Given the promise of stem cell therapies, scientists throughout the world are conducting stem cell research using various kinds of stem cells including human embryonic stem cells. However, HESC research is very controversial in some societies as the extraction of stem cells involves the destruction of the human embryo. The ethical concerns of this kind of research have led scientists to search for other methods to derive stem cells that do not involve the destruction of embryos. These different types of (...) stem cell research are said to sidestep the ethical dilemma associated with HESC research and so are considered as ethically acceptable ways to obtain stem cells; possibly, they may even mark the end of HESC research. However, each of these stem cell methods presents its own challenges, scientific and ethical, as this article explores. This paper examines the impact of the emergence of different types of stem cell research and discusses whether it is still necessary for scientists to conduct the contentious HESC research. (shrink)

The secretory pathway delivers proteins synthesized at the rough endoplasmic reticulum (RER) to various subcellular locations via the Golgi apparatus. Currently, efforts are focused on understanding the molecular machineries driving individual processes at the RER and Golgi that package, modify and transport proteins. However, studies are routinely performed using non‐dividing cells. This obscures the critical issue of how the secretory pathway is affected by cell division. Indeed, several studies have indicated that protein trafficking is down‐regulated during mitosis. Moreover, the RER (...) and Golgi apparatus exhibit gross reorganization in mitosis. Here I provide a relatively neglected perspective of how the mitotic cyclin‐dependent kinase (CDK1) could regulate various stages of the secretory pathway. I highlight several aspects of the mitotic control of protein trafficking that remain unresolved and suggest that further studies on how the mitotic CDK1 influences the secretory pathway are necessary to obtain a deeper understanding of protein transport. (shrink)

This article explores the notion of the unconscious (das Unbewusste) in terms of its nature and constitutive manifestations in consciousness. In contrast to the psychoanalytic formulation, the unconscious is conceptualized here distinctively as sedimentation (die Sedimentierung) within the Husserlian framework. All `experiences sediment and are “stored” in a darkened, affectless region of the psyche, which is nonetheless not in any sense separated from the sphere of consciousness. Rather, the sedimented experiences move dynamically between the unconscious and consciousness, constantly affecting and (...) manifesting in the upcoming conscious activities of the subject. Based on this conceptualization, I suggest a schematic understanding of the manifestations of the unconscious, or sedimentation, in consciousness. The conceptual division of consciousness into the sphere of understanding (Verstandessphäre), sphere of affect (Gemütssphäre) and sphere of volition (Willenssphäre) allows us to speak of the corresponding threefold manifestations of the unconscious in each of these spheres as type (Typus), mood (Stimmung) and habits (Habitus). Having their genetic “origin” in sedimented experiences, these structural moments play a constitutive role in upcoming conscious activities of the intentional subject. Furthermore, I demonstrate that each of these moments is characterized by a distinctive kind of horizonality, in light of which a deepened understanding of the genetic concept of horizon-consciousness (Horizontbewusstsein) is obtained. Despite the conceptual tripartition, I emphasize at the end the essential intertwinement of the three structural moments in such conscious performance as association. (shrink)

In this paper I argue that a greater understanding of the part of ethics in leadership will improve leadership studies. Debates over thedefinition of leadership are really debates over what researchers think constitutes good leadership. The ultimate question is not “What is leadership?” but “What is good leadership?” The word good is refers to both ethics and competence. Research into leadership ethics would explore the ethical issues of current leadership research, serve as a critical study of the field, analyze and (...) expand normative theories of leadership, and develop new theories, research questions and ways of thinking about leadership. (shrink)

Despite his producing voluminous writings beyond Utopia, scholarly consensus seems to be that if we want to understand the political thought of Thomas More, we must turn to this ‘little book’. This approach, however, has yielded little consensus about how to categorise More as a political thinker, as Utopia is notoriously and intentionally enigmatic. This article attempts to generate a portrait of More as a political thinker by going beyond an investigation of Utopia alone and taking into consideration those texts (...) often overlooked or rejected by scholars, primarily his polemical and religious writings. Doing so provides an outline of More as a thinker concerned with themes of natural and artificial inequality, popular authority and representation and, at the least, justifies the exercise of reading More’s work beyond Utopia. (shrink)

