A recent paper shows that in gene expression space the manifold spanned by normal tissues and the manifold spanned by the corresponding tumors are disjoint. The statement is based on a two-dimensional projection of gene expression data. In the present paper, we show that, for the multi-dimensional vectors defining the centers of cloud samples: 1. The closest tumor to a given normal tissue is the tumor developed in that tissue, 2. Two normal tissues define quasi-orthogonal directions, 3. A tumor may (...) have a projection onto its corresponding normal tissue, but it is quasi-orthogonal to all other normal tissues, and 4. The cancer manifold is roughly obtained by translating the normal tissue manifold along an orthogonal direction defined by a global cancer progression axis. These geometrical properties add a new characterization of normal tissues and tumors and may have biological significance. Indeed, normal tissues at the vertices of a high-dimensional simplex could indicate genotype optimization for given tissue functions, and a way of avoiding errors in embryonary development. On the other hand, the cancer progression axis could define relevant pan-cancer genes and seems to be consistent with the atavistic theory of tumors. (shrink)

O que surge de uma descrição fenomenológica das experiências de tontura e vertigem para uma teoria fenomenológica geral da constituição do mundo? O que surge dessa contribuição para o projeto geral de uma fenomenologia da dor? Neste artigo, tentamos responder a ambas as perguntas, mostrando as suas ligações íntimas. Para isto, será necessário fazer uma descrição fenomenológica de ambos os fenómenos que permita mostrar as possíveis limitações de respetiva determinação clínica, recentemente estabelecidas por autores como Bisdorff, Von Brevern, Lempert e (...) Newman-‑Toker. Através de sucessivas descrições fenomenológicas da experiência de vertigem e tontura, tentaremos mostrar a importância do eixo da verticalidade na teoria fenomenológica da constituição do mundo, bem como a sua relação com o eixo da horizontalidade. (shrink)

Resumen En el año 2022 se celebra el 1900 aniversario de la visita del emperador Adriano a Hispania. La bibliografía científica ya ha estudiado este acontecimiento, aclarando muchos de los sucesos, la identidad de algunos de los personajes que pudieron venir con el Príncipe y las actuaciones de éste en la península Ibérica. En algunos casos, los testimonios conocidos no permiten una datación que los sitúe durante la presencia imperial en el territorio. Quedan también algunas incógnitas, como el verdadero recorrido (...) de su viaje. Este trabajo tiene un doble objetivo: hacer un estado de la cuestión sobre la visita e identificar los preparativos que se hicieron en Hispania ante el anuncio de un viaje de Adriano. Las iniciativas parecen haber afectado a las tres provincias, que se habrían preparado para la estancia o incluso para el posible paso de la comitiva por sus territorios, aunque en muchos casos esto no llegara a ocurrir. (shrink)

Background: The decision whether to initiate cardiopulmonary resuscitation may sometimes be ethically complex. While studies have addressed some of these issues, along with the role of nurses in cardiopulmonary resuscitation, most have not considered the importance of nurses acting as advocates for their patients with respect to cardiopulmonary resuscitation. Research objective: To explore what the nurse’s advocacy role is in cardiopulmonary resuscitation from the perspective of patients, relatives, and health professionals in the Basque Country (Spain). Research design: An exploratory critical (...) qualitative study was conducted from October 2015 to March 2016. Thematic analysis was used to analyse the data. Participants: Four discussion groups were held: one with patients and relatives (n = 8), two with nurses (n = 7 and n = 6, respectively), and one with physicians (n = 5). Ethical considerations: Approval was obtained from the Basque Country Clinical Research Ethics Committee. Findings: Three significant themes were identified: (a) accompanying patients during end of life in a context of medical dominance, (b) maintaining the pact of silence, and (c) yielding to legal uncertainty and concerns. Discussion: The values and beliefs of the actors involved, as well as pre-established social and institutional rules reduced nurses’ advocacy to that of intermediaries between the physician and the family within the hospital environment. On the contrary, in primary health care, nurses participated more actively within the interdisciplinary team. Conclusion: This study provides key information for the improvement and empowerment for ethical nursing practice in a cardiac arrest, and provides the perspective of patients and relatives, nurses and physicians. (shrink)

