Graphical AbstractThe third annual meeting of the EpiGeneSys network brought together epigenetics and systems biologists to report on collaborative projects that apply quantitative approaches to understanding complex epigenetic processes. The figure shown represents one meeting highlight, which was the unexpected emergence of genotype versus epigenotype in control of cell state.

Drawing on philosophy, political and social theory, decision-theory, economics, psychology, history and literature, Jon Elster's classic book Sour Grapes continues and complements the arguments of his acclaimed earlier book, Ulysses and the Sirens. Elster begins with an analysis of the notation of rationality, before tackling the notions of irrational behavior, desires and belief with highly sophisticated arguments that subvert the orthodox theories of rational choice. Presented in a fresh series livery and with a specially commissioned preface written by Richard Holton, (...) illuminating its continuing importance to philosophical enquiry, Sour Grapes has been revived for a new generation of readers. (shrink)

I discuss three recent counterexamples to the transitivity of grounding due to Jonathan Schaffer. I argue that the counterexamples don’t work and draw some conclusions about the relationship between grounding and explanation.

Jon Elster has written a comprehensive, wide-ranging book on the emotions in which he considers the full range of theoretical approaches. Drawing on history, literature, philosophy and psychology, Elster presents a complete account of the role of the emotions in human behaviour. While acknowledging the importance of neurophysiology and laboratory experiment for the study of emotions, Elster argues that the serious student of the emotions can learn more from the great thinkers and writers of the past, from Aristotle to Jane (...) Austen. He attaches particular importance to the work of the French moralists, notably La Rochefoucauld, who demonstrated the way esteem and self-esteem shape human motivation. The book also maintains a running dialogue with economists and rational-choice theorists. Combining methodological and theoretical arguments with empirical case-studies and written with Elster's customary verve and economy, this book has great cross-disciplinary appeal. (shrink)

A truthmaker for a proposition P is exact if it contains nothing irrelevant to P. What are the exact truthmakers for necessitated propositions? This paper makes progress on this issue by showing how to extend Fine’s truthmaker semantics for intuitionistic logic to an exact truthmaker semantics for intuitionistic modal logic. The project is of interest also to the classical logician: while all distinctively classical theorems may be true, they differ from the intuitionistic ones in how they are made true. This (...) sheds new light on the status of the T and B axioms. (shrink)

A logic of grounding where what is grounded can be a collection of truths is a “many-many” logic of ground. The idea that grounding might be irreducibly many-many has recently been suggested by Dasgupta. In this paper I present a range of novel philosophical and logical reasons for being interested in many-many logics of ground. I then show how Fine’s State-Space semantics for the Pure Logic of Ground can be extended to the many-many case, giving rise to the Pure Logic (...) of Many-Many Ground. In the second, more technical, part of the paper, I do two things. First, I present an alternative formalization of plg; this allows us to simplify Fine’s completeness proof for plg. Second, I formalize plmmg using an infinitary sequent calculus and prove that this formalization is sound and complete. (shrink)

Jon Stewart's study is a major re-evaluation of the complex relations between the philosophies of Kierkegaard and Hegel. The standard view on the subject is that Kierkegaard defined himself as explicitly anti-Hegelian, indeed that he viewed Hegel's philosophy with disdain. Jon Stewart shows convincingly that Kierkegaard's criticism was not of Hegel but of a number of contemporary Danish Hegelians. Kierkegaard's own view of Hegel was in fact much more positive to the point where he was directly influenced by some of (...) Hegel's work. Any scholar working in the tradition of Continental philosophy will find this an insightful and provocative book with implications for the subsequent history of philosophy in the twentieth century. The book will also appeal to scholars in religious studies and the history of ideas. (shrink)

In bioethics, the first decade of the twenty-first century was characterized by the emergence of interest in the ethical, legal, and social aspects of neuroscience research. At the same time an ongoing extension of the topics and phenomena addressed by neuroscientists was observed alongside its rise as one of the leading disciplines in the biomedical science. One of these phenomena addressed by neuroscientists and moral psychologists was the neural processes involved in moral decision-making. Today both strands of research are often (...) addressed under the label of neuroethics. To understand this development we recalled literature from 1995 to 2012 stored in the Mainz Neuroethics Database (i) to investigate the quantitative development of scientific publications in neuroethics; (ii) to explore changes in the topics of neuroethics research within the defined time interval; (iii) to illustrate the interdependence of different research topics within the neuroethics literature; (iv) to show the development of the distribution of neuroethics research on peer-reviewed journals; and (v) to display the academic background and affiliations of neuroethics Researchers ... (shrink)

Could φ’s partially grounding ψ itself be a partial ground for ψ? I show that it follows from commonly accepted principles in the logic of ground that this sometimes happens. It also follows from commonly accepted principles that this never happens. I show that this inconsistency turns on different principles than the puzzles of ground already discussed in the literature, and I propose a way of resolving the inconsistency.