"Over many centuries, philosophers, theologians, and poets have been fascinated by the interplay of will and desire in the human psyche. Does will follow or precede desire? How can we bond them and thus unite body, soul, and spirit in harmonic concord? For fresh insights to these age-old questions, Dr. Joanne Stroud enlists the tools of modern psychology. Her eclectic probe of basic human drives moves from the awesome power of Eros, the great liberator of antiquity, through the impact (...) of the monotheistic faiths on will and desire, and finally to the discordant views of the great philosophers and psychologists of the modern era, among them Nietzsche, Freud, Jung, and the little known but magnetic Frenchman, Gaston Bachelard." "Love and will, human aspirations and desires, are caught - the author concludes - in a whirlwind of change, with impersonal scientific data supplanting the myths, the ancient lore, the stories rich in imagery, that previously contoured human behavior. As a result we live, in W.B. Yeat's famous phrase, in "the age of disordered will."" "In the twentieth century will became recognized only in its more conscious applications, as almost synonymous with ego. With this increasing reverence for the strong ego, will was elevated (by psychologists, among many others) to new egotistical summits as a potent tool of power. The more subtle aspects of will, such as the way it delineates identity, have been neglected, the author contends, and can only be recaptured by an understanding of how will becomes bonded to desire."--BOOK JACKET.Title Summary field provided by Blackwell North America, Inc. All Rights Reserved. (shrink)

Understanding the nature of science has long been a desired outcome of science education, despite ongoing disagreements about the content, structure, and focus of NOS expectations. Addressing the concern that teachers likely focus only on student learning expectations appearing in standards documents, this study examines the current state of NOS in science education standards documents from nine diverse countries to determine the overt NOS learning expectations that appeared, NOS statements provided near those learning expectations, but not identified as learning outcomes, (...) and NOS statements found in ancillary text. Findings indicate that NOS ideas rarely occur as expectations for student learning and are far more commonly found in ancillary material. Moreover, consensus was not apparent in the overt learning outcomes for students. Given the well-documented poor state of NOS instruction and the consistent lack of NOS appearing in published curriculum materials, the NOS standards appearing in nearly all documents analyzed are unlikely to provide sufficient conceptual or pedagogical support for NOS to be accurately interpreted or translated into meaningful experiences for students. (shrink)

Unlike many commentators who tend to see Schweitzer's mission one-sidedly, I show the coexistence of liberal and conservative elements in his mission. While his mission intent was mostly motivated by the former, his mission practices largely show the latter. In this essay, I analyze them in detail in three parts. I first explain how such opposite elements can coexist by applying Dipesh Chakrabarty's notion of provincializing Europe. Like most nineteenth-century Western liberals, Schweitzer advocated Enlightenment rights for Europeans, but denied them (...) to the colonized. I then argue that Schweitzer's mission was motivated by the liberal elements of his theology. When his critical theology led him to deny the divinity of Jesus, he found a new basis for Christianity in Jesus? ethical activism, which led him to become a medical missionary to Africa. I then examine Schweitzer's conservative practices in Africa: by applying the developmental model of Hegelian-Marxist historicism to African society, Schweitzer opposed both decolonization and advanced learning to Africans. Schweitzer's missionary practices in Africa, I therefore conclude, were more conservative than those of the typical European missionary. (shrink)

As the first monograph on waiting in Christian traditions, this study breaks new ground by revealing how waiting becomes a stabilizing force that helps to solidify Christian identity and community. It analyzes various forms of Christian waiting through the lens of Paul Ricoeur’s ideas about ideology and utopia.