Our aim in this article is to put into practice, in the field of social sciences, the principles that Husserl displayed in his book from 1936, "The crisis of European sciences and transcendental phenomenology”. In that seminal work, Husserl reflected on the mathematization of nature and produced an historical meditation on the essence of geometry. Here we will try to extend the reach of Husserlian postulates in order to deal with economics and, more specifically, with the theory of money. We (...) think that, in certain social sciences, and in particular in those with a clear mathematical penchant like economics, the use of formalization often helps to cover an uncritical use of phenomenologically ungrounded idealizations. This fact ultimately results in a massive concealment of the true sense of some of its principal phenomenanamely, money. It is worth mentioning that this concern does not have its roots only in phenomenology, for even academic monetary theory openly acknowledges that we lack an understanding of the meaning of money which could help us clarify and prevent financial crisis and economic collapses. Crisis, in short, are not the result of a deep understanding of the concept of money; on the contrary, they highlight the fact that we don’t really know what money is. Thus, our goal here is to illustrate the possibilities offered by the phenomenological method in its application to the question of money. It is in this sense that the research taking place here can be understood as a “phenomenological critique of monetary theory”.En el presente artículo se pretende llevar a cabo una aplicación de los principios que Husserl lleva a cabo en su obra de 1936, “La crisis de las ciencias europeas y la fenomenología transcendental”, a las ciencias sociales; concretamente, al concepto de dinero. En su obra de 1936, Husserl puso el énfasis en la matematización de la naturaleza, centrándose sobre todo en la meditación histórica sobre la geometría. Pero en el caso de algunas ciencias sociales, como la economía, la utilización libre de construcciones idealizadoras fenomenológicamente infundadas, como en el caso del dinero, está teniendo como resultado un enorme encubrimiento de sentido del fenómeno monetario. Esto no es vivido tan solo desde la feno-menología: desde la propia teoría monetaria se reconoce que estamos faltos de una comprensión del sentido del dinero que nos ayude a clarificar y prevenir de manera suficiente las crisis financieras. Estas crisis no son fruto de que hayamos comprendido demasiado bien el concepto de dinero, sino de que todavía estamos faltos de una comprensión profunda del sentido del dinero. Aquí pretendemos ilustrar las posibilidades que el método fenomenológico ofrece, aplicado al caso del dinero. En este sentido, pueden considerarse las investigaciones que tienen lugar aquí como “crítica fenomenológica de la teoría monetaria”. (shrink)

The lockdown resulting from coronavirus disease 2019 has had a huge impact on peoples’ health. In sport specifically, athletes have had to deal with frustration of their objectives and changes in their usual training routines. The challenging and disruptive situation could hold implications for their well-being. This study examined the effect of the COVID-19 lockdown on changes in athletes’ reported eudaimonic well-being and goal motives over time. The relationship of resilience to changes in subjective vitality was also determined, and changes (...) in athletes’ goal motives were examined as potential mediators. Participants were 127 Spanish university athletes aged between 18 and 34 years. Approximately 4 months before the start of the lockdown in Spain, athletes responded to a questionnaire assessing their resilience, goal motives, and subjective vitality. Around 6 months later into the lockdown period, athletes’ goal motives and subjective vitality were assessed again. Growth modeling using hierarchical linear models revealed a significant decrease of autonomous goal motives and subjective vitality during the lockdown, but athletes did not show change over time in controlled goal motives. Path analysis, adjusting T2 measures for their corresponding T1 measures, showed that resilience significantly predicted changes in athletes’ autonomous goal motives, which then accounted for changes in subjective vitality. The indirect effect was significant. Resilience did not predict changes in athletes’ controlled goal motives. However, changes in controlled goal motives negatively predicted changes in subjective vitality during lockdown. The findings suggest negative impacts of the COVID-19 lockdown on athletes’ goal motives and eudaimonic well-being. Results also support the hypothesized mediational role of autonomous goal motives in the relationship between resilience and subjective vitality during the lockdown. As such, findings confirm the relevance of resilience to a key feature of athletes’ eudaimonic well-being and the importance of enhancing their autonomous goal striving. (shrink)

El presente artículo pretende investigar el alcance, la función y la articulación que juega la modificación de neutralidad en “Ideas I”. A través del análisis de su estructura, se llegará a la conclusión de que, en cierto sentido, la modificación de neutralidad puede suponer una temprana vía de acceso a las temáticas que años más tarde serán desarrolladas en la “Crisis de las ciencias europeas”, interpretación ya sugerida por Brainard. Se sugiere, asimismo, un aumento de la presencia de los modos (...) de la conciencia neutralizada en el quehacer matemático propio de algunas actitudes “modeli-zadoras” de algunas ciencias sociales.This article aims to investigate the scope, function and articulation of neutrality modification in "Ideen I". Through the analysis of its structure, it will come to the conclusion that, in a certain sense, the neutrality modification can be an early path to the themes that years later will be developed in the "Crisis of European Sciences", as Brainard’s interpretation suggest. It also comes up with an increase in the presence of modes of neutralized consciousness in own mathematical work of some "modeler" attitudes of some social sciences. (shrink)

En este artículo se pretende poner de manifiesto las restricciones impuestas por el Estado español a la libertad de movimiento. Una vez descritas estas restricciones en las tres primeras olas de la pandemia de la Covid-19, se reflexiona sobre los posibles excesos del gobierno aumentando su control sobre una ciudadanía preocupada y con temor hacia la pandemia. Sin embargo, existe una consecuencia inesperada en las actitudes políticas de las personas: una reducción de las preferencias hacia la democracia, a favor del (...) autoritarismo. (shrink)

