Cellular reprogramming can manipulate the identity of cells to generate the desired cell types1– 3. The use of cell intrinsic components, including oocyte cytoplasm and transcription factors, can enforce somatic cell reprogramming to pluripotent stem cells4– 7. By contrast, chemical stimulation by exposure to small molecules offers an alternative approach that can manipulate cell fate in a simple and highly controllable manner8– 10. However, human somatic cells are refractory to chemical stimulation owing to their stable epigenome2,11,12 and reduced plasticity13,14; it (...) is therefore challenging to induce human pluripotent stem cells by chemical reprogramming. Here we demonstrate, by creating an intermediate plastic state, the chemical reprogramming of human somatic cells to human chemically induced pluripotent stem cells that exhibit key features of embryonic stem cells. The whole chemical reprogramming trajectory analysis delineated the induction of the intermediate plastic state at the early stage, during which chemical-induced dedifferentiation occurred, and this process was similar to the dedifferentiation process that occurs in axolotl limb regeneration. Moreover, we identified the JNK pathway as a major barrier to chemical reprogramming, the inhibition of which was indispensable for inducing cell plasticity and a regeneration-like program by suppressing pro-inflammatory pathways. Our chemical approach provides a platform for the generation and application of human pluripotent stem cells in biomedicine. This study lays foundations for developing regenerative therapeutic strategies that use well-defined chemicals to change cell fates in humans. (shrink)

Stock price data have the characteristics of time series. At the same time, based on machine learning long short-term memory which has the advantages of analyzing relationships among time series data through its memory function, we propose a forecasting method of stock price based on CNN-LSTM. In the meanwhile, we use MLP, CNN, RNN, LSTM, CNN-RNN, and other forecasting models to predict the stock price one by one. Moreover, the forecasting results of these models are analyzed and compared. The data (...) utilized in this research concern the daily stock prices from July 1, 1991, to August 31, 2020, including 7127 trading days. In terms of historical data, we choose eight features, including opening price, highest price, lowest price, closing price, volume, turnover, ups and downs, and change. Firstly, we adopt CNN to efficiently extract features from the data, which are the items of the previous 10 days. And then, we adopt LSTM to predict the stock price with the extracted feature data. According to the experimental results, the CNN-LSTM can provide a reliable stock price forecasting with the highest prediction accuracy. This forecasting method not only provides a new research idea for stock price forecasting but also provides practical experience for scholars to study financial time series data. (shrink)

As the stock market is an important part of the national economy, more and more investors have begun to pay attention to the methods to improve the return on investment and effectively avoid certain risks. Many factors affect the trend of the stock market, and the relevant information has the nature of time series. This paper proposes a composite model CNN-BiSLSTM to predict the closing price of the stock. Bidirectional special long short-term memory improved on bidirectional long short-term memory adds (...) 1 − tanh function in the output gate which makes the model better predict the stock price. The model extracts advanced features that influence stock price through convolutional neural network, and predicts the stock closing price through BiSLSTM after the data processed by CNN. To verify the effectiveness of the model, the historical data of the Shenzhen Component Index from July 1, 1991, to October 30, 2020, are used to train and test the CNN-BiSLSTM. CNN-BiSLSTM is compared with multilayer perceptron, recurrent neural network, long short-term memory, BiLSTM, CNN-LSTM, and CNN-BiLSTM. The experimental results show that the mean absolute error, root-mean-squared error, and R-square evaluation indicators of the CNN-BiSLSTM are all optimal. Therefore, CNN-BiSLSTM can accurately predict the closing price of the Shenzhen Component Index of the next trading day, which can be used as a reference for the majority of investors to effectively avoid certain risks. (shrink)

