Mistake-making is a common feature of life; it can be given a rigorous theoretical framework. The theory, though, faces a challenge from the ‘functions debate’. Perhaps mistakes are merely malfunctions, so a theory of mistakes requires a stance on functions. However, mistake theory views mistakes as distinct phenomena, not just malfunctions. The functions debate is largely separate from the concept of biological mistakes. While the selected effects theory, for instance, may retain its place within a pluralistic view of function, embracing (...) a robust concept of normativity that goes beyond a relatively narrow conception of function can drive future experimental research. (shrink)

Organisms and other biological entities are mistake-prone: they get things wrong. The entities of pure physics, such as atoms and inorganic molecules, do not make mistakes: they do what they do according to physical law, with no room for error except on the part of the physicist or their theory. We set out a novel framework for understanding biology and its demarcation from physics – that of mistake-making. We distinguish biological mistakes from mere failures. We then propose a rigorous definition (...) of mistakes that, although invoking the concept of function, is compatible with various views about what functions are. The definition of mistake-making is agential, since mistakes do not just happen ¬– at least in the sense analysed here – but are made. This requires, then, a notion of biological agency which we set out as a definition of the Minimal Biological Agent. The paper then considers a series of objections to the theory presented here, along with our replies. Two key features of our theory of mistakes are, first, that it is a supplement to, not a replacement for, existing general frameworks within which biology is understood and practised. Secondly, it is designed to be experimentally productive. Hence we end with a series of case studies where mistake theory can be shown to be useful in the potential generation of research questions and novel hypotheses of interest to the working biologist. (shrink)

Professor J. L. Austin published only reluctantly during his life time so that we are getting much of his major work after his death. I think this an enormous pity as there would be much to be learned from his answers to the criticisms which have already been given to his books by critical reviewers. I differ from many of the reviewers in that I think How To Do Things With Words is one of the most important books, if (...) not the most important, to come out since Wittgenstein's Philosophical Investigations. Like the Investigations, to a superficial glance it exists in isolation. That is, in it there is little discussion of current or traditional philosophical problems and the application of what is said to these problems is a matter, in large part, for the reader. The book itself consists in a set of relatively simple sentences, almost all of them about some aspect of the English language; it therefore represents not so much a problem of interpretation as the problem of which way up we shall look at it. The obvious way to look at it, the way Austin explicitly offers us, is as the Pursuit of the Performative. For reasons I shall give later, I do not think this is the best way to look at it but it is the way with which I shall start. (shrink)

Bringing together powerful new tools from set theory and the philosophy of language, this book proposes a solution to one of the few unresolved paradoxes from antiquity, the Paradox of the Liar. Treating truth as a property of propositions, not sentences, the authors model two distinct conceptions of propositions: one based on the standard notion used by Bertrand Russell, among others, and the other based on J.L. Austin's work on truth. Comparing these two accounts, the authors show that while (...) the Russellian conception of the relation between sentences, propositions, and truth is crucially flawed in limiting cases, the Austinian perspective has fruitful applications to the analysis of semantic paradox. In the course of their study of a language admitting circular reference and containing its own truth predicate, Barwise and Etchemendy also develop a wide range of model-theoretic techniques--based on a new set-theoretic tool, Peter Aczel's theory of hypersets--that open up new avenues in logical and formal semantics. (shrink)

The question Jon Elster addresses in this challenging book is what binds societies together and prevents them from disintegrating into chaos and war. He analyses two concepts of social order: stable, predictable patterns of behaviour, and co-operative behaviour. The book examines various aspects of collective action and bargaining from the perspective of rational-choice theory and the theory of social norms. It is a fundamental assumption of the book that social norms provide an important kind of motivation for action that is (...) irreducible to rationality. The book represents a major statement by Elster, which will be of particular interest to political scientists, political philosophers, sociologists, and economists. (shrink)

The detailed analysis of a particular quasi-historical numerical example is used to illustrate the way in which a Bayesian personalist approach to scientific inference resolves the Duhemian problem of which of a conjunction of hypotheses to reject when they jointly yield a prediction which is refuted. Numbers intended to be approximately historically accurate for my example show, in agreement with the views of Lakatos, that a refutation need have astonishingly little effect on a scientist's confidence in the ‘hard core’ of (...) a successful research programme even when a comparable confirmation would greatly enhance that confidence. Timeo Danaos et dona ferentis. (shrink)