This is a review article of Corpus of Mesopotamian Anti-Witchcraft Rituals, vol. 1. By Tzvi Abusch and Daniel Schwemer. Ancient Magic and Divination, vol. 8/1. Leiden: Brill, 2011. Pp. xvi + 482, plates. $255.

There is little empirical evidence showing a direct link between a capacity for statistical learning (SL) and proficiency with natural language. Moreover, discussion of the role of SL in language acquisition has seldom focused on literacy development. Our study addressed these issues by investigating the relationship between SL and reading ability in typically developing children and healthy adults. We tested SL using visually presented stimuli within a triplet learning paradigm and examined reading ability by administering the Wide Range Achievement Test (...) (WRAT-4; Wilkinson & Robertson, 2006). A total of 38 typically developing children (mean age of 9;5 years, range 6;4–12;5) and 37 healthy adults (mean age of 21 years, range 18–34) were assessed. In children, SL was significantly related to reading ability. Importantly, this relationship was independent of grade and also age. The adult data, too, revealed that SL was significantly related to reading ability. A regression analysis of the combined child and adult data revealed that SL accounted for a unique amount of variance in reading ability, after age and attention had been taken into consideration. For the first time, this study provides empirical evidence that a capacity for more effective SL is related to higher reading ability in the general population. (shrink)

In spite of some recent bad news coming out of America our Associate Editor reports positively on the business ethics scene there both in the business community and in a recent major Conference. She holds the Coston Family Chair in Leadership and Ethics at Jepson School of Leadership Studies, University of Richmond, Richmond, Virginia 23173, USA.

Now reissued in hardback, this classic uses an apple to effectively explain the Holy Trinity to young children. Children learn that God is three persons--Father, Son, and Holy Spirit--but is one God. Features refreshed artwork.

The thought of Thomas More -- Early life, education, and poetry -- Utopia and common things -- Richard III and the stage play of politics -- The common corps of Christendom -- Influence.

It is often assumed that pet ownership improves peoples’ wellbeing, but evidence of this pet effect has been mixed. We extended past research on pet personality, the pet effect, and value congruence to examine whether people perceive their pets to have humanlike values and if owner-pet values similarity has a positive effect on owners’ life satisfaction. In a large and diverse sample of Australian dog and cat owners, we find that people imbue their dogs and cats with humanlike values in (...) a way that reflects the theoretical circular structure of values. Importantly, perceptions of the values of dogs and cats differed in that dogs were perceived to prioritize more social-focus values, whereas cats were perceived to prioritize more personal-focus values. Additionally, we find that similarity in the values profile of dog owners and their dogs is positively associated with life satisfaction, but this was not the case for cats. However, when we examined associations between individual values similarity and life satisfaction, our results suggest a more complex and nuanced picture of both direct and indirect similarity effects. (shrink)

BackgroundFear of cancer recurrence is common amongst cancer survivors. There is rapidly growing research interest in FCR but a need to prioritize research to address the most pressing clinical issues and reduce duplication and fragmentation of effort. This study aimed to establish international consensus among clinical and academic FCR experts regarding priorities for FCR research.MethodsMembers of the International Psycho-oncology Society Fear of Cancer Recurrence Special Interest Group were invited to participate in an online Delphi study. Research domains identified in Round (...) 1 were presented and discussed at a focus group to consolidate the domains and items prior to presentation in further survey rounds aimed at gaining consensus on research priorities of international significance.ResultsThirty four research items were identified in Round 1 and 33 of the items were consolidated into six overarching themes through a focus group discussion with FCR experts. The 33 research items were presented in subsequent rounds of the delphi technique. Twenty one participants contributed to delphi round 1, 16 in round 2, and 25 and 29 participants for subsequent delphi rounds. Consensus was reached for 27 items in round 3.1. A further four research items were identified by panelists and included in round 3.2. After round 3.2, 35 individual research items were ratified by the panelists. Given the high levels of consensus and stability between rounds, no further rounds were conducted. Overall intervention research was considered the most important focus for FCR research. Panelists identified models of care that facilitate greater access to FCR treatment and evaluation of the effectiveness of FCR interventions in real world settings as the two research items of highest priority. Defining the mechanisms of action and active components across FCR/P interventions was the third highest priority identified.ConclusionThe findings of this study outline a research agenda for international FCR research. Intervention research to identify models of care that increase access to treatment are based on a flexible approach based on symptom severity and can be delivered within routine clinical care were identified as research areas to prioritize. Greater understanding of the active components and mechanisms of action of existing FCR interventions will facilitate increased tailoring of interventions to meet patient need. (shrink)