A reciprocal relation has been identified between teacher emotion and teacher professional identity. However, the underlying mechanism explaining this complex interaction remains underexamined. Moreover, limited attention has been paid to the emotional dimension of student-teachers' development of professional identity during university coursework. To bridge this gap, the present study explores how student-teachers' emotions reciprocally interact with their professional identities, drawing data from questionnaires, reflections, and interviews with students taking courses related to language teaching in a teacher-training university. Both quantitative and (...) qualitative data delineated the intertwined trajectories of student-teachers' emotional experiences and the development of professional identity in the learning process of becoming teachers. Mainly triggered by course-related factors, student-teachers experienced a wide array of emotions, of which the polarity and intensity were determined and mediated by their goals and actions deriving from their professional identities. Those aroused emotions, in turn, signaled the developmental process of professional identity and promoted or hindered their emerging identities. This paper concludes with some implications for initial teacher education programs. (shrink)

The relationship between neuroticism and mobile phone use is a hot research topic in the academic community. The purpose of this study was to investigate the roles of self-emotional assessment and love status in the mechanism through which college students’ neuroticism influences mobile phone use.We construct a moderated mediation model, and taking 869 Chinese college students as the research object and testing the mediating role of self-emotional assessment and the moderating role of love status. The results show that: neuroticism was (...) significantly positively related to mobile phone use and significantly negatively related to self-emotional assessment; self-emotional assessment was significantly positively related to mobile phone use; self-emotional assessment had a masking effect on the relationship between neuroticism and mobile phone use; love status not only moderated the relationship between self-emotional assessment and mobile phone use but also moderated the process through which self-emotional assessment masked the effect of neuroticism on mobile phone use. Our research expands the literature on the mechanisms underlying the effects of neuroticism on mobile phone use, enriches the understanding of the pertinent boundary conditions, and provides a better explanatory basis for the mobile phone use of college students. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Remembering Lewis E. HahnGeorge C. H. Sun, President, John Howie, Professor Emeritus, Thomas Alexander, Professor and Director of Graduate Studies, Kenneth W. Stikkers, Professor and Chair, Randall Auxier, Professor, Robert Hahn, Professor, Joseph Wu, Professor Emeritus, Elizabeth R. Eames, Professor Emeritus, Martin Lu, Professor of Philosophy, George Kimball Plochmann, Professor Emeritus, Matt Sronkoski, Philosophy Graduate and Academic Adviser, Dave Clarke, Professor Emeritus, Eugenie Gatens-Robinson, Professor Emerita, Hans H. Rudnick, (...) Professor Emeritus, Stephen Bickham, Professor EmeritusPresident, and Don Mikula (bio)The following testimonials were offered on the occasion of a memorial gathering for Dr. Lewis E. Hahn held on February 19, 2005, and were compiled for presentation here by Sharon (Hahn) Crowell.A Tribute to Dr. Lewis E. Hahn (1908-2004) from a Global PerspectiveGeorge C. H. Sun President, Thomé H. Fang Institute, Inc., Mobile, AlabamaAmong the philosophical community in both the East and the West, no word of introduction is needed for our beloved Master, who was the recipient of numerous distinctions and honors, with titles that included "Man of the Year in Philosophy" and "Award of Lifetime Achievement." The very name "Lewis E. Hahn" itself already stands now for genuineness, dedication, and fulfillment.A great work is a dialogue with eternity; a great person is such a work. In less than thirty years he succeeded in developing Carbondale from what had been a small college town in the Midwest into the Mecca of American philosophy. His most important achievements were the Dewey Center and the Pepper Archives that he helped install at SIUC These, among other such institutions, will remain a unique contribution, a glory of American philosophy, and a monument in the history of human thought.For posterity Lewis E. Hahn will remain an object of wonder and amazement. How is it possible for one human being to have accomplished so much, so well, and in so short a span of time—less than one century—in breadth, depth, and diversity? Some one hundred years ago, by bridging the gap between the New World and the Old, William James was hailed as the great genius of international friendship among philosophical thinkers, but we now find a greater genius in Lewis E. Hahn, who succeeded in bringing together the peoples of East and West from at least four continents: Europe, Australia, America (both North and Latin America), and Asia. To my knowledge, few of his predecessors and contemporaries have been half so widely read and liberal-minded as he was, in view of the range and scope of the Library of Living Philosophers that he helped continue after the passing of its founder, Dr. Paul A. Schilpp.What type of man was Hahn, our younger generation will wonder? Only a pluralist approach can help us understand the true character of such a legendary pluralist-contextualist. In short, he was "a full personality." As I recall, while working on my dissertation with him in the 1970s, we had a brief discussion on Confucius, the sage of ancient China. "A full personality!" was his laconic assessment. Suddenly I realized, to quote the Analects: "The Master is talking about himself!" For, as the Buddhists put it, only a Buddha can understand a Buddha. Or, as William James put it, only one who has philosophy can appreciate philosophy. Many friends [End Page 1] of my generation admire him so much; Te Chen of Hong Kong calls him "a great Confucian in America." Those who regret the loss of many precious Confucian virtues in China today have now rediscovered them in the person of Lewis E. Hahn! If Nietzsche called Kant "a great Chinese in Königsberg," it is simply because he had not encountered our own Master.A paradigm of academic leadership, Dr. Hahn is simply irreplaceable—this is a tribute I personally heard in Carbondale in the late 1960s. It is not an exaggeration to say that he was a superb administrator, and he could have been the best Secretary of the State we ever had, for he possessed more in the way of philosophical wisdom than all his predecessors put together! As a great teacher, he was no less "serene, good, learned, wise, and ardent" than... (shrink)