En este trabajo nos ocupamos de considerar la aportación que una fenomenología del reflejo especular proporciona a la comprensión del funcionamiento de la Terapia del Espejo en el tratamiento sintomático del dolor del miembro fantasma. El desarrollo de la exposición consta de dos apartados: uno primero dedicado a una fundamentación fenomenológica general de la percepción especular, y un segundo dedicado a la explicación de la percepción de reflejos según la fenomenología de Husserl, y su posible aplicación a la explicación del (...) funcionamiento de la terapia del espejo. (shrink)

This book examines influential conceptions of sport and then analyses the interplay of challenging borderline cases with the standard definitions of sport. It is meant to inspire more thought and debate on just what sport is, how it relates to other activities and human endeavors, and what we can learn about ourselves by studying sport.

Con el presente artículo se buscará un acercamiento a la representación visual de algunas corporalidades que se problematizan a partir de su exclusión del sistema neoliberal, cuerpos que se utilizan o se desechan, como los marcados por el signo de la vejez o la prostitución, los cuales, sin embargo, la fotógrafa chilena Carla Yovane agrupa, en un gesto político de resistencia, bajo el signo de cuerpo sensible en sus series “¿A qué distancia miramos la diferencia?”, “Bar Clave 424 B” y (...) “Cuba”. Diamela Eltit, Sayak Valencia, Joan Fontcuberta, Georges Didi-Huberman y, obviamente, Le Breton, serán los autores teóricos que se ocuparán para el análisis de la propuesta. (shrink)

Este artículo busca el reconocimiento del trabajo de los educadores de adultos y sus luchas desde el fin de la dictadura hasta la actualidad para asentar las bases de la educación de adultos.Con una metodología cualitativa de corte exploratorio, basada en entrevistas en profundidad a los profesionales que estuvieron involucrados, este artículo describe los orígenes, las dificultades encontradas y los procesos llevados a cabo en la creación y reconocimiento oficial del centro de educación de adultos Joan Carles I, situado (...) en el barrio de La Mariola de Lleida, que tiene una idiosincrasia propia. (shrink)

Le présent volume rassemble les conférences prononcées dans le IIe Séminaire International de l’AEIHM (Asociación Española de Investigación de Historia de las Mujeres). Tenu en 2005, le séminaire précédent avait été centré sur l’œuvre de la théoricienne américaine Joan Scott. Celui-ci – qui a eu lieu en 2007 – a suivi le même questionnement sur l’inscription internationale des courants épistémologiques féministes en Espagne mais il a abordé l’influence particulière des théoriciennes française...

Mortensen studies dual intuitionistic logic by dualizing topos internal logic, but he did not study a sequent calculus. In this paper I present a sequent calculus for complement-topos logic, which throws some light on the problem of giving a dualization for LJ.

Standard accounts on the nature of the firm are highly dependent on explanations by Coase, coupled with inputs from agency theory and shareholder theory. This paper carries out their critique in light of personalist and common good postulates. It shows how personalist and common good principles create a framework that not only accommodates business ethics better but also affords a more compelling understanding of business as a whole.

This article discusses the debate about vaccination as a case of public scientific technological controversy. In the vaccination controversy there is a scientific question, the effectiveness of vaccines in the elimination of diseases; a question of risk assessment, possible adverse effects and the possibility that immunization causes idiopathic diseases; an ethical question, the balance of rights between the two groups and the limits of the freedom of choice of treatment; and a political issue, who must take decisions about immunization and (...) whether immunization should be mandatory. The results of the analysis of the controversy suggest that the attitudes of the anti-vaccination groups towards vaccination are largely explained by their worldview which comes majorly from New Age beliefs. This worldview causes differences in the interpretation of evidence, law, risk and science. (shrink)

Este trabajo ha sido seleccionado para la V Olimpiada de Filosofía que organiza FICUM en la modalidad de secundaria y bachillerato, para promocionar la filosofía entre los jóvenes.

En el presente artículo se tratará de reflexionar acerca del estatus ontológico del concepto de identidad personal a partir de las así denominadas propuestas «narrativistas» de los filósofos Daniel Dennett y Clément Rosset. No se pretende tanto abordar la pregunta sobre la existencia última de dicha identidad cuanto hacerse cargo de cómo se nos aparece, las similitudes que presenta el proceso de construcción identitaria con el proceso narrativo y el papel activo tanto de uno mismo como de los demás en (...) su edificación. (shrink)

En torno al libro de Hannah Arendt Los orígenes del totalitarismo se buscan explicaciones a la lógica del Estado totalitario, es decir, su modo de operar y sus consecuencias en el ámbito de la libertad, del reconocimiento y del modo de vida que los sujetos pueden esperar en tal Estado. Se encuentra que el terror que se impone logra una deshumanización de los sujetos que, al haber perdido todo lo racional, se encuentran en el territorio de lo inconcebible.