldom been checked against close observationof corporate behavior. In this article, Ipresent a case study, based on field research,of one voluntary initiative to useinternational standards and best practice forenvironmental protection in the AmazonRainforest, by a US-based oil company,Occidental Petroleum (Oxy) in Ecuador. The moststriking finding is that the company refuses todisclose the precise standards that apply toits operations. This, and the refusal todisclose other (...) important environmentalinformation, make it impossible to verifyindependently Oxy''s claims of environmentalexcellence, or assess the effectiveness of theinitiative. At the same time, Oxy uses theinvocation of international standards to wrapitself in a veneer of corporate responsibility;reassure government officials and localresidents; cultivate confusion about standardsand practices that apply to the operations;deflect meaningful oversight and transparency;and arbitrarily legitimize norms that have beendefined by special interests. In short,international standards offer great promise forneeded environmental improvements; but can alsobe used to impede, rather than advance,corporate responsibility and the development ofeffective environmental law at the nationallevel. These findings suggest that for theapplication of international standards to bemeaningful, the international community needsto move beyond statements of principle anddevelop mechanisms that can be used toevaluate, verify, and monitor independentlyenvironmental claims by TNCs. (shrink)

General discussion of grounding, including its formal features, relations to other notions, and applications. (Originally published 2014; revised 2021).

Although it is very often taken for granted that there is something fundamental, the literature appears to have developed with little to no careful consideration of what exactly it is that the fundamentalia are supposed to do. If we are to have a good reason to believe that there is something fundamental, we need not only to know what exactly it is that the fundamentalia are invoked for, but why it is that nothing else is available for the task to (...) hand. A good argument in defense of fundamentality, then, will contain an assumption that stipulates an explanatory target; along with a second, crucial, assumption that tells us that no dependent entity is available to do the work that needs to be done. In this paper, I explore both of these assumptions. (shrink)

Contains responses from social critic Judith Butler to essays on her work from across the social sciences, humanities, and behavioral sciences.