Angelaki, Volume 16, Issue 4, Page 73-85, December 2011.

of (from British Columbia Philosophy Graduate Conference) In moral reasoning, we sometimes encounter situations where what our ethical principles tell us to do and what we actually do conflict. In legal ethics, such anomalies arise for lawyers in defending a client who commits perjury. Wallace argues that such lawyers have not mastered the practice of truth-telling, and thus suffer from some sort of moral deficiency. However, due to the complexities of legal practice, particularly the value of truth and evidence, lawyers (...) must learn to accommodate cases of perjury into their moral taxonomies, and this is not a simple feat. In addition, I examine the ethics of lying in everyday life, such as in cases of protecting reputation or feelings. As such, I posit that Wallace is oversimplifying the situation and individuals in “perjured client” cases actually have a better and more realistic grasp on the exercise of practical ethics than he claims. (shrink)

Advances in science have led to a new vision for toxicity testing based on human cell systems that will be more predictive, have higher throughput, cost less money, and be more comparable to real‐life exposures in humans, while using many fewer animals. This vision, embraced by leading scientific and regulatory groups, is a paradigm shift from animal‐based to human‐based testing that signals a major change in focus and promotes the development of new approaches to understanding the toxicity of chemicals in (...) humans. Information gained from these new approaches will likely affect other areas of research as well, leading to less reliance on animals in the future. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Joanne Wood LORDJIM AND THE CONSEQUENCES OF KANTIAN AUTONOMY Autonomy IS the fundamental principle of Kantian ethics. This is so because his moral system is based on the crucial idea that nothing in the world can be called "good without qualification except a good will."1 Thus a good will is good in and of itself, without regard to any possible end. For such a will, morality is categorical, (...) for only with such an imperative can moral laws be said to be laws ofcomplete freedom, and willed without regard to any other interest. Thus autonomy is a necessary condition for a good will, because any heteronomous worth a will could achieve would by definition be conditional, and would therefore violate Kant's notion of the unconditional worth of a good will. However, it is precisely this notion of the absolute worth a good will merits on its own that would seem to bear looking into: there is something intuitively wrong with Kant's assertion that even if"it should happen that, by a particularly unfortunate fate or by the niggardly provision of a stepmotherly nature, this will should be wholly lacking in power to accomplish its purpose," it would still "sparkle like a jewel in its own right, as something that had its full worth in itselP (p. 10). The idea implied in this passage, that a good will could exist somehow apart from the world and any effects achieved therein, is problematic to say the least. How could such a will be known? The metaphor ofa "sparklingjewel" is striking, but flawed: ajewel exists in the world, for all eyes to see if they know where to look, whereas a good will exists in the hearts of men. It is for this reason thatJoseph Conrad's LordJim is a fitting supplement to understanding the implications of a Kantian view of morality, for the central concern of the novel is the moral ambiguity that results from our common obscurity ofvision into ourselves and those around us. Given this 57 58Philosophy and Literature ambiguity, which Kant recognizes when he says, "even the strictest examination can never lead us entirely behind the secret incentives, for, when moral worth is in question, it is not a matter of actions which one sees but ofdieir inner principles which one does not see" (p. 23). It seems then irresponsible still to maintain that the worth ofa good will is independent of the way of the world. Since it is evident that if results or other empirical factors are invalid tojudge intentions, then the only judge capable of assessing in advance what maxim is being acted upon is the moral agent; morality becomes a matter of strictly individual conscience or reason. The moral agent thus becomes romanticized, a lone figure needing no other guidance than that which his or her own reason can provide in order to lead a truly good life. LordJim challenges just such a conception of individualist or self-sufficient morality. Due to the essential ambiguity ofwhatjim himselfis, the novel is an extremely difficult one to read. This is further complicated by the fact that, after the first four chapters, the reader is never given an impersonal view ofJim, but instead Marlow's painstaking efforts to fit together the puzzle ofJim's character: "I don't pretend I understood him. The views he let me have of himself were like those glimpses through the shifting rents in a thick fog— bits of vivid and vanishing detail, giving no connected idea of the general aspect of a country... they were no good for purposes of orientation."2 Given this cloud of uncertainty, Jim remains an enigma from beginning to end. The reader is treated to various judgments ofhim during this time from a wide range of viewpoints which Marlow perhaps pursues in an effort to shed some light on the subject, but which nonetheless leave us in darkness because they all omit one factor or another. There is no Authority in this book. The facts ofJim's case are relatively straightforward: it is the interpretation of what lies behind them, ofJim's "inner principles," which is extraordinarily complex. Jim is working as first mate on... (shrink)