***Translated a Korean-language book to English with Dr. Chang-Seong Hong*** Venerable Hyun-Eung's Enlightenment and History is the first book of Buddhist philosophy of history published in South Korea; possibly the first of its kind in the world. In this book of telling points and clear visions, Hyun-Eung discusses East Asian Buddhist traditions in light of Western-philosophical perspectives and presents his views on the theory and praxis in contemporary Buddhism in a way that Western readers can easily understand. East Asian Buddhist (...) philosophy has had little introduction to English-speaking societies compared with the philosophies of other traditions in Buddhism. This book provides penetrating insight into such major issues of East Asian Mahayana Buddhism as enlightenment, compassion, emptiness, and sudden enlightenment in the Zen traditions. Hyun-Eung s approach is creative, clear, logical, and methodologically modernized. Hyun-Eung s Buddhist philosophy of history is not a mere product of armchair philosophy. He wrote most essays in this book during the 1980 s while South Korea was undergoing serious political turmoil as it tried to overthrow a government backed by military generals. This book presents a philosophy that evolved from his contemplations on the real issues of South Korean society. Defining the ideal form of life as the life of bodhisattva in Mahayana Buddhism, Hyun-Eung summarizes the theme of this book as follows: My book Enlightenment and History is a collection of essays that interpret Buddhist doctrines under a new light. In particular, this book interprets bodhisattva as the combination of bodhi (enlightenment) and sattva (life, history), and defines the life of bodhisattva as enlightenment s becoming history and history s becoming enlightenment. This is the representative of all the new interpretations in this book. Also, I classify the issue of fact judgments on how to understand facts and phenomena as the area of bodhi (enlightenment) and the issue of value judgments on how to live life as the area of sattva (history), and thereby I make their logical differences clear. However, at the same time, I claim that harmonizing these two areas into one area of life is the model of a nice and practical life, which is the bodhisattva that Mahayana Buddhism praises. From Introduction. (shrink)

養尊處優的生活，養成有稜有角的嬌性；披著一襲刺蝟花衣的她，穿梭於人生的追尋。直到無意搭上慈濟列車，她發揮勇於承擔的力量，不但改變自己，更影響了別人。在精進蛻變的菩薩道上，她的生命如彩蝶般蛹變而璀璨，她 就是慈濟委員---紀媽咪。.