Using only uncontentious principles from the logic of ground I construct an infinitely descending chain of ground without a lower bound. I then compare the construction to the constructions due to Dixon and Rabin and Rabern.

Grounding is bicollective if it is possible for some truths δ,δ,... to be grounded in the some truths γ,γ,... without its being the case that each δi is grounded in some subcollection of γ,γ,.... In this paper I show how to do develop a hypergraph-theoretic account of bicollective ground, taking the notion of immediate ground as basic. I also indicate how bicollective ground helps with formulating mathematical structuralism.

"--Daniel Weinstock, University of Montreal "This short book presents a broad synthesis of Jon Elster's work on reason and rationality, and their complex relations to interest and passion.

Seemingly natural principles about the logic of ground generate cycles of ground; how can this be if ground is asymmetric? The goal of the theory of decycling is to find systematic and principled ways of getting rid of such cycles of ground. In this paper—drawing on graph-theoretic and topological ideas—I develop a general framework in which various theories of decycling can be compared. This allows us to improve on proposals made earlier by Fine and Litland. However, it turns out that (...) there is no unique method of decycling. An important upshot is that the notion of asymmetric ground may be indeterminate. (shrink)

Tome I: Afrikaans to Dutch -- Tome II: English -- Tome III: Estonian to Hebrew -- Tome IV: Hungarian to Korean -- Tome V: Latvian to Ukrainian -- Tome VI: Figures A-H -- Tome VII: Figures I-Z.

This essay examines Perth as portrayed through the lyrics of popular songs written by people who grew up in the city. These lyrics tend to reproduce the dominant myths about the city: that it is isolated, that it is self-satisfied, that little happens there. Perth became the focus of song lyrics during the late 1970s time of punk with titles such as ‘Arsehole of the Universe’ and ‘Perth Is a Culture Shock’. Even the Eurogliders’ 1984 hit, ‘Heaven Must Be There’, (...) is based on a rejection of life in Perth. However, Perth was also home to Dave Warner, whose songs in the 1970s and early 1980s offered vignettes, which is itself a title of one of Warner’s tracks, of the youthful, male suburban experience. The essay goes on to examine songs by the Triffids, Bob Evans, Sleepy Township and the Panda Band. (shrink)

The claim that corporations are not people is perhaps the most frequently voiced criticism of the United States Supreme Court decision Citizens United v. Federal Election Commission. There is something obviously correct about this claim. While the nature and extent of obligations with respect to group agents like corporations and labor unions is far from clear, it is manifest in moral understanding and deeply embedded in legal practice that there is no general requirement to treat them like natural persons. Group (...) agents may be denied rights to marry, vote, or run for public office. More generally the need to guard against discrimination, the core injustice in racism and sexism, has no direct application to the case of group agents. There is also something obviously incorrect about the claim that corporations are not people. The legal practice of treating some group agents as persons under law is ancient, found already in Roman law at the time of Justinian. In this essay I propose that reflection on this tension reveals that fundamental revision to the doctrine of legal personhood is needed. More specifically I propose that legal personhood be decomposed into at least two elements—standing and liability—and that legal systems reject the principle that an entity possesses one just in case it possesses the other. The import of this change ramifies broadly. Decomposing legal personhood not only enables a satisfactory account of the status of corporations and labor unions, who as such have liability but not standing, it also enables a satisfactory account of the status of those who as such have standing but not liability: severely mentally disabled persons, very young children, and non-human animals with phenomenal consciousness but lacking capacities to understand reasons and justifications. (shrink)

En el cristianismo, un elemento se eleva por sobre los demás en su darse: la gracia, dación gratuita que Dios otorga a su criatura. Principalmente, la gracia se entiende y estudia como aquel don dado a la naturaleza de la criatura para su complementación o perfección. Sin embargo, el tema no encuentra su agotamiento ahí, pues la gracia también puede ser dispensada para la finalización de un designio intrahistórico, tal como narran los Evangelios.