Environmental journalism has been criticized by various special interest groups and some editors for advocacy and faulted for inaccuracies. Sources, in turn, many from the science communities, have been accused of inaccessibility, and public relations representatiws from both industry and environmental organizations are regularly blamed for unethical behaviors rangingfrom hyperbole to more serious discussion or omission of factual information. This article reports a preliminary study of ethical decision making among members of the Society of Environmental Journalists, identifying ethical motivation diljerences (...) using the Ethical Motivation Scale. The implications of the reported dominant extrinsic guides are discussed in light of a proposed protocol for ethical environmental communication. (shrink)

The relation between Australia’s First Nations peoples and settler-colonial Australians may be characterised as having “miscarried” to the extent that colonial difference is unacknowledged,...

This paper argues that the figure of the child performs a critical function for the middle-class social imaginary, representing both an essential “innocence” of the liberal individual, and an excluded, unconscious remainder of its project of control through the management of knowledge. While childhood is invested with affect and value, children’s agency and opportunities for social participation are restricted insofar as they are seen both to represent an elementary humanity and to fall short of full rationality, citizenship and identity. The (...) diverse permutations of this figure, as it develops in the middle-class imagination, are traced from the writings of John Locke to the films of Michael Haneke (via Charles Dickens and Henry James), to interrogate what this ambivalence regarding childhood reflects about middle-class, adult identity. (shrink)

This address uses the question “Is business ethics getting better?” as a heuristic for discussing the importance of history in understanding business and ethics. The paper uses a number of examples to illustrate how the same ethical problems in business have been around for a long time. It describes early attempts at the Harvard Business School to use business history as a means of teaching students about moral and social values. In the end, the author suggests that history may be (...) another way to teach ethics, enrich business ethics courses, and develop the perspective and vision in future business leaders. (shrink)

Chapters in this outstanding text are grouped into sections focusing on major themes. Each features an overview, a debate chapter, and several viewpoint chapters. This format gives students the opportunity fo analyze conflicting viewpoints and encourages critical thinking. The text boasts a well-known and well-respected author group, allowing students to learn from recognized leaders in the field. (Includes a FREE MERLIN website. at:www.harcourthealth.com/merlin/Dochterman/current/).

This piece returns to the writer’s memoir essays about her mother’s chronic lung disease to examine the relationship between the act of caregiving and the act of writing. In arguing for important differences between the clinical, healing imperatives of narrative medicine and the primacy for the writer of self-reflection, personal need and career, the essay demonstrates how writing remains in many ways at odds with the obligations and the hopes of caregiving. At the same time, the essay argues that writing (...) her mother’s stories of illness holds the potential for both honor and mutuality—and can, in fact, constitute a form of caregiving. (shrink)