Although he is best known as the founder of pragmatism, the name that Charles Sanders Peirce prefers to use for his comprehensive system of thought is "synechism" because the principle of continuity is its central thesis. This paper arranges and summarizes numerous quotations and citations from his voluminous writings to formalize and explicate his distinctive mathematical conceptions of hyperbolic and topical continuity, both of which are derived from the direct observation of time as their paradigmatic manifestation, and then apply them (...) in normative science and metaphysics, especially logic as semeiotic and cosmology. The resulting conclusion is that the intelligibility of the universe is plausibly explained by conceiving it as one immense sign, a vast inferential process: a semiosic continuum whose connected constituent signs are indefinite until deliberately marked off, with God the Creator as its overall dynamical object in the infinite past and God completely revealed as its overall final interpretant in the infinite future. (shrink)

Bayesian probability is normally defined over a fixed language or eventspace. But in practice language is susceptible to change, and thequestion naturally arises as to how Bayesian degrees of belief shouldchange as language changes. I argue here that this question poses aserious challenge to Bayesianism. The Bayesian may be able to meet thischallenge however, and I outline a practical method for changing degreesof belief over changes in finite propositional languages.

Side effects are ubiquitous in medicine and they often play a role in treatment decisions for patients and clinicians alike. Philosophers and health researchers often use side effects to illustrate issues with contemporary medical research and practice. However, technical definitions of ‘side effect’ differ among health authorities. Thus, determining the side effects of an intervention can differ depending on whose definition we assume. Here I review some of the common definitions of side effect and highlight their issues. In response, I (...) offer an account of side effects as jointly (i) unintended and (ii) effects due to the causal capacities or invariances of an intervention. I discuss (i) by examining the intentions or reasons behind therapeutic interventions, and I discuss (ii) by appealing to a manipulationist model of causation. The analysis here highlights that side effects are conceptually distinct from related outcomes like adverse events, adverse drug reactions, and placebo effects. The analysis also allows for reflection on the utility of ‘side effect’ as a technical term in medical research and practice. (shrink)

Grounding is bicollective if it is possible for some truths δ,δ,... to be grounded in the some truths γ,γ,... without its being the case that each δi is grounded in some subcollection of γ,γ,.... In this paper I show how to do develop a hypergraph-theoretic account of bicollective ground, taking the notion of immediate ground as basic. I also indicate how bicollective ground helps with formulating mathematical structuralism.

Seemingly natural principles about the logic of ground generate cycles of ground; how can this be if ground is asymmetric? The goal of the theory of decycling is to find systematic and principled ways of getting rid of such cycles of ground. In this paper—drawing on graph-theoretic and topological ideas—I develop a general framework in which various theories of decycling can be compared. This allows us to improve on proposals made earlier by Fine and Litland. However, it turns out that (...) there is no unique method of decycling. An important upshot is that the notion of asymmetric ground may be indeterminate. (shrink)

Using a Solomon four-group design, we investigate the effect of a case-based critical thinking intervention on students’ critical thinking skills. We randomly assign 31 sessions of business classes to four groups and collect data from three sources: in-class performance, university records, and Internet surveys. Our 2 × 2 ANOVA results showed no significant between-subjects differences. Contrary to our expectations, students improve their critical thinking skills, with or without the intervention. Female and Caucasian students improve their critical thinking skills, but males (...) and non-Caucasian do not. Positive performance goals and negative mastery goals enhance and decrease improvements of their CTA scores, respectively. ACT and age are related to pre- and post-test. Gender is related to pre-test. GPA is related to post-test. Results shed light on the Pygmalion effect, the Galatea effect, ability, motivation, and opportunity as signals for human capital, and business ethics. (shrink)

A truthmaker for a proposition P is exact if it contains nothing irrelevant to P. What are the exact truthmakers for necessitated propositions? This paper makes progress on this issue by showing how to extend Fine’s truthmaker semantics for intuitionistic logic to an exact truthmaker semantics for intuitionistic modal logic. The project is of interest also to the classical logician: while all distinctively classical theorems may be true, they differ from the intuitionistic ones in how they are made true. This (...) sheds new light on the status of the T and B axioms. (shrink)

It is argued in this paper that the valid argument forms coming under the general heading of Demonstrative Induction have played a highly significant role in the history of theoretical physics. This situation was thoroughly appreciated by several earlier philosophers of science and deserves to be more widely known and understood.

: The present study considers Ibn Sînâ's (Lat. Avicenna) account of induction (istiqra') and experimentation (tajriba). For Ibn Sînâ induction purportedly provided the absolute, necessary and certain first principles of a science. Ibn Sînâ criticized induction, arguing that it can neither guarantee the necessity nor provide the primitiveness required of first principles. In it place, Ibn Sînâ developed a theory of experimentation, which avoids the pitfalls of induction by not providing absolute, but conditional, necessary and certain first principles. The theory (...) of experimentation that emerges though not modern, does have elements that are similar to a modern conception of scientific method. (shrink)

There is a widespread and largely unchallenged assumption within philosophy that the word ‘normal’ is ambiguous: i.e., that it can mean different things in different contexts. This assumption appears in work within topics as varied as the philosophy of biology, medicine, justification, causation, and more. In this paper I argue that we currently lack any independent reason for adopting such an assumption. The reason that would most likely be offered in its favour requires us to ignore an alternative and equally (...) plausible explanation for the seeming variety of different meanings that ‘normal’ is taken to have. Meanwhile, the well-known conjunction reduction test for ambiguity provides no evidence for the ambiguity of ‘normal’, and in fact suggests that maintaining this ambiguity claim is more difficult than has been initially supposed. Therefore, with the way things stand at present, it should not be assumed without argument that ‘normal’ is an ambiguous term. (shrink)

Casgevy, the world’s first approved CRISPR-based cell therapy, has been priced at $2.2 million per patient. Although this hefty price tag was widely anticipated, the extremely high cost of this and other cell and gene therapies poses a major ethical issue in terms of equitable access and global health. In this Perspective, we argue that lowering the prices of future CRISPR therapies is an urgent ethical imperative. Although we focus on Casgevy as a case study, much of our analysis can (...) be extrapolated to the controversies over affordable access to other gene and cell therapies. First, we explain why this first-of-its-kind CRISPR therapy might be so expensive. We then analyze the ethical issues of equity and global health of early CRISPR treatments. Next, we discuss potential solutions to lower the prices of CRISPR gene therapies. We conclude that the approval of CRISPR transforms our obligations of justice and compels us to bring future gene therapies to the maximum possible number of patients with serious genetic diseases at affordable prices. (shrink)

La metateoría estructuralista concibe las teorías científicas como redes formadas por elementos teóricos que poseen la misma estructura conceptual y están interconectados por relaciones de especialización. Además, postula que gran parte de la práctica científica tiene como fin concretar el elemento básico de estas redes añadiéndoles elementos más especializados. Así, pues, concibe el núcleo básico de elementos de una teoría como el paradigma que guía su evolución y la práctica científica normal como la adición, a redes preexistentes, de nuevos elementos (...) teóricos. En el artículo se propone que, en la ecología de poblaciones, el patrón de la actividad científica es diferente, pues es habitual el uso conjunto de elementos de distintas redes. Se introduce la noción de “constelación teórica” para dar cuenta de estas prácticas científicas de integración, en una misma unidad epistémica, de elementos teóricos de redes distintas. (shrink)

Post-market pharmaceutical surveillance or ‘pharmacovigilance’ relies on the reporting of suspected adverse drug reactions to regulatory databases. Recently, more ‘active’ methods that directly involve patients in identifying and reporting suspected adverse drug reactions have been suggested. This is different than traditional ‘passive’ methods, e.g., using databases without contacting patients directly. Though there are benefits to active pharmacovigilance, it is not without its potential risks. Here I highlight one of those risks – the nocebo effect. Nocebo effects are harms that are (...) thought to arise by conditioning or negative expectation. If a patient engaged in active pharmacovigilance is improperly motivated to seek out and report suspected adverse drug reactions, nocebo harms can occur. Not only is this a bioethical concern about harm, but it is also an epistemic or data-quality problem. Since nocebo effects are not due to the pharmacological properties of the drugs under investigation, nocebo effects reported as suspected adverse drug reactions constitute false positives in these databases. (shrink)

The prospect of human genetic enhancement requires an institutional response, and probably the creation of new institutions. The governance of genetic enhancement technologies, moreover, needs to be global in scope. In this article, I analyze the debate on the global governance of human genetic enhancement. I begin by offering a philosophical justification for the need to adopt a global framework for governance of technologies that would facilitate the improvement of non-pathological genetic traits. I then summarize the main concrete proposals that (...) have recently emerged to govern genome editing at the global level. Finally, I develop some impediments that limit the impetus for global governance of genetic enhancement. (shrink)

Asa Gray , a Harvard botanist, was America's foremost interpreter and defender of the ideas of Charles Darwin and, like Darwin, a proponent of theistic evolution.