Hesiod: Kierkegaard and the Greek Gods -- Homer: Kierkegaard's Use of the Homeric Poems -- Plutarch: A Constant Cultural Reference -- Sophocles: The Tragic of Kierkegaard's Modern Antigone -- Index of Persons -- Index of Subjects.

In “Proof-Theoretic Justification of Logic”, building on work by Dummett and Prawitz, I show how to construct use-based meaning-theories for the logical constants. The assertability-conditional meaning-theory takes the meaning of the logical constants to be given by their introduction rules; the consequence-conditional meaning-theory takes the meaning of the logical constants to be given by their elimination rules. I then consider the question: given a set of introduction rules \, what are the strongest elimination rules that are validated by an assertability (...) conditional meaning-theory based on \? I prove that the intuitionistic introduction rules are the strongest rules that are validated by the intuitionistic elimination rules. I then prove that intuitionistic logic is the strongest logic that can be given either an assertability-conditional or consequence-conditional meaning-theory. In “Grounding Grounding” I discuss the notion of grounding. My discussion revolves around the problem of iterated grounding-claims. Suppose that \ grounds \; what grounds that \ grounds that \? I argue that unless we can get a satisfactory answer to this question the notion of grounding will be useless. I discuss and reject some proposed accounts of iterated grounding claims. I then develop a new way of expressing grounding, propose an account of iterated grounding-claims and show how we can develop logics for grounding. In “Is the Vagueness Argument Valid?” I argue that the Vagueness Argument in favor of unrestricted composition isn’t valid. However, if the premisses of the argument are true and the conclusion false, mereological facts fail to supervene on non-mereological facts. I argue that this failure of supervenience is an artifact of the interplay between the necessity and determinacy operators and that it does not mean that mereological facts fail to depend on non-mereological facts. I sketch a deflationary view of ontology to establish this. (shrink)

ABSTRACTCritical Theory and contemporary psychoanalytic perspectives share many compatibilities in offering a constructive critique of society. Psychoanalysis teaches us that whatever values and ideals societies adopt, they are always mediated through unconscious psychic processes that condition the collective in both positive and negative ways, and in terms of relations of recognition and patterns of social justice. Contemporary critical theory may benefit from engaging post-classical and current trends in psychoanalytic thought that have direct bearing on the ways we conceive of and (...) observe how individuals operate within social collectives. In particular, Axel Honneth relies on psychoanalytic sources that are dated. Critical theory would profit from engaging post-object relations schools such as self psychology, analytical psychology, psychoanalytic intersubjectivity theory, relationality, and contemporary attachment theory that are more nuanced yet can supplement Winnicottian perspectives. Implications for contemporary theory need to reflect upon how the psychosocial matrix of self and society both facilitate and hinder optimal social arrangements and fabrics of justice as it takes up the question of normativity. It is within this context that I hope to introduce contemporary psychoanalytic paradigms that move beyond classical models yet complement redirecting shifts in emphasis both psychoanalysis and Critical Theory attempt to accomplish. I suggest that an applied psychoanalytic explication on social phenomenology can expand the interpretive depth and breadth of human relations and open up a permissible space for interdisciplinary discourse. Here new vistas emerge for a proposed synthesis between the two schools of thought. (shrink)

© The Authors 2017. Published by Oxford University Press on behalf of The Analysis Trust. All rights reserved. For Permissions, please email: [email protected] key virtue of Vague Objects and Vague Identity is how it includes so many essays that consider the particular ways vagueness manifests in different kinds of entities, including meanings, part-whole relations, the very small as understood by quantum mechanics, people, sensations, sets, ordinals, cardinals and abstractions. In every case, the author has something interesting to say not just (...) about vagueness but about the metaphysical category in question.One theme that unifies the diverse discussions is Gareth Evans’s brief 1978 note, ‘Can There Be Vague Objects?’ Let ‘▽’ stands for ‘it is indeterminate whether’, ‘λ’ stands for what it does in the lambda calculus, and ‘⊥’ be the absurdity constant. Then, Evans’s initial argument is: ▽ assumptionλx[▽]b 1... (shrink)

This paper examines a number of questions about the degree to which the clinical practice of medicine is affected, if at all, by the legal systems in four countries: Chile, Germany, Japan and the United States. The focus on these four countries in four different regions of the world offers a unique perspective within which to examine medical treatment decisions made by patients and their proxies or surrogates, the potential role for universal written instruments such as advance directives, the cross-professional (...) tensions between clinical and legal concerns in very distinct cultures, and the degree to which legal activities can change or affect clinical realities in the context of these different political and health care systems. We have incorporated, whenever relevant, the insights of many disciplines, including the social sciences, in analyzing the existing interrelations between law and behavior in this specific context. Der Beitrag untersucht, inwieweit die klinische Praxis in vier Ländern mit unterschiedlichen Rechtssystemen und Berufskulturen durch Rechtsnormen oder das Verständnis von Recht beeinflußt wird. Es wird gefragt, welche Funktion rechtliche Interventionen bei der Veränderung von Verhaltensnormen in unterschiedlichen Gesundheitssystemen haben können. Folgende Themenbereiche werden diskutiert: Entscheidungen über die medizinische Behandlung, die von Patienten und ihren Angehörigen oder Stellvertretern getroffen werden; die mögliche Rolle umfassender schriftlicher Verfügungen wie z.B. der Patiententestamente ; die berufsübergreifenden Spannungen zwischen medizinischen und rechtlichen Belangen in sehr unterschiedlichen Kulturen; der Einfluß, den gesetzgeberische Aktivitäten im Kontext der verschiedenen politischen und Gesundheitssysteme auf die medizinische Wirklichkeit haben. Bei ihrer Analyse der in diesem Zusammenhang bestehenden Beziehungen im Verhältnis von Recht und Verhalten haben die Autoren die Erkenntnisse vieler Disziplinen unter Einschluß der Sozialwissenschaften, soweit sie als relevant erscheinen, in ihren Beitrag eingearbeitet. (shrink)

Presenting results from a Norwegian empirical study of student texts and moral education textbooks, this article contributes to the evaluation and development of contextual approaches to moral education. Theoretical perspectives from Seyla Benhabib and Mark Tappan are discussed in the light of empirical data. In particular, while textbooks focus primarily on norm aspects of morality, student texts display interactions between relation‐oriented and norm‐oriented cultural tools, indicating a possible synthesis of care and justice aspects of morality, as suggested by Benhabib. A (...) hegemony of a ‘language of justice’ over a ‘language of care’, as suggested by Benhabib and Tappan, is possibly reflected in the uneven distribution of ethical perspectives in textbooks. Student texts, however, show close interactions between relation‐oriented and norm‐oriented aspects of morality, and also indicate a female superiority in the mastery of both norm‐oriented and relation‐oriented language. (shrink)

Jon Stewart, one of the world’s leading experts on the work of Søren Kierkegaard, has here compiled the most comprehensive single-volume overview of Kierkegaard studies currently available. Includes contributions from an international array of Kierkegaard scholars from across the disciplines Covers all of the major disciplines within the broad field of Kierkegaard research, including philosophy; theology and religious studies; aesthetics, the arts and literary theory; and social sciences and politics Elucidates Kierkegaard’s contribution to each of these areas through examining the (...) sources he drew upon, charting the reception of his ideas, and analyzing his unique conceptual insights into each topic Demystifies the complex field of Kierkegaard studies creating an accessible entry-point into his thought and writings for readers new to his work. (shrink)

The goal of this paper is to expose the research misconduct of pharmaceutical industry-sponsored clinical trials via three short case studies of corrupted psychiatric trials that were conducted in the United States. We discuss the common elements that enable the misrepresentation of clinical trial results including ghostwriting for medical journals, the role of key opinion leaders as co-conspirators with the pharmaceutical industry and the complicity of top medical journals in failing to uphold standards of science and peer review. We conclude (...) that the corruption of industry-sponsored clinical trials is one of the major obstacles facing evidence-based medicine. (shrink)

This chapter examines the conception of the notion of toleration in Great Britain during the seventeenth century. It explores the origin of the concept of toleration and suggests that John Locke's theory in Epistola provides the most decisively philosophical iteration of the British sectarian pluralist argument for toleration in the seventeenth century. The chapter also considers the relevant works of Thomas Hobbes, William Chillingworth, and Roger Williams.