Like Machiavelli's The Prince and the Japanese Book of Five Rings, Sun Tzu's The Art of War is as timely for business people today as it was for military strategists in ancient China. Written in China more than 2,000 years ago, Sun Tzu's classic The Art of War is the first known study of the planning and conduct of military operations. These terse, aphoristic essays are unsurpassed in comprehensiveness and depth of understanding, examining not only battlefield maneuvers, but also relevant (...) economic, political, and psychological factors. Indeed, the precepts outlined by Sun Tzu regularly applied outside the realm of military theory. It is read avidly by Japanese businessmen and was touted in the movie Wall Street as the corporate raider's bible. Providing a much-needed translation of this classic, Samuel Griffith has made this powerful and unique work even more relevant to the modern world. Including an explanatory introduction and selected commentaries on the work, this edition makes Sun Tzu's strategical and tactical principles accessible not only students of Chinese history competition. (shrink)

Philip J. Ivanhoe's translation of Sun Tzu's _Art of War_ will be warmly embraced by students. His discussion in the Introduction about the text’s dating and authorship, as well as Chinese attitudes towards things military, is concise, informative, and up-to-date. The translation itself is a marvel--its language is simple and direct, making it immensely readable and clear.--Keith Knapp, is Westvaco Professor of National Security Studies, Department of History, The Citadel, The Military College of South Carolina.

1. Huai hai yi tan ; Si shu jin yu -- 2. Zuo cui ti ping -- 3. Zhuang yi yao shan -- 4. Sun Shanfu du xue wen ji ; Xue kong jing she shi gao ; Lun xia xi guan shi zhu sheng xi wen ; You xin yao cao ; Ji yi ; Sun Ying'ao bei ke ji yi.

This article argues that resolutions are reason-giving: when an agent resolves to φ, she incurs an additional normative reason to φ. I argue that the reasons we incur from making resolutions are importantly similar to the reasons we incur from making promises. My account explains why it can be rational for an agent to act on a past resolution even if temptation causes preference and even judgment shifts at the time of action, and offers a response to a common objection (...) to the normativity of resolutions known as the bootstrapping problem, on which if resolutions were reason-giving they would problematically allow us to bootstrap any action into rationality simply by resolving to perform it. (shrink)

v. 1. Tan suo zhe dao lu de tan suo -- v. 2. Lukaqi yu Makesi -- v. 3. Makesi zhu yi zhe xue ji ben wen ti yan jiu -- v. 4. Makesi zhu yi zhe xue jing dian wen xian yan jiu.

Hume begins his discussion of causation with the promise that he will explain fully the relation of cause and effect, and argues strenuously that there is no impression from which the idea of necessary connection is derived. At the end of his discussion, he summarizes his views by offering his "two definitions of cause" where he asserts that the causal relation can be nothing but the regular succession of cause and effect. This is traditionally thought to be evidence for the (...) view that Hume reduces causation to regular succession and that he denies causal realism which asserts that there are necessary connections in nature to be taken into consideration. ;There is no evidence for the claim that Hume distinguishes between what we know of causation and what causation in itself is. On the contrary, he denies the existence of an external physical world and limits reality to our ideas. It seems to be a mistake, therefore, to claim that he believes that there are necessary connections that we can never know. ;Just as there are analytical elements, there are both naturalistic and sceptical elements in his philosophy. However, the way in which these three elements are interrelated is quite different. His natural theory of belief does not concern causal realism but our causal beliefs. He never claims that we have a natural belief that there are necessary connections in nature. What he claims is that after the observation of a regular succession of cause and effect, the experience of the cause not only brings the idea of the effect into our mind but brings this idea together with an "impression of necessity". When we examine the way in which Hume characterizes this impression, we see that it plays an important role in Hume's theory of natural beliefs. It is the irresistible way in which the idea of the effect enters into our mind. It is what, Hume calls the "vivacity" or "violence" which turns a simple conception of the idea of the effect into a causal belief about the occurrence of this effect. And this is the context in which Hume introduces his scepticism. It does not consist of his belief that we lack knowledge of causation but consists of his criticism of our nature in forming such causal beliefs. (shrink)