In lieu of an abstract, here is a brief excerpt of the content:Philosophy and Rhetoric 39.1 (2006) 72-84 [Access article in PDF] "The Limbo of Ethical Simulacra": A Reply to Ron Greene Dana L. Cloud Department of Communication Studies University of Texas, Austin Steve Macek Department of Speech Communication North Central College James Arnt Aune Department of Communication Texas A&M University In two recent articles, "Another Materialist Rhetoric," and "Rhetoric and Capitalism" (1998, 2004), Ronald Walter Greene pays considerable attention (...) to Marxist rhetorical theory, especially the work of Dana L. Cloud (1994, 2001a, 2001b, 2002) and James Arnt Aune (1994, 2001). These essays usefully point up what is at stake in the debate between poststructuralist theory and Marxism: whether an instrumental, class-based, socialist critical and political project is still feasible and necessary in today's world. Rejecting both Aune's Marxist-humanist approach and Cloud's more economic vision of agency, Greene claims that the changing character of global capitalism and recognition of the "constitutive power" of discourse render rhetorical criticism and practical politics on a Marxist basis untenable. Although we appreciate Greene's engagement with Marxism, we contend that the arguments sketched out in his essays are theoretically and politically flawed.First, Greene's criticisms are directed against a crude caricature of Marxist epistemology that obscures the complexity of theories of representation and ideology in the historical materialist tradition. Second, underwriting Greene's entire project are confused, and in some cases demonstrably false, assessments of the nature and historical trajectory of world capitalism and of the current prospects for class-based social movements. Finally, Greene endorses something like a democratic project but offers no normative criteria for such a project beyond the immanence of always-already present communicative agency and the excesses of joy afforded (to some) by the capitalist system. We will examine each of these shortcomings in turn. [End Page 72] Real Lies: The Complexity of Marxist Epistemology Greene and other poststructuralists charge Marxist theorists in the field of rhetorical studies with holding a dubious representational theory of truth.1 In contrast, Greene embraces a critical approach that examines "how rhetorical practices create the conditions of possibility for a governing apparatus to judge and program reality" and that views "what is in the true" as rhetorically produced (1998, 22). At odds with Greene's approach, Marxists claim that, in a range of ways, ideological discourses reflect, distort, and/or negotiate with the objective social realities, interests, and lived experiences of contending classes in capitalist society. Moreover, we believe that—by means of interpretive, historical, and empirical research—Marxist scholars and activists may develop fuller and more accurate theoretical "representations" of such realities and interests and of the various ways they shape our lives and our political struggles.2This is not to say, however, that the process is simple or mechanistic. Marxist critical practice retains the evaluative power of realism without laying claim to absolute or unmediated empirical knowledge; moreover, we do not believe that ideas are mechanistically generated epiphenomena of economic motive. Discourses, as any communication scholar would agree and as Greene points out, do have effects or "effectivities." Yet anyone interested in a normative political project (which Greene wishes to escape, a point to which we shall return) must recognize the possibility of falsehood. However, as Raymond Geuss (1981) argues, falsehood is not only a matter of empirical misrepresentation. In addition to epistemic falsehood, ideological discourses may exhibit both functional falsehood (referring to how even plausible ideas can bolster oppressive power) and genetic falsehood (ideas promulgated by those with ulterior motives, or intentional mystification).Similarly, analytic Marxist Jon Elster (1985) offers a view of ideology that regards discourses as more than simple epiphenomena of economic situations and struggles.3 Elster describes three overlapping forms of ideological production: the interest-based dissemination of distorted ideas, the failure of social imagination associated with widespread support for the capitalist system and U.S. imperialism, and the psychological comfort of palliative discourses such as religion and patriotism.4 Understanding how widespread adherence to common-sense ideas is accomplished is a project central to... (shrink)

Considering public moral attitudes is a hallmark of the anticipatory governance of emerging biotechnologies, such as heritable human genome editing. However, such anticipatory governance often overlooks that future morality is open to change and that future generations may perform different moral assessments on the very biotechnologies we are trying to govern in the present. In this article, we identify an ’anticipatory gap’ that has not been sufficiently addressed in the discussion on the public governance of heritable genome editing, namely, uncertainty (...) about the moral visions of future generations about the emerging applications that we are currently attempting to govern now. This paper motivates the relevance of this anticipatory gap, identifying the challenges it generates and offering various recommendations so that moral uncertainty does not lead to governance paralysis with regard to human germline genome editing. (shrink)

Until approximately twenty years ago, advances in the study of human genetics had little influence on the practice of medicine. In the 1980s, this changed dramatically with the mapping of the altered genes that cause cystic fibrosis and Huntington disease. In just a few years, these discoveries led to DNA-based tests that enabled clinicians to determine whether prospective parents were carriers of CF or whether an individual carried the Huntington gene and, as a result, would almost certainly develop the disease.Observers (...) interested in the social and economic implications of genetic technology realized that such genetic tests could be used by insurance companies to predict which insurance applicants were likely to become ill or even die from these diseases. (